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Blood, 16 July 2009, Vol. 114, No. 3, pp. 501-510. Prepublished online as a Blood First Edition Paper on April 16, 2009; DOI 10.1182/blood-2008-12-195453. This Article Full Text (PDF) All Versions of this Article: blood-2008-12-195453v1 114/3/501    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Stefanovic, A. Articles by Lossos, I. S Search for Related Content PubMed PubMed Citation Articles by Stefanovic, A. Articles by Lossos, I. S Related Collections Related Articles in Blood Online Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted December 31, 2008 Accepted April 9, 2009 Extranodal marginal zone lymphoma of the ocular adnexa Alexandra Stefanovic and Izidore S Lossos* Division of Hematology-Oncology, Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL, United States Department of Molecular and Cellular Pharmacology, University of Miami, Miami, FL, United States * Corresponding author; email: ilossos{at}med.miami.edu. Lymphomas of the ocular adnexa are a heterogeneous group of malignancies, comprising approximately 1-2% of non-Hodgkin lymphomas (NHL) and 8% of extranodal lymphomas. The most common subtype, accounting for up to 80% of cases of primary ocular adnexal lymphoma, is marginal zone lymphoma of MALT type. In the recent past, there have been significant advances in our understanding of the clinical characteristics, morphology and phenotype, etiology, pathogenesis, diagnosis, natural history, treatment approaches, outcome and prognostic factors of this disease entity. Novel immunologic and molecular techniques have aided in the distinction between MALT lymphoma and other lymphoproliferative disorders and led to the identification of tissue markers of prognostic significance. Modern imaging modalities provide invaluable tools for accurate staging and treatment planning. Besides radiotherapy and chemotherapy, a variety of new treatment options have emerged in the management of patients with ocular adnexal MALT lymphoma, especially monoclonal antibody therapy and antibiotic therapy against Chlamydia psittaci, which has been associated with the pathogenesis of ocular adnexal lymphomas in some parts of the world. In this review, we are presenting a state of the art summary on ocular adnexal MALT lymphomas. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? Related Articles in Blood Online: Bugs and marginal zone lymphoma of the ocular adnexae: is the future already here? Maurilio Ponzoni, Riccardo Dolcetti, Claudio Doglioni, and Andrés J. M. Ferreri Blood 2009 114: 3499. [Full Text] [PDF] Response: Variability in the prevalence of Chlamydophila psittaci infection in patients with OAML Alexandra Stefanovic and Izidore S. Lossos Blood 2009 114: 3499-3500. [Full Text] [PDF] This article has been cited by other articles: M. Ponzoni, R. Dolcetti, C. Doglioni, and A. J. M. Ferreri Bugs and marginal zone lymphoma of the ocular adnexae: is the future already here? Blood, October 15, 2009; 114(16): 3499 - 3499. [Full Text] [PDF]

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