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Blood, 23 April 2009, Vol. 113, No. 17, pp. 3931-3937. Prepublished online as a Blood First Edition Paper on November 24, 2008; DOI 10.1182/blood-2008-10-185256. This Article Full Text (PDF) Supplemental Appendix All Versions of this Article: blood-2008-10-185256v1 113/17/3931    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Au, W.-y. Articles by Liang, R. Search for Related Content PubMed PubMed Citation Articles by Au, W.-y. Articles by Liang, R. Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted October 24, 2008 Accepted November 15, 2008 Clinical differences between nasal and extranasal NK/T-cell lymphoma: a study of 136 cases from the International Peripheral T-cell Lymphoma Project Wing-yan Au, Dennis D. Weisenburger, Tanin Intragumtornchai, Shigeo Nakamura, Won-Seog Kim, Ivy Sng, Julie Vose, James O. Armitage, and Raymond Liang* Department of Medicine, Queen Mary Hospital, Hong Kong, China Departments of Internal Medicine and Pathology and Microbiology, University of Nebraska Medical Center, Omaha, NE, United States Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand Department of Pathology and Clinical Laboratories, Nagoya University Hospital, Nagoya, Japan Division of Hemato-Oncology, Department of Medicine, Samsung Medical Center, Sunkyunkwan University School of Medicine, Seoul, Korea, Republic of Department of Pathology, Singapore General Hospital, Singapore, Singapore * Corresponding author; email: rliang{at}hkucc.hku.hk. Among 1153 new adult cases of extranodal NK/T-cell lymphoma from 1990-2002 at 22 centers in 13 countries, 136 cases (11.8%) of extranodal NK/T-cell lymphoma were identified (nasal 68%, extranasal 26%, aggressive/unclassifiable 6%). The disease frequency was higher in Asian than in Western countries and in Continental Asia than in Japan. There were no differences in age, gender, ethnicity or immunophenotypic profile between the nasal and extranasal cases, but the latter had more adverse clinical features. The median overall survival (OS) was better in nasal compared to the extranasal cases in early (2.96 vs. 0.36 yrs, p<0.001) and late stage disease (0.8 vs. 0.28 yrs, p=0.031). The addition of radiotherapy for early stage nasal cases yielded survival benefit (p=0.045). Among nasal cases, both the International Prognostic Index (p=0.0057) and Korean NK/T-cell Prognostic Index (p<0.001) were prognostic. In addition, Ki67 proliferation >50%, transformed tumor cells >40%, elevated CRP, anemia (<11g/dl) and thrombocytopenia (<150x109/l) predicts poorer OS for nasal disease. No histological or clinical feature was predictive in extranasal disease. We conclude that the clinical features and treatment response of extranasal NK/T-cell lymphoma are different from of those of nasal lymphoma. However, the underlying features responsible for these differences remain to be defined. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Differences between nasal and extranasal NK/T-cell lymphoma Ritsuro Suzuki, Junji Suzumiya, and Kazuo Oshimi Blood 2009 113: 6260-6261. [Full Text] [PDF] Response: Prognosis of stage I/II nonnasal extranodal NK/T cell lymphoma Wing-yan Au, Dennis D Weisenburger, Raymond Liang, and for the International Peripheral T-cell Lymphoma Project Blood 2009 113: 6261-6262. [Full Text] [PDF] This article has been cited by other articles: Z.-Y. Wang, Y.-X. Li, W.-H. Wang, J. Jin, H. Wang, Y.-W. Song, Q.-F. Liu, S.-L. Wang, Y.-P. Liu, S.-N. Qi, et al. Primary radiotherapy showed favorable outcome in treating extranodal nasal-type NK/T-cell lymphoma in children and adolescents Blood, November 26, 2009; 114(23): 4771 - 4776. [Abstract] [Full Text] [PDF] M. Yamaguchi, K. Tobinai, M. Oguchi, N. Ishizuka, Y. Kobayashi, Y. Isobe, K. Ishizawa, N. Maseki, K. Itoh, N. Usui, et al. Phase I/II Study of Concurrent Chemoradiotherapy for Localized Nasal Natural Killer/T-Cell Lymphoma: Japan Clinical Oncology Group Study JCOG0211 J. Clin. Oncol., November 20, 2009; 27(33): 5594 - 5600. [Abstract] [Full Text] [PDF] R. Suzuki, J. Suzumiya, M. Yamaguchi, S. Nakamura, J. Kameoka, H. Kojima, M. Abe, T. Kinoshita, T. Yoshino, K. Iwatsuki, et al. Prognostic factors for mature natural killer (NK) cell neoplasms: aggressive NK cell leukemia and extranodal NK cell lymphoma, nasal type Ann. Onc., October 22, 2009; (2009) mdp418v1. [Abstract] [Full Text] [PDF] W.-y. Au, D. D Weisenburger, R. Liang, and for the International Peripheral T-cell Lymphoma P Response: Prognosis of stage I/II nonnasal extranodal NK/T cell lymphoma Blood, June 11, 2009; 113(24): 6261 - 6262. [Full Text] [PDF] R. Suzuki, J. Suzumiya, and K. Oshimi Differences between nasal and extranasal NK/T-cell lymphoma Blood, June 11, 2009; 113(24): 6260 - 6261. [Full Text] [PDF]

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