Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 1 November 2008, Vol. 112, No. 9, pp. 3772-3776.
Prepublished online as a Blood First Edition Paper on August 14, 2008; DOI 10.1182/blood-2008-04-151761.

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2008-04-151761v1
112/9/3772    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Arhel, N. J
Right arrow Articles by Charneau, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Arhel, N. J
Right arrow Articles by Charneau, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted April 14, 2008
Accepted June 17, 2008

Lack of endogenous TRIM5alpha-mediated restriction in rhesus macaque dendritic cells

Nathalie J Arhel, Sebastien Nisole, Laetitia Carthagena, Frederic Coutant, Philippe Souque, Audrey Brussel, Jerome Estaquier, and Pierre Charneau*

Virology Department, Institut Pasteur, Paris, France
Department of Infectious Diseases, Institut Cochin, INSERM U567, Paris, France
Physiopathology of Lentiviral Infections, Institut Pasteur, Paris, France
INSERM U841, Faculte Creteil Henri Mondor, Creteil, France

* Corresponding author; email: charneau{at}pasteur.fr.

Rhesus macaques are resistant to infection by HIV-1 as a result of an innate cellular restriction mechanism attributable to the expression of rhTRIM5{alpha}, a member of the large tripartite motif (TRIM) protein family. TRIM5{alpha}-mediated restriction, which occurs before reverse transcription through targeting of the HIV-1 capsid, has been identified in a number of macaque primary cells and cell lines and is thought to occur in all macaque cell types. We report, however, that rhesus macaque dendritic cells (DC) lack TRIM5{alpha}-mediated restriction and are equally permissive to HIV-1 infection as human DC. Evidence suggests that although TRIM5{alpha} RNA levels are normal in these cells, the protein may be dysfunctional. We propose that abrogation of TRIM5{alpha}-mediated restriction in DC, while still operative in cells that replicate HIV-1 (macrophages, T lymphocytes), illustrates the need for innate mechanisms to not inhibit adaptive immune responses in order to ensure an optimal fight against pathogens.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 J. Virol.Home page
A.-S. Beignon, K. Mollier, C. Liard, F. Coutant, S. Munier, J. Riviere, P. Souque, and P. Charneau
Lentiviral Vector-Based Prime/Boost Vaccination against AIDS: Pilot Study Shows Protection against Simian Immunodeficiency Virus SIVmac251 Challenge in Macaques
J. Virol., November 1, 2009; 83(21): 10963 - 10974.
[Abstract] [Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020