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Blood, 2 April 2009, Vol. 113, No. 14, pp. 3209-3217. Prepublished online as a Blood First Edition Paper on December 19, 2008; DOI 10.1182/blood-2008-07-167601. This Article Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2008-07-167601v1 113/14/3209    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lecuroux, C. Articles by Venet, A. Search for Related Content PubMed PubMed Citation Articles by Lecuroux, C. Articles by Venet, A. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 10, 2008 Accepted December 11, 2008 Identification of a particular HIV-specific CD8+ T cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection Camille Lecuroux*, Isabelle Girault, Alejandra Urrutia, Jean-Marc Doisne, Christiane Deveau, Cecile Goujard, Laurence Meyer, Martine Sinet, and Alain Venet Universite Paris-Sud, Hopital du Kremlin-Bicetre, INSERM U802, Le Kremlin-Bicetre, France Universite Rene Descartes, Hopital Cochin/Saint Vincent de Paul, INSERM U561, Paris, France Universite Paris-Sud, Hopital du Kremlin-Bicetre, INSERM U822, Le Kremlin-Bicetre, France * Corresponding author; email: camille.lecuroux{at}u-psud.fr. CD8+ T cells play an important role in controlling viral infections. Defective CD8+ T cell responses during HIV infection could contribute to viral persistence. Early initiation of highly active antiretroviral therapy (HAART) during acute primary HIV infection (PHI) helps to preserve HIV-specific immune responses. Here, we describe a particular CD27+ CD45RO-/RA+ HIV-specific CD8+ T cell in subjects treated early during the primary infection. These cells, which were present at a very low frequency during PHI, increased markedly after early treatment, while their frequency remained unchanged in untreated subjects and in subjects treated later. These non-naive antigen-experienced cells are in a resting state and have characteristics of long-lived memory cells. They also possess direct effector capabilities such as cytokine production, and are able to proliferate and to acquire cytotoxic functions on reactivation. Our results suggest that these HIV-specific CD27+ CD45RO-/RA+ CD8+ T cells, observed when early viral replication is inhibited, form a pool of resting cells with memory characteristics. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. Saez-Cirion, M. Sinet, S. Y. Shin, A. Urrutia, P. Versmisse, C. Lacabaratz, F. Boufassa, V. Avettand-Fenoel, C. Rouzioux, J.-F. Delfraissy, et al. Heterogeneity in HIV Suppression by CD8 T Cells from HIV Controllers: Association with Gag-Specific CD8 T Cell Responses J. Immunol., June 15, 2009; 182(12): 7828 - 7837. [Abstract] [Full Text] [PDF]

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