Blood online
Home About Blood Authors Subscriptions Permission Advertising Public Access contact us
 

 
Advanced
Current Issue
First Edition
Future Articles
Archives
Submit to Blood
Search
American Society of Hematology
Meeting Abstracts
Email Alerts
 Blood, 21 May 2009, Vol. 113, No. 21, pp. 5246-5249.
Prepublished online as a Blood First Edition Paper on March 17, 2009; DOI 10.1182/blood-2008-11-191544.

This Article
Right arrow Full Text (PDF)
Right arrow All Versions of this Article:
blood-2008-11-191544v1
113/21/5246    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Right arrow Rights and Permissions
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Sozer, S.
Right arrow Articles by Hoffman, R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sozer, S.
Right arrow Articles by Hoffman, R.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

arrow to previous article Previous Article  |  Next Article next article arrow

Submitted November 25, 2008
Accepted March 7, 2009

The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome

Selcuk Sozer, Maria Isabel Fiel, Thomas Schiano, Mingjiang Xu, John Mascarenhas, and Ronald Hoffman*

Tisch Cancer Institute, Department of Medicine, Mount Sinai School of Medicine, New York, NY, United States
Department of Pathology, Mount Sinai School of Medicine, New York, NY, United States
Division of Liver Diseases, Department of Medicine, Mount Sinai School of Medicine, New York, NY, United States
Myeloproliferative Disorder Research Consortium, New York, NY, United States

* Corresponding author; email: ronald.hoffman{at}mssm.edu.

Patients with myeloproliferative disorders (MPD) are at a high risk of developing thrombotic events. Several investigators have hypothesized that endothelial cell (EC) abnormalities might contribute to this prothrombotic state. Budd-Chiari syndrome (BCS) and portal vein thrombosis have been reported to be associated with JAK2V617F positive hematopoiesis. We explored whether JAK2V617F was present in EC in the vessels of polycythemia vera (PV) patients with BCS using laser capture microdissection (LCM) followed by nested PCR or RT-PCR. The EC of the two BCS patients with PV were homozygous for the JAK2V617F and were shown to express transcripts characteristic of EC but not hematopoietic cells. EC of the other BCS patient with PV and 2 patients with hepatoportal sclerosis without PV contained exclusively wild type JAK2. The presence of JAK2V617F in both EC and hematopoietic cells belonging to BCS patients with PV indicate that EC in PV are involved by the malignant process and that in a subpopulation of the patients the disease might originate from a common cell of origin for hematopoietic and endothelial cells.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 haematolHome page
F. Cervantes, E. Arellano-Rodrigo, and A. Alvarez-Larran
Blood cell activation in myeloproliferative neoplasms
Haematologica, November 1, 2009; 94(11): 1484 - 1488.
[Full Text] [PDF]


click for free articles
home about blood authors subscriptions permissions advertising public access contact us
  Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020