|
|
Blood, 15 November 2008, Vol. 112, No. 10, pp. 3995-4002.
Prepublished online as a Blood First Edition Paper on August 28, 2008; DOI 10.1182/blood-2008-05-155960.
 Previous Article | Next Article 
Submitted May 13, 2008
Accepted August 8, 2008
Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection
Melissa T Bartman, Zhanna Kaidarova, Dale Hirschkorn, Ronald A. Sacher, Joy Fridey, George Garratty, Joan Gibble, James W Smith, Bruce Newman, Anthony E Yeo, and Edward L Murphy*
School of Public Health, University of California Berkeley, Berkeley, CA, United States
Blood Systems Research Institute, San Francisco, CA, United States
Hoxworth Blood Center, University of Cincinnati, Academic Health Center, Cincinnati, OH, United States
Transfusion Medicine, City of Hope National Medical Center, Duarte, CA, United States
American Red Cross Blood Services, Southern California Region, Pomona, CA, United States
American Red Cross Blood Services, Greater Chesapeake & Potomac Region, Baltimore, MD, United States
Sylvan N. Goldman Center, Oklahoma Blood Institute, Oklahoma City, OK, United States
American Red Cross Blood Services, Southeastern Michigan Region, Detroit, MI, United States
Laboratory Medicine, University of California San Francisco, San Francisco, CA, United States
* Corresponding author; email: murphy{at}ucsf.edu.
Human T-lymphotropic viruses types I and II (HTLV-I and HTLV-II) cause chronic infections of T-lymphocytes that may lead to leukemia and myelopathy. However, their long-term effects on blood counts and hematopoiesis are poorly understood. We followed 151 HTLV-I-seropositive, 387 HTLV-II-seropositive, and 799 HTLV-seronegative former blood donors from five US blood centers for a median of 14.0 years. Complete blood counts were performed every two years. Multivariable repeated measures analyses were conducted to evaluate the independent effect of HTLV infection and potential confounders on nine hematologic measurements. HTLV-II subjects had significant (P<0.05) increases in their adjusted lymphocyte counts (+126 cells/mm3; approx +7%), hemoglobin (+0.2 gm/dL) and mean corpuscular volume (1.0 fL) compared to seronegative subjects. Both HTLV-I and -II subjects had higher adjusted platelet counts (+16,544 and +21,657 cells/mm3; p<0.05) than seronegatives. Among all subjects, time led to decreases in platelet count and lymphocyte counts, and to increases in MCV and monocytes. Sex, race, smoking and alcohol consumption all had significant effects on blood counts. The HTLV-II effect on lymphocytes is novel and may be related to viral transactivation or immune response. HTLV-I and -II associations with higher platelet counts suggest viral effects on hematopoietic growth factors or cytokines.
 CiteULike  Connotea  Del.icio.us  Digg  Reddit  Technorati What's this?
Related Article in Blood Online:
-
Hematologic hints of HTLV-2 in US blood donors
- Mark A. Beilke
Blood 2008 112: 3919-3920.
[Full Text]
[PDF]
This article has been cited by other articles:
|
|
|
|
 
M. Halin, E. Douceron, I. Clerc, C. Journo, N. L. Ko, S. Landry, E. L. Murphy, A. Gessain, I. Lemasson, J.-M. Mesnard, et al.
Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription
Blood,
September 17, 2009;
114(12):
2427 - 2438.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
G. Besson and M. Kazanji
One-Step, Multiplex, Real-Time PCR Assay with Molecular Beacon Probes for Simultaneous Detection, Differentiation, and Quantification of Human T-Cell Leukemia Virus Types 1, 2, and 3
J. Clin. Microbiol.,
April 1, 2009;
47(4):
1129 - 1135.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
