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Blood, 1 December 2008, Vol. 112, No. 12, pp. 4598-4608. Prepublished online as a Blood First Edition Paper on September 11, 2008; DOI 10.1182/blood-2008-06-162651. This Article Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2008-06-162651v1 112/12/4598    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Malleret, B. Articles by Vaslin, B. Search for Related Content PubMed PubMed Citation Articles by Malleret, B. Articles by Vaslin, B. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 13, 2008 Accepted August 5, 2008 Primary infection with simian immunodeficiency virus: plasmacytoid dendritic cell homing to lymph nodes, type I IFN, and immune suppression Benoit Malleret, Benjamin Maneglier, Ingrid Karlsson, Pierre Lebon, Michelina Nascimbeni, Leila Perie, Patricia Brochard, Benoit Delache, Julien Calvo, Thibault Andrieu, Odile Spreux-Varoquaux, Anne Hosmalin, Roger Le Grand, and Bruno Vaslin* Institute of Emerging Diseases and Innovative Therapies (IMETI), Division of Immuno-Virology (SIV), CEA, Fontenay-aux-Roses, France Pharmacologie, Universite Versailles-Saint Quentin, Suresnes, France Universite Paris-Sud, UMR-E01, Orsay, France Service de Virologie, Hopital Cochin-Saint-Vincent-de-Paul, Paris, France Universite Paris Descartes, CNRS (UMR8104), Institut Cochin, Paris, France INSERM U567, Paris, France Service de Biologie, Centre Hospitalier de Versailles, Le Chesnay, French Southern Territories * Corresponding author; email: bruno.vaslin{at}cea.fr. Plasmacytoid dendritic cells (pDC) are antigen-presenting cells which develop into type-I interferon (IFN-I)-producing cells in response to pathogens. Their role in HIV pathogenesis needs to be understood. We analyzed their dynamics in relation with innate and adaptive immunity very early during the acute phase of simian immunodeficiency virus (SIV) infection in 18 macaques. PDC counts decreased in blood and increased in peripheral lymph nodes, consistent with early recruitment in secondary lymphoid tissues. These changes correlated with the kinetic and intensity of viremia and were associated with a peak of plasma IFN-I. IFN-I and viremia were positively correlated with functional activity of the immune suppression associated enzyme IDO and FoxP3+CD8+ T cells, which both negatively correlated with SIV-specific T-cell proliferation and CD4+ T-cell activation. These data suggest that pDC and IFN-I play a key role in shaping innate and adaptive immunity towards suppressive pathways during the acute phase of SIV/HIV primary infection. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G. Stary, I. Klein, S. Kohlhofer, F. Koszik, T. Scherzer, L. Mullauer, H. Quendler, N. Kohrgruber, and G. Stingl Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients Blood, October 29, 2009; 114(18): 3854 - 3863. [Abstract] [Full Text] [PDF] E. Billerbeck, N. Nakamoto, B. Seigel, H. E. Blum, K.-M. Chang, and R. Thimme Determinants of in vitro expansion of different human virus-specific FoxP3+ regulatory CD8+ T cells in chronic hepatitis C virus infection J. Gen. Virol., July 1, 2009; 90(7): 1692 - 1701. [Abstract] [Full Text] [PDF] M. Nascimbeni, L. Perie, L. Chorro, S. Diocou, L. Kreitmann, S. Louis, L. Garderet, B. Fabiani, A. Berger, J. Schmitz, et al. Plasmacytoid dendritic cells accumulate in spleens from chronically HIV-infected patients but barely participate in interferon-{alpha} expression Blood, June 11, 2009; 113(24): 6112 - 6119. [Abstract] [Full Text] [PDF]

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