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Blood, 15 October 2008, Vol. 112, No. 8, pp. 3057-3064.
Prepublished online as a Blood First Edition Paper on August 1, 2008; DOI 10.1182/blood-2008-05-160176.
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Submitted May 30, 2008
Accepted July 25, 2008
Clinical features and treatment outcome of nasal-type NK/T cell lymphoma of Waldeyer's ring
Ye-Xiong Li*, Hui Fang, Qing-Feng Liu, Jiade Lu, Shu-Nan Qi, Hua Wang, Jing Jin, Wei-Hu Wang, Yue-Ping Liu, Yong-Wen Song, Shu-Lian Wang, Xin-Fan Liu, Xiao-Li Feng, and Zi-Hao Yu
Department of Radiation Oncology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Department of Radiation Oncology, National University Hospital of Singapore, Singapore, Singapore
Department of Pathology, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
* Corresponding author; email: yexiong{at}yahoo.com.
The clinical characteristics and prognosis remain unclear for nasal-type NK/T-cell lymphoma of Waldeyer's ring (WR-NKTL). The aim of this study is to determine the clinical features and outcome. Ninety-one patients with WR-NKTL were reviewed. According to Ann Arbor system, 15, 56, 12, and 8 patients had stage I, II, III, and IV. Of patients with stage I and II, 54 received combined chemotherapy and radiotherapy (CMT), 13 received radiotherapy alone, and 4 patients received chemotherapy alone. All 20 patients with stage III/IV received primary chemotherapy. The disease is characterized by predominant young males, good performance, a propensity for nodal involvement, frequent stage II-IV diseases, low frequency of elevated LDH, low-risk international prognostic index (IPI), high sensitivity to radiotherapy, and intermediate sensitivity to chemotherapy. The 5-year overall survival and progression-free survival for all patients were 65% and 51%, respectively. The age, B symptoms, stage, and IPI were important prognostic factors. CMT tended to improve the survival compared with radiotherapy alone for patients with stage I and II diseases. Both nodal involvement and distant extranodal dissemination were the primary failure patterns. WR-NKTL appears to have distinct clinical characteristics and favorable outcomes.
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