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Blood, 29 January 2009, Vol. 113, No. 5, pp. 1184-1191. Prepublished online as a Blood First Edition Paper on October 16, 2008; DOI 10.1182/blood-2008-06-162180. This Article Full Text (PDF) Supplemental Methods and Figures All Versions of this Article: blood-2008-06-162180v1 113/5/1184    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Pramanik, K. Articles by Ramchandran, R. Search for Related Content PubMed PubMed Citation Articles by Pramanik, K. Articles by Ramchandran, R. Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 9, 2008 Accepted September 23, 2008 Dusp-5 and Snrk-1 coordinately function during vascular development and disease Kallal Pramanik, Chang Zoon Chun, Maija K Garnaas, Ganesh V Samant, Keguo Li, Mark A Horswill, Paula E North, and Ramani Ramchandran* Department of Pediatrics, CRI Developmental Vascular Biology Program, Medical College of Wisconsin, Milwaukee, WI, United States Department of Pediatric Pathology, Translational and Biomedical Research Center, Medical College of Wisconsin, Milwaukee, WI, United States * Corresponding author; email: rramchan{at}mcw.edu. Mitogen-activated protein kinases (MAPKs) play an integral role in several cellular processes. To regulate MAPKs, cells express members of a counteracting group of proteins called phosphatases. In this study, we have identified a specific role that one member of this family of phosphatases, dual specific phosphatase-5 (Dusp-5) plays in vascular development in vivo. We have determined that dusp-5 is expressed in angioblasts and in established vasculature and that it counteracts the function of a serine threonine kinase, Snrk-1, which also plays a functional role in angioblast development. Together, Dusp-5 and Snrk-1 control angioblast populations in the lateral plate mesoderm with Dusp-5 functioning downstream of Snrk-1. Importantly, mutations in dusp-5 and snrk-1 have been identified in affected tissues of patients with vascular anomalies, implicating the Snrk-1-Dusp-5 signaling pathway in human disease. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: The hunting of the Snrk Jack L. Arbiser and Levi Fried Blood 2009 113: 983-984. [Full Text] [PDF] This article has been cited by other articles: C. Z. Chun, S. Kaur, G. V. Samant, L. Wang, K. Pramanik, M. K. Garnaas, K. Li, L. Field, D. Mukhopadhyay, and R. Ramchandran Snrk-1 is involved in multiple steps of angioblast development and acts via notch signaling pathway in artery-vein specification in vertebrates Blood, January 29, 2009; 113(5): 1192 - 1199. [Abstract] [Full Text] [PDF]

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