Cover figure courtesy of Barbui et al, "Review: The Impact of All-trans-Retinoic Acid on the Coagulopathy of Acute Promyelocytic Leukemia." Acute promyelocytic leukemia cells interact with the hemostatic system in multiple ways, including their release of cellular procoagulants and fibrinolytic proteins, and inflammatory cytokines which induce a thrombogenic state in endothelial cells. All-trans-retinoic acid counteracts many of these effects. 3093