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Blood, 22 January 2009, Vol. 113, No. 4, pp. 887-892. Prepublished online as a Blood First Edition Paper on October 10, 2008; DOI 10.1182/blood-2008-07-167064. This Article Full Text (PDF) Supplemental Figures All Versions of this Article: blood-2008-07-167064v1 113/4/887    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Fabriek, B. O. Articles by van den Berg, T. K. Search for Related Content PubMed PubMed Citation Articles by Fabriek, B. O. Articles by van den Berg, T. K. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 14, 2008 Accepted September 16, 2008 The macrophage scavenger receptor CD163 functions as an innate immune sensor for bacteria Babs O. Fabriek, Robin van Bruggen, Dong Mei Deng, Antoon J.M. Ligtenberg, Kamran Nazmi, Karin Schornagel, Rianka P.M. Vloet, Christine D. Dijkstra, and Timo K. van den Berg* Department of Molecular Cell Biology and Immunology, VU medical center, Amsterdam, Netherlands Sanquin Research and Landsteiner Laboratory, Academic Medical Center, Amsterdam, Netherlands Department of Cariology Endodontology Pedodontology, Academic Centre for Dentistry, Amsterdam, Netherlands Department of Dental Basic Sciences, Academic Centre for Dentistry, Amsterdam, Netherlands * Corresponding author; email: t.k.vandenberg{at}sanquin.nl. The plasma membrane glycoprotein receptor CD163 is a member of the scavenger receptor cystein-rich (SRCR) superfamily class B that is highly expressed on resident tissue macrophages in vivo. Previously, the molecule has been shown to act as a receptor for hemoglobin-haptoglobin complexes and to mediate cell-cell interactions between macrophages and developing erythroblasts in erythroblastic islands. Here, we provide evidence for a potential role for CD163 in host defense. In particular, we demonstrate that CD163 can function as a macrophage receptor for bacteria. CD163 was shown to bind both gram-positive and gram-negative bacteria, and a previously identified cell-binding motif in the second scavenger domain of CD163 was sufficient to mediate this binding. Expression of CD163 in monocytic cells promoted bacteria-induced pro-inflammatory cytokine production. Finally, newly generated antagonistic antibodies against CD163 were able to potently inhibit cytokine production elicited by bacteria in freshly isolated human monocytes. These findings identify CD163 as a macrophage receptor for bacteria and suggest that, during bacterial infection, CD163 on resident tissue macrophages acts as an innate immune sensor and inducer of local inflammation. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: G E Boeckxstaens and W J de Jonge Neuroimmune mechanisms in postoperative ileus Gut, September 1, 2009; 58(9): 1300 - 1311. [Abstract] [Full Text] [PDF]

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