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Blood, 1 November 2008, Vol. 112, No. 9, pp. 3582-3586. Prepublished online as a Blood First Edition Paper on June 17, 2008; DOI 10.1182/blood-2008-04-151076. This Article Full Text (PDF) All Versions of this Article: blood-2008-04-151076v1 112/9/3582    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Kristinsson, S. Y Articles by Landgren, O. Search for Related Content PubMed PubMed Citation Articles by Kristinsson, S. Y Articles by Landgren, O. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted April 11, 2008 Accepted June 7, 2008 Deep vein thrombosis following monoclonal gammopathy of undetermined significance (MGUS) and multiple myeloma Sigurdur Y Kristinsson, Thomas R Fears, Gloria Gridley, Ingemar Turesson, Ulf-Henrik Mellqvist, Magnus Bjorkholm, and Ola Landgren* Department of Medicine, Division of Hematology, Karolinska University Hospital, Stockholm, Sweden Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, MD, United States Hematology Section, Malmo University Hospital, Malmo, Sweden Department of Medicine, Section of Hematology and Coagulation, Sahlgrenska University Hospital, Gothenburg, Sweden * Corresponding author; email: landgreo{at}mail.nih.gov. Patients with multiple myeloma (MM) have an increased risk of deep venous thrombosis (DVT), particularly when treated with immunomodulatory drugs. Recently, two small hospital-based studies observed individuals with the MM precursor condition, monoclonal gammopathy of undetermined significance (MGUS), to be at increased risk of developing DVT. Among 4,196,197 veterans hospitalized at least once at U.S. Veterans Affairs hospitals, we identified a total of 2,374 MGUS and 6,192 MM patients. In the entire study population, there were 39,272 persons diagnosed with a DVT (crude incidence 0.9 per 1000 person-years). A total of 31 and 151 DVTs occurred among MGUS and MM patients, respectively (crude incidence 3.1 and 8.7 per 1000 person-years, respectively; p<0.01). Compared to the entire study population, the relative risk (RR) of DVT following a diagnosis of MGUS and MM was 3.3 (2.3-4.7) and 9.2 (7.9-10.8), respectively. The most prominent excess risk of DVT was found during the first year following diagnosis of MGUS (RR=8.4, 5.7-12.2) and MM (RR=11.6, 9.2-14.5). Among 229 MGUS cases (9.5%) that progressed to MM only one individual had a DVT diagnosis prior to transformation. Our findings suggest the operation of shared underlying mechanisms causing coagulation abnormalities among patients with MGUS and MM. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: MGUS: not so benign after all Michael J. Kovacs Blood 2008 112: 3533. [Full Text] [PDF] This article has been cited by other articles: O. Landgren, R. A. Kyle, and V. Rajkumar Response: Multiple myeloma is universally preceded by a prolonged premalignant stage: novel clinical insights and future directions Blood, September 10, 2009; 114(11): 2356 - 2357. [Full Text] [PDF]

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