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Receive this page by email each issue: [Sign up for eTOCs] Other Issues: February 1 2008; 111 (3)   [Index by Author]  [Cover Caption]  [Complete Inside Blood PDF]         INSIDE BLOOD        BLOOD WORK        ASH 50TH ANNIVERSARY REVIEW        PLENARY PAPERS        PERSPECTIVE        CHEMOKINES, CYTOKINES, AND INTERLEUKINS        CLINICAL TRIALS AND OBSERVATIONS        HEMATOPOIESIS        HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY        IMMUNOBIOLOGY        NEOPLASIA        RED CELLS        STEM CELLS IN HEMATOLOGY        TRANSPLANTATION        CORRESPONDENCE        ERRATA Find articles in this issue containing these words: [Search ALL Issues] Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) | Advertising (PDF) To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. INSIDE BLOOD: The yin and yang of Fc receptors in ITP Steven E. McKenzie Blood 2008 111: 971-972. [Full Text] [PDF]   Shear elegance: regulation of thrombus growth by shear stress William E. Hobbs, II and José A. López Blood 2008 111: 972. [Full Text] [PDF]   Sexuality in long-term survivors Gerard Socié Blood 2008 111: 972-973. [Full Text] [PDF]   Not too late for imatinib Ruben A. Mesa Blood 2008 111: 973-974. [Full Text] [PDF]   Platelets may serve up biomarkers Bruce S. Sachais Blood 2008 111: 974. [Full Text] [PDF]   Different partners in different places? Michael P. Cancro Blood 2008 111: 975. [Full Text] [PDF]   Stem-cell trafficking at vascular borders Sarah Hutchinson and Nikolaus S. Trede Blood 2008 111: 975-976. [Full Text] [PDF]   Tissue factor in granulocytes: yes and NO L. Vijaya Mohan Rao Blood 2008 111: 976-977. [Full Text] [PDF]   Normal no more Fernando Suarez-Saiz and Mark D. Minden Blood 2008 111: 977-978. [Full Text] [PDF]   Fixing bones before birth Alan W. Flake Blood 2008 111: 978-979. [Full Text] [PDF]   The yin-yang of platelet granules Charles S. Abrams Blood 2008 111: 979. [Full Text] [PDF]   Iron caught on the shuttle Günter Weiss Blood 2008 111: 980. [Full Text] [PDF]   BLOOD WORK: Anorexia nervosa: marrow morphology Blood 2008 111: 987. [Full Text] [PDF]   ASH 50TH ANNIVERSARY REVIEW: Historical review: megakaryopoiesis and thrombopoiesis Kenneth Kaushansky Blood 2008 111: 981-986. [Abstract] [Full Text] [PDF]   PLENARY PAPERS: Sexual function changes during the 5 years after high-dose treatment and hematopoietic cell transplantation for malignancy, with case-matched controls at 5 years Karen L. Syrjala, Brenda F. Kurland, Janet R. Abrams, Jean E. Sanders, and Julia R. Heiman Blood 2008 111: 989-996. Prepublished online September 18, 2007; DOI 10.1182/blood-2007-06-096594 [Abstract] [Full Text] [PDF]   PERSPECTIVE: Treatment and prevention of pain due to vaso-occlusive crises in adults with sickle cell disease: an educational void Lawrence R. Solomon Blood 2008 111: 997-1003. Prepublished online October 16, 2007; DOI 10.1182/blood-2007-07-089144 [Abstract] [Full Text] [PDF] [Supplemental Appendices and Table]   CHEMOKINES, CYTOKINES, AND INTERLEUKINS: TACI, unlike BAFF-R, is solely activated by oligomeric BAFF and APRIL to support survival of activated B cells and plasmablasts Claudia Bossen, Teresa G. Cachero, Aubry Tardivel, Karine Ingold, Laure Willen, Max Dobles, Martin L. Scott, Aris Maquelin, Elodie Belnoue, Claire-Anne Siegrist, Stéphane Chevrier, Hans Acha-Orbea, Helen Leung, Fabienne Mackay, Jürg Tschopp, and Pascal Schneider Blood 2008 111: 1004-1012. Prepublished online October 17, 2007; DOI 10.1182/blood-2007-09-110874 [Abstract] [Full Text] [PDF] [Supplemental Methods and Figures]   Retinoic acid inhibits Th17 polarization and enhances FoxP3 expression through a Stat-3/Stat-5 independent signaling pathway Kevin M. Elias, Arian Laurence, Todd S. Davidson, Geoffrey Stephens, Yuka Kanno, Ethan M. Shevach, and John J. O'Shea Blood 2008 111: 1013-1020. Prepublished online October 19, 2007; DOI 10.1182/blood-2007-06-096438 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Transgenic blockade of interleukin 6 transsignaling abrogates inflammation Björn Rabe, Athena Chalaris, Ulrike May, Georg H. Waetzig, Dirk Seegert, Anwen S. Williams, Simon A. Jones, Stefan Rose-John, and Jürgen Scheller Blood 2008 111: 1021-1028. Prepublished online November 7, 2007; DOI 10.1182/blood-2007-07-102137 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   CLINICAL TRIALS AND OBSERVATIONS: Copy number variation of the activating FCGR2C gene predisposes to idiopathic thrombocytopenic purpura Willemijn B. Breunis, Edwin van Mirre, Marrie Bruin, Judy Geissler, Martin de Boer, Marjolein Peters, Dirk Roos, Masja de Haas, Harry R. Koene, and Taco W. Kuijpers Blood 2008 111: 1029-1038. Prepublished online September 7, 2007; DOI 10.1182/blood-2007-03-079913 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Favorable long-term follow-up results over 6 years for response, survival, and safety with imatinib mesylate therapy in chronic-phase chronic myeloid leukemia after failure of interferon- treatment Andreas Hochhaus, Brian Druker, Charles Sawyers, Francois Guilhot, Charles A. Schiffer, Jorge Cortes, Dietger W. Niederwieser, Carlo Gambacorti, Richard M. Stone, John Goldman, Thomas Fischer, Stephen G. O'Brien, Jose J. Reiffers, Manisha Mone, Tillmann Krahnke, Moshe Talpaz, and Hagop M. Kantarjian Blood 2008 111: 1039-1043. Prepublished online October 11, 2007; DOI 10.1182/blood-2007-07-103523 [Abstract] [Full Text] [PDF]   Outcomes in CCG-2961, a Children's Oncology Group Phase 3 Trial for untreated pediatric acute myeloid leukemia: a report from the Children's Oncology Group Beverly J. Lange, Franklin O. Smith, James Feusner, Dorothy R. Barnard, Patricia Dinndorf, Stephen Feig, Nyla A. Heerema, Carola Arndt, Robert J. Arceci, Nita Seibel, Margie Weiman, Kathryn Dusenbery, Kevin Shannon, Sandra Luna-Fineman, Robert B. Gerbing, and Todd A. Alonzo Blood 2008 111: 1044-1053. Prepublished online November 13, 2007; DOI 10.1182/blood-2007-04-084293 [Abstract] [Full Text] [PDF] [Supplemental Appendix and Figure]   Prospective multicenter trial comparing repeated immunosuppressive therapy with stem-cell transplantation from an alternative donor as second-line treatment for children with severe and very severe aplastic anemia Yoshiyuki Kosaka, Hiroshi Yagasaki, Kimihiko Sano, Ryoji Kobayashi, Hiroshi Ayukawa, Takashi Kaneko, Hiromasa Yabe, Masahiro Tsuchida, Hideo Mugishima, Akira Ohara, Akira Morimoto, Yoshitoshi Otsuka, Shouichi Ohga, Fumio Bessho, Tatsutoshi Nakahata, Ichiro Tsukimoto, and Seiji Kojima, on behalf of the Japan Childhood Aplastic Anemia Study Group Blood 2008 111: 1054-1059. Prepublished online November 7, 2007; DOI 10.1182/blood-2007-08-099168 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Phase 1 study of the histone deacetylase inhibitor vorinostat (suberoylanilide hydroxamic acid [SAHA]) in patients with advanced leukemias and myelodysplastic syndromes Guillermo Garcia-Manero, Hui Yang, Carlos Bueso-Ramos, Alessandra Ferrajoli, Jorge Cortes, William G. Wierda, Stefan Faderl, Charles Koller, Gail Morris, Gary Rosner, Andrey Loboda, Valeria R. Fantin, Sophia S. Randolph, James S. Hardwick, John F. Reilly, Cong Chen, Justin L. Ricker, J. Paul Secrist, Victoria M. Richon, Stanley R. Frankel, and Hagop M. Kantarjian Blood 2008 111: 1060-1066. Prepublished online October 25, 2007; DOI 10.1182/blood-2007-06-098061 [Abstract] [Full Text] [PDF] [Supplemental Tables]   Identification of distinct prognostic subgroups in low- and intermediate-1–risk myelodysplastic syndromes by flow cytometry Arjan A. van de Loosdrecht, Theresia M. Westers, August H. Westra, Angelika M. Dräger, Vincent H. J. van der Velden, and Gert J. Ossenkoppele Blood 2008 111: 1067-1077. Prepublished online October 30, 2007; DOI 10.1182/blood-2007-07-098764 [Abstract] [Full Text] [PDF]   Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results Lionel Adès, Miguel A. Sanz, Sylvie Chevret, Pau Montesinos, Patrice Chevallier, Emmanuel Raffoux, Edo Vellenga, Agnès Guerci, Arnaud Pigneux, Francoise Huguet, Consuelo Rayon, Anne Marie Stoppa, Javier de la Serna, Jean-Yves Cahn, Sandrine Meyer-Monard, Thomas Pabst, Xavier Thomas, Stéphane de Botton, Ricardo Parody, Juan Bergua, Thierry Lamy, Anne Vekhoff, Silvia Negri, Norbert Ifrah, Hervé Dombret, Augustin Ferrant, Dominique Bron, Laurent Degos, and Pierre Fenaux Blood 2008 111: 1078-1084. Prepublished online November 1, 2007; DOI 10.1182/blood-2007-07-099978 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Brain parenchyma involvement as isolated central nervous system relapse of systemic non-Hodgkin lymphoma: an International Primary CNS Lymphoma Collaborative Group report Nancy D. Doolittle, Lauren E. Abrey, Tamara N. Shenkier, Siegal Tali, Jacoline E.C. Bromberg, Edward A. Neuwelt, Carole Soussain, Kristoph Jahnke, Patrick Johnston, Gerald Illerhaus, David Schiff, Tracy Batchelor, Silvia Montoto, Dale F. Kraemer, and Emanuele Zucca Blood 2008 111: 1085-1093. Prepublished online October 25, 2007; DOI 10.1182/blood-2007-07-101402 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Safety and efficacy of ofatumumab, a fully human monoclonal anti-CD20 antibody, in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: a phase 1-2 study Bertrand Coiffier, Stéphane Lepretre, Lars Møller Pedersen, Ole Gadeberg, Henrik Fredriksen, Marinus H. J. van Oers, James Wooldridge, Janusz Kloczko, Jerzy Holowiecki, Andrzej Hellmann, Jan Walewski, Mimi Flensburg, Jørgen Petersen, and Tadeusz Robak Blood 2008 111: 1094-1100. Prepublished online November 14, 2007; DOI 10.1182/blood-2007-09-111781 [Abstract] [Full Text] [PDF]   BiRD (Biaxin [clarithromycin]/Revlimid [lenalidomide]/dexamethasone) combination therapy results in high complete- and overall-response rates in treatment-naive symptomatic multiple myeloma. Ruben Niesvizky, David S. Jayabalan, Paul J. Christos, Jessica R. Furst, Tara Naib, Scott Ely, Jessica Jalbrzikowski, Roger N. Pearse, Faiza Zafar, Karen Pekle, April LaRow, Richard Lent, Tomer Mark, Hearn J. Cho, Tsiporah Shore, Jeffrey Tepler, John Harpel, Michael W. Schuster, Susan Mathew, John P. Leonard, Madhu Mazumdar, Selina Chen-Kiang, and Morton Coleman Blood 2008 111: 1101-1109. Prepublished online November 7, 2007; DOI 10.1182/blood-2007-05-090258 [Abstract] [Full Text] [PDF] [Supplemental Tables]   Impact of immune thrombocytopenia on the clinical course of chronic lymphocytic leukemia Carlo Visco, Marco Ruggeri, Maria Laura Evangelista, Roberto Stasi, Roberta Zanotti, Ilaria Giaretta, Achille Ambrosetti, Domenico Madeo, Giovanni Pizzolo, and Francesco Rodeghiero Blood 2008 111: 1110-1116. Prepublished online November 6, 2007; DOI 10.1182/blood-2007-09-111492 [Abstract] [Full Text] [PDF]   Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells Vladan P. Cokic, Silvana A. Andric, Stanko S. Stojilkovic, Constance T. Noguchi, and Alan N. Schechter Blood 2008 111: 1117-1123. Prepublished online November 9, 2007; DOI 10.1182/blood-2007-05-088732 [Abstract] [Full Text] [PDF]   Brief report  Development of an allele-specific minimal residual disease assay for patients with juvenile myelomonocytic leukemia Sophie Archambeault, Nikki J. Flores, Ayami Yoshimi, Christian P. Kratz, Miriam Reising, Alexandra Fischer, Peter Noellke, Franco Locatelli, Petr Sedlacek, Christian Flotho, Marco Zecca, Peter D. Emanuel, Robert P. Castleberry, Charlotte M. Niemeyer, Peter Bader, and Mignon L. Loh Blood 2008 111: 1124-1127. Prepublished online November 13, 2007; DOI 10.1182/blood-2007-06-093302 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Brief report  Complex inheritance pattern of dyskeratosis congenita in two families with 2 different mutations in the telomerase reverse transcriptase gene Hong-Yan Du, Elena Pumbo, Peter Manley, Joshua J. Field, Susan J. Bayliss, David B. Wilson, Philip J. Mason, and Monica Bessler Blood 2008 111: 1128-1130. Prepublished online November 27, 2007; DOI 10.1182/blood-2007-10-120907 [Abstract] [Full Text] [PDF] [Supplemental Table]   HEMATOPOIESIS: Characterization and localization of side population (SP) cells in zebrafish kidney hematopoietic tissue Isao Kobayashi, Kazuyuki Saito, Tadaaki Moritomo, Kyosuke Araki, Fumio Takizawa, and Teruyuki Nakanishi Blood 2008 111: 1131-1137. Prepublished online October 11, 2007; DOI 10.1182/blood-2007-08-104299 [Abstract] [Full Text] [PDF] [Supplemental Material and Figures]   The role of Ikaros in human erythroid differentiation Marilyne Dijon, Florence Bardin, Anne Murati, Michèle Batoz, Christian Chabannon, and Cécile Tonnelle Blood 2008 111: 1138-1146. Prepublished online October 12, 2007; DOI 10.1182/blood-2007-07-098202 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Live imaging of emerging hematopoietic stem cells and early thymus colonization Karima Kissa, Emi Murayama, Agustin Zapata, Alfonso Cortés, Emmanuelle Perret, Christophe Machu, and Philippe Herbomel Blood 2008 111: 1147-1156. Prepublished online October 12, 2007; DOI 10.1182/blood-2007-07-099499 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures][Supplemental Videos][Supplemental Videos]   Fibroblast growth factor controls the timing of Scl, Lmo2, and Runx1 expression during embryonic blood development Maggie Walmsley, David Cleaver, and Roger Patient Blood 2008 111: 1157-1166. Prepublished online October 17, 2007; DOI 10.1182/blood-2007-03-081323 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Junctional adhesion molecule-A, JAM-A, is a novel cell-surface marker for long-term repopulating hematopoietic stem cells Yasuyoshi Sugano, Masaki Takeuchi, Ayami Hirata, Hirokazu Matsushita, Toshio Kitamura, Minoru Tanaka, and Atsushi Miyajima Blood 2008 111: 1167-1172. Prepublished online November 6, 2007; DOI 10.1182/blood-2007-03-081554 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Strontium can increase some osteoblasts without increasing hematopoietic stem cells Stefania Lymperi, Nicole Horwood, Stephen Marley, Myrtle Y. Gordon, Andrew P. Cope, and Francesco Dazzi Blood 2008 111: 1173-1181. Prepublished online October 30, 2007; DOI 10.1182/blood-2007-03-082800 [Abstract] [Full Text] [PDF] [Supplemental Figure]   CREB is a critical regulator of normal hematopoiesis and leukemogenesis Jerry C. Cheng, Kentaro Kinjo, Dejah R. Judelson, Jenny Chang, Winston S. Wu, Ingrid Schmid, Deepa B. Shankar, Noriyuki Kasahara, Renata Stripecke, Ravi Bhatia, Elliot M. Landaw, and Kathleen M. Sakamoto Blood 2008 111: 1182-1192. Prepublished online November 1, 2007; DOI 10.1182/blood-2007-04-083600 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Cyclin-dependent kinase phosphorylation of RUNX1/AML1 on 3 sites increases transactivation potency and stimulates cell proliferation Linsheng Zhang, Florence B. Fried, Hong Guo, and Alan D. Friedman Blood 2008 111: 1193-1200. Prepublished online November 14, 2007; DOI 10.1182/blood-2007-08-109702 [Abstract] [Full Text] [PDF]   HEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY: Platelet-associated PF-4 as a biomarker of early tumor growth David Cervi, Tai-Tung Yip, Nandita Bhattacharya, Vladimir N. Podust, Jon Peterson, Abdo Abou-Slaybi, George N. Naumov, Elise Bender, Nava Almog, Joseph E. Italiano, Jr, Judah Folkman, and Giannoula L. Klement Blood 2008 111: 1201-1207. Prepublished online October 3, 2007; DOI 10.1182/blood-2007-04-084798 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Granulocytes do not express but acquire monocyte-derived tissue factor in whole blood: evidence for a direct transfer Elena M. Egorina, Mikhail A. Sovershaev, Jan O. Olsen, and Bjarne Østerud Blood 2008 111: 1208-1216. Prepublished online October 18, 2007; DOI 10.1182/blood-2007-08-107698 [Abstract] [Full Text] [PDF] [Supplemental Methods and Figures]   Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5 Yun Chen and David H. Gorski Blood 2008 111: 1217-1226. Prepublished online October 23, 2007; DOI 10.1182/blood-2007-07-104133 [Abstract] [Full Text] [PDF]   Angiogenesis is regulated by a novel mechanism: pro- and antiangiogenic proteins are organized into separate platelet granules and differentially released Joseph E. Italiano, Jr, Jennifer L. Richardson, Sunita Patel-Hett, Elisabeth Battinelli, Alexander Zaslavsky, Sarah Short, Sandra Ryeom, Judah Folkman, and Giannoula L. Klement Blood 2008 111: 1227-1233. Prepublished online October 25, 2007; DOI 10.1182/blood-2007-09-113837 [Abstract] [Full Text] [PDF]   Fine specificity of drug-dependent antibodies reactive with a restricted domain of platelet GPIIIA Julie A. Peterson, Tamara N. Nelson, Adam J. Kanack, and Richard H. Aster Blood 2008 111: 1234-1239. Prepublished online October 24, 2007; DOI 10.1182/blood-2007-09-112680 [Abstract] [Full Text] [PDF]   The tertiary structure and domain organization of coagulation factor VIII Betty W. Shen, Paul Clint Spiegel, Chong-Hwan Chang, Jae-Wook Huh, Jung-Sik Lee, Jeanman Kim, Young-Ho Kim, and Barry L. Stoddard Blood 2008 111: 1240-1247. Prepublished online October 26, 2007; DOI 10.1182/blood-2007-08-109918 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Application of high-throughput screening to identify a novel IIb-specific small- molecule inhibitor of IIbβ3-mediated platelet interaction with fibrinogen Robert Blue, Marta Murcia, Charles Karan, Markéta Jirousková, and Barry S. Coller Blood 2008 111: 1248-1256. Prepublished online October 31, 2007; DOI 10.1182/blood-2007-08-105544 [Abstract] [Full Text] [PDF] [Supplemental Videos]   Critical role for the mitochondrial permeability transition pore and cyclophilin D in platelet activation and thrombosis Shawn M. Jobe, Katina M. Wilson, Lorie Leo, Alejandro Raimondi, Jeffery D. Molkentin, Steven R. Lentz, and Jorge Di Paola Blood 2008 111: 1257-1265. Prepublished online November 7, 2007; DOI 10.1182/blood-2007-05-092684 [Abstract] [Full Text] [PDF]   The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6–/– mice Yann Cheli, Deborah Jensen, Patrizia Marchese, David Habart, Tim Wiltshire, Michael Cooke, José A. Fernandez, Jerry Ware, Zaverio M. Ruggeri, and Thomas J. Kunicki Blood 2008 111: 1266-1273. Prepublished online November 8, 2007; DOI 10.1182/blood-2007-09-111369 [Abstract] [Full Text] [PDF]   Deletion of murine kininogen gene 1 (mKng1) causes loss of plasma kininogen and delays thrombosis Sergei Merkulov, Wan-Ming Zhang, Anton A. Komar, Alvin H. Schmaier, Ellen Barnes, Yihua Zhou, Xincheng Lu, Takayuki Iwaki, Francis J. Castellino, Guangbin Luo, and Keith R. McCrae Blood 2008 111: 1274-1281. Prepublished online November 13, 2007; DOI 10.1182/blood-2007-06-092338 [Abstract] [Full Text] [PDF]   Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke D. Martijn O. Pruissen, Arjen J. C. Slooter, Frits R. Rosendaal, Yolanda van der Graaf, and Ale Algra Blood 2008 111: 1282-1286. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-08-110254 [Abstract] [Full Text] [PDF]   Activation of the p53 pathway down-regulates the osteoprotegerin expression and release by vascular endothelial cells Paola Secchiero, Federica Corallini, Erika Rimondi, Cristina Chiaruttini, Maria Grazia di Iasio, Alessandra Rustighi, Giannino Del Sal, and Giorgio Zauli Blood 2008 111: 1287-1294. Prepublished online November 13, 2007; DOI 10.1182/blood-2007-05-092031 [Abstract] [Full Text] [PDF]   Brief report  Functional imaging of shear-dependent activity of ADAMTS13 in regulating mural thrombus growth under whole blood flow conditions Yasuaki Shida, Kenji Nishio, Mitsuhiko Sugimoto, Tomohiro Mizuno, Masaaki Hamada, Seiji Kato, Masanori Matsumoto, Kazuo Okuchi, Yoshihiro Fujimura, and Akira Yoshioka Blood 2008 111: 1295-1298. Prepublished online October 10, 2007; DOI 10.1182/blood-2007-09-110700 [Abstract] [Full Text] [PDF]   Brief report  Deletion of 3 residues from the C-terminus of MCFD2 affects binding to ERGIC-53 and causes combined factor V and factor VIII deficiency Beat Nyfeler, Yukiko Kamiya, Françoise Boehlen, Kazuo Yamamoto, Koichi Kato, Philippe de Moerloose, Hans-Peter Hauri, and Marguerite Neerman-Arbez Blood 2008 111: 1299-1301. Prepublished online October 30, 2007; DOI 10.1182/blood-2007-09-112854 [Abstract] [Full Text] [PDF]   Brief report  Differential in vivo potential of endothelial progenitor cells from human umbilical cord blood and adult peripheral blood to form functional long-lasting vessels Patrick Au, Laurence M. Daheron, Dan G. Duda, Kenneth S. Cohen, James A. Tyrrell, Ryan M. Lanning, Dai Fukumura, David T. Scadden, and Rakesh K. Jain Blood 2008 111: 1302-1305. Prepublished online November 9, 2007; DOI 10.1182/blood-2007-06-094318 [Abstract] [Full Text] [PDF] [Supplemental Methods, Figures, and Video]   Brief report  Induction of an inhibitor antibody to factor XI in a patient with severe inherited factor XI deficiency by Rh immune globulin Michal Zucker, Ariella Zivelin, Jerome Teitel, and Uri Seligsohn Blood 2008 111: 1306-1308. Prepublished online November 20, 2007; DOI 10.1182/blood-2007-08-108449 [Abstract] [Full Text] [PDF]   IMMUNOBIOLOGY: Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell–mediated lysis of myeloma Jumei Shi, Guido J. Tricot, Tarun K. Garg, Priyangi A. Malaviarachchi, Susann M. Szmania, Rachel E. Kellum, Brian Storrie, Arend Mulder, John D. Shaughnessy, Jr, Bart Barlogie, and Frits van Rhee Blood 2008 111: 1309-1317. Prepublished online October 18, 2007; DOI 10.1182/blood-2007-03-078535 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Human intrathymic lineage commitment is marked by differential CD7 expression: identification of CD7– lympho-myeloid thymic progenitors Qian-Lin Hao, Aswathi A. George, Judy Zhu, Lora Barsky, Ewa Zielinska, Xiuli Wang, Mary Price, Shundi Ge, and Gay M. Crooks Blood 2008 111: 1318-1326. Prepublished online October 24, 2007; DOI 10.1182/blood-2007-08-106294 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Mesenchymal stem cells inhibit natural killer–cell proliferation, cytotoxicity, and cytokine production: role of indoleamine 2,3-dioxygenase and prostaglandin E2 Grazia Maria Spaggiari, Andrea Capobianco, Heba Abdelrazik, Flavio Becchetti, Maria Cristina Mingari, and Lorenzo Moretta Blood 2008 111: 1327-1333. Prepublished online October 19, 2007; DOI 10.1182/blood-2007-02-074997 [Abstract] [Full Text] [PDF]   Repertoire and frequency of immune cells reactive to Epstein-Barr virus–derived autologous lymphoblastoid cell lines Sumita Bhaduri-McIntosh, Marisa J. Rotenberg, Benjamin Gardner, Marie Robert, and George Miller Blood 2008 111: 1334-1343. Prepublished online October 17, 2007; DOI 10.1182/blood-2007-07-101907 [Abstract] [Full Text] [PDF]   Clonal expansion of immunoglobulin M+CD27+ B cells in HCV-associated mixed cryoglobulinemia Edgar D. Charles, Rashidah M. Green, Svetlana Marukian, Andrew H. Talal, Gerond V. Lake-Bakaar, Ira M. Jacobson, Charles M. Rice, and Lynn B. Dustin Blood 2008 111: 1344-1356. Prepublished online October 17, 2007; DOI 10.1182/blood-2007-07-101717 [Abstract] [Full Text] [PDF] [Supplemental Figures]   RHAMM-R3 peptide vaccination in patients with acute myeloid leukemia, myelodysplastic syndrome, and multiple myeloma elicits immunologic and clinical responses Michael Schmitt, Anita Schmitt, Markus T. Rojewski, Jinfei Chen, Krzysztof Giannopoulos, Fei Fei, Yingzhe Yu, Marlies Götz, Marta Heyduk, Gerd Ritter, Daniel E. Speiser, Sacha Gnjatic, Philippe Guillaume, Mark Ringhoffer, Richard F. Schlenk, Peter Liebisch, Donald Bunjes, Hiroshi Shiku, Hartmut Dohner, and Jochen Greiner Blood 2008 111: 1357-1365. Prepublished online October 31, 2007; DOI 10.1182/blood-2007-07-099366 [Abstract] [Full Text] [PDF]   Dasatinib, a small-molecule protein tyrosine kinase inhibitor, inhibits T-cell activation and proliferation Andrew E. Schade, Gary L. Schieven, Robert Townsend, Anna M. Jankowska, Vojkan Susulic, Rosemary Zhang, Hadrian Szpurka, and Jaroslaw P. Maciejewski Blood 2008 111: 1366-1377. Prepublished online October 25, 2007; DOI 10.1182/blood-2007-04-084814 [Abstract] [Full Text] [PDF]   4-1BB regulates NKG2D costimulation in human cord blood CD8+ T cells Young-June Kim, Myung-Kwan Han, and Hal E. Broxmeyer Blood 2008 111: 1378-1386. Prepublished online November 16, 2007; DOI 10.1182/blood-2007-01-069450 [Abstract] [Full Text] [PDF]   Multicentric Castleman disease is associated with polyfunctional effector memory HHV-8–specific CD8+ T cells Amélie Guihot, Eric Oksenhendler, Lionel Galicier, Anne-Geneviève Marcelin, Laura Papagno, Anne-Sophie Bedin, Félix Agbalika, Nicolas Dupin, Jacques Cadranel, Brigitte Autran, and Guislaine Carcelain Blood 2008 111: 1387-1395. Prepublished online November 13, 2007; DOI 10.1182/blood-2007-03-080648 [Abstract] [Full Text] [PDF]   Interferon regulatory factors 4 and 8 induce the expression of Ikaros and Aiolos to down-regulate pre–B-cell receptor and promote cell-cycle withdrawal in pre–B-cell development Shibin Ma, Simanta Pathak, Long Trinh, and Runqing Lu Blood 2008 111: 1396-1403. Prepublished online October 30, 2007; DOI 10.1182/blood-2007-08-110106 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Induction of regulatory T cell–resistant helper CD4+ T cells by bacterial vector Hiroyoshi Nishikawa, Takemasa Tsuji, Elke Jäger, Gabriel Briones, Gerd Ritter, Lloyd J. Old, Jorge E. Galán, Hiroshi Shiku, and Sacha Gnjatic Blood 2008 111: 1404-1412. Prepublished online November 6, 2007; DOI 10.1182/blood-2007-09-113761 [Abstract] [Full Text] [PDF] [Supplemental Figure]   An immune escape screen reveals Cdc42 as regulator of cancer susceptibility to lymphocyte-mediated tumor suppression Celio A. Marques, Patricia S. Hähnel, Catherine Wölfel, Sonja Thaler, Christoph Huber, Matthias Theobald, and Martin Schuler Blood 2008 111: 1413-1419. Prepublished online October 30, 2007; DOI 10.1182/blood-2007-05-089458 [Abstract] [Full Text] [PDF] [Supplemental Figure]   On the dynamics of acute EBV infection and the pathogenesis of infectious mononucleosis Vey Hadinoto, Michael Shapiro, Thomas C. Greenough, John L. Sullivan, Katherine Luzuriaga, and David A. Thorley-Lawson Blood 2008 111: 1420-1427. Prepublished online November 8, 2007; DOI 10.1182/blood-2007-06-093278 [Abstract] [Full Text] [PDF] [Supplemental Methods, Table, and Figures]   NKG2D ligand expression in AML increases in response to HDAC inhibitor valproic acid and contributes to allorecognition by NK-cell lines with single KIR-HLA class I specificities Stefan Diermayr, Heike Himmelreich, Bojana Durovic, Arina Mathys-Schneeberger, Uwe Siegler, Ulrich Langenkamp, Jan Hofsteenge, Alois Gratwohl, André Tichelli, Monika Paluszewska, Wieslaw Wiktor-Jedrzejczak, Christian P. Kalberer, and Aleksandra Wodnar-Filipowicz Blood 2008 111: 1428-1436. Prepublished online November 9, 2007; DOI 10.1182/blood-2007-07-101311 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figure]   A common pathway mediated through Toll-like receptors leads to T- and natural killer–cell immunosuppression Ilan Vaknin, Liora Blinder, Lynn Wang, Roi Gazit, Elena Shapira, Olga Genina, Mark Pines, Eli Pikarsky, and Michal Baniyash Blood 2008 111: 1437-1447. Prepublished online November 8, 2007; DOI 10.1182/blood-2007-07-100404 [Abstract] [Full Text] [PDF] [Supplemental Figure]   LMP1 signaling can replace CD40 signaling in B cells in vivo and has unique features of inducing class-switch recombination to IgG1 Julia Rastelli, Cornelia Hömig-Hölzel, Jane Seagal, Werner Müller, Andrea C. Hermann, Klaus Rajewsky, and Ursula Zimber-Strobl Blood 2008 111: 1448-1455. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-10-117655 [Abstract] [Full Text] [PDF] [Supplemental Figures]   NK-cell activation and antibody-dependent cellular cytotoxicity induced by rituximab-coated target cells is inhibited by the C3b component of complement Siao-Yi Wang, Emilian Racila, Ronald P. Taylor, and George J. Weiner Blood 2008 111: 1456-1463. Prepublished online November 16, 2007; DOI 10.1182/blood-2007-02-074716 [Abstract] [Full Text] [PDF]   CD28 provides T-cell costimulation and enhances PI3K activity at the immune synapse independently of its capacity to interact with the p85/p110 heterodimer Fabien Garçon, Daniel T. Patton, Juliet L. Emery, Emilio Hirsch, Robert Rottapel, Takehiko Sasaki, and Klaus Okkenhaug Blood 2008 111: 1464-1471. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-08-108050 [Abstract] [Full Text] [PDF] [Supplemental Figures and Videos]   The endogenous danger signal, crystalline uric acid, signals for enhanced antibody immunity Marshall D. Behrens, Wolfgang M. Wagner, Christopher J. Krco, Courtney L. Erskine, Kimberly R. Kalli, James Krempski, Ekram A. Gad, Mary L. Disis, and Keith L. Knutson Blood 2008 111: 1472-1479. Prepublished online November 20, 2007; DOI 10.1182/blood-2007-10-117184 [Abstract] [Full Text] [PDF]   Apoptosis of dendritic cells induced by decoy receptor 3 (DcR3) Ren-In You, Yung-Chi Chang, Po-Min Chen, Wei-Shu Wang, Tsui-Ling Hsu, Chih-Ya Yang, Chun-Ting Lee, and Shie-Liang Hsieh Blood 2008 111: 1480-1488. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-09-114850 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Indirect involvement of allergen-captured mast cells in antigen presentation Taku Kambayashi, Jan D. Baranski, Rebecca G. Baker, Tao Zou, Eric J. Allenspach, Jonathan E. Shoag, Peter L. Jones, and Gary A. Koretzky Blood 2008 111: 1489-1496. Prepublished online November 21, 2007; DOI 10.1182/blood-2007-07-102111 [Abstract] [Full Text] [PDF] [Supplemental Video]   Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase Yuichi Aiba, Megumi Kameyama, Tetsuo Yamazaki, Thomas F. Tedder, and Tomohiro Kurosaki Blood 2008 111: 1497-1503. Prepublished online November 19, 2007; DOI 10.1182/blood-2007-08-109769 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Dendritic cells loaded with apoptotic antibody-coated tumor cells provide protective immunity against B-cell lymphoma in vivo Suzanne N. Franki, Kristopher K. Steward, David J. Betting, Kamran Kafi, Reiko E. Yamada, and John M. Timmerman Blood 2008 111: 1504-1511. Prepublished online November 9, 2007; DOI 10.1182/blood-2007-03-080507 [Abstract] [Full Text] [PDF] [Supplemental Methods and Figure]   Brief report  Factor H autoantibodies in atypical hemolytic uremic syndrome correlate with CFHR1/CFHR3 deficiency Mihály Józsi, Christoph Licht, Stefanie Strobel, Svante L. H. Zipfel, Heiko Richter, Stefan Heinen, Peter F. Zipfel, and Christine Skerka Blood 2008 111: 1512-1514. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-09-109876 [Abstract] [Full Text] [PDF] [Supplemental Table and Figure]   NEOPLASIA: Constitutively activated STAT3 promotes cell proliferation and survival in the activated B-cell subtype of diffuse large B-cell lymphomas B. Belinda Ding, J. Jessica Yu, Raymond Y.-L. Yu, Lourdes M. Mendez, Rita Shaknovich, Yonghui Zhang, Giorgio Cattoretti, and B. Hilda Ye Blood 2008 111: 1515-1523. Prepublished online October 19, 2007; DOI 10.1182/blood-2007-04-087734 [Abstract] [Full Text] [PDF] [Supplemental Methods, Tables, and Figure]   Stereotyped patterns of somatic hypermutation in subsets of patients with chronic lymphocytic leukemia: implications for the role of antigen selection in leukemogenesis Fiona Murray, Nikos Darzentas, Anastasia Hadzidimitriou, Gerard Tobin, Myriam Boudjogra, Cristina Scielzo, Nikolaos Laoutaris, Karin Karlsson, Fanny Baran-Marzsak, Athanasios Tsaftaris, Carol Moreno, Achilles Anagnostopoulos, Federico Caligaris-Cappio, Dominique Vaur, Christos Ouzounis, Chrysoula Belessi, Paolo Ghia, Fred Davi, Richard Rosenquist, and Kostas Stamatopoulos Blood 2008 111: 1524-1533. Prepublished online October 24, 2007; DOI 10.1182/blood-2007-07-099564 [Abstract] [Full Text] [PDF] [Supplemental Tables][Supplemental Tables]   Chromosomal lesions and uniparental disomy detected by SNP arrays in MDS, MDS/MPD, and MDS-derived AML Lukasz P. Gondek, Ramon Tiu, Christine L. O'Keefe, Mikkael A. Sekeres, Karl S. Theil, and Jaroslaw P. Maciejewski Blood 2008 111: 1534-1542. Prepublished online October 22, 2007; DOI 10.1182/blood-2007-05-092304 [Abstract] [Full Text] [PDF] [Supplemental Table and Figure]   Cbfβ-SMMHC impairs differentiation of common lymphoid progenitors and reveals an essential role for RUNX in early B-cell development Ya-Huei Kuo, Rachel M. Gerstein, and Lucio H. Castilla Blood 2008 111: 1543-1551. Prepublished online October 16, 2007; DOI 10.1182/blood-2007-07-104422 [Abstract] [Full Text] [PDF]   FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications Susan P. Whitman, Amy S. Ruppert, Michael D. Radmacher, Krzysztof Mrózek, Peter Paschka, Christian Langer, Claudia D. Baldus, Jing Wen, Frederick Racke, Bayard L. Powell, Jonathan E. Kolitz, Richard A. Larson, Michael A. Caligiuri, Guido Marcucci, and Clara D. Bloomfield Blood 2008 111: 1552-1559. Prepublished online October 16, 2007; DOI 10.1182/blood-2007-08-107946 [Abstract] [Full Text] [PDF] [Supplemental Appendix, Tables and Figures]   Prognostic factors in childhood anaplastic large cell lymphoma: results of a large European intergroup study Marie-Cécile Le Deley, Alfred Reiter, Denise Williams, Georges Delsol, Ilske Oschlies, Keith McCarthy, Martin Zimmermann, and Laurence Brugières, on behalf of the European Intergroup for Childhood Non-Hodgkin Lymphoma Blood 2008 111: 1560-1566. Prepublished online October 23, 2007; DOI 10.1182/blood-2007-07-100958 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   FLT3-ITD cooperates with inv(16) to promote progression to acute myeloid leukemia Hyung-Gyoon Kim, Kyoko Kojima, C. Scott Swindle, Claudiu V. Cotta, Yongliang Huo, Vishnu Reddy, and Christopher A. Klug Blood 2008 111: 1567-1574. Prepublished online October 29, 2007; DOI 10.1182/blood-2006-06-030312 [Abstract] [Full Text] [PDF]   Cytogenetic features of acute lymphoblastic and myeloid leukemias in pediatric patients with Down syndrome: an iBFM-SG study Erik Forestier, Shai Izraeli, Berna Beverloo, Oskar Haas, Andrea Pession, Kyra Michalová, Batia Stark, Christine J. Harrison, Andrea Teigler-Schlegel, and Bertil Johansson Blood 2008 111: 1575-1583. Prepublished online October 30, 2007; DOI 10.1182/blood-2007-09-114231 [Abstract] [Full Text] [PDF] [Supplemental Appendix, Tables, and Figures]   Comprehensive biomarker and genomic analysis identifies p53 status as the major determinant of response to MDM2 inhibitors in chronic lymphocytic leukemia Chris Saddler, Peter Ouillette, Lisa Kujawski, Sanjeev Shangary, Moshe Talpaz, Mark Kaminski, Harry Erba, Kerby Shedden, Shaomeng Wang, and Sami N. Malek Blood 2008 111: 1584-1593. Prepublished online October 30, 2007; DOI 10.1182/blood-2007-09-112698 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figure]   Mediation of apoptosis by and antitumor activity of lumiliximab in chronic lymphocytic leukemia cells and CD23+ lymphoma cell lines Nuzhat I. Pathan, Peter Chu, Kandasamy Hariharan, Carolyn Cheney, Arturo Molina, and John Byrd Blood 2008 111: 1594-1602. Prepublished online November 21, 2007; DOI 10.1182/blood-2007-03-082024 [Abstract] [Full Text] [PDF]   The centrosome index is a powerful prognostic marker in myeloma and identifies a cohort of patients that might benefit from aurora kinase inhibition Wee J. Chng, Esteban Braggio, George Mulligan, Barbara Bryant, Ellen Remstein, Riccardo Valdez, Ahmet Dogan, and Rafael Fonseca Blood 2008 111: 1603-1609. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-06-097774 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Antigen activation and impaired Fas-induced death-inducing signaling complex formation in T-large-granular lymphocyte leukemia Jun Yang, P. K. Epling-Burnette, Jeffrey S. Painter, JianXiang Zou, Fanqi Bai, Sheng Wei, and Thomas P. Loughran, Jr Blood 2008 111: 1610-1616. Prepublished online November 9, 2007; DOI 10.1182/blood-2007-06-093823 [Abstract] [Full Text] [PDF]   Functionally associated targets in mantle cell lymphoma as defined by DNA microarrays and RNA interference Eva Ortega-Paino, Johan Fransson, Sara Ek, and Carl A. K. Borrebaeck Blood 2008 111: 1617-1624. Prepublished online November 16, 2007; DOI 10.1182/blood-2007-02-068791 [Abstract] [Full Text] [PDF]   Scan of 977 nonsynonymous SNPs in CLL4 trial patients for the identification of genetic variants influencing prognosis Gabrielle S. Sellick, Rachel Wade, Susan Richards, David G. Oscier, Daniel Catovsky, and Richard S. Houlston Blood 2008 111: 1625-1633. Prepublished online November 15, 2007; DOI 10.1182/blood-2007-08-110130 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Gene transactivation without direct DNA binding defines a novel gain-of-function for PML-RAR Sake van Wageningen, Marleen C. Breems-de Ridder, Jeannet Nigten, Gorica Nikoloski, Claudia A. J. Erpelinck-Verschueren, Bob Löwenberg, Theo de Witte, Daniel G. Tenen, Bert A. van der Reijden, and Joop H. Jansen Blood 2008 111: 1634-1643. Prepublished online November 19, 2007; DOI 10.1182/blood-2007-04-081125 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Protein kinase C–associated kinase is required for NF-B signaling and survival in diffuse large B-cell lymphoma cells Sang-Woo Kim, David W. Oleksyn, Randall M. Rossi, Craig T. Jordan, Ignacio Sanz, Luojing Chen, and Jiyong Zhao Blood 2008 111: 1644-1653. Prepublished online November 19, 2007; DOI 10.1182/blood-2007-05-088591 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Combination of proteasome in