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About the Cover for Blood 113 (24)
Tiam1 is a Rac activator involved in PKCζ/Par polarity signaling, essential for stabilization of polarization during T-cell migration. T cells (green) crawl on top of endothelial monolayers (purple) to reach suitable transmigration sites at endothelial junctions (paracellular migration). Tiam1-deficient T cells are unable to crawl on endothelial cells and, as a consequence, initiate an alternative transmigration route through individual endothelial cells (transcellular migration). This suggests that T cells are able to change their route of transendothelial migration according to their polarization status and crawling capacity. See the article by Gérard et al on page 6138. [Table of Contents] |
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| Copyright © 2009 by American Society of Hematology Online ISSN: 1528-0020 | |||||||||
