SEARCH:   Advanced

Blood, 5 February 2009, Vol. 113, No. 6, pp. 1225-1230. Prepublished online as a Blood First Edition Paper on October 22, 2008; DOI 10.1182/blood-2008-08-174128. This Article Full Text (PDF) All Versions of this Article: blood-2008-08-174128v1 113/6/1225    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lijfering, W. M. Articles by van der Meer, J. Search for Related Content PubMed PubMed Citation Articles by Lijfering, W. M. Articles by van der Meer, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 12, 2008 Accepted October 8, 2008 Clinical relevance of decreased free protein S levels. Results from a retrospective family cohort study involving 1143 relatives Willem M. Lijfering*, Rene Mulder, Min Ki ten Kate, Nic J.G.M. Veeger, Andre B. Mulder, and Jan van der Meer Division of Haemostasis, Thrombosis and Rheology, Department of Hematology, University Medical Center Groningen, Groningen, Netherlands Department of Epidemiology, University Medical Center Groningen, Groningen, Netherlands * Corresponding author; email: w.lijfering{at}int.umcg.nl. Conflicting data have been reported on the risk for venous thrombosis in subjects with low free protein S levels. We performed a post-hoc analysis in a single-center retrospective thrombophilic family cohort, to define the optimal free protein S level that can identify subjects at risk for venous thrombosis. 1143 relatives were analyzed. Relatives with venous thrombosis (mean age 39 years) had lower free protein S levels than relatives without venous thrombosis (P< 0.001), which was most pronounced in the lowest quartile. Only relatives with free protein S levels < 5th percentile (< 41 IU/dL) or < 2.5th percentile (< 33 IU/dL) were at higher risk of first venous thrombosis compared to the upper quartile (> 91 IU/dL); annual incidence 1.20% (95% confidence interval [CI], 0.72-1.87) and 1.81% (95% CI, 1.01-2.99), respectively; adjusted hazard ratios 5.6, (95% CI, 2.7-11.5) and 11.3 (95% CI, 5.4-23.6). Recurrence rates were 12.12% (95 CI, 5.23-23.88) and 12.73% (95% CI, 5.12-26.22) per year; adjusted hazard ratios 3.0 (95% CI, 1.03-8.5) and 3.4 (95% CI, 1.1-10.3). In conclusion, free protein S level can identify young subjects at risk for venous thrombosis in thrombophilic families, although the cut-off level lies far below the normal range in healthy volunteers. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: M. Makris Thrombophilia: grading the risk Blood, May 21, 2009; 113(21): 5038 - 5039. [Full Text] [PDF] W. M. Lijfering, J.-L. P. Brouwer, N. J. G. M. Veeger, I. Bank, M. Coppens, S. Middeldorp, K. Hamulyak, M. H. Prins, H. R. Buller, and J. van der Meer Selective testing for thrombophilia in patients with first venous thrombosis: results from a retrospective family cohort study on absolute thrombotic risk for currently known thrombophilic defects in 2479 relatives Blood, May 21, 2009; 113(21): 5314 - 5322. [Abstract] [Full Text] [PDF]

	Copyright © 2008 by American Society of Hematology         Online ISSN: 1528-0020