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Blood, 5 March 2009, Vol. 113, No. 10, pp. 2298-2301. Prepublished online as a Blood First Edition Paper on January 13, 2009; DOI 10.1182/blood-2008-08-174953. This Article Full Text (PDF) Supplemental Tables All Versions of this Article: blood-2008-08-174953v1 113/10/2298    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by O'Shea, D. Articles by Fitzgibbon, J. Search for Related Content PubMed PubMed Citation Articles by O'Shea, D. Articles by Fitzgibbon, J. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted August 21, 2008 Accepted December 23, 2008 Regions of acquired uniparental disomy at diagnosis of follicular lymphoma are associated with both overall survival and risk of transformation Derville O'Shea*, Ciaran O'Riain, Manu Gupta, Rachel Waters, Youwen Yang, David Wrench, John Gribben, Andreas Rosenwald, German Ott, Lisa M. Rimsza, Harald Holte, Jean-Baptiste Cazier, Nathalie A. Johnson, Elias Campo, Wing C. Chan, Randy D. Gascoyne, Bryan D. Young, Louis M. Staudt, T. Andrew Lister, and Jude Fitzgibbon Centre for Medical Oncology, Barts and the London School of Medicine, London, United Kingdom Centre for Statistics in Medicine, Oxford University, Oxford, United Kingdom Institute of Pathology, University of Wurzburg, Wurzburg, Germany Department of Clinical Pathology, Robert-Bosch-Krankenhaus, Stuttgart, Germany Department of Pathology, and Arizona Cancer Center, University of Arizona, Tucson, AZ, United States Department of Oncology, Cancer Clinic Norwgian Radium Hospital, Oslo, Norway Bioinformatics and Biostatistics, Cancer Research UK, London, United Kingdom Department of Pathology and Division of Medical Oncology, British Columbia Cancer Agency, Vancouver, BC, Canada Department of Pathology and Hospital Clinic, Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), University of Barcelona, Barcelona, Spain Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States Metabolism Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, MD, United States * Corresponding author; email: derville.oshea{at}cancer.org.uk. Acquired homozygosity in the form of segmental acquired uniparental disomy (aUPD) has been described in follicular lymphoma (FL) and is usually due to mitotic recombination. SNP array analysis was performed using the Affymetrix 10K 2.0 Gene-chip array on DNA from 185 diagnostic FL patients to assess the prognostic relevance of aUPD. Genetic abnormalities were detected in 118/182 (65%) patients. Number of abnormalities was predictive of outcome; > 3 abnormalities was associated with inferior overall survival (OS) (p<0.03). Sites of recurrent aUPD were detected on 6p (n=25), 16p (n=22), 12q (n=17), 1p36 (n=14), 10q (n=8) and 6q (n=8). On multivariate analysis aUPD 1p36 correlated with shorter OS (p=0.05). aUPD 16p was predictive of transformation (p=0.03) and correlated with poorer progression free survival (p=0.02). aUPD is frequent at diagnosis of FL and impacts on probability of disease transformation and clinical outcome. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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