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Blood, 15 January 2009, Vol. 113, No. 3, pp. 726-732. Prepublished online as a Blood First Edition Paper on October 22, 2008; DOI 10.1182/blood-2008-07-171926. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2008-07-171926v1 113/3/726    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Cooley, S. Articles by Weisdorf, D. J Search for Related Content PubMed PubMed Citation Articles by Cooley, S. Articles by Weisdorf, D. J Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted July 30, 2008 Accepted October 4, 2008 Donors with group B KIR haplotypes improve relapse-free survival after unrelated hematopoietic cell transplantation for acute myelogenous leukemia Sarah Cooley*, Elizabeth Trachtenberg, Tracy L Bergemann, Koy Saeteurn, John Klein, Chap T Le, Steven G E Marsh, Lisbeth A Guethlein, Peter Parham, Jeffrey S Miller, and Daniel J Weisdorf University of Minnesota, Minneapolis, MN, United States Immunogenetics, Children's Hospital and Research Center, Oakland, CA, United States Biostatistics, Medical College of Wisconsin, Milwaukee, WI, United States Immunogenetics, Anthony Nolan Research Institute, London, United Kingdom Immunogenetics, Stanford University, Stanford, CA, United States * Corresponding author; email: cool0023{at}umn.edu. Survival for patients with Acute Myeloid Leukemia (AML) is limited by treatment-related mortality (TRM) and relapse after unrelated donor (URD) hematopoietic cell transplantation (HCT). Natural killer (NK) cell alloreactivity, determined by donor killer-cell immunoglobulin-like receptors (KIR) and recipient HLA, correlates with successful HCT for AML. Hypothesizing that donor KIR genotype (A/A: two A KIR haplotypes; B/x: at least one B haplotype) would affect outcomes, we genotyped donors and recipients from 209 HLA-matched and 239 mismatched T-replete URD transplantations for AML. Three year overall survival was significantly higher after transplantation from a KIR B/x donor (31% [95% CI: 26-36] vs. 20% [95% CI: 13-27]; p = 0.007). Multivariate analysis demonstrated a 30% improvement in the relative risk of relapse-free survival with B/x donors compared to A/A donors (RR 0.70 [95% CI 0.55-0.88]; p=.002). B/x donors were associated with a higher incidence of chronic GVHD (RR 1.51 [95% CI 1.01-2.18]; p=.03), but not of acute GVHD, relapse or TRM. This analysis demonstrates that unrelated donors with KIR B haplotypes confer significant survival benefit to patients receiving T-replete HCT for AML. KIR genotyping of prospective donors, in addition to HLA typing, should be performed to identify HLA-matched donors with B KIR haplotypes. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: J. M. Venstrom, J. Zheng, N. Noor, K. E. Danis, A. W. Yeh, I. Y. Cheung, B. Dupont, R. J. O'Reilly, N.-K. V. Cheung, and K. C. Hsu KIR and HLA Genotypes Are Associated with Disease Progression and Survival following Autologous Hematopoietic Stem Cell Transplantation for High-Risk Neuroblastoma Clin. Cancer Res., December 1, 2009; 15(23): 7330 - 7334. [Abstract] [Full Text] [PDF]

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