SEARCH:   Advanced

Blood, 19 February 2009, Vol. 113, No. 8, pp. 1639-1650. Prepublished online as a Blood First Edition Paper on October 10, 2008; DOI 10.1182/blood-2008-05-159665. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-05-159665v1 113/8/1639    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Iwanaga, M. Articles by Tomonaga, M. Search for Related Content PubMed PubMed Citation Articles by Iwanaga, M. Articles by Tomonaga, M. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted May 27, 2008 Accepted September 19, 2008 Relationship between monoclonal gammopathy of undetermined significance and radiation exposure in Nagasaki atomic bomb survivors Masako Iwanaga*, Masuko Tagawa, Kunihiro Tsukasaki, Tatsuki Matsuo, Ken-ichi Yokota, Yasushi Miyazaki, Takuya Fukushima, Tomoko Hata, Yoshitaka Imaizumi, Daisuke Imanishi, Jun Taguchi, Sabro Momita, Shimeru Kamihira, and Masao Tomonaga Department of Hematology and Molecular Medicine, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan Department of Internal Medicine, Nagasaki Atomic Bomb Casualty Council Health Management Center, Nagasaki, Japan Biostatistics Section, Division of Scientific Data Registry, Atomic Bomb Disease Institute, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan Department of Laboratory Medicine,, Nagasaki University Graduate School of Biomedical Science, Nagasaki, Japan * Corresponding author; email: masakoiw{at}nagasaki-u.ac.jp. Radiation exposure is a possible predisposing factor for monoclonal gammopathy of undetermined significance (MGUS), but the association has been uncertain. We investigated the relationship between radiation exposure and MGUS prevalence by using data from the M-protein screening for Nagasaki atomic bomb survivors during 1988-2004. Radiation exposure was assessed by exposure distance from the hypocenter and exposure radiation dose. We computed prevalence ratios (PRs) and the 95% confidence intervals (CIs) adjusting for exposure age and sex. A total of 1082 MGUS were identified from 52525 participants. MGUS prevalence was significantly higher in people exposed at distance within 1.5 km than beyond 3.0 km (PR, 1.4; 95%CI, 1.1-1.9) among those exposed at ages 20 years or younger, but it was not found among those exposed at ages 20 years or older. MGUS prevalence was also significantly higher in people exposed to more than 0.1Gy than those exposed to less than 0.01Gy (PR, 1.7; 95%CI, 1.0-2.8) among those exposed at ages 20 years or younger. Thus, people exposed at younger age exhibited significantly high risk of MGUS when exposed to high radiation dose. There was no clear association between radiation exposure and the malignant progression of MGUS. Further detailed analysis is needed. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: A role for ionizing radiation in myelomagenesis? Ola Landgren Blood 2009 113: 1616-1617. [Full Text] [PDF] This article has been cited by other articles: O. Landgren A role for ionizing radiation in myelomagenesis? Blood, February 19, 2009; 113(8): 1616 - 1617. [Full Text] [PDF]

	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020