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Blood, 9 July 2009, Vol. 114, No. 2, pp. 264-267. Prepublished online as a Blood First Edition Paper on May 4, 2009; DOI 10.1182/blood-2009-01-198697. This Article Full Text (PDF) Supplemental Methods and Tables All Versions of this Article: blood-2009-01-198697v1 114/2/264    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Lan, Q. Articles by Wang, S. S. Search for Related Content PubMed PubMed Citation Articles by Lan, Q. Articles by Wang, S. S. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 12, 2009 Accepted April 15, 2009 Genetic variation in caspase genes and risk of non-Hodgkin lymphoma: a pooled analysis of three population-based case-control studies Qing Lan*, Lindsay M. Morton, Bruce Armstrong, Patricia Hartge, Idan Menashe, Tongzhang Zheng, Mark P. Purdue, James R. Cerhan, Yawei Zhang, Andrew Grulich, Wendy Cozen, Meredith Yeager, Theodore R. Holford, Claire M. Vajdic, Scott Davis, Brian Leaderer, Anne Kricker, Maryjean Schenk, Shelia H. Zahm, Nilanjan Chatterjee, Stephen J. Chanock, Nathaniel Rothman, and Sophia S. Wang Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Rockville, MD, United States School of Public Health, The University of Sydney, Sydney, NSW, Australia Department of Epidemiology and Public Health, Yale School of Medicine, New Haven, CT, United States Mayo Clinic, College of Medicine, Rochester, MN, United States National Centre in HIV Epidemiology and Clinical Research, University of New South Wales, Sydney, NSW, United States Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA, United States Core Genotyping Facility, Advanced Technology Center, National Cancer Institute, NIH, DHHS, Gaithersburg, MD, United States UNSW Cancer Research Centre, Prince of Wales Clinical School, University of New South Wales, Sydney, Australia Fred Hutchinson Cancer Research Center and University of Washington, Seattle, WA, United States Department of Family Medicine and Karmanos Cancer Institute, Wayne State University, Detroit, MI, United States * Corresponding author; email: qingl{at}mail.nih.gov. Caspases play a critical role in regulation of apoptosis, cell differentiation, inflammation, and innate immunity, and several are mutated or have altered expression in non-Hodgkin lymphoma (NHL). To study the impact of genetic variation in caspases on NHL risk, we analyzed tag single nucleotide polymorphisms (SNPs) in 12 caspase and related genes in three population-based case-control studies (1,946 cases and 1,808 controls). Gene-based analysis, adjusting for the number of tag SNPs genotyped in each gene, showed significant associations for CASP8, CASP9, and CASP1. SNP-based analysis showed that CASP8 rs6736233 (odds ratio (OR)CG=1.21; ORCC=2.13; p-trend=0.011); CASP9 rs4661636 (ORCT=0.89; ORTT=0.77; p-trend=0.014); and CASP1 rs1785882 (ORAT=1.12; ORAA=1.30; p-trend=0.0054) were significantly associated with NHL risk and consistent across studies. It is noteworthy that genetic variants in CASP8 were associated with risk of all major NHL subtypes. Our findings suggest that genetic variation in caspases may play an important role in lymphomagenesis. CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

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