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Receive this page by email each issue: [Sign up for eTOCs] Other Issues:   November 5 2009; 114 (19)   [Index by Author]  [Cover Caption] [Complete Inside Blood PDF]         INSIDE BLOOD        BLOOD WORK        PLENARY PAPERS        REVIEW ARTICLES        HOW I TREAT        CLINICAL TRIALS AND OBSERVATIONS        GENE THERAPY        HEMATOPOIESIS AND STEM CELLS        IMMUNOBIOLOGY        LYMPHOID NEOPLASIA        MYELOID NEOPLASIA        PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS        PLATELETS AND THROMBOPOIESIS        RED CELLS, IRON, AND ERYTHROPOIESIS        THROMBOSIS AND HEMOSTASIS        TRANSFUSION MEDICINE        TRANSPLANTATION        VASCULAR BIOLOGY        CORRESPONDENCE Find articles in this issue containing these words: [Search ALL Issues] Table of Contents (PDF) | Editorial Board (PDF) | Front Matter (PDF) | Back Matter (PDF) | Advertising (PDF) To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. INSIDE BLOOD: T regulatory cells turn on T regulatory cells David W. Scott Blood 2009 114: 3975-3976. [Full Text] [PDF]   Heterogeneity in the AML stem cell pool Laura E. Hays Blood 2009 114: 3976-3977. [Full Text] [PDF]   MAL: not just a leukemia inducer Katya Ravid Blood 2009 114: 3977-3978. [Full Text] [PDF]   Denser matters Robert A. S. Ariëns Blood 2009 114: 3978-3979. [Full Text] [PDF]   Immunogenicity reloaded Willy Albert Flegel Blood 2009 114: 3979-3980. [Full Text] [PDF]   Are 2 cords better than 1? Meghan Delaney Blood 2009 114: 3980-3981. [Full Text] [PDF]   BLOOD WORK: Tophaceous gout with congenital dyserythropoietic anemia Blood 2009 114: 3982. [Full Text] [PDF]   PLENARY PAPERS: Modeling the functional heterogeneity of leukemia stem cells: role of STAT5 in leukemia stem cell self-renewal Michael Heuser, Laura M. Sly, Bob Argiropoulos, Florian Kuchenbauer, Courteney Lai, Andrew Weng, Malina Leung, Grace Lin, Christy Brookes, Stephen Fung, Peter J. Valk, Ruud Delwel, Bob Löwenberg, Gerald Krystal, and R. Keith Humphries Blood 2009 114: 3983-3993. Prepublished online August 10, 2009; DOI 10.1182/blood-2009-06-227603 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   REVIEW ARTICLES: The pleiotropic role of the fibrinogen ' chain in hemostasis Shirley Uitte de Willige, Kristina F. Standeven, Helen Philippou, and Robert A. S. Ariëns Blood 2009 114: 3994-4001. Prepublished online August 17, 2009; DOI 10.1182/blood-2009-05-217968 [Abstract] [Full Text] [PDF]   HOW I TREAT: How I treat EBV lymphoproliferation Helen E. Heslop Blood 2009 114: 4002-4008. Prepublished online September 1, 2009; DOI 10.1182/blood-2009-07-143545 [Abstract] [Full Text] [PDF]   CLINICAL TRIALS AND OBSERVATIONS: Deferasirox pharmacokinetics in patients with adequate versus inadequate response Deborah Chirnomas, Amber Lynn Smith, Jennifer Braunstein, Yaron Finkelstein, Luis Pereira, Anke K. Bergmann, Frederick D. Grant, Carole Paley, Michael Shannon, and Ellis J. Neufeld Blood 2009 114: 4009-4013. Prepublished online September 1, 2009; DOI 10.1182/blood-2009-05-222729 [Abstract] [Full Text] [PDF] [Supplemental Tables]   A protective role for early oral exposures in the etiology of young adult Hodgkin lymphoma Wendy Cozen, Ann S. Hamilton, Peng Zhao, Muhammad T. Salam, Dennis M. Deapen, Bharat N. Nathwani, Lawrence M. Weiss, and Thomas M. Mack Blood 2009 114: 4014-4020. Prepublished online September 8, 2009; DOI 10.1182/blood-2009-03-209601 [Abstract] [Full Text] [PDF] [Supplemental Table]   Pancreatic iron loading predicts cardiac iron loading in thalassemia major Leila J. Noetzli, Jhansi Papudesi, Thomas D. Coates, and John C. Wood Blood 2009 114: 4021-4026. Prepublished online September 2, 2009; DOI 10.1182/blood-2009-06-225615 [Abstract] [Full Text] [PDF]   Phase 3 randomized, placebo-controlled, double-blind study of high-dose continuous infusion cytarabine alone or with laromustine (VNP40101M) in patients with acute myeloid leukemia in first relapse Francis Giles, Norbert Vey, Daniel DeAngelo, Karen Seiter, Wendy Stock, Robert Stuart, Darinka Boskovic, Arnaud Pigneux, Martin Tallman, Joseph Brandwein, Jonathan Kell, Tadeusz Robak, Peter Staib, Xavier Thomas, Ann Cahill, Maher Albitar, and Susan O'Brien Blood 2009 114: 4027-4033. Prepublished online August 26, 2009; DOI 10.1182/blood-2009-06-229351 [Abstract] [Full Text] [PDF]   GENE THERAPY: CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII–specific immune responses in plasmid-mediated gene therapy–treated hemophilia mice Carol H. Miao, Benjamin R. Harmeling, Steven F. Ziegler, Benjamin C. Yen, Troy Torgerson, Liping Chen, Roger J. Yau, Baowei Peng, Arthur R. Thompson, Hans D. Ochs, and David J. Rawlings Blood 2009 114: 4034-4044. Prepublished online August 27, 2009; DOI 10.1182/blood-2009-06-228155 [Abstract] [Full Text] [PDF] [Supplemental Figures]   HEMATOPOIESIS AND STEM CELLS: Erythroid dysplasia, megaloblastic anemia, and impaired lymphopoiesis arising from mitochondrial dysfunction Michael L. Chen, T. Daniel Logan, Maryann L. Hochberg, Suresh G. Shelat, Xiang Yu, Gregory E. Wilding, Wei Tan, Gregory C. Kujoth, Tomas A. Prolla, Mary A. Selak, Mondira Kundu, Martin Carroll, and James E. Thompson Blood 2009 114: 4045-4053. Prepublished online September 4, 2009; DOI 10.1182/blood-2008-08-169474 [Abstract] [Full Text] [PDF] [Supplemental Methods]   In vivo prostaglandin E2 treatment alters the bone marrow microenvironment and preferentially expands short-term hematopoietic stem cells Benjamin J. Frisch, Rebecca L. Porter, Benjamin J. Gigliotti, Adam J. Olm-Shipman, Jonathan M. Weber, Regis J. O'Keefe, Craig T. Jordan, and Laura M. Calvi Blood 2009 114: 4054-4063. Prepublished online September 2, 2009; DOI 10.1182/blood-2009-03-205823 [Abstract] [Full Text] [PDF] [Supplemental Figure][Supplemental Table and Figure]   Dysfunctional expansion of hematopoietic stem cells and block of myeloid differentiation in lethal sepsis Sonia Rodriguez, Angelo Chora, Boyan Goumnerov, Christen Mumaw, W. Scott Goebel, Luis Fernandez, Hasan Baydoun, Harm HogenEsch, David M. Dombkowski, Carol A. Karlewicz, Susan Rice, Laurence G. Rahme, and Nadia Carlesso Blood 2009 114: 4064-4076. Prepublished online August 20, 2009; DOI 10.1182/blood-2009-04-214916 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Brief report  Spatial gradients of blood vessels and hematopoietic stem and progenitor cells within the marrow cavities of the human skeleton Vincent A. Bourke, Christopher J. Watchman, John D. Reith, Marda L. Jorgensen, Arnaud Dieudonnè, and Wesley E. Bolch Blood 2009 114: 4077-4080. Prepublished online September 11, 2009; DOI 10.1182/blood-2008-12-192922 [Abstract] [Full Text] [PDF]   IMMUNOBIOLOGY: Fibronectin maintains survival of mouse natural killer (NK) cells via CD11b/Src/β-catenin pathway Ting Zhang, Shuxun Liu, Pengyuan Yang, Chaofeng Han, Jianli Wang, Juan Liu, Yanmei Han, Yizhi Yu, and Xuetao Cao Blood 2009 114: 4081-4088. Prepublished online September 8, 2009; DOI 10.1182/blood-2009-05-219881 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Interleukin-21 restores immunoglobulin production ex vivo in patients with common variable immunodeficiency and selective IgA deficiency Stephan Borte, Qiang Pan-Hammarström, Chonghai Liu, Ulrich Sack, Michael Borte, Ulf Wagner, Dagmar Graf, and Lennart Hammarström Blood 2009 114: 4089-4098. Prepublished online September 8, 2009; DOI 10.1182/blood-2009-02-207423 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figure]   Comprehensive assessment of T-cell receptor β-chain diversity in β T cells Harlan S. Robins, Paulo V. Campregher, Santosh K. Srivastava, Abigail Wacher, Cameron J. Turtle, Orsalem Kahsai, Stanley R. Riddell, Edus H. Warren, and Christopher S. Carlson Blood 2009 114: 4099-4107. Prepublished online August 25, 2009; DOI 10.1182/blood-2009-04-217604 [Abstract] [Full Text] [PDF] [Supplemental Error Correction, Methods, and Tables]   Uptake of CCR7 and acquisition of migratory properties by human KIR+ NK cells interacting with monocyte-derived DC or EBV cell lines: regulation by KIR/HLA-class I interaction Emanuela Marcenaro, Claudia Cantoni, Silvia Pesce, Carola Prato, Daniela Pende, Sophie Agaugué, Lorenzo Moretta, and Alessandro Moretta Blood 2009 114: 4108-4116. Prepublished online September 11, 2009; DOI 10.1182/blood-2009-05-222265 [Abstract] [Full Text] [PDF] [Supplemental Methods]   Different NK cell–activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity Stephanie M. Wood, Marie Meeths, Samuel C. C. Chiang, Anne Grete Bechensteen, Jaap J. Boelens, Carsten Heilmann, Hisanori Horiuchi, Steen Rosthøj, Olga Rutynowska, Jacek Winiarski, Jennifer L. Stow, Magnus Nordenskjöld, Jan-Inge Henter, Hans-Gustaf Ljunggren, and Yenan T. Bryceson Blood 2009 114: 4117-4127. Prepublished online August 24, 2009; DOI 10.1182/blood-2009-06-225359 [Abstract] [Full Text] [PDF]   The role of the human cytomegalovirus UL111A gene in down-regulating CD4+ T-cell recognition of latently infected cells: implications for virus elimination during latency Allen K. L. Cheung, David J. Gottlieb, Bodo Plachter, Sandra Pepperl-Klindworth, Selmir Avdic, Anthony L. Cunningham, Allison Abendroth, and Barry Slobedman Blood 2009 114: 4128-4137. Prepublished online August 25, 2009; DOI 10.1182/blood-2008-12-197111 [Abstract] [Full Text] [PDF]   Brief report  Wild-type FOXP3 is selectively active in CD4+CD25hi regulatory T cells of healthy female carriers of different FOXP3 mutations Sara Di Nunzio, Massimiliano Cecconi, Laura Passerini, Alicia N. McMurchy, Udo Baron, Ivana Turbachova, Silvia Vignola, Erica Valencic, Alberto Tommasini, Anne Junker, Giantonio Cazzola, Sven Olek, Megan K. Levings, Lucia Perroni, Maria Grazia Roncarolo, and Rosa Bacchetta Blood 2009 114: 4138-4141. Prepublished online September 8, 2009; DOI 10.1182/blood-2009-04-214593 [Abstract] [Full Text] [PDF] [Supplemental Methods and Table]   LYMPHOID NEOPLASIA: Vaccine site inflammation potentiates idiotype DNA vaccine-induced therapeutic T cell–, and not B cell–, dependent antilymphoma immunity Hong Qin, Soung-chul Cha, Sattva S. Neelapu, Yanyan Lou, Jinsong Wei, Yong-Jun Liu, and Larry W. Kwak Blood 2009 114: 4142-4149. Prepublished online September 11, 2009; DOI 10.1182/blood-2009-05-219683 [Abstract] [Full Text] [PDF]   Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells Lisa S. Chen, Sanjeev Redkar, David Bearss, William G. Wierda, and Varsha Gandhi Blood 2009 114: 4150-4157. Prepublished online September 4, 2009; DOI 10.1182/blood-2009-03-212852 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Eµ-BCL10 mice exhibit constitutive activation of both canonical and noncanonical NF-B pathways generating marginal zone (MZ) B-cell expansion as a precursor to splenic MZ lymphoma Zhaoyang Li, Hongsheng Wang, Liquan Xue, Dong-Mi Shin, Derry Roopenian, Wu Xu, Chen-Feng Qi, Mark Y. Sangster, Carlos J. Orihuela, Elaine Tuomanen, Jerold E. Rehg, Xiaoli Cui, Quangeng Zhang, Herbert C. Morse, III, and Stephan W. Morris Blood 2009 114: 4158-4168. Prepublished online August 20, 2009; DOI 10.1182/blood-2008-12-192583 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   miR-128b is a potent glucocorticoid sensitizer in MLL-AF4 acute lymphocytic leukemia cells and exerts cooperative effects with miR-221 Ai Kotani, Daon Ha, James Hsieh, Prakash K. Rao, Diana Schotte, Monique L. den Boer, Scott A. Armstrong, and Harvey F. Lodish Blood 2009 114: 4169-4178. Prepublished online September 11, 2009; DOI 10.1182/blood-2008-12-191619 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Aberrant splicing of the E-cadherin transcript is a novel mechanism of gene silencing in chronic lymphocytic leukemia cells Sanjai Sharma and Alan Lichtenstein Blood 2009 114: 4179-4185. Prepublished online September 10, 2009; DOI 10.1182/blood-2009-03-206482 [Abstract] [Full Text] [PDF] [Supplemental Tables]   MYELOID NEOPLASIA: BMS-214662 induces mitochondrial apoptosis in chronic myeloid leukemia (CML) stem/progenitor cells, including CD34+38– cells, through activation of protein kinase Cβ Francesca Pellicano, Mhairi Copland, Heather G. Jorgensen, Joanne Mountford, Brian Leber, and Tessa L. Holyoake Blood 2009 114: 4186-4196. Prepublished online September 8, 2009; DOI 10.1182/blood-2009-05-219550 [Abstract] [Full Text] [PDF] [Supplemental Tables]   E3 ligase–defective Cbl mutants lead to a generalized mastocytosis and myeloproliferative disease Srinivasa Rao Bandi, Christian Brandts, Marion Rensinghoff, Rebekka Grundler, Lara Tickenbrock, Gabriele Köhler, Justus Duyster, Wolfgang E. Berdel, Carsten Müller-Tidow, Hubert Serve, on behalf of the Study Alliance Leukemias, and Bülent Sargin Blood 2009 114: 4197-4208. Prepublished online September 4, 2009; DOI 10.1182/blood-2008-12-190934 [Abstract] [Full Text] [PDF] [Supplemental Appendix and Figures]   PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS: A fundamental role of mAbp1 in neutrophils: impact on β2 integrin–mediated phagocytosis and adhesion in vivo Jürgen Schymeinsky, Ronald Gerstl, Ingrid Mannigel, Katy Niedung, David Frommhold, Klaus Panthel, Jürgen Heesemann, Michael Sixt, Thomas Quast, Waldemar Kolanus, Attila Mocsai, Jürgen Wienands, Markus Sperandio, and Barbara Walzog Blood 2009 114: 4209-4220. Prepublished online July 28, 2009; DOI 10.1182/blood-2009-02-206169 [Abstract] [Full Text] [PDF] [Supplemental Methods, Figures, and Videos]   PLATELETS AND THROMBOPOIESIS: MAL/SRF complex is involved in platelet formation and megakaryocyte migration by regulating MYL9 (MLC2) and MMP9 Laure Gilles, Dominique Bluteau, Siham Boukour, Yunhua Chang, Yanyan Zhang, Thomas Robert, Philippe Dessen, Najet Debili, Olivier A. Bernard, William Vainchenker, and Hana Raslova Blood 2009 114: 4221-4232. Prepublished online September 1, 2009; DOI 10.1182/blood-2009-03-209932 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   RED CELLS, IRON, AND ERYTHROPOIESIS: Coupled transcription-splicing regulation of mutually exclusive splicing events at the 5' exons of protein 4.1R gene Shu-Ching Huang, Aeri Cho, Stephanie Norton, Eva S. Liu, Jennie Park, Anyu Zhou, Indira D. Munagala, Alexander C. Ou, Guang Yang, Amittha Wickrema, Tang K. Tang, and Edward J. Benz, Jr Blood 2009 114: 4233-4242. Prepublished online September 3, 2009; DOI 10.1182/blood-2009-02-206219 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Plasmodium falciparum–infected erythrocytes induce NF-B regulated inflammatory pathways in human cerebral endothelium Abhai K. Tripathi, Wei Sha, Vladimir Shulaev, Monique F. Stins, and David J. Sullivan, Jr Blood 2009 114: 4243-4252. Prepublished online August 27, 2009; DOI 10.1182/blood-2009-06-226415 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Chromosome looping at the human -globin locus is mediated via the major upstream regulatory element (HS –40) Douglas Vernimmen, Fatima Marques-Kranc, Jacqueline A. Sharpe, Jacqueline A. Sloane-Stanley, William G. Wood, Helen A. C. Wallace, Andrew J. H. Smith, and Douglas R. Higgs Blood 2009 114: 4253-4260. Prepublished online August 20, 2009; DOI 10.1182/blood-2009-03-213439 [Abstract] [Full Text] [PDF] [Supplemental Figures]   THROMBOSIS AND HEMOSTASIS: Characterization of complement factor H–related (CFHR) proteins in plasma reveals novel genetic variations of CFHR1 associated with atypical hemolytic uremic syndrome Cynthia Abarrategui-Garrido, Rubén Martínez-Barricarte, Margarita López-Trascasa, Santiago Rodríguez de Córdoba, and Pilar Sánchez-Corral Blood 2009 114: 4261-4271. Prepublished online September 10, 2009; DOI 10.1182/blood-2009-05-223834 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives Anetta Undas, Krystyna Zawilska, Mariola Ciesla-Dul, Agata Lehmann-Kopydlowska, Agnieszka Skubiszak, Katarzyna Ciepluch, and Wieslawa Tracz Blood 2009 114: 4272-4278. Prepublished online August 18, 2009; DOI 10.1182/blood-2009-05-222380 [Abstract] [Full Text] [PDF]   TRANSFUSION MEDICINE: Brief report  Immunogenicity of blood group antigens: a mathematical model corrected for antibody evanescence with exclusion of naturally occurring and pregnancy-related antibodies Christopher A. Tormey and Gary Stack Blood 2009 114: 4279-4282. Prepublished online August 27, 2009; DOI 10.1182/blood-2009-06-227793 [Abstract] [Full Text] [PDF]   TRANSPLANTATION: Cytotoxic T lymphocyte therapy with donor T cells prevents and treats adenovirus and Epstein-Barr virus infections after haploidentical and matched unrelated stem cell transplantation Ann M. Leen, Anne Christin, Gary D. Myers, Hao Liu, Conrad R. Cruz, Patrick J. Hanley, Alana A. Kennedy-Nasser, Kathryn S. Leung, Adrian P. Gee, Robert A. Krance, Malcolm K. Brenner, Helen E. Heslop, Cliona M. Rooney, and Catherine M. Bollard Blood 2009 114: 4283-4292. Prepublished online August 21, 2009; DOI 10.1182/blood-2009-07-232454 [Abstract] [Full Text] [PDF]   Relapse risk after umbilical cord blood transplantation: enhanced graft-versus-leukemia effect in recipients of 2 units Michael R. Verneris, Claudio G. Brunstein, Juliet Barker, Margaret L. MacMillan, Todd DeFor, David H. McKenna, Michael J. Burke, Bruce R. Blazar, Jeffrey S. Miller, Philip B. McGlave, Daniel J. Weisdorf, and John E. Wagner Blood 2009 114: 4293-4299. Prepublished online August 25, 2009; DOI 10.1182/blood-2009-05-220525 [Abstract] [Full Text] [PDF]   VASCULAR BIOLOGY: Repulsive axon guidance molecule Slit3 is a novel angiogenic factor Bing Zhang, Ursula M. Dietrich, Jian-Guo Geng, Roy Bicknell, Jeffrey D. Esko, and Lianchun Wang Blood 2009 114: 4300-4309. Prepublished online September 9, 2009; DOI 10.1182/blood-2008-12-193326 [Abstract] [Full Text] [PDF] [Supplemental Methods and Figures]   Bone marrow stem and progenitor cell contribution to neovasculogenesis is dependent on model system with SDF-1 as a permissive trigger Gerard J. Madlambayan, Jason M. Butler, Koji Hosaka, Marda Jorgensen, Dongtao Fu, Steven M. Guthrie, Anitha K. Shenoy, Adam Brank, Kathryn J. Russell, Jaclyn Otero, Dietmar W. Siemann, Edward W. Scott, and Christopher R. Cogle Blood 2009 114: 4310-4319. Prepublished online August 28, 2009; DOI 10.1182/blood-2009-03-211342 [Abstract] [Full Text] [PDF] [Supplemental Methods, Figures, and Videos]   CORRESPONDENCE: Cutaneous tumor lysis syndrome in a patient with HTLV-1 adult T-cell lymphoma/leukemia Jean-David Bouaziz, Nadège Cordel, Geoffroy Hickman, Claire Fieschi, Nicolas Ortonne, and Martine Bagot Blood 2009 114: 4320-4321. [Full Text] [PDF]   Integrity of the CBL gene in mature B-cell malignancies Morgan R. McKeller, Ryan S. Robetorye, Patricia L. M. Dahia, and Ricardo C. T. Aguiar Blood 2009 114: 4321-4322. [Full Text] [PDF]   To see an article, click its [Full Text] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

	Copyright © 2009 by American Society of Hematology         Online ISSN: 1528-0020