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Blood, 1 October 2008, Vol. 112, No. 7, pp. 2675-2680. Prepublished online as a Blood First Edition Paper on July 9, 2008; DOI 10.1182/blood-2008-05-157412. This Article Full Text (PDF) All Versions of this Article: blood-2008-05-157412v1 112/7/2675    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Chamberlain, A. M Articles by Cushman, M. Search for Related Content PubMed PubMed Citation Articles by Chamberlain, A. M Articles by Cushman, M. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 15, 2008 Accepted June 23, 2008 High-Density Lipoprotein Cholesterol and Venous Thromboembolism in the Longitudinal Investigation of Thromboembolism Etiology (LITE) Alanna M Chamberlain, Aaron R Folsom*, Susan R Heckbert, Wayne D Rosamond, and Mary Cushman Division of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN, United States Department of Epidemiology, Cardiovascular Health Research Unit, University of Washington, Seattle, WA, United States Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States Department of Medicine, Division of Hematology/Oncology, University of Vermont, Burlington, VT, United States * Corresponding author; email: folso001{at}umn.edu. We determined prospectively the risk of VTE in relation to baseline HDL-c in 19,049 participants of the Longitudinal Investigation of Thromboembolism Etiology (LITE), which was comprised of 14,490 participants of the Atherosclerosis Risk in Communities (ARIC) study and 4,559 participants of the Cardiovascular Health Study (CHS). Additionally, we determined the risk of VTE in relation to baseline subfractions of HDL (HDL2 and HDL3) and apolipoprotein A-I (apoA-I) in 14,488 participants of the ARIC study. Age-adjusted incidence rates of VTE by HDL-c quartile ranged from 1.64 to 1.91 per 1000 person-years in men and 1.40 to 1.94 per 1000 person-years in women; however, there was no apparent trend of VTE incidence across HDL-c quartiles for either sex. The multivariate adjusted hazard ratios of VTE by HDL-c quartiles (with quartile 4 as the referent group) were nonsignificant for both genders and ranged between 0.91 and 0.99 for men and 0.78 and 1.22 for women. Results did not differ in separate evaluations of idiopathic and secondary VTE. In the ARIC study, there was no trend of VTE hazard ratios across quartiles of HDL2, HDL3, or apoA-I. Low HDL-c does not appear to be an important VTE risk factor. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: R. J. Glynn, E. Danielson, F. A.H. Fonseca, J. Genest, A. M. Gotto Jr., J. J.P. Kastelein, W. Koenig, P. Libby, A. J. Lorenzatti, J. G. MacFadyen, et al. A Randomized Trial of Rosuvastatin in the Prevention of Venous Thromboembolism N. Engl. J. Med., April 30, 2009; 360(18): 1851 - 1861. [Abstract] [Full Text] [PDF]

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