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November 12, 2009; 114 (20)

      Down REVIEW ARTICLE
      Down HOW I TREAT
      Down CLINICAL TRIALS AND OBSERVATIONS
      Down GENE THERAPY
      Down HEMATOPOIESIS AND STEM CELLS
      Down IMMUNOBIOLOGY
      Down LYMPHOID NEOPLASIA
      Down MYELOID NEOPLASIA
      Down PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS
      Down PLATELETS AND THROMBOPOIESIS
      Down RED CELLS, IRON, AND ERYTHROPOIESIS
      Down THROMBOSIS AND HEMOSTASIS
      Down TRANSPLANTATION
      Down VASCULAR BIOLOGY

REVIEW ARTICLEBack

G. Socie and B. R. Blazar
Acute graft-versus-host disease: from the bench to the bedside

HOW I TREATBack

H. M. Prince, S. Whittaker, and R. T. Hoppe
How I treat mycosis fungoides and Sezary syndrome

CLINICAL TRIALS AND OBSERVATIONSBack

D. A. Jacobsohn, A. L. Gilman, A. Rademaker, B. Browning, M. Grimley, L. Lehmann, E. R. Nemecek, K. Thormann, K. R. Schultz, and G. B. Vogelsang
Evaluation of pentostatin in corticosteroid-refractory chronic graft-versus-host disease in children: a Pediatric Blood and Marrow Transplant Consortium study

R. J. Garg, H. Kantarjian, S. O'Brien, A. Quintas-Cardama, S. Faderl, Z. Estrov, and J. Cortes
The use of nilotinib or dasatinib after failure to 2 prior tyrosine kinase inhibitors: long-term follow-up

B. Paiva, M.-B. Vidriales, G. Mateo, J. J. Perez, M. A. Montalban, A. Sureda, L. Montejano, N. C. Gutierrez, A. Garcia de Coca, N. de las Heras, M. V. Mateos, M. C. Lopez-Berges, R. Garcia-Boyero, J. Galende, J. Hernandez, L. Palomera, D. Carrera, R. Martinez, J. de la Rubia, A. Martin, Y. Gonzalez, J. Blade, J. J. Lahuerta, A. Orfao, and J. F. San Miguel on behalf of the GEM (Grupo Espanol de MM)/PETHEMA (Programa para el Estudio de la Terapeutica en Hemopatias Malignas) Cooperative Study Groups
Brief report. The persistence of immunophenotypically normal residual bone marrow plasma cells at diagnosis identifies a good prognostic subgroup of symptomatic multiple myeloma patients

GENE THERAPYBack

B. Peng, P. Ye, D. J. Rawlings, H. D. Ochs, and C. H. Miao
Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy

HEMATOPOIESIS AND STEM CELLSBack

Y. Kubota, M. Osawa, L. M. Jakt, K. Yoshikawa, and S.-I. Nishikawa
Necdin restricts proliferation of hematopoietic stem cells during hematopoietic regeneration

D. C. Goldman, A. S. Bailey, D. L. Pfaffle, A. Al Masri, J. L. Christian, and W. H. Fleming
BMP4 regulates the hematopoietic stem cell niche

Y. D. Ma, C. Park, H. Zhao, K. A. Oduro, Jr, X. Tu, F. Long, P. M. Allen, S. L. Teitelbaum, and K. Choi
Defects in osteoblast function but no changes in long-term repopulating potential of hematopoietic stem cells in a mouse chronic inflammatory arthritis model

IMMUNOBIOLOGYBack

K. Hochweller, T. Miloud, J. Striegler, S. Naik, G. Hammerling, and N. Garbi
Homeostasis of dendritic cells in lymphoid organs is controlled by regulation of their precursors via a feedback loop

G. Gruenbacher, H. Gander, A. Rahm, W. Nussbaumer, N. Romani, and M. Thurnher
CD56+ human blood dendritic cells effectively promote TH1-type gamma delta T-cell responses

M. Taillardet, G. Haffar, P. Mondiere, M.-J. Asensio, H. Gheit, N. Burdin, T. Defrance, and L. Genestier
The thymus-independent immunity conferred by a pneumococcal polysaccharide is mediated by long-lived plasma cells

LYMPHOID NEOPLASIABack

A. V. Kurtova, K. Balakrishnan, R. Chen, W. Ding, S. Schnabl, M. P. Quiroga, M. Sivina, W. G. Wierda, Z. Estrov, M. J. Keating, M. Shehata, U. Jager, V. Gandhi, N. E. Kay, W. Plunkett, and J. A. Burger
Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance

E. J. Volanakis, R. T. Williams, and C. J. Sherr
Stage-specific Arf tumor suppression in Notch1-induced T-cell acute lymphoblastic leukemia

L.-A. Sutton, E. Kostareli, A. Hadzidimitriou, N. Darzentas, A. Tsaftaris, A. Anagnostopoulos, R. Rosenquist, and K. Stamatopoulos
Extensive intraclonal diversification in a subgroup of chronic lymphocytic leukemia patients with stereotyped IGHV4-34 receptors: implications for ongoing interactions with antigen

T. Enzler, A. P. Kater, W. Zhang, G. F. Widhopf II, H.-Y. Chuang, J. Lee, E. Avery, C. M. Croce, M. Karin, and T. J. Kipps
Chronic lymphocytic leukemia of Emu -TCL1 transgenic mice undergoes rapid cell turnover that can be offset by extrinsic CD257 to accelerate disease progression

B. Varghese, A. Widman, J. Do, B. Taidi, D. K. Czerwinski, J. Timmerman, S. Levy, and R. Levy
Generation of CD8+ T cell-mediated immunity against idiotype-negative lymphoma escapees

Z. Li, W. Zhang, M. Wu, S. Zhu, C. Gao, L. Sun, R. Zhang, N. Qiao, H. Xue, Y. Hu, S. Bao, H. Zheng, and J.-D. J. Han
Gene expression-based classification and regulatory networks of pediatric acute lymphoblastic leukemia

S. Baskar, J. M. Suschak, I. Samija, R. Srinivasan, R. W. Childs, S. Z. Pavletic, M. R. Bishop, and C. Rader
A human monoclonal antibody drug and target discovery platform for B-cell chronic lymphocytic leukemia based on allogeneic hematopoietic stem cell transplantation and phage display

A. Mottok, C. Renne, M. Seifert, E. Oppermann, W. Bechstein, M.-L. Hansmann, R. Kuppers, and A. Brauninger
Brief report. Inactivating SOCS1 mutations are caused by aberrant somatic hypermutation and restricted to a subset of B-cell lymphoma entities

MYELOID NEOPLASIABack

M. Rahmani, A. Anderson, J. R. Habibi, T. R. Crabtree, M. Mayo, H. Harada, A. Ferreira-Gonzalez, P. Dent, and S. Grant
The BH3-only protein Bim plays a critical role in leukemia cell death triggered by concomitant inhibition of the PI3K/Akt and MEK/ERK1/2 pathways

PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESISBack

M. Hiasa, M. Abe, A. Nakano, A. Oda, H. Amou, S. Kido, K. Takeuchi, K. Kagawa, K. Yata, T. Hashimoto, S. Ozaki, K. Asaoka, E. Tanaka, K. Moriyama, and T. Matsumoto
GM-CSF and IL-4 induce dendritic cell differentiation and disrupt osteoclastogenesis through M-CSF receptor shedding by up-regulation of TNF-alpha converting enzyme (TACE)

K. Szczur, Y. Zheng, and M.-D. Filippi
The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signaling

PLATELETS AND THROMBOPOIESISBack

C. Licht, F. G. Pluthero, L. Li, H. Christensen, S. Habbig, B. Hoppe, D. F. Geary, P. F. Zipfel, and W. H. A. Kahr
Platelet-associated complement factor H in healthy persons and patients with atypical HUS

RED CELLS, IRON, AND ERYTHROPOIESISBack

I. De Domenico, D. McVey Ward, and J. Kaplan
Specific iron chelators determine the route of ferritin degradation

THROMBOSIS AND HEMOSTASISBack

N. Yadav, K. Sumod, S. Kumar, M. Jain, A. Halder, R. Saxena, and A. Mukhopadhyay
The therapeutic effect of bone marrow-derived liver cells in the phenotypic correction of murine hemophilia A

D. E. Sabatino, C. F. Freguia, R. Toso, A. Santos, E. P. Merricks, H. H. Kazazian Jr, T. C. Nichols, R. M. Camire, and V. R. Arruda
Brief report. Recombinant canine B-domain-deleted FVIII exhibits high specific activity and is safe in the canine hemophilia A model

TRANSPLANTATIONBack

E. Cantarelli, R. Melzi, A. Mercalli, V. Sordi, G. Ferrari, C. W. Lederer, E. Mrak, A. Rubinacci, M. Ponzoni, G. Sitia, L. G. Guidotti, E. Bonifacio, and L. Piemonti
Bone marrow as an alternative site for islet transplantation

N. Beyersdorf, X. Ding, T. Hunig, and T. Kerkau
Superagonistic CD28 stimulation of allogeneic T cells protects from acute graft-versus-host disease

VASCULAR BIOLOGYBack

H. Laubli, K.-S. Spanaus, and L. Borsig
Selectin-mediated activation of endothelial cells induces expression of CCL5 and promotes metastasis through recruitment of monocytes

R. C. Doebele, F. T. Schulze-Hoepfner, J. Hong, A. Chlenski, B. D. Zeitlin, K. Goel, S. Gomes, Y. Liu, M. K. Abe, J. E. Nor, M. W. Lingen, and M. R. Rosner
A novel interplay between Epac/Rap1 and mitogen-activated protein kinase kinase 5/ extracellular signal-regulated kinase 5 (MEK5/ERK5) regulates thrombospondin to control angiogenesis

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