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Blood, 7 May 2009, Vol. 113, No. 19, pp. 4677-4680. Prepublished online as a Blood First Edition Paper on December 18, 2008; DOI 10.1182/blood-2008-09-179366. This Article Full Text (PDF) Supplemental Table and Figures All Versions of this Article: blood-2008-09-179366v1 113/19/4677    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by McCann, K. J Articles by Ottensmeier, C. H Search for Related Content PubMed PubMed Citation Articles by McCann, K. J Articles by Ottensmeier, C. H Related Collections Related Article in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted September 15, 2008 Accepted December 2, 2008 Primary CNS lymphoma: tumor-related clones exist in the blood and bone marrow with evidence for separate development Katy J McCann, Margaret Ashton-Key, KellyAnn Smith, Freda K Stevenson*, and Christian H Ottensmeier Translational Immunotherapy Group, Cancer Sciences Division, University of Southampton School of Medicine, Southampton, Hampshire, United Kingdom Department of Cellular Pathology, Southampton University Hospitals NHS Trust, Southampton, Hampshire, United Kingdom Genetic Vaccine Group, Cancer Sciences Division, University of Southampton School of Medicine, Southampton, Hampshire, United Kingdom * Corresponding author; email: fs{at}soton.ac.uk. Primary central nervous system lymphoma (PCNSL) is an aggressive B-cell tumor that is defined clinically by the absence of systemic disease. We have used immunoglobulin variable (V)-gene analysis to identify tumor cells at the CNS site in 12 cases and to probe the involvement of peripheral tissues in 3 patients. Clonal tracking revealed tumor cells in the bone marrow and/or blood for 3/3 cases, with evidence for increased V-gene mutational activity at peripheral sites. In 2/3 cases, intraclonal variant analysis revealed identity with the brain biopsy, but detected additional variants unique to extracerebral sites. These findings suggest that peripheral tumor cells can undergo separate development locally with no re-entry into the brain. PCNSL appears to have both CNS-specific and systemic components with limited interchange. The more malignant behavior of tumor cells in the CNS suggests either a local environmental influence or a less malignant phenotype of the peripheral clone. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Article in Blood Online: Primary central nervous system lymphoma: coming or going? Lisa M. DeAngelis Blood 2009 113: 4483-4484. [Full Text] [PDF] This article has been cited by other articles: L. M. DeAngelis Primary central nervous system lymphoma: coming or going? Blood, May 7, 2009; 113(19): 4483 - 4484. [Full Text] [PDF]

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