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Blood, 15 November 2008, Vol. 112, No. 10, pp. 4247-4249. Prepublished online as a Blood First Edition Paper on August 18, 2008; DOI 10.1182/blood-2008-05-157974. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-05-157974v1 112/10/4247    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lan, Q. Articles by Rothman, N. Search for Related Content PubMed PubMed Citation Articles by Lan, Q. Articles by Rothman, N. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 22, 2008 Accepted July 30, 2008 A prospective study of mitochondrial DNA copy number and risk of non-Hodgkin lymphoma Qing Lan*, Unhee Lim, Chin-San Liu, Stephanie J. Weinstein, Stephen Chanock, Matthew R Bonner, Jarmo Virtamo, Demetrius Albanes, and Nathaniel Rothman Division of Cancer Epidemiology & Genetics, National Cancer Institute, Rockville, MD, United States Epidemiology Program, Cancer Research Center of Hawaii, Honolulu, HI, United States Department of Neurology and Vascular and Genomic Research Center, Changhua Christian Hospital, Changhua, Taiwan Department of Social and Preventive Medicine, University at Buffalo the State University of New York, Buffalo, NY, United States Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, Finland * Corresponding author; email: qingl{at}mail.nih.gov. Mitochondrial DNA (mtDNA) copy number is increased in chronic lymphocytic leukemia (CLL) patients, in Burkitt lymphoma and Epstein Barr virus-transformed lymphoblastoid cell lines, and in T-cells activated via the T-cell receptor. We hypothesized that having a higher mtDNA copy number in peripheral white blood cell DNA from healthy subjects would be associated with future risk of non-Hodgkin lymphoma (NHL). We analyzed mtDNA copy number in 104 incident male NHL cases and 104 matched controls within the prospective Alpha Tocopherol, Beta-Carotene (ATBC) Cancer Prevention cohort. There was a dose-response relationship between tertiles of mtDNA copy number and risk of NHL [Odds Ratios (OR), 95% Confidence Interval (CI): 1.0; 1.4 (0.7-2.8); and 2.4 (1.0-5.5), respectively; ptrend=0.046]. The effect was most pronounced for the CLL/small lymphocytic lymphoma (SLL) subtype [OR: 1.0; 3.2 (0.7-15.7); 14.1 (1.9-103.2); ptrend=0.009]. These results suggest that mtDNA copy number could be associated with the risk of NHL, particularly CLL/SLL. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: Q. Lan, L. M. Morton, B. Armstrong, P. Hartge, I. Menashe, T. Zheng, M. P. Purdue, J. R. Cerhan, Y. Zhang, A. Grulich, et al. Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of 3 population-based case-control studies Blood, July 9, 2009; 114(2): 264 - 267. [Abstract] [Full Text] [PDF]

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