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About the Cover for Blood 112 (5)
A homology model of the ADAMTS13 metalloprotease (magenta) and disintegrin-like domains (cyan) is shown in the center, with the active site Zn2+ ion (green) and the three structural Ca2+ ions (grey) shown as spheres. ADAMTS13 is flanked by the native folded VWF A2 domain (top left) in which the target Tyr1605-Met1606 (red) bond is buried in the fourth strand of a beta sheet, and by a partially unfolded VWF A2 domain (bottom left) in which this bond is exposed to ADAMTS13. See the related article by Gao et al beginning on page 1713. [Table of Contents] |
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| Copyright © 2009 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
