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 Blood, 18 June 2009, Vol. 113, No. 25, pp. 6361-6371.
Prepublished online as a Blood First Edition Paper on April 20, 2009; DOI 10.1182/blood-2008-12-192997.

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Submitted December 3, 2008
Accepted April 13, 2009

IL-15 produced and trans-presented by DCs underlies homeostatic competition between CD8 and {gamma}{delta} T cells in vivo

Jeong-su Do and Booki Min*

Department of Immunology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH, United States

* Corresponding author; email: minb{at}ccf.org.

Homeostatic mechanism by which peripheral T cell subsets are maintained in vivo remains largely unknown. Using a T cell proliferation model under lymphopenic settings we now demonstrate that {gamma}{delta} T cells limit CD8 T cell expansion but not the initial proliferation following transfer into lymphopenic recipients. IL-15 produced by and trans-presented on the membrane of the CD11c+ DCs is the key factor that mediates homeostatic competition between CD8 and {gamma}{delta} T cells, revealing previously unrecognized IL-15-dependent homeostatic mechanisms between different T cell subsets in vivo.


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J.-s. Do and B. Min
Differential requirements of MHC and of DCs for endogenous proliferation of different T-cell subsets in vivo
PNAS, December 1, 2009; 106(48): 20394 - 20398.
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