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Blood, 4 June 2009, Vol. 113, No. 23, pp. 5743-5746. Prepublished online as a Blood First Edition Paper on April 3, 2009; DOI 10.1182/blood-2009-01-201988. This Article Full Text (PDF) Supplemental Table All Versions of this Article: blood-2009-01-201988v1 113/23/5743    most recent Alert me when this article is cited Alert me if a correction is posted Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Rights and Permissions Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ai, W. Z. Articles by Levy, R. Search for Related Content PubMed PubMed Citation Articles by Ai, W. Z. Articles by Levy, R. Social Bookmarking                   What's this?  Previous Article  |  Next Article  Submitted January 28, 2009 Accepted March 22, 2009 Anti-idiotype antibody response after vaccination correlates with better overall survival in follicular lymphoma Weiyun Z. Ai, Robert Tibshirani, Behnaz Taidi, Debra Czerwinski, and Ronald Levy* Department of Medicine, Division of Hematology and Oncology, University of California, San Francisco, CA, United States Department of Health Research and Policy, Stanford University School of Medicine, Stanford, CA, United States Department of Internal Medicine, Division of Medical Oncology, Stanford University School of Medicine, Stanford, CA, United States * Corresponding author; email: levy{at}stanford.edu. Previous studies demonstrated that vaccination-induced tumor-specific immune response is associated with superior clinical outcome in follicular lymphoma patients. Here, we investigated whether this positive correlation extends to overall survival (OS). We analyzed 91 untreated patients who received CVP chemotherapy followed by idiotype vaccination. Idiotype proteins were produced either by the hybridoma method or by expression of recombinant idiotype-encoding sequences in mammalian or plant-based expression systems. We found that achieving a CR/CRu to CVP and making an anti-Idiotype antibody are two independent factors that each correlated with longer OS at 10 years (90% vs 68% with or without a CR/CRu, p = 0.024; 90% vs 69% with or without tumor-specific antibody production, p = 0.027). In the subset of patients received hybridoma-generated vaccines, we found that anti-Idiotype production was even more highly associated with superior OS (p=0.0016), and this was the case even in patients with a PR to CVP (p=0.0008). CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this? This article has been cited by other articles: A. G. Ramsay, A. J. Clear, G. Kelly, R. Fatah, J. Matthews, F. MacDougall, T. A. Lister, A. M. Lee, M. Calaminici, and J. G. Gribben Follicular lymphoma cells induce T-cell immunologic synapse dysfunction that can be repaired with lenalidomide: implications for the tumor microenvironment and immunotherapy Blood, November 19, 2009; 114(21): 4713 - 4720. [Abstract] [Full Text] [PDF]

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