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 Blood, 15 January 2009, Vol. 113, No. 3, pp. 563-566.
Prepublished online as a Blood First Edition Paper on October 28, 2008; DOI 10.1182/blood-2008-06-162750.

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Submitted June 12, 2008
Accepted October 7, 2008

Both primitive and definitive blood cells are derived from Flk-1+ mesoderm

Jesse J Lugus, Changwon Park, Yunglin D. Ma, and Kyunghee Choi*

Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, United States
Developmental Biology Program, Washington University School of Medicine, St. Louis, MO, United States
Molecular Cell Biology Program, Washington University School of Medicine, St. Louis, MO, United States

* Corresponding author; email: kchoi{at}wustl.edu.

Emerging evidence suggests that all hematopoietic and endothelial cells originate from Flk-1+ mesoderm in the mouse. However, this concept has not been completely proven, especially for the origin of blood cells. Utilizing either Flk1+/Cre;Rosa26R-EYFP or Flk1+/Cre;Rosa26R-LacZ mice, we permanently marked Flk-1+ cells and their progenies to determine the relationship between hematopoietic tissues and cells that express Flk-1. In embryos, all blood cells within the yolk sac and aorta were of Flk-1+ origin. Additionally, nearly all CD45+ cells in bone marrow and circulating blood in adults were of Flk-1+ origin. These results provide clear evidence that all blood cells, primitive and definitive, in mice are derived from Flk-1+ mesodermal cells.


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