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 Blood, 2 April 2009, Vol. 113, No. 14, pp. 3172-3181.
Prepublished online as a Blood First Edition Paper on January 30, 2009; DOI 10.1182/blood-2008-07-170035.

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Submitted July 23, 2008
Accepted January 16, 2009

Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis

Frederic Pendino*, Eric Nguyen, Inge Jonassen, Bjarte Dysvik, Abdulkader Azouz, Michel Lanotte, Evelyne Segal-Bendirdjian, and Johan R. Lillehaug

Department of Molecular Biology, University of Bergen, Bergen, Norway
Inserm U685, Hopital Saint-Louis, Institut Universitaire d'Hematologie, Paris, France
Bergen Center for Computational Science, Bergen, Norway

* Corresponding author; email: frederic.pendino{at}inserm.fr.

Retinoids triggers differentiation of acute promyelocytic leukemia (APL) blasts by transcriptional regulation of myeloid regulatory genes. By using a microarray approach, we have identified a novel retinoid-responsive gene (CXXC5) encoding a nuclear factor (Retinoid-Inducible Nuclear Factor, RINF) that contains a CXXC-type zinc finger motif. RINF expression correlates with retinoid-induced differentiation of leukemic cells, and with cytokine-induced myelopoiesis of normal CD34+ progenitors. Furthermore, shRNA-interference suggests for this gene a regulatory function in both normal and tumoral myelopoiesis. Interestingly, RINF localizes to 5q31.3, a small region often deleted in myeloid leukemia (AML/MDS) and suspected to harbor one or several tumor suppressor gene.


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