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Blood, 19 March 2009, Vol. 113, No. 12, pp. 2629-2636. Prepublished online as a Blood First Edition Paper on December 15, 2008; DOI 10.1182/blood-2008-06-164806. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-06-164806v1 113/12/2629    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Asano, N. Articles by Nakamura, S. Search for Related Content PubMed PubMed Citation Articles by Asano, N. Articles by Nakamura, S. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted June 23, 2008 Accepted November 14, 2008 Age-related EBV-associated B-cell lymphoproliferative disorders: comparison with EBV-positive classical Hodgkin lymphoma in elderly patients Naoko Asano*, Kazuhito Yamamoto, Jun-Ichi Tamaru, Takashi Oyama, Fumihiro Ishida, Koichi Ohshima, Tadashi Yoshino, Naoya Nakamura, Shigeo Mori, Osamu Yoshie, Yoshie Shimoyama, Yasuo Morishima, Tomohiro Kinoshita, and Shigeo Nakamura Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan Department of Hematology and Cell Therapy, Aichi Cancer Center, Nagoya, Japan Department of Pathology, Saitama Medical Center, Saitama Medical School, Kawagoe, Japan Department of Hematology, Nagoya 2nd Red Cross Hospital, Nagoya, Japan Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan Department of Pathology, School of Medicine, Kurume University, Kurume, Japan Department of Pathology, Okayama University Graduate School of Medicine and Dentistry, Okayama, Japan Department of Pathology, Tokai University School of Medicine, Kanagawa, Japan Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan Department of Microbiology, Kinki University School of Medicine, Osaka, Japan Department of Hematology, Nagoya University School of Medicine, Nagoya, Japan * Corresponding author; email: naasano{at}shinshu-u.ac.jp. Age-related Epstein-Barr virus-associated B-cell lymphoproliferative disorder (aEBVLPD) is a disease group characterized by EBV-associated large B-cell lymphoma in elderly adults without predisposing immunodeficiency. In nearly one-third of cases, aEBVLPD occurs as a polymorphous subtype with reactive cell-rich components, bearing a morphological similarity to classical Hodgkin lymphoma (cHL). The aim of this study was to clarify clinicopathological differences between the polymorphic subtype of aEBVLPD (n=34) and EBV+cHL (n=108) in patients aged 50 years or older. Results showed that aEBVLPD was more closely associated with aggressive clinical parameters than cHL, with a higher age at onset (71 vs. 63 years); lower male predominance (male:female ratio, 1.4 vs. 3.3); and a higher rate of involvement of the skin (18% vs. 2%), gastrointestinal tract (15% vs. 4%) and lung (12% vs. 2%). aEBVLPD was further histopathologically characterized by a higher ratio of geographical necrosis, greater increase (>30%) in cytotoxic T cells among background lymphocytes, higher positivity for CD20 and EBNA2, and absence of CD15 expression. As predicted by the clinical profile, aEBVLPD had a significantly poorer prognosis than EBV+cHL (P<0.0001). The polymorphous subtype of aEBVLPD constitutes an aggressive group with an immune response distinct from EBV+cHL, and requires the development of innovative therapeutic strategies. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. I. Cohen, H. Kimura, S. Nakamura, Y.-H. Ko, and E. S. Jaffe Epstein-Barr virus-associated lymphoproliferative disease in non-immunocompromised hosts: a status report and summary of an international meeting, 8-9 September 2008 Ann. Onc., September 1, 2009; 20(9): 1472 - 1482. [Abstract] [Full Text] [PDF]

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