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Blood's First Edition Papers: Last updated September 2, 2010 [View by section] To enable Blood's readers to learn about new scientific findings at the earliest possible moment, the Journal has decided to prepublish, in manuscript format, all accepted articles shortly after acceptance as "First Edition Papers." First Edition Papers have undergone full scientific review but none of the editorial preparation, such as copyediting, typesetting, and proofreading, which is mandatory for all articles published in the regular print and online issues of Blood. Disclaimer More about Blood's First Edition Papers: To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. 2 September 2010 Xingkui Xue, Nancy K. Pech, W. Christopher Shelley, Edward F. Srour, Mervin C. Yoder, and Mary C. Dinauer Antibody targeting KIT as pre-transplant conditioning in immunocompetent mice Blood First Edition Paper, prepublished online September 2, 2010;DOI 10.1182/blood-2010-07-295949[Abstract][PDF][Supplemental Methods, Table, and Figures]  Subhrajit Biswas, Qiong Shi, Lauren Matise, Susan Cleveland, Utpal Dave, and Sandra Zinkel A role for pro-apoptotic Bax and Bak in T cell differentiation and transformation Blood First Edition Paper, prepublished online September 2, 2010;DOI 10.1182/blood-2010-04-279687[Abstract][PDF][Supplemental Figures]  Yuriko Kawamori, Yoshio Katayama, Noboru Asada, Kentaro Minagawa, Mari Sato, Atsuo Okamura, Manabu Shimoyama, Kimie Nakagawa, Toshio Okano, Mitsune Tanimoto, Shigeaki Kato, and Toshimitsu Matsui Importance of Vitamin D receptor for neuronal control of hematopoietic stem cell niche Blood First Edition Paper, prepublished online September 2, 2010;DOI 10.1182/blood-2010-04-279216[Abstract][PDF][ Supplemental Tables and Figures ]  Mercy Guech-Ongey, Edgar P. Simard, William F. Anderson, Eric A. Engels, Kishor Bhatia, Susan S. Devesa, and Sam M. Mbulaiteye AIDS-related Burkitt lymphoma in the United States: what do age and CD4 lymphocyte patterns tell us about etiology and/or biology? Blood First Edition Paper, prepublished online September 2, 2010;DOI 10.1182/blood-2010-03-275917[Abstract][PDF]  Karen E. Anderson, Tamara A.M. Chessa, Keith Davidson, Robert B. Henderson, Simon Walker, Tanya Tolmachova, Katarzyna Grys, Oliver Rausch, Miguel Seabra, Victor L. J. Tybulewicz, Len R. Stephens, and Phillip T. Hawkins PtdIns3P and Rac direct the assembly of the NADPH oxidase on a novel, pre-phagosomal compartment during FcR-mediated phagocytosis in primary mouse neutrophils Blood First Edition Paper, prepublished online September 2, 2010;DOI 10.1182/blood-2010-03-275602[Abstract][PDF][Supplemental Methods, Figures, and Videos]  Baofeng Zhao, Changzoon Chun, Zhong Liu, Mark A. Horswill, Kallal Pramanik, George A. Wilkinson, Ramani Ramchandran, and Robert Q. Miao Nogo-B receptor is essential for angiogenesis in zebrafish via Akt pathway Blood First Edition Paper, prepublished online September 2, 2010;DOI 10.1182/blood-2010-02-271577[Abstract][PDF][ Supplemental Methods and Figures ]  1 September 2010 Arvind Dev, Jing Fang, Pradeep Sathyanarayana, Anamika Pradeep, Christine Emerson, and Don M. Wojchowski During EPO or anemia challenge, erythroid progenitor cells transit through a selectively expandable proerythroblast pool Blood First Edition Paper, prepublished online September 1, 2010;DOI 10.1182/blood-2009-12-258947[Abstract][PDF][Supplemental Figures]  Priscilla P. L. Chiu, Hong Jiang, and John E. Dick Leukemia-initiating cells in human T-lymphoblastic leukemia exhibit glucocorticoid resistance Blood First Edition Paper, prepublished online September 1, 2010;DOI 10.1182/blood-2010-06-292300[Abstract][PDF][Supplemental Tables]  Aditya Mandawat, Warren Fiskus, Kathleen M. Buckley, Kelly Robbins, Rekha Rao, Ramesh Balusu, Jean-Marc Navenot, Zi-Xuan Wang, Celalettin Ustun, Daniel G. Chong, Peter Atadja, Nobutaka Fujii, Stephen C. Peiper, and Kapil Bhalla Pan-histone deacetylase (HDAC) inhibitor panobinostat depletes CXCR4 levels and signaling and exerts synergistic anti-myeloid activity in combination with CXCR4 antagonists Blood First Edition Paper, prepublished online September 1, 2010;DOI 10.1182/blood-2010-05-284414[Abstract][PDF]  Amina Haouala, Nicolas Widmer, Michel A. Duchosal, Michael Montemurro, Thierry Buclin, and Laurent A. Decosterd Drug interactions with the tyrosine kinase inhibitors imatinib, dasatinib, and nilotinib Blood First Edition Paper, prepublished online September 1, 2010;DOI 10.1182/blood-2010-07-294330[Abstract][PDF]  Yesim Dargaud, Anne Lienhart, and Claude Negrier Prospective assessment of thrombin generation test for dose monitoring of bypassing therapy in hemophilia patients with inhibitors undergoing elective surgery Blood First Edition Paper, prepublished online September 1, 2010;DOI 10.1182/blood-2010-06-291906[Abstract][PDF]  Nicola Martinelli, Domenico Girelli, Barbara Lunghi, Mirko Pinotti, Giovanna Marchetti, Giovanni Malerba, Pier Franco Pignatti, Roberto Corrocher, Oliviero Olivieri, and Francesco Bernardi Polymorphisms at LDLR locus may be associated with coronary artery disease through modulation of coagulation factor VIII activity and independently from lipid profile Blood First Edition Paper, prepublished online September 1, 2010;DOI 10.1182/blood-2010-03-277079[Abstract][PDF][Supplemental Tables and Figure]  31 August 2010 Jinshui Fan, Li Li, Donald Small, and Feyruz Rassool Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: implications for genomic instability and therapy Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2010-03-272591[Abstract][PDF][Supplemental Figures]  Cristina Cunha, Mauro Di Ianni, Silvia Bozza, Gloria Giovannini, Silvia Zagarella, Teresa Zelante, Carmen D'Angelo, Antonio Pierini, Lucia Pitzurra, Franca Falzetti, Alessandra Carotti, Katia Perruccio, Jean-Paul Latgé, Fernando Rodrigues, Andrea Velardi, Franco Aversa, Luigina Romani, and Agostinho Carvalho Dectin-1 Y238X polymorphism associates with susceptibility to invasive aspergillosis in hematopoietic transplantation through impairment of both recipient- and donor-dependent mechanisms of antifungal immunity Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2010-04-279307[Abstract][PDF]  Christofer Diakos, Sheng Zhong, Yuanyuan Xiao, Mi Zhou, Gisele M. Vasconcelos, Gerd Krapf, Ru-Fang Yeh, Shichun Zheng, Michelle Kang, John K. Wiencke, Maria S. Pombo-de-Oliveira, Renate Panzer-Grümayer, and Joseph L. Wiemels TEL-AML1 regulation of survivin and apoptosis via miRNA-494 and miRNA-320a Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2009-02-206706[Abstract][PDF][Supplemental Table]  Yukiya Yamamoto, Sachiko Tsuzuki, Motohiro Tsuzuki, Kousuke Handa, Yoko Inaguma, and Nobuhiko Emi BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemia Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2010-01-264432[Abstract][PDF][Supplemental Methods, Table, and Figures]  Steven L. Highfill, Paulo C. Rodriguez, Qing Zhou, Christine A. Goetz, Brent H. Koehn, Rachelle Veenstra, Patricia A. Taylor, Angela Panoskaltsis-Mortari, Jonathan S. Serody, David H. Munn, Jakub Tolar, Augusto C. Ochoa, and Bruce R. Blazar Bone marrow myeloid-derived suppressor cells (MDSC) inhibit graft-versus-host (GVHD) disease via an arginase-1 dependent mechanism that is upregulated by IL-13 Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2010-06-287839[Abstract][PDF][Supplemental Figures]  Albert Wölfler, Astrid A. Danen-van Oorschot, Jurgen R. Haanstra, Marijke Valkhof, Claudia Bodner, Eric Vroegindeweij, Paulette van Strien, Alexandra Novak, Tom Cupedo, and Ivo P. Touw Lineage-instructive function of C/EBP in multipotent hematopoietic cells and early thymic progenitors Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2010-03-275404[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Hong Zhang, Ester C. Löwenberg, Jeffrey R. Crosby, A. Robert MacLeod, Chenguang Zhao, Dacao Gao, Chris Black, Alexey S. Revenko, Joost C.M. Meijers, Erik S. Stroes, Marcel Levi, and Brett P. Monia Inhibition of the intrinsic coagulation pathway factor XI by antisense oligonucleotides: a novel antithrombotic strategy with lowered bleeding risk Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2010-04-277798[Abstract][PDF][Supplemental Videos]  Karen Keeshan, Will Bailis, Priya H. Dedhia, Maria E. Vega, Olga Shestova, Lanwei Xu, Kristin Toscano, Sacha N. Uljon, Stephen C. Blacklow, and Warren S. Pear Transformation by Tribbles homologue 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2009-10-247361[Abstract][PDF][Supplemental Figures]  Sara Bringhen, Alessandra Larocca, Davide Rossi, Maide Cavalli, Mariella Genuardi, Roberto Ria, Silvia Gentili, Francesca Patriarca, Chiara Nozzoli, Anna Levi, Tommasina Guglielmelli, Giulia Benevolo, Vincenzo Callea, Vincenzo Rizzo, Clotilde Cangialosi, Pellegrino Musto, Luca De Rosa, Anna Marina Liberati, Mariella Grasso, Antonietta P Falcone, Andrea Evangelista, Michele Cavo, Gianluca Gaidano, Mario Boccadoro, and Antonio Palumbo Efficacy and safety of once weekly bortezomib in multiple myeloma patients Blood First Edition Paper, prepublished online August 31, 2010;DOI 10.1182/blood-2010-07-294983[Abstract][PDF][Supplemental Appendix]  30 August 2010 Cees E. van der Poel, Roos A. Karssemeijer, Peter Boross, Joke A. van der Linden, Miranda Blokland, Jan G.J. van de Winkel, and Jeanette H.W. Leusen Cytokine induced immune complex binding to the high affinity IgG receptor, FcRI, in the presence of monomeric IgG Blood First Edition Paper, prepublished online August 30, 2010;DOI 10.1182/blood-2010-04-280214[Abstract][PDF][Supplemental Figures]  Michael Pfreundschuh How I treat elderly patients with diffuse large B-cell lymphoma Blood First Edition Paper, prepublished online August 30, 2010;DOI 10.1182/blood-2010-07-259333[Abstract][PDF]  Daniel Sanghoon Shin, Sang Hee Min, Laura Russell, Rongbao Zhao, Andras Fiser, and I. David Goldman Functional roles of aspartate residues of the human proton-coupled folate transporter (PCFT; SLC46A1); D156, mutated in hereditary folate malabsorption, is critical for protein stability; D109 is irreplaceable Blood First Edition Paper, prepublished online August 30, 2010;DOI 10.1182/blood-2010-06-291237[Abstract][PDF]  Susanne Schnittger, Claudia Haferlach, Madlen Ulke, Tamara Alpermann, Wolfgang Kern, and Torsten Haferlach IDH1 mutations are detected in 6.6% of 1414 AML patients and are associated with intermediate risk karyotype and unfavorable prognosis in adults younger than 60 years and unmutated NPM1 status Blood First Edition Paper, prepublished online August 30, 2010;DOI 10.1182/blood-2010-02-267955[Abstract][PDF]  Dharminder Chauhan, Ajita V. Singh, Monette Aujay, Christopher J. Kirk, Madhavi Bandi, Bryan Ciccarelli, Noopur Raje, Paul Richardson, and Kenneth C. Anderson A novel orally active proteasome inhibitor ONX 0912 trigger in vitro and in vivo cytotoxicity in multiple myeloma Blood First Edition Paper, prepublished online August 30, 2010;DOI 10.1182/blood-2010-04-276626[Abstract][PDF]  27 August 2010 Gudrun Göhring, Kyra Michalova, H. Berna Beverloo, David Betts, Jochen Harbott, Oskar A. Haas, Gitte Kerndrup, Laura Sainati, Eva Bergstraesser, Henrik Hasle, Jan Stary, Monika Trebo, Marry M. van den Heuvel-Eibrink, Marco Zecca, Elisabeth R. van Wering, Alexandra Fischer, Peter Noellke, Brigitte Strahm, Franco Locatelli, Charlotte M. Niemeyer, and Brigitte Schlegelberger Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome Blood First Edition Paper, prepublished online August 27, 2010;DOI 10.1182/blood-2010-04-280313[Abstract][PDF][Supplemental Tables]  Caterina Casari, Mirko Pinotti, Stefano Lancellotti, Elena Adinolfi, Alessandra Casonato, Raimondo De Cristofaro, and Francesco Bernardi The dominant-negative von Willebrand factor gene deletion p.P1105_C1926delinsR: molecular mechanism and modulation Blood First Edition Paper, prepublished online August 27, 2010;DOI 10.1182/blood-2010-02-268920[Abstract][PDF][Supplemental Tables and Figures]  Weihong Tang, Saonli Basu, Xiaoxiao Kong, James S. Pankow, Nena Aleksic, Adrian Tan, Mary Cushman, Eric Boerwinkle, and Aaron R. Folsom Genome-wide association study identifies novel loci for plasma levels of protein C: the ARIC study Blood First Edition Paper, prepublished online August 27, 2010;DOI 10.1182/blood-2010-05-283739[Abstract][PDF][Supplemental Tables and Figures]  26 August 2010 Yi Feng, Yanping Yang, Manoela M. Ortega, Jessica N. Copeland, Mingcai Zhang, Jennifer B. Jacob, Timothy A. Fields, Jay L. Vivian, and Patrick E. Fields Early mammalian erythropoiesis requires the Dot1L methyltransferase Blood First Edition Paper, prepublished online August 26, 2010;DOI 10.1182/blood-2010-03-276501[Abstract][PDF][Supplemental Figures]  Shaji Kumar, Angela Dispenzieri, Jerry A. Katzmann, Dirk R. Larson, Colin L. Colby, Martha Q. Lacy, Suzanne R. Hayman, Francis K. Buadi, Nelson Leung, Steve R. Zeldenrust, Marina Ramirez-Alvarado, Raynell J. Clark, Robert A. Kyle, S. Vincent Rajkumar, and Morie A. Gertz Serum immunoglobulin free light chain measurement in AL amyloidosis: prognostic value and correlations with clinical features Blood First Edition Paper, prepublished online August 26, 2010;DOI 10.1182/blood-2010-06-290668[Abstract][PDF]  Jean-Philippe Bastien, Gorazd Krosl, Cynthia Therien, Marissa Rashkovan, Christian Scotto, Sandra Cohen, David S. Allan, Donna Hogge, R. Maarten Egeler, Claude Perreault, and Denis Claude Roy Photodepletion differentially affects CD4+ Tregs versus CD4+ effector T cells from patients with chronic graft-versus-host disease Blood First Edition Paper, prepublished online August 26, 2010;DOI 10.1182/blood-2010-03-273193[Abstract][PDF][Supplemental Figures]  Kori L. Wallace and Joel Linden Adenosine A2A receptors induced on iNKT and NK cells reduce pulmonary inflammation and injury in mice with sickle cell disease Blood First Edition Paper, prepublished online August 26, 2010;DOI 10.1182/blood-2010-06-290643[Abstract][PDF]  Hideaki Nakajima, Miyuki Ito, David S. Smookler, Fumi Shibata, Yumi Fukuchi, Yoshihiro Morikawa, Yuichi Ikeda, Fumio Arai, Toshio Suda, Rama Khokha, and Toshio Kitamura TIMP-3 recruits quiescent hematopoietic stem cells into active cell cycle and expands multipotent progenitor pool Blood First Edition Paper, prepublished online August 26, 2010;DOI 10.1182/blood-2010-01-266528[Abstract][PDF][Supplemental Methods, Tables, and Figures]  25 August 2010 Florence Vallelian, Christian A. Schaer, Theresa Kaempfer, Peter Gehrig, Elena Duerst, Gabriele Schoedon, and Dominik J. Schaer Glucocorticoid treatment skews human monocyte differentiation into a hemoglobin-clearance phenotype with enhanced heme-iron recycling and antioxidant capacity Blood First Edition Paper, prepublished online August 25, 2010;DOI 10.1182/blood-2010-04-277319[Abstract][PDF][Supplemental Tables and Figures]  Krisztián Csomós, István Német, László Fésüs, and Zoltán Balajthy Tissue transglutaminase contributes to the all-trans retinoic acid induced differentiation syndrome phenotype in the NB4 model of acute promyelocytic leukemia Blood First Edition Paper, prepublished online August 25, 2010;DOI 10.1182/blood-2010-01-266064[Abstract][PDF][Supplemental Tables and Figure]  Amber N. Stratman, Amy E. Schwindt, Kristine M. Malotte, and George E. Davis Endothelial-derived PDGF-BB and HB-EGF coordinately regulate pericyte recruitment during vasculogenic tube assembly and stabilization Blood First Edition Paper, prepublished online August 25, 2010;DOI 10.1182/blood-2010-05-286872[Abstract][PDF][Supplemental Figures and Videos]  Zhi-Min Gu, Ying-Li Wu, Mei-Yi Zhou, Chuan-Xu Liu, Han-Zhang Xu, Hua Yan, Yong Zhao, Ying Huang, Han-Dong Sun, and Guo-Qiang Chen Pharicin B stabilizes retinoic acid receptor- and presents synergistic differentiation induction with ATRA in myeloid leukemic cells Blood First Edition Paper, prepublished online August 25, 2010;DOI 10.1182/blood-2010-02-267963[Abstract][PDF][Supplemental Methods, Table, and Figures]  Rémi Letestu, Vincent Lévy, Virginie Eclache, Fanny Baran-Marszak, Dominique Vaur, Dina Naguib, Olivier Schischmanoff, Sandrine Katsahian, Florence Nguyen-Khac, Frédéric Davi, Hélène Merle-Béral, Xavier Troussard, and Florence Cymbalista Prognosis of Binet stage A chronic lymphocytic leukemia patients: the strength of routine parameters Blood First Edition Paper, prepublished online August 25, 2010;DOI 10.1182/blood-2010-06-288274[Abstract][PDF][Supplemental Tables and Figures]  Victoria J Weston, Ceri E Oldreive, Anna Skowronska, David G Oscier, Guy Pratt, Martin JS Dyer, Graeme Smith, Judy E Powell, Zbigniew Rudzki, Pamela Kearns, Paul AH Moss, A Malcolm R Taylor, and Tatjana Stankovic The PARP inhibitor olaparib induces significant killing of ATM deficient lymphoid tumour cells in vitro and in vivo Blood First Edition Paper, prepublished online August 25, 2010;DOI 10.1182/blood-2010-01-265769[Abstract][PDF][Supplemental Methods, Tables, and Figures]  24 August 2010 Irina Velichutina, Rita Shaknovich, Huimin Geng, Nathalie A. Johnson, Randy D. Gascoyne, Ari M. Melnick, and Olivier Elemento EZH2-mediated epigenetic silencing in germinal center B cells contributes to proliferation and lymphomagenesis Blood First Edition Paper, prepublished online August 24, 2010;DOI 10.1182/blood-2010-04-280149[Abstract][PDF][Supplemental Table and Figures]  Joshua N. Beilke, Jonathan Benjamin, and Lewis L. Lanier The requirement for NKG2D in NK cell-mediated rejection of parental bone marrow grafts is determined by inhibitory receptors for MHC class I expressed by the graft recipient Blood First Edition Paper, prepublished online August 24, 2010;DOI 10.1182/blood-2010-05-285031[Abstract][PDF]  Carol Moreno, Kate Hodgson, Gerardo Ferrer, Montse Elena, Xavier Filella, Arturo Pereira, Tycho Baumann, and Emili Montserrat Autoimmune cytopenias in chronic lymphocytic leukemia: prevalence, clinical associations, and prognostic significance Blood First Edition Paper, prepublished online August 24, 2010;DOI 10.1182/blood-2010-05-286500[Abstract][PDF][Supplemental Figures]  Laura Tassone, Daniele Moratto, William Vermi, Maria De Francesco, Lucia D Notarangelo, Fulvio Porta, Vassilios Lougaris, Fabio Facchetti, Alessandro Plebani, and Raffaele Badolato Defect of plasmacytoid dendritic cells in warts, hypogammaglobulinemia, infections, myelokathexis (WHIM) syndrome patients Blood First Edition Paper, prepublished online August 24, 2010;DOI 10.1182/blood-2010-03-272096[Abstract][PDF][Supplemental Table and Figures]  Troy A. McEachron, Rafal Pawlinski, Kristy L. Richards, Frank C. Church, and Nigel Mackman Protease-activated receptors mediate cross-talk between coagulation and fibrinolysis Blood First Edition Paper, prepublished online August 24, 2010;DOI 10.1182/blood-2010-06-293126[Abstract][PDF][Supplemental Figure]  German Ott, Marita Ziepert, Wolfram Klapper, Heike Horn, Monika Szczepanowski, Heinz-Wolfram Bernd, Christoph Thorns, Alfred C. Feller, Dido Lenze, Michael Hummel, Harald Stein, Hans-Konrad Müller-Hermelink, Matthias Frank, Martin-Leo Hansmann, Thomas F. E. Barth, Peter Möller, Sergio Cogliatti, Michael Pfreundschuh, Norbert Schmitz, Lorenz Trümper, Markus Loeffler, and Andreas Rosenwald Immunoblastic morphology but not the immunohistochemical GCB/non-GCB classifier predicts outcome in diffuse large B-cell lymphoma in the RICOVER-60 trial of the DSHNHL Blood First Edition Paper, prepublished online August 24, 2010;DOI 10.1182/blood-2010-03-276766[Abstract][PDF][Supplemental Appendix]  23 August 2010 Alison J. Moskowitz, Joachim Yahalom, Tarun Kewalramani, Jocelyn C. Maragulia, Jill M. Vanak, Andrew D. Zelenetz, and Craig H. Moskowitz Pre-transplant functional imaging predicts outcome following autologous stem cell transplant for relapsed and refractory Hodgkin lymphoma Blood First Edition Paper, prepublished online August 23, 2010;DOI 10.1182/blood-2010-05-282756[Abstract][PDF]  Jacqueline Boultwood, Andrea Pellagatti, Andrew NJ McKenzie, and James S Wainscoat Advances in the 5q- syndrome Blood First Edition Paper, prepublished online August 23, 2010;DOI 10.1182/blood-2010-04-273771[Abstract][PDF]  Yuri Kasama, Satoshi Sekiguchi, Makoto Saito, Kohsuke Tanaka, Masaaki Satoh, Kazuhiko Kuwahara, Nobuo Sakaguchi, Motohiro Takeya, Yoichi Hiasa, Michinori Kohara, and Kyoko Tsukiyama-Kohara Persistent expression of the full genome of hepatitis C virus in B cells induces spontaneous development of B-cell lymphomas in vivo Blood First Edition Paper, prepublished online August 23, 2010;DOI 10.1182/blood-2010-05-283358[Abstract][PDF][Supplemental Table and Figures]  Joëlle Starck, Michèle Weiss-Gayet, Colette Gonnet, Boris Guyot, Jean-Michel Vicat, and François Morlé Inducible fli-1 gene deletion in adult mice modifies several myeloid lineage commitment decisions and accelerates proliferation arrest and terminal erythrocytic differentiation Blood First Edition Paper, prepublished online August 23, 2010;DOI 10.1182/blood-2010-02-270405[Abstract][PDF][Supplemental Table and Figures]  Regis Peffault de Latour, Valeria Visconte, Tomoiku Takaku, Colin Wu, Andrew J. Erie, Annahita K. Sarcon, Marie J. Desierto, Phillip Scheinberg, Keyvan Keyvanfar, Olga Nunez, Jichun Chen, and Neal S. Young Th17 immune responses contribute to the pathophysiology of aplastic anemia Blood First Edition Paper, prepublished online August 23, 2010;DOI 10.1182/blood-2010-01-266098[Abstract][PDF][Supplemental Figure]  Sandra Lopez-Vergès, Jeffrey M. Milush, Suchitra Pandey, Vanessa A. York, Janice Arakawa-Hoyt, Hanspeter Pircher, Phillip J. Norris, Douglas F. Nixon, and Lewis L. Lanier CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK cell subset Blood First Edition Paper, prepublished online August 23, 2010;DOI 10.1182/blood-2010-04-282301[Abstract][PDF][Supplemental Methods and Figures]  Dereje D. Jima, Jenny Zhang, Cassandra Jacobs, Kristy L. Richards, Cherie H. Dunphy, William W. L. Choi, Wing Yan Au, Gopesh Srivastava, Magdalena B. Czader, David A. Rizzieri, Anand S. Lagoo, Patricia L. Lugar, Karen P. Mann, Christopher R. Flowers, Leon Bernal-Mizrachi, Kikkeri N. Naresh, Andrew M. Evens, Leo I. Gordon, Micah Luftig, Daphne R. Friedman, J. Brice Weinberg, Michael A. Thompson, Javed I. Gill, Qingquan Liu, Tam How, Vladimir Grubor, Yuan Gao, Amee Patel, Han Wu, Jun Zhu, Gerard C. Blobe, Peter E. Lipsky, Amy Chadburn, and Sandeep S. Dave Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs Blood First Edition Paper, prepublished online August 23, 2010;DOI 10.1182/blood-2010-05-285403[Abstract][PDF][Supplemental Methods, Tables, and Figures]  20 August 2010 Brian Parkin, Harry Erba, Peter Ouillette, Diane Roulston, Anjali Purkayastha, Judith Karp, Moshe Talpaz, Lisa Kujawski, Sajid Shakhan, Cheng Li, Kerby Shedden, and Sami N. Malek Acquired genomic copy number aberrations and survival in adult acute myelogenous leukemia Blood First Edition Paper, prepublished online August 20, 2010;DOI 10.1182/blood-2010-01-266999[Abstract][PDF][Supplemental Tables and Figures]  Rika Kanezaki, Tsutomu Toki, Kiminori Terui, Gang Xu, RuNan Wang, Akira Shimada, Asahito Hama, Hirokazu Kanegane, Kiyoshi Kawakami, Mikiya Endo, Daisuke Hasegawa, Kazuhiro Kogawa, Souichi Adachi, Yasuhiko Ikeda, Shotaro Iwamoto, Takashi Taga, Yoshiyuki Kosaka, Seiji Kojima, Yasuhide Hayashi, and Etsuro Ito Down syndrome and GATA1 mutations in transient abnormal myeloproliferative disorder: mutation classes correlate with progression to myeloid leukemia Blood First Edition Paper, prepublished online August 20, 2010;DOI 10.1182/blood-2010-05-282426[Abstract][PDF][Supplemental Figures]  Benjamin Terrier, Ivan Bièche, Thierry Maisonobe, Ingrid Laurendeau, Michèlle Rosenzwajg, Jean-Emmanuel Kahn, Marie-Claude Diemert, Lucile Musset, Michel Vidaud, Damien Sène, Nathalie Costedoat-Chalumeau, Du Le Thi-Huong, Zahir Amoura, David Klatzmann, Patrice Cacoub, and David Saadoun IL-25: a cytokine linking eosinophils and adaptative immunity in Churg-Strauss syndrome Blood First Edition Paper, prepublished online August 20, 2010;DOI 10.1182/blood-2010-02-267542[Abstract][PDF]  19 August 2010 Philippe Moreau, Arnaud Jaccard, Lotfi Benboubker, Bruno Royer, Xavier Leleu, Franck Bridoux, Gilles Salles, Veronique Leblond, Murielle Roussel, May Alakl, Olivier Hermine, Lucie Planche, Jean-Luc Harousseau, and Jean-Paul Fermand Lenalidomide in combination with melphalan and dexamethasone in patients with newly-diagnosed AL amyloidosis: a multicenter phase 1/2 dose escalation study Blood First Edition Paper, prepublished online August 19, 2010;DOI 10.1182/blood-2010-07-294405[Abstract][PDF]  Wenli Liu, Hyun Woo Lee, Yueqin Liu, Ruihong Wang, and Griffin P. Rodgers Olfactomedin 4 is a novel target gene of retinoic acids and 5-aza-2'-deoxycytidine involved in human myeloid leukemia cell growth, differentiation, and apoptosis Blood First Edition Paper, prepublished online August 19, 2010;DOI 10.1182/blood-2009-10-246439[Abstract][PDF][Supplemental Methods and Figures]  Victoria J Burton, Loredana I Ciuclan, Alan M Holmes, David M Rodman, Christoph Walker, and David C Budd Bone morphogenetic protein receptor-II regulates pulmonary artery endothelial cell barrier function Blood First Edition Paper, prepublished online August 19, 2010;DOI 10.1182/blood-2010-05-285973[Abstract][PDF][Supplemental Methods and Figure]  Achille Aouba, Sophie Georgin-Lavialle, Christian Pagnoux, Nicolas Martin Silva, Amédée Renand, Françoise Galateau-Salle, Sophie Le Toquin, Henri Bensadoun, Frederique Larousserie, Stéphane Silvera, Nicole Provost, Sophie Candon, Raphaèle Seror, Mathilde de Menthon, Olivier Hermine, Loïc Guillevin, and Boris Bienvenu Rationale and efficacy of interleukin-1 targeting in Erdheim-Chester disease Blood First Edition Paper, prepublished online August 19, 2010;DOI 10.1182/blood-2010-04-279240[Abstract][PDF]  Aleksandra Rizo, Sarah J. Horton, Sandra Olthof, Bert Dontje, Albertina Ausema, Ronald van Os, Vincent van den Boom, Edo Vellenga, Gerald de Haan, and Jan Jacob Schuringa BMI1 collaborates with BCR-ABL in leukemic transformation of human CD34+ cells Blood First Edition Paper, prepublished online August 19, 2010;DOI 10.1182/blood-2010-02-270660[Abstract][PDF][Supplemental Tables and Figures]  Qi-Quan Huang, Harris Perlman, Zan Huang, Robert Birkett, Lixin Kan, Hemant Agrawal, Alexander Misharin, Sandeep Gurbuxani, John D. Crispino, and Richard M. Pope FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis Blood First Edition Paper, prepublished online August 19, 2010;DOI 10.1182/blood-2009-11-252841[Abstract][PDF][Supplemental Figures]  Lubica Rauova, Jessica D. Hirsch, Teshell K. Greene, Li Zhai, Vincent M. Hayes, M. Anna Kowalska, Douglas B. Cines, and Mortimer Poncz Monocyte-bound PF4 in the pathogenesis of heparin-induced thrombocytopenia Blood First Edition Paper, prepublished online August 19, 2010;DOI 10.1182/blood-2010-03-276964[Abstract][PDF][Supplemental Figures and Videos]  18 August 2010 Joan Isern, Stuart T. Fraser, Zhiyong He, Hailan Zhang, and Margaret H. Baron Dose-dependent regulation of primitive erythroid maturation and identity by the transcription factor Eklf Blood First Edition Paper, prepublished online August 18, 2010;DOI 10.1182/blood-2010-04-281196[Abstract][PDF][Supplemental Methods and Figures]  Helen E White, Paul Matejtschuk, Peter Rigsby, Jean Gabert, Feng Lin, Y Lynn Wang, Susan Branford, Martin C. Müller, Nathalie Beaufils, Emmanuel Beillard, Dolors Colomer, Dana Dvorakova, Hans Ehrencrona, Hyun-Gyung Goh, Hakim El Housni, Dan Jones, Veli Kairisto, Suzanne Kamel-Reid, Dong-Wook Kim, Stephen Langabeer, Edmond SK Ma, Richard D. Press, Giuliana Romeo, Lihui Wang, Katerina Zoi, Timothy Hughes, Giuseppe Saglio, Andreas Hochhaus, John M. Goldman, Paul Metcalfe, and Nicholas CP Cross Establishment of the 1st World Health Organization International Genetic Reference Panel for quantitation of BCR-ABL mRNA Blood First Edition Paper, prepublished online August 18, 2010;DOI 10.1182/blood-2010-06-291641[Abstract][PDF][Supplemental Methods and Tables]  Carole Berger, Kristin Hoffmann, Juan G. Vasquez, Shrikant Mane, Julia Lewis, Renata Filler, Aiping Lin, Hongyu Zhao, Tyler Durazzo, Abigail Baird, William Lin, Francine Foss, Inger Christensen, Michael Girardi, Robert Tigelaar, and Richard Edelson Rapid generation of maturationally synchronized human dendritic cells: contribution to the clinical efficacy of extracorporeal photochemotherapy Blood First Edition Paper, prepublished online August 18, 2010;DOI 10.1182/blood-2009-11-256040[Abstract][PDF]  Teresa Freire, Xiaoming Zhang, Edith Dériaud, Christelle Ganneau, Sophie Vichier-Guerre, Elie Azria, Odile Launay, Richard Lo-Man, Sylvie Bay, and Claude Leclerc Glycosidic Tn-based vaccines targeting dermal DC favor germinal center B cell development and potent antibody responses in the absence of adjuvant Blood First Edition Paper, prepublished online August 18, 2010;DOI 10.1182/blood-2010-04-279133[Abstract][PDF][Supplemental Figures]  Joanna B. Opalinska, Alexey Bersenev, Zhe Zhang, Alec A. Schmaier, John Choi, Yu Yao, Janine D'Souza, Wei Tong, and Mitchell J. Weiss MicroRNA expression in maturing murine megakaryocytes Blood First Edition Paper, prepublished online August 18, 2010;DOI 10.1182/blood-2010-06-292920[Abstract][PDF]  17 August 2010 Björn Petri, Andre Broermann, Hang Li, Alexander G. Khandoga, Alexander Zarbock, Fritz Krombach, Tobias Goerge, Stefan W. Schneider, Claire Jones, Bernhard Nieswandt, Martin K. Wild, and Dietmar Vestweber Von Willebrand factor promotes leukocyte extravasation Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-03-276311[Abstract][PDF][Supplemental Methods and Figure]  Andrew J. Steele, Archibald G. Prentice, Kate Cwynarski, A. Victor Hoffbrand, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, and R. Gitendra Wickremasinghe The JAK3-selective inhibitor PF-956980 reverses the resistance to cytotoxic agents induced by interleukin-4 treatment of chronic lymphocytic leukemia cells: potential for reversal of cytoprotection by the microenvironment Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2009-09-245811[Abstract][PDF][Supplemental Tables and Figures]  Xiaolei Wang, Huanbin Xu, Bapi Pahar, Xavier Alvarez, Linda C. Green, Jason Dufour, Terri Moroney-Rasmussen, Andrew A. Lackner, and Ronald S. Veazey Simian immunodeficiency virus selectively infectsproliferating CD4+ T cells in neonatal rhesus macaques Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-03-273482[Abstract][PDF]  Peter D. Burbelo, Sarah K. Browne, Elizabeth P. Sampaio, Giuseppe Giaccone, Rifat Zaman, Ervand Kristosturyan, Arun Rajan, Li Ding, Kathryn H. Ching, Arlene Berman, Joao B. Oliveira, Amy P. Hsu, Caitlin M. Klimavicz, Michael J. Iadarola, and Steven M. Holland Anti-cytokine autoantibodies are associated with opportunistic infection in patients with thymic neoplasia Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-05-286161[Abstract][PDF][Supplemental Figures]  Larry D. Cripe, Hajime Uno, Elisabeth M. Paietta, Mark R. Litzow, Rhett P. Ketterling, John M. Bennett, Jacob M. Rowe, Hillard M. Lazarus, Selina Luger, and Martin S. Tallman Zosuquidar, a novel modulator of P-glycoprotein, does not improve the outcome of older patients with newly diagnosed acute myeloid leukemia: a randomized, placebo-controlled, trial of the Eastern Cooperative Oncology Group (ECOG 3999) Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-04-277269[Abstract][PDF]  Daniel Martin-Perez, Miguel A. Piris, and Margarita Sanchez-Beato Polycomb proteins in hematologic malignancies Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-05-267096[Abstract][PDF]  Mirza Suljagic, Pablo G. Longo, Sara Bennardo, Emerald Perlas, Giuseppe Leone, Luca Laurenti, and Dimitar G. Efremov The Syk inhibitor fostamatinib disodium (R788) inhibits tumor growth in the Eµ-TCL1 transgenic mouse model of CLL by blocking antigen-dependent B cell receptor signaling Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-03-275180[Abstract][PDF][Supplemental Figures]  Leah N. Cueni, Lu Chen, Hui Zhang, Daniela Marino, Reto Huggenberger, Annamari Alitalo, Roberta Bianchi, and Michael Detmar Podoplanin-Fc reduces lymphatic vessel formation in vitro and in vivo and causes disseminated intravascular coagulation when transgenically expressed in the skin Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-04-278564[Abstract][PDF][Supplemental Methods and Figures]  Mohamad Mohty, Myriam Labopin, Liisa Volin, Alois Gratwohl, Gérard Socié, Jordi Esteve, Reza Tabrizi, Amon Nagler, and Vanderson Rocha Reduced-intensity versus conventional myeloablative conditioning allogeneic stem cell transplantation for patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-02-266551[Abstract][PDF][Supplemental Appendix]  Fei Liu, Jae Y. Lee, Huijun Wei, Osamu Tanabe, James D. Engel, Sean J. Morrison, and Jun-Lin Guan FIP200 is required for the cell-autonomous maintenance of fetal hematopoietic stem cells Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-06-288589[Abstract][PDF][Supplemental Figures]  Yankel Gabet, Sanjeev K. Baniwal, Nathalie Leclerc, Yunfan Shi, Alice E. Kohn-Gabet, Jon Cogan, Alexis Dixon, Marilyn Bachar, Lixin Guo, Jack E. Turman Jr., and Baruch Frenkel Krox20/EGR2 deficiency accelerates cell growth and differentiation in the monocytic lineage and decreases bone mass Blood First Edition Paper, prepublished online August 17, 2010;DOI 10.1182/blood-2010-01-263830[Abstract][PDF]  16 August 2010 Shang-Ju Wu, Shang-Yi Huang, Chien-Ting Lin, Yu-Jr Lin, Chee-Jen Chang, and Hwei-Fang Tien The incidence of chronic lymphocytic leukemia in Taiwan, 1986-2005: a distinct, increasing trend with birth-cohort effect Blood First Edition Paper, prepublished online August 16, 2010;DOI 10.1182/blood-2010-05-285221[Abstract][PDF][Supplemental Table and Figure]  Elena Lukina, Nora Watman, Elsa Avila Arreguin, Marta Dragosky, Marcelo Iastrebner, Hanna Rosenbaum, Mici Phillips, Gregory M. Pastores, Ravi S. Kamath, Daniel I. Rosenthal, Mathilde Kaper, Tejdip Singh, Ana Cristina Puga, and M. Judith Peterschmitt Improvement in hematological, visceral, and skeletal manifestations of Gaucher disease type 1 with oral eliglustat tartrate (Genz-112638) treatment: two-year results of a Phase 2 study Blood First Edition Paper, prepublished online August 16, 2010;DOI 10.1182/blood-2010-06-293902[Abstract][PDF]  Harriet A. Purvis, Jeroen N. Stoop, Jelena Mann, Steven Woods, Anne E. Kozijn, Sophie Hambleton, John H. Robinson, John D. Isaacs, Amy E. Anderson, and Catharien M.U. Hilkens Low strength T-cell activation promotes Th17 responses Blood First Edition Paper, prepublished online August 16, 2010;DOI 10.1182/blood-2010-03-272153[Abstract][PDF][Supplemental Figure]  Hayakazu Sumida, Kyoko Noguchi, Yasuyuki Kihara, Manabu Abe, Keisuke Yanagida, Fumie Hamano, Shinichi Sato, Kunihiko Tamaki, Yasuyuki Morishita, Mitsunobu R. Kano, Caname Iwata, Kohei Miyazono, Kenji Sakimura, Takao Shimizu, and Satoshi Ishii LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis Blood First Edition Paper, prepublished online August 16, 2010;DOI 10.1182/blood-2010-03-272443[Abstract][PDF][Supplemental Methods and Figures]  Ulrik Lausten-Thomsen, Hans Ole Madsen, Therese Risom Vestergaard, Henrik Hjalgrim, Jacob Nersting, and Kjeld Schmiegelow Prevalence of t(12;21)[ETV6-RUNX1]-positive cells in healthy neonates Blood First Edition Paper, prepublished online August 16, 2010;DOI 10.1182/blood-2010-05-282764[Abstract][PDF]  Ingrid G Winkler, Natalie A Sims, Allison R Pettit, Valérie Barbier, Bianca Nowlan, Falak Helwani, Ingrid J Poulton, Nico van Rooijen, Kylie A Alexander, Liza J Raggatt, and Jean-Pierre Lévesque Bone marrow macrophages maintain hematopoietic stem cell (HSC) niches and their depletion mobilizes HSC Blood First Edition Paper, prepublished online August 16, 2010;DOI 10.1182/blood-2009-11-253534[Abstract][PDF][Supplemental Figures]  Keir M. Balla, Geanncarlo Lugo-Villarino, Jan M. Spitsbergen, David L. Stachura, Yan Hu, Karina Bañuelos, Octavio Romo-Fewell, Raffi V. Aroian, and David Traver Eosinophils in the zebrafish: prospective isolation, characterization, and eosinophilia induction by helminth determinants Blood First Edition Paper, prepublished online August 16, 2010;DOI 10.1182/blood-2010-03-267419[Abstract][PDF][Supplemental Figures]  13 August 2010 Zhidan Tu, Hong Bu, James E Dennis, and Feng Lin Efficient osteoclast differentiation requires local complement activation Blood First Edition Paper, prepublished online August 13, 2010;DOI 10.1182/blood-2010-01-263590[Abstract][PDF]  Meral Gunay-Aygun, Yifat Zivony-Elboum, Fatma Gumruk, Dan Geiger, Mualla Cetin, Morad Khayat, Robert Kleta, Nehama Kfir, Yair Anikster, Judith Chezar, Mauricio Arcos-Bugos, Adel Shalata, Horia Stanescu, Joseph Manaster, Mutlu Arat, Hailey Edwards, Andrew S Freiberg, P Suzanne Hart, Lauren C Riney, Katherine Patzel, Pranoot Tanpaiboon, Tom Markello, Marjan Huizing, Irina Maric, McDonald Horne, Beate E Kehrel, Kerstin Jurk, Nancy F Hansen, Praveen F Cherukuri, Marypat Jones, Pedro Cruz, Jim C Mullikin, Alan Nurden, James G White, William A Gahl, and Tzippora Falik-Zaccai Gray platelet syndrome: natural history of a large patient cohort and locus assignment to chromosome 3p Blood First Edition Paper, prepublished online August 13, 2010;DOI 10.1182/blood-2010-05-286534[Abstract][PDF][Supplemental Table and Figure]  Stephanie A. Smith, Sharon H. Choi, Rebecca Davis-Harrison, Jillian Huyck, John Boettcher, Chad M. Rienstra, and James H. Morrissey Polyphosphate exerts differential effects on blood clotting, depending on polymer size Blood First Edition Paper, prepublished online August 13, 2010;DOI 10.1182/blood-2010-01-266791[Abstract][PDF][Supplemental Figures]  J. Joseph Melenhorst, Ann M Leen, Catherine M Bollard, Máire F Quigley, David A Price, Cliona M Rooney, Malcolm K Brenner, A John Barrett, and Helen E Heslop Allogeneic virus-specific T cells with HLA alloreactivity do not produce GVHD in human subjects Blood First Edition Paper, prepublished online August 13, 2010;DOI 10.1182/blood-2010-06-289991[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Carolyn Sangokoya, Marilyn J. Telen, and Jen-Tsan Chi MicroRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease Blood First Edition Paper, prepublished online August 13, 2010;DOI 10.1182/blood-2009-04-214817[Abstract][PDF][Supplemental Methods, Tables, and Figures]  John Quinn, Janet Glassford, Laura Percy, Philippa Munson, Teresa Marafioti, Manuel Rodriguez-Justo, and Kwee Yong APRIL promotes cell cycle progression in primary multiple myeloma cells: influence of D-type cyclin group and translocation status Blood First Edition Paper, prepublished online August 13, 2010;DOI 10.1182/blood-2010-01-264424[Abstract][PDF][Supplemental Figures]  Christine Ragu, Gaelle Elain, Elena Mylonas, Chris Ottolenghi, Nicolas Cagnard, Dominique Daegelen, Emmanuelle Passegué, William Vainchenker, Olivier A Bernard, and Virginie Penard-Lacronique The transcription factor SRF regulates hematopoietic stem cells adhesion Blood First Edition Paper, prepublished online August 13, 2010;DOI 10.1182/blood-2009-11-251587[Abstract][PDF][Supplemental Tables and Figures]  12 August 2010 Bayard L. Powell, Barry Moser, Wendy Stock, Robert E. Gallagher, Cheryl L. Willman, Richard M. Stone, Jacob M. Rowe, Steven Coutre, James H. Feusner, John Gregory, Stephen Couban, Frederick R. Appelbaum, Martin S. Tallman, and Richard A. Larson Arsenic trioxide improves event-free and over-all survival for adults with acute promyelocytic leukemia: North American Leukemia Intergroup Study C9710 Blood First Edition Paper, prepublished online August 12, 2010;DOI 10.1182/blood-2010-02-269621[Abstract][PDF][Supplemental Appendix]  Raquel del Toro, Claudia Prahst, Thomas Mathivet, Geraldine Siegfried, Joshua S. Kaminker, Bruno Larrivee, Christiane Breant, Antonio Duarte, Nobuyuki Takakura, Akiyoshi Fukamizu, Josef Penninger, and Anne Eichmann Identification and functional analysis of endothelial tip cell-enriched genes Blood First Edition Paper, prepublished online August 12, 2010;DOI 10.1182/blood-2010-02-270819[Abstract][PDF][Supplemental Methods and Figures]  Dirk Lievens, Alma Zernecke, Tom Seijkens, Oliver Soehnlein, Linda Beckers, Imke CA Munnix, Erwin Wijnands, Pieter Goossens, Roger van Kruchten, Larissa Thevissen, Louis Boon, Richard A Flavell, Randolph J Noelle, Norbert Gerdes, Erik A Biessen, Mat JAP Daemen, Johan WM Heemskerk, Christian Weber, and Esther Lutgens Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis Blood First Edition Paper, prepublished online August 12, 2010;DOI 10.1182/blood-2010-01-261206[Abstract][PDF][Supplemental Table and Figures]  Shintaro Nakao, Souska Zandi, Yasuaki Hata, Shuhei Kawahara, Ryoichi Arita, Alexander Schering, Dawei Sun, Mark I. Melhorn, Yasuhiro Ito, Nuria Lara-Castillo, Tatsuro Ishibashi, and Ali Hafezi-Moghadam Blood vessel endothelial VEGFR-2 delays lymphangiogenesis: an endogenous trapping mechanism links lymph- and angiogenesis Blood First Edition Paper, prepublished online August 12, 2010;DOI 10.1182/blood-2010-02-267427[Abstract][PDF][Supplemental Figure and Video]  Thomas Kindler, Daniel B. Lipka, and Thomas Fischer FLT3 as a therapeutic target in AML: still challenging after all these years Blood First Edition Paper, prepublished online August 12, 2010;DOI 10.1182/blood-2010-04-261867[Abstract][PDF]  Magali Pederzoli-Ribeil, Francesco Maione, Dianne Cooper, Adam Al-Kashi, Jesmond Dalli, Mauro Perretti, and Fulvio D'Acquisto Design and characterization of a cleavage-resistant Annexin A1 mutant to control inflammation in the microvasculature Blood First Edition Paper, prepublished online August 12, 2010;DOI 10.1182/blood-2010-02-270520[Abstract][PDF]  David Dornan, Olivia Spleiss, Ru-Fang Yeh, Guillemette Duchateau-Nguyen, Annika Dufour, Jianguo Zhi, Tadeusz Robak, Sergey I. Moiseev, Anna Dmoszynska, Philippe Solal-Celigny, Krzysztof Warzocha, Javier Loscertales, John Catalano, Boris V. Afanasiev, Loree Larratt, Viktor A. Rossiev, Isabelle Bence-Bruckler, Christian H. Geisler, Marco Montillo, Michael K. Wenger, and Martin Weisser Effect of FCGR2A and FCGR3A variants on CLL outcome Blood First Edition Paper, prepublished online August 12, 2010;DOI 10.1182/blood-2010-03-272765[Abstract][PDF]  11 August 2010 Michael Hudecek, Thomas M. Schmitt, Sivasubramanian Baskar, Maria Teresa Lupo-Stanghellini, Tetsuya Nishida, Tori N. Yamamoto, Marie Bleakley, Cameron J. Turtle, Wen-Chung Chang, Harvey A. Greisman, Brent Wood, David G. Maloney, Michael C. Jensen, Christoph Rader, and Stanley R. Riddell The B-cell tumor associated antigen ROR1 can be targeted with T-cells modified to express a ROR1-specific chimeric antigen receptor Blood First Edition Paper, prepublished online August 11, 2010;DOI 10.1182/blood-2010-05-283309[Abstract][PDF][Supplemental Figures]  Gaetana Lanzi, Simona Ferrari, Mauno Vihinen, Stefano Caraffi, Necil Kutukculer, Luisa Schiaffonati, Alessandro Plebani, Luigi Daniele Notarangelo, Anna Maria Fra, and Silvia Giliani Different molecular behavior of CD40 mutants causing hyper-IgM syndrome Blood First Edition Paper, prepublished online August 11, 2010;DOI 10.1182/blood-2010-03-274241[Abstract][PDF][Supplemental Table and Figures]  Stephanie Delluc, Gilles Ravot, and Bernard Maillere Quantification of the pre-existing CD4 T cell repertoire specific for human erythropoietin reveals its immunogenicity potential Blood First Edition Paper, prepublished online August 11, 2010;DOI 10.1182/blood-2010-04-280875[Abstract][PDF][Supplemental Table]  Steven I. Park, Jaideep Shenoi, John M. Pagel, Don K. Hamlin, D. Scott Wilbur, Nural Orgun, Aimee L. Kenoyer, Shani Frayo, Amanda Axtman, Tom Bäck, Yukang Lin, Darrell R. Fisher, Ajay K. Gopal, Damian J. Green, and Oliver W. Press Conventional and pretargeted radioimmunotherapy using bismuth-213 to target and treat non-Hodgkin lymphomas expressing CD20: a preclinical model toward optimal consolidation therapy to eradicate minimal residual disease Blood First Edition Paper, prepublished online August 11, 2010;DOI 10.1182/blood-2010-05-282327[Abstract][PDF]  H. Joachim Deeg and Brenda M. Sandmaier Who is fit for allogeneic transplantation? Blood First Edition Paper, prepublished online August 11, 2010;DOI 10.1182/blood-2010-07-259358[Abstract][PDF]  10 August 2010 Richard C Harvey, Charles G Mullighan, Xuefei Wang, Kevin K Dobbin, George S Davidson, Edward J Bedrick, I-Ming Chen, Susan R Atlas, Huining Kang, Kerem Ar, Carla S Wilson, Walker Wharton, Maurice Murphy, Meenakshi Devidas, Andrew J Carroll, Michael J Borowitz, W Paul Bowman, James R Downing, Mary Relling, Jun Yang, Deepa Bhojwani, William L Carroll, Bruce Camitta, Gregory H Reaman, Malcolm Smith, Stephen P Hunger, and Cheryl L Willman Identification of novel cluster groups in pediatric high-risk B-precursor acute lymphoblastic leukemia with gene expression profiling: correlation with genome-wide DNA copy number alterations, clinical characteristics, and outcome Blood First Edition Paper, prepublished online August 10, 2010;DOI 10.1182/blood-2009-08-239681[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Jennifer J. Turner, Lindsay M. Morton, Martha S. Linet, Christina A. Clarke, Marshall E. Kadin, Claire M. Vajdic, Alain Monnereau, Marc Maynadié, Brian C.-H. Chiu, Rafael Marcos-Gragera, Adele Seniori Costantini, James R. Cerhan, and Dennis D. Weisenburger InterLymph hierarchical classification of lymphoid neoplasms for epidemiologic research based on the WHO Classification (2008): update and future directions Blood First Edition Paper, prepublished online August 10, 2010;DOI 10.1182/blood-2010-06-289561[Abstract][PDF]  Ann C. Zovein, Kirsten A. Turlo, Ryan M. Ponec, Maureen R. Lynch, Kevin C. Chen, Jennifer J. Hofmann, Timothy C. Cox, Judith C. Gasson, and M. Luisa Iruela-Arispe Vascular remodeling of the vitelline artery initiates extra-vascular emergence of hematopoietic clusters Blood First Edition Paper, prepublished online August 10, 2010;DOI 10.1182/blood-2010-04-279497[Abstract][PDF][Supplemental Figures and Videos]  Sara Calattini, Irini Sereti, Phillip Scheinberg, Hiroshi Kimura, Richard W. Childs, and Jeffrey I. Cohen Detection of EBV genomes in plasmablasts/plasma cells and non-B cells in the blood of most patients with EBV lymphoproliferative disorders using Immuno-FISH Blood First Edition Paper, prepublished online August 10, 2010;DOI 10.1182/blood-2010-05-285452[Abstract][PDF][Supplemental Methods, Table, and Figures]  Hsuan-Shun Huang, Der-Shan Sun, Te-Sheng Lien, and Hsin-Hou Chang Dendritic cells modulate platelet activity in IVIg-mediated amelioration of ITP in mice Blood First Edition Paper, prepublished online August 10, 2010;DOI 10.1182/blood-2010-03-275123[Abstract][PDF][Supplemental Figures]  9 August 2010 Adam J. Hartigan, Lara E. Kallal, and Cory M. Hogaboam CCR7 impairs hematopoiesis following hematopoietic stem cell transplantation increasing susceptibility to invasive aspergillosis Blood First Edition Paper, prepublished online August 9, 2010;DOI 10.1182/blood-2010-01-265454[Abstract][PDF][Supplemental Figures]  Kannayakanahalli M. Dayananda, Indrajeet Singh, Nandini Mondal, and Sriram Neelamegham Von Willebrand Factor self-association on platelet GpIb under hydrodynamic shear: effect on shear-induced platelet activation Blood First Edition Paper, prepublished online August 9, 2010;DOI 10.1182/blood-2010-02-269266[Abstract][PDF][Supplemental Methods and Figures]  Niklas K. Björkström, Peggy Riese, Frank Heuts, Sandra Andersson, Cyril Fauriat, Martin A. Ivarsson, Andreas T. Björklund, Malin Flodström-Tullberg, Jakob Michaëlsson, Martin E. Rottenberg, Carlos A. Guzmán, Hans-Gustaf Ljunggren, and Karl-Johan Malmberg Expression patterns of NKG2A, KIR, and CD57 define a process of CD56dim NK cell differentiation uncoupled from NK cell education Blood First Edition Paper, prepublished online August 9, 2010;DOI 10.1182/blood-2010-04-281675[Abstract][PDF][Supplemental Figures]  Maha Othman, Yvette Chirinian, Christine Brown, Colleen Notley, Nicholas Hickson, Daniel Hampshire, Suzanne Buckley, Simon Waddington, Alan L Parker, Andrew Baker, Paula James, and David Lillicrap Functional characterization of a 13 bp deletion (c.-1522_-1510del13) in the promoter of the von Willebrand factor gene in type 1 von Willebrand disease Blood First Edition Paper, prepublished online August 9, 2010;DOI 10.1182/blood-2009-12-261131[Abstract][PDF]  Sivahari P Gorantla, Tobias N Dechow, Rebekka Grundler, Anna Lena Illert, Christian Meyer zum Büschenfelde, Marcus Kremer, Christian Peschel, and Justus Duyster Oncogenic JAK2V617F requires an intact SH2-like domain for constitutive activation and induction of a myeloproliferative disease in mice Blood First Edition Paper, prepublished online August 9, 2010;DOI 10.1182/blood-2009-07-236133[Abstract][PDF][Supplemental Methods and Figures]  Degui Geng, Liqin Zheng, Ratika Srivastava, Nicole Asprodites, Cruz Velasco-Gonzalez, and Eduardo Davila When toll-like receptor and T-cell receptor signals collide: a mechanism for enhanced CD8 T-cell effectors function Blood First Edition Paper, prepublished online August 9, 2010;DOI 10.1182/blood-2010-02-268169[Abstract][PDF]  6 August 2010 Rachel Lubong Sabado, Meagan O'Brien, Abhignya Subedi, Li Qin, Nan Hu, Elizabeth Taylor, Oliver Dibben, Andrea Stacey, Jacques Fellay, Kevin V Shianna, Frederick Siegal, Michael Shodell, Kokila Shah, Marie Larsson, Jeffrey Lifson, Arthur Nadas, Michael Marmor, Richard Hutt, David Margolis, Donald Garmon, Martin Markowitz, Fred Valentine, Persephone Borrow, and Nina Bhardwaj Evidence of dysregulation of dendritic cells in primary HIV infection Blood First Edition Paper, prepublished online August 6, 2010;DOI 10.1182/blood-2010-03-273763[Abstract][PDF][Supplemental Tables and Figures]  Shigeki Ohtake, Shuichi Miyawaki, Hiroyuki Fujita, Hitoshi Kiyoi, Katsuji Shinagawa, Noriko Usui, Hirokazu Okumura, Koichi Miyamura, Chiaki Nakaseko, Yasushi Miyazaki, Atsushi Fujieda, Tadashi Nagai, Takahisa Yamane, Masafumi Taniwaki, Masatomo Takahashi, Fumiharu Yagasaki, Yukihiko Kimura, Norio Asou, Hisashi Sakamaki, Hiroshi Handa, Sumihisa Honda, Kazunori Ohnishi, Tomoki Naoe, and Ryuzo Ohno Randomized study of induction therapy comparing standard-dose idarubicin with high-dose daunorubicin in adult patients with previously untreated acute myeloid leukemia: JALSG AML201 Study Blood First Edition Paper, prepublished online August 6, 2010;DOI 10.1182/blood-2010-03-273243[Abstract][PDF][Supplemental Appendix]  Alexander E. Smith, Azim M. Mohamedali, Austin Kulasekararaj, ZiYi Lim, Joop Gäken, Nicholas C. Lea, Bartlomiej Przychodzen, Syed A. Mian, Erick E. Nasser, Claire Shooter, Nigel B. Westwood, Corinna Strupp, Norbert Gattermann, Jaroslaw P. Maciejewski, Ulrich Germing, and Ghulam J. Mufti Next-generation sequencing of the TET2 gene in 355 MDS and CMML patients reveals low abundance mutant clones with early origins, but indicates no definite prognostic value Blood First Edition Paper, prepublished online August 6, 2010;DOI 10.1182/blood-2010-03-274704[Abstract][PDF][Supplemental Methods, Tables, and Figure]  Ruby Fernandez-Boyanapalli, S. Courtney Frasch, David W. H. Riches, R. William Vandivier, Peter M. Henson, and Donna L. Bratton PPAR activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease Blood First Edition Paper, prepublished online August 6, 2010;DOI 10.1182/blood-2010-02-272005[Abstract][PDF][Supplemental Figures]  Wen-Chien Chou, Huai-Hsuan Huang, Hsin-An Hou, Chien-Yuan Chen, Jih-Luh Tang, Ming Yao, Woei Tsay, Bor-Sheng Ko, Shang-Ju Wu, Shang-Yi Huang, Szu-Chun Hsu, Yao-Chang Chen, Yen-Ning Huang, Yi-Chang Chang, Fen-Yu Lee, Min-Chih Liu, Chia-Wen Liu, Mei-Hsuan Tseng, Chi-Fei Huang, and Hwei-Fang Tien Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations Blood First Edition Paper, prepublished online August 6, 2010;DOI 10.1182/blood-2010-05-283291[Abstract][PDF][Supplemental Tables and Figures]  Estelle Oberlin, Maud Fleury, Denis Clay, Laurence Petit-Cocault, Jean-Jacques Candelier, Benoît Mennesson, Thierry Jaffredo, and Michèle Souyri VE-cadherin expression allows identification of a new class of hematopoietic stem cells within human embryonic liver Blood First Edition Paper, prepublished online August 6, 2010;DOI 10.1182/blood-2010-03-272625[Abstract][PDF][Supplemental Tables and Figures]  5 August 2010 Thamar Bryn van Dijk, Nynke Gillemans, Farzin Pourfarzad, Kirsten van Lom, Marieke von Lindern, Frank Grosveld, and Sjaak Philipsen Fetal globin expression is regulated by Friend of Prmt1 Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-03-274399[Abstract][PDF][Supplemental Table and Figures]  Sergey A. Sinenko, Tony Hung, Tatiana Moroz, Quynh-Minh Tran, Sohrab Sidhu, Matthew D. Cheney, Nancy A. Speck, and Utpal Banerjee Genetic manipulation of AML1-ETO-induced expansion of hematopoietic precursors in a Drosophila model Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-03-276998[Abstract][PDF][Supplemental Figures]  Weili Bao, James B. Bussel, Susanne Heck, Wu He, Marissa Karpoff, Nayla Boulad, and Karina Yazdanbakhsh Improved regulatory T cell activity in patients with chronic immune thrombocytopenia treated with thrombopoietic agents Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-04-281717[Abstract][PDF][Supplemental Figures]  Marie-Berengere Troadec, Diane McVey Ward, Eric Lo, Jerry Kaplan, and Ivana De Domenico Induction of FPN1 transcription by MTF-1 reveals a role for ferroportin in transition metal efflux Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-04-278614[Abstract][PDF][Supplemental Figure]  Mark Bower How I treat HIV-associated multicentric Castleman's disease Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-07-290213[Abstract][PDF]  Alexandre Dubrac, Cathy Quemener, Eric Lacazette, Fréderic Lopez, Catherine Zanibellato, Wen-Guey Wu, Andréas Bikfalvi, and Hervé Prats Functional divergence between two chemokines is conferred by single amino acid change Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-03-274852[Abstract][PDF][Supplemental Methods, Table, and Figures]  Elena Ortona, Antonella Capozzi, Tania Colasanti, Fabrizio Conti, Cristiano Alessandri, Agostina Longo, Tina Garofalo, Paola Margutti, Roberta Misasi, Munther A Khamashta, Graham RV Hughes, Guido Valesini, and Maurizio Sorice Vimentin/cardiolipin complex as a new antigenic target of the antiphospholipid syndrome Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-04-279208[Abstract][PDF][Supplemental Table and Figure]  Wayne Roberts, Simbarashe Magwenzi, Ahmed Aburima, and Khalid M. Naseem Thrombinspondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade Blood First Edition Paper, prepublished online August 5, 2010;DOI 10.1182/blood-2010-01-265561[Abstract][PDF][Supplemental Videos]  4 August 2010 James N. George How I treat patients with thrombotic thrombocytopenic purpura - 2010 Blood First Edition Paper, prepublished online August 4, 2010;DOI 10.1182/blood-2010-07-271445[Abstract][PDF]  Elisa Bianchi, Roberta Zini, Simona Salati, Elena Tenedini, Ruggiero Norfo, Enrico Tagliafico, Rossella Manfredini, and Sergio Ferrari c-Myb supports erythropoiesis through the transactivation of KLF1 and LMO2 expression Blood First Edition Paper, prepublished online August 4, 2010;DOI 10.1182/blood-2009-08-238311[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Claudio G. Brunstein, Jonathan A. Gutman, Daniel J. Weisdorf, Ann E. Woolfrey, Todd E. DeFor, Theodore A. Gooley, Michael R. Verneris, Frederick R. Appelbaum, John E. Wagner, and Colleen Delaney Allogeneic hematopoietic cell transplantation for hematological malignancy: relative risks and benefits of double umbilical cord blood Blood First Edition Paper, prepublished online August 4, 2010;DOI 10.1182/blood-2010-05-285304[Abstract][PDF]  Bao Hoang, Patrick Frost, Yijiang Shi, Eileen Belanger, Angelica Benavides, Gholam Pezeshkpour, Susanna Cappia, Tommasina Guglielmelli, Joseph Gera, and Alan Lichtenstein Targeting TORC2 in multiple myeloma with a new mTOR kinase inhibitor Blood First Edition Paper, prepublished online August 4, 2010;DOI 10.1182/blood-2010-05-285726[Abstract][PDF][Supplemental Figure]  Oleksii A. Skorokhod, Luisa Caione, Tiziana Marrocco, Giorgia Migliardi, Valentina Barrera, Paolo Arese, Wanda Piacibello, and Evelin Schwarzer Inhibition of erythropoiesis in malaria anemia: role of hemozoin and hemozoin-generated 4-hydroxynonenal Blood First Edition Paper, prepublished online August 4, 2010;DOI 10.1182/blood-2010-03-272781[Abstract][PDF][Supplemental Table and Figures]  3 August 2010 Willemijn Hobo, Frans Maas, Niken Adisty, Theo de Witte, Nicolaas Schaap, Robbert van der Voort, and Harry Dolstra siRNA silencing of PD-L1 and PD-L2 on dendritic cells augments expansion and function of minor histocompatibility antigen-specific CD8+ T cells Blood First Edition Paper, prepublished online August 3, 2010;DOI 10.1182/blood-2010-04-278739[Abstract][PDF]  Yasuyuki Saito, Hiroko Iwamura, Tetsuya Kaneko, Hiroshi Ohnishi, Yoji Murata, Hideki Okazawa, Yoshitake Kanazawa, Miho Sato-Hashimoto, Hisae Kobayashi, Per-Arne Oldenborg, Makoto Naito, Yoriaki Kaneko, Yoshihisa Nojima, and Takashi Matozaki Regulation by SIRP of dendritic cell homeostasis in lymphoid tissues Blood First Edition Paper, prepublished online August 3, 2010;DOI 10.1182/blood-2010-03-277244[Abstract][PDF][Supplemental Methods and Figures]  Gabriel Courties, Virginia Seiffart, Jessy Presumey, Virginie Escriou, Daniel Scherman, Jochen Zwerina, Gisela Ruiz, Natalia Zietara, Jadwiga Jablonska, Siegfried Weiss, Andrea Hoffmann, Christian Jorgensen, Florence Apparailly, and Gerhard Gross In vivo RNAi-mediated silencing of TAK1 decreases inflammatory Th1 and Th17 cells through targeting of myeloid cells Blood First Edition Paper, prepublished online August 3, 2010;DOI 10.1182/blood-2010-02-269605[Abstract][PDF][Supplemental Figures]  Kelli P.A. MacDonald, James S. Palmer, Steven Cronau, Elke Seppanen, Stuart Olver, Neil C. Raffelt, Rachel Kuns, Allison R. Pettit, Andrew Clouston, Brandon Wainwright, Dan Branstetter, Jeffrey Smith, Raymond J. Paxton, Douglas Pat Cerretti, Lynn Bonham, Geoffrey R. Hill, and David A. Hume An antibody against the colony-stimulating factor 1 receptor (CSF1R) depletes the resident subset of monocytes and tissue and tumor-associated macrophages but does not inhibit inflammation Blood First Edition Paper, prepublished online August 3, 2010;DOI 10.1182/blood-2010-02-266296[Abstract][PDF][Supplemental Methods and Figures]  Xin Liu, Lindsay Ryland, Jun Yang, Aijun Liao, Cesar Aliaga, Rebecca Watts, Su-Fern Tan, James Kaiser, Sriram S. Shanmugavelandy, Andrew Rogers, Kathleen Loughran, Bailey Petersen, Jonathan Yuen, Fanxue Meng, Kendall Thomas Baab, Nancy Ruth Jarbadan, Kathleen Broeg, Ranran Zhang, Jason Liao, Thomas Joseph Sayers, Mark Kester, and Thomas P. Loughran Jr. Targeting of survivin by nanoliposomal ceramide induces complete remission in a rat model of NK-LGL leukemia Blood First Edition Paper, prepublished online August 3, 2010;DOI 10.1182/blood-2010-02-271080[Abstract][PDF]  2 August 2010 Jieqing Zhu, Jianghai Zhu, Ana Negri, Davide Provasi, Marta Filizola, Barry S. Coller, and Timothy A. Springer The closed headpiece of integrin IIbβ3 and its complex with an IIbβ3-specific antagonist that does not induce opening Blood First Edition Paper, prepublished online August 2, 2010;DOI 10.1182/blood-2010-04-281154[Abstract][PDF][Supplemental Methods and Figures]  Steven M. Kornblau, David McCue, Neera Singh, Wenjing Chen, Zeev Estrov, and Kevin R. Coombes Recurrent expression signatures of cytokines and chemokines are present and are independently prognostic in acute myelogenous leukemia and myelodysplasia Blood First Edition Paper, prepublished online August 2, 2010;DOI 10.1182/blood-2010-01-262071[Abstract][PDF][Supplemental Tables and Figures]  Ken Maes, Elizabeta Nemeth, G. David Roodman, Alissa Huston, Flavia Esteve, Cesar Freytes, Natalie Callander, Eirini Katodritou, Lisa Tussing-Humphreys, Seth Rivera, Karin Vanderkerken, Alan Lichtenstein, and Tomas Ganz In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2 Blood First Edition Paper, prepublished online August 2, 2010;DOI 10.1182/blood-2010-03-274571[Abstract][PDF][Supplemental Figure]  Timothy P. Hughes, Andreas Hochhaus, Susan Branford, Martin C. Müller, Jaspal S. Kaeda, Letizia Foroni, Brian J. Druker, François Guilhot, Richard A. Larson, Stephen G. O'Brien, Marc S. Rudoltz, Manisha Mone, Elisabeth Wehrle, Vijay Modur, John M. Goldman, and Jerald P. Radich Long-term prognostic significance of early molecular response to imatinib in newly diagnosed chronic myeloid leukemia: an analysis from the international randomized study of interferon versus STI571 (IRIS) Blood First Edition Paper, prepublished online August 2, 2010;DOI 10.1182/blood-2010-03-273979[Abstract][PDF][Supplemental Appendix]  30 July 2010 Ben T. Atkinson, Reema Jasuja, Vivien Chen, Prathima Nandivada, Bruce Furie, and Barbara C. Furie Laser-induced endothelial cell activation supports fibrin formation Blood First Edition Paper, prepublished online July 30, 2010;DOI 10.1182/blood-2010-05-283986[Abstract][PDF]  Fujiko Tsukahara and Yoshiro Maru Bag1 directly routes immature BCR-ABL for proteasomal degradation Blood First Edition Paper, prepublished online July 30, 2010;DOI 10.1182/blood-2009-10-249623[Abstract][PDF][Supplemental Figures]  29 July 2010 Christopher P. Fox, Tracey A. Haigh, Graham S. Taylor, Heather M. Long, Steven P. Lee, Claire Shannon-Lowe, Simon O'Connor, Catherine M. Bollard, Javeed Iqbal, Wing C Chan, Alan B Rickinson, Andrew I Bell, and Martin Rowe A novel latent membrane 2 transcript expressed in Epstein-Barr virus-positive NK and T cell lymphoproliferative disease encodes a target for cellular immunotherapy Blood First Edition Paper, prepublished online July 29, 2010;DOI 10.1182/blood-2010-06-292268[Abstract][PDF][Supplemental Table]  Lei Yang, Lin Wang, Chun-hong Zhao, Xiao-juan Zhu, Yu Hou, Jun Peng, and Ming Hou Contributions of TRAIL mediated megakaryocyte apoptosis to impaired megakaryocyte and platelet production in immune thrombocytopenia Blood First Edition Paper, prepublished online July 29, 2010;DOI 10.1182/blood-2010-02-267435[Abstract][PDF]  Claudia Cocco, Sara Canale, Chiara Frasson, Emma Di Carlo, Emanuela Ognio, Domenico Ribatti, Ignazia Prigione, Giuseppe Basso, and Irma Airoldi Interleukin (IL)-23 acts as anti-tumor agent on childhood B-acute lymphoblastic leukemia cells Blood First Edition Paper, prepublished online July 29, 2010;DOI 10.1182/blood-2009-10-248245[Abstract][PDF]  Till Strowig, Obinna Chijioke, Paolo Carrega, Frida Arrey, Sonja Meixlsperger, Patrick C. Rämer, Guido Ferlazzo, and Christian Münz Human NK cells of mice with reconstituted human immune system components require pre-activation to acquire functional competence Blood First Edition Paper, prepublished online July 29, 2010;DOI 10.1182/blood-2010-02-270678[Abstract][PDF][Supplemental Figures]  Nicolas Chapuis, Sophie Park, Laurent Leotoing, Jerome Tamburini, Frederique Verdier, Valerie Bardet, Alexa S Green, Lise Willems, Fabrice Agou, Norbert Ifrah, François Dreyfus, Georges Bismuth, Veronique Baud, Catherine Lacombe, Patrick Mayeux, and Didier Bouscary IB kinase overcomes PI3K/Akt and ERK/MAPK to control FOXO3a activity in acute myeloid leukemia Blood First Edition Paper, prepublished online July 29, 2010;DOI 10.1182/blood-2009-12-260711[Abstract][PDF][Supplemental Tables and Figures]  Peter J. Shaw, Fangyu Kan, Kwang Woo Ahn, Stephen R. Spellman, Mahmoud Aljurf, Mouhab Ayas, Michael Burke, Mitchell S. Cairo, Allen R. Chen, Stella M. Davies, Haydar Frangoul, James Gajewski, Robert Peter Gale, Kamar Godder, Gregory A. Hale, Martin B. A. Heemskerk, John Horan, Naynesh Kamani, Kimberly A. Kasow, Ka Wah Chan, Stephanie J. Lee, Wing H. Leung, Victor A. Lewis, David Miklos, Machteld Oudshoorn, Effie W. Petersdorf, Olle Ringdén, Jean Sanders, Kirk R. Schultz, Adriana Seber, Michelle Setterholm, Donna A. Wall, Lolie Yu, and Michael A. Pulsipher Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related or matched unrelated donors Blood First Edition Paper, prepublished online July 29, 2010;DOI 10.1182/blood-2010-01-261958[Abstract][PDF][Supplemental Table]  28 July 2010 Reema Jasuja, Bruce Furie, and Barbara C. Furie Endothelium-derived but not platelet-derived protein disulfide isomerase is required for thrombus formation in vivo Blood First Edition Paper, prepublished online July 28, 2010;DOI 10.1182/blood-2010-04-278184[Abstract][PDF][Supplemental Figures]  Stefania Gorini, Giulia Callegari, Giulia Romagnoli, Caterina Mammi, Domenico Mavilio, Giuseppe Rosano, Massimo Fini, Francesco Di Virgilio, Sara Gulinelli, Simonetta Falzoni, Andrea Cavani, Davide Ferrari, and Andrea la Sala ATP secreted by endothelial cells blocks CX3CL1-elicited natural killer cell chemotaxis and cytotoxicity via P2Y11 receptor activation Blood First Edition Paper, prepublished online July 28, 2010;DOI 10.1182/blood-2009-12-260828[Abstract][PDF][Supplemental Figures]  James N. Kochenderfer, Wyndham H. Wilson, John E. Janik, Mark E. Dudley, Maryalice Stetler-Stevenson, Steven A. Feldman, Irina Maric, Mark Raffeld, Debbie-Ann N. Nathan, Brock J. Lanier, Richard A. Morgan, and Steven A. Rosenberg Eradication of B-lineage cells and regression of lymphoma in a patient treated with autologous T cells genetically-engineered to recognize CD19 Blood First Edition Paper, prepublished online July 28, 2010;DOI 10.1182/blood-2010-04-281931[Abstract][PDF][Supplemental Methods, Table, and Figures]  Alexa S. Green, Nicolas Chapuis, Thiago Trovati Maciel, Lise Willems, Mireille Lambert, Christophe Arnoult, Olivier Boyer, Valerie Bardet, Sophie Park, Marc Foretz, Benoit Viollet, Norbert Ifrah, François Dreyfus, Olivier Hermine, Ivan Cruz Moura, Catherine Lacombe, Patrick Mayeux, Didier Bouscary, and Jerome Tamburini The LKB1/AMPK signaling pathway has tumor suppressor activity in acute myeloid leukemia through the repression of mTOR-dependent oncogenic mRNA translation Blood First Edition Paper, prepublished online July 28, 2010;DOI 10.1182/blood-2010-02-269837[Abstract][PDF][Supplemental Methods, Table, and Figures]  Cheolho Cheong, Jae-Hoon Choi, Laura Vitale, Li-Zhen He, Christine Trumpfheller, Leonia Bozzacco, Yoonkyung Do, Godwin Nchinda, Sung Ho Park, Durga Bhavani Dandamudi, Elina Shrestha, Maggi Pack, Han-Woong Lee, Tibor Keler, Ralph M. Steinman, and Chae Gyu Park Improved cellular and humoral immune responses in vivo following targeting of HIV Gag to dendritic cells within human anti-human DEC205 monoclonal antibody Blood First Edition Paper, prepublished online July 28, 2010;DOI 10.1182/blood-2010-06-288068[Abstract][PDF]  Hagop Kantarjian, Farhad Ravandi, Susan O'Brien, Jorge Cortes, Stefan Faderl, Guillermo Garcia-Manero, Elias Jabbour, William Wierda, Tapan Kadia, Sherry Pierce, Jianqin Shan, Michael Keating, and Emil J. Freireich Intensive chemotherapy does not benefit most older patients (age 70 years or older) with acute myeloid leukemia Blood First Edition Paper, prepublished online July 28, 2010;DOI 10.1182/blood-2010-03-276485[Abstract][PDF][Supplemental Tables]  27 July 2010 Kimberly Noonan, Luigi Marchionni, Judy Anderson, Drew Pardoll, G. David Roodman, and Ivan Borrello A novel role of IL-17 producing lymphocytes in mediating lytic bone disease in multiple myeloma Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-05-283895[Abstract][PDF][Supplemental Figure]  Antonio F. Santidrián, Diana M. González-Gironès, Daniel Iglesias-Serret, Llorenç Coll-Mulet, Ana M. Cosialls, Mercè de Frias, Clara Campàs, Eva González-Barca, Esther Alonso, Verena Labi, Benoit Viollet, Adalberto Benito, Gabriel Pons, Andreas Villunger, and Joan Gil AICAR induces apoptosis independently of AMPK and p53 through upregulation of the BH3-only proteins BIM and NOXA in chronic lymphocytic leukemia cells Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-05-283960[Abstract][PDF][Supplemental Figures]  Lan V. Pham, Archito T. Tamayo, Changping Li, Carlos Bueso-Ramos, and Richard J. Ford An epigenetic chromatin-remodeling role for NFATc1 in transcriptional regulation of growth and survival genes in diffuse large B-cell lymphomas Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2009-12-257378[Abstract][PDF]  Sasidhar Vemula, Baskar Ramdas, Philip Hanneman, Joseph Martin, Hilary E. Beggs, and Reuben Kapur Essential role for focal adhesion kinase in regulating stress hematopoiesis Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-01-262790[Abstract][PDF][Supplemental Figures]  Milena Sant, Claudia Allemani, Carmen Tereanu, Roberta De Angelis, Riccardo Capocaccia, Otto Visser, Rafael Marcos-Gragera, Marc Maynadié, Arianna Simonetti, Jean-Michel Lutz, and Franco Berrino Incidence of hematological malignancies in Europe by morphological subtype: results of the HAEMACARE project Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-05-282632[Abstract][PDF][Supplemental Appendix and Table]  Sarah M Taylor, Kathleen R Nevis, Hannah L Park, Gregory C Rogers, Stephen L Rogers, Jeanette G Cook, and Victoria L Bautch Angiogenic factor signaling regulates centrosome duplication in endothelial cells of developing blood vessels Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-01-266197[Abstract][PDF][Supplemental Figures]  Nathaniel T. Jeanson and David T. Scadden Vitamin D receptor (VDR) deletion leads to increased hematopoietic stem and progenitor cells residing in the spleen Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-04-280552[Abstract][PDF]  Satoshi Nishiwaki, Yoshihiro Inamoto, Hisashi Sakamaki, Mineo Kurokawa, Hiroatsu Iida, Hiroyasu Ogawa, Takahiro Fukuda, Yukiyasu Ozawa, Naoki Kobayashi, Masanobu Kasai, Takehiko Mori, Koji Iwato, Takashi Yoshida, Makoto Onizuka, Keisei Kawa, Yasuo Morishima, Ritsuro Suzuki, Yoshiko Atsuta, and Koichi Miyamura Allogeneic stem cell transplantation for adult Philadelphia chromosome-negative acute lymphocytic leukemia: comparable survival rates but different risk factors between related and unrelated transplantation in first complete remission Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-02-269571[Abstract][PDF]  Sylvain Thepot, Raphael Itzykson, Valerie Seegers, Emmanuel Raffoux, Bruno Quesnel, Yasmine Chait, Lucile Sorin, Francois Dreyfus, Thomas Cluzeau, Jacques Delaunay, Laurence Sanhes, Virginie Eclache, Caroline Dartigeas, Pascal Turlure, Stephanie Harel, Celia Salanoubat, Jean-Jacques Kiladjian, Pierre Fenaux, and Lionel Adès Treatment of progression of Philadelphia negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2010-03-274811[Abstract][PDF]  Paul R. Coleman, Christopher N. Hahn, Matthew Grimshaw, Ying Lu, Xiaochun Li, Peter J. Brautigan, Konstanze Beck, Roland Stocker, Mathew A. Vadas, and Jennifer R. Gamble Stress-induced premature senescence mediated by a novel gene, SENEX, results in an anti-inflammatory phenotype in endothelial cells Blood First Edition Paper, prepublished online July 27, 2010;DOI 10.1182/blood-2009-11-252700[Abstract][PDF][Supplemental Methods and Figures]  26 July 2010 Lis R. V. Antonelli, Yolanda Mahnke, Jessica N. Hodge, Brian O. Porter, Daniel L. Barber, Rebecca DerSimonian, Jamieson H. Greenwald, Gregg Roby, JoAnn Mican, Alan Sher, Mario Roederer, and Irini Sereti Elevated frequencies of highly activated CD4+ T cells in HIV+ patients developing immune reconstitution inflammatory syndrome Blood First Edition Paper, prepublished online July 26, 2010;DOI 10.1182/blood-2010-05-285080[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Jens Stanelle, Claudia Döring, Martin-Leo Hansmann, and Ralf Küppers Mechanisms of aberrant GATA-3 expression in classical Hodgkin lymphoma and its consequences for the cytokine profile of Hodgkin and Reed/Sternberg cells Blood First Edition Paper, prepublished online July 26, 2010;DOI 10.1182/blood-2010-01-265827[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Alexandra H. Filipovich, Kejian Zhang, Andrew L. Snow, and Rebecca A. Marsh X-linked lymphoproliferative syndromes: brothers or distant cousins? Blood First Edition Paper, prepublished online July 26, 2010;DOI 10.1182/blood-2010-03-275909[Abstract][PDF]  Martina Seiffert, Angela Schulz, Sibylle Ohl, Hartmut Döhner, Stephan Stilgenbauer, and Peter Lichter Soluble CD14 is a novel monocyte-derived survival factor for chronic lymphocytic leukemia cells, which is induced by CLL cells in vitro, and present at abnormally high levels in vivo Blood First Edition Paper, prepublished online July 26, 2010;DOI 10.1182/blood-2010-05-284505[Abstract][PDF][Supplemental Table and Figure]  Alexandra Berger, Patricia Benveniste, Steven A. Corfe, Anne H. Tran, Mary Barbara, Andrew Wakeham, Tak W. Mak, Norman N. Iscove, and Christopher J. Paige Targeted deletion of the tachykinin 4 gene (TAC4-/-) influences the early stages of B lymphocyte development Blood First Edition Paper, prepublished online July 26, 2010;DOI 10.1182/blood-2010-06-291062[Abstract][PDF]  Levelle D. Harris, Nichole R. Klatt, Carol Vinton, Judith A. Briant, Brian Tabb, Kristin Ladell, Jeffrey Lifson, Jacob D. Estes, David A. Price, Vanessa M. Hirsch, and Jason M. Brenchley Mechanisms underlying T cell subset perturbations in SIV-infected Asian rhesus macaques Blood First Edition Paper, prepublished online July 26, 2010;DOI 10.1182/blood-2010-05-283549[Abstract][PDF][Supplemental Figures]  23 July 2010 Adele K. Fielding How I treat Philadelphia chromosome positive acute lymphoblastic leukaemia Blood First Edition Paper, prepublished online July 23, 2010;DOI 10.1182/blood-2010-01-242750[Abstract][PDF]  John J. Strouse, Megan E. Reller, David G. Bundy, Martha Amoako, Maria Cancio, Rachel N. Han, Alexandra Valsamakis, and James F. Casella Severe pandemic H1N1 and seasonal influenza in children and young adults with sickle cell disease Blood First Edition Paper, prepublished online July 23, 2010;DOI 10.1182/blood-2010-05-282194[Abstract][PDF][Supplemental Table]  Can-Lan Sun, Liton Francisco, Toana Kawashima, Wendy Leisenring, Leslie L. Robison, K. Scott Baker, Daniel J. Weisdorf, Stephen J. Forman, and Smita Bhatia Prevalence and predictors of chronic health conditions after hematopoietic cell transplantation: a report from the Bone Marrow Transplant Survivor Study Blood First Edition Paper, prepublished online July 23, 2010;DOI 10.1182/blood-2009-06-229369[Abstract][PDF][Supplemental Table]  Susan P. Whitman, Kati Maharry, Michael D. Radmacher, Heiko Becker, Krzysztof Mrózek, Dean Margeson, Kelsi B. Holland, Yue-Zhong Wu, Sebastian Schwind, Klaus H. Metzeler, Jing Wen, Maria R. Baer, Bayard L. Powell, Thomas H. Carter, Jonathan E. Kolitz, Meir Wetzler, Joseph O. Moore, Richard M. Stone, Andrew J. Carroll, Richard A. Larson, Michael A. Caligiuri, Guido Marcucci, and Clara D. Bloomfield FLT3 internal tandem duplication associates with adverse outcome and gene- and microRNA-expression signatures in patients 60 years of age or older with primary cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study Blood First Edition Paper, prepublished online July 23, 2010;DOI 10.1182/blood-2010-05-283648[Abstract][PDF][Supplemental Methods, Appendix, Tables, and Figures]  Daniel L. Barber, Katrin D. Mayer-Barber, Lis R. V. Antonelli, Mark S. Wilson, Sandra White, Patricia Caspar, Sara Hieny, Irini Sereti, and Alan Sher Th1 driven immune reconstitution disease in Mycobacterium avium infected mice Blood First Edition Paper, prepublished online July 23, 2010;DOI 10.1182/blood-2010-05-286336[Abstract][PDF][Supplemental Figure]  Mark Crowther, Wendy Lim, and Mark A. Crowther Systematic review and meta-analysis methodology Blood First Edition Paper, prepublished online July 23, 2010;DOI 10.1182/blood-2010-05-280883[Abstract][PDF]  22 July 2010 Claire L Green, Catherine M Evans, Robert K Hills, Alan K Burnett, David C Linch, and Rosemary E Gale The prognostic significance of IDH1 mutations in younger adult patients with acute myeloid leukemia is dependent on FLT3/ITD status Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2010-02-270926[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Dan Xu, Siying Wang, Wen-Mei Yu, Gordon Chan, Toshiyuki Araki, Kevin D. Bunting, Benjamin G. Neel, and Cheng-Kui Qu A gain-of-function mutation in Ptpn11 (Shp-2) phosphatase induces myeloproliferative disease by aberrant activation of hematopoietic stem cells Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2010-01-265652[Abstract][PDF][Supplemental Tables and Figures]  Adrianna Vlachos and Ellen Muir How I treat Diamond Blackfan anemia Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2010-02-251090[Abstract][PDF]  Güllü Görgün, Elisabetta Calabrese, Ender Soydan, Teru Hideshima, Giulia Perrone, Madhavi Bandi, Diana Cirstea, Loredana Santo, Yiguo Hu, Yu-Tzu Tai, Sabikun Nahar, Naoya Mimura, Claire Fabre, Noopur Raje, Nikhil Munshi, Paul Richardson, and Kenneth C. Anderson Immunomodulatory effects of lenalidomide and pomalidomide on interaction of tumor and bone marrow accessory cells in multiple myeloma Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2010-04-279893[Abstract][PDF][Supplemental Methods and Figure]  Nathalie Bles, Larissa Di Pietrantonio, Jean-Marie Boeynaems, and Didier Communi ATP confers tumorigenic properties to dendritic cells by inducing amphiregulin secretion Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2010-01-265611[Abstract][PDF]  Hima Bansal, Sanjay Bansal, Manjeet Rao, Kevin P Foley, Jim Sang, David A Proia, Ronald K Blackman, Weiwen Ying, James Barsoum, Maria R Baer, Kevin Kelly, Ronan Swords, Gail Tomlinson, Minoo Battiwalla, Francis J Giles, Kelvin P Lee, and Swaminathan Padmanabhan Heat shock protein 90 regulates the expression of Wilms' tumor 1 protein in myeloid leukemias Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2009-10-247239[Abstract][PDF][Supplemental Table and Figures]  Holger W. Auner, Christine Beham-Schmid, Niall Dillon, and Pierangela Sabbattini The life-span of short-lived plasma cells is partly determined by a block on activation of apoptotic caspases acting in combination with endoplasmic reticulum stress Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2009-10-250423[Abstract][PDF][Supplemental Figures]  Ruben A. Mesa, Xiaopan Yao, Larry D. Cripe, Chin Yang Li, Mark Litzow, Elisabeth Paietta, Jacob M. Rowe, Ayalew Tefferi, and Martin S. Tallman Lenalidomide and prednisone for myelofibrosis: Eastern Cooperative Oncology Group (ECOG) phase-2 trial E4903 Blood First Edition Paper, prepublished online July 22, 2010;DOI 10.1182/blood-2010-05-287417[Abstract][PDF]  21 July 2010 Tobias Woehrle, Linda Yip, Abdallah Elkhal, Yuka Sumi, Yu Chen, Yongli Yao, Paul A. Insel, and Wolfgang G. Junger Pannexin-1 hemichannel-mediated ATP release together with P2X1 and P2X4 receptors regulate T cell activation at the immune synapse Blood First Edition Paper, prepublished online July 21, 2010;DOI 10.1182/blood-2010-04-277707[Abstract][PDF][Supplemental Figures]  Poonam Tewary, De Yang, Gonzalo de la Rosa, Yana Li, Michael W. Finn, Alan M. Krensky, Carol Clayberger, and Joost J. Oppenheim Granulysin activates antigen-presenting cells through TLR4 and acts as an immune alarmin Blood First Edition Paper, prepublished online July 21, 2010;DOI 10.1182/blood-2010-03-273953[Abstract][PDF][Supplemental Methods and Figures]  Norbert Schmitz, Lorenz Trümper, Marita Ziepert, Maike Nickelsen, Anthony D. Ho, Bernd Metzner, Norma Peter, Markus Loeffler, Andreas Rosenwald, and Michael Pfreundschuh Treatment and prognosis of mature T-cell and NK-cell lymphoma: an analysis of patients with T-cell lymphoma treated in studies of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL) Blood First Edition Paper, prepublished online July 21, 2010;DOI 10.1182/blood-2010-02-270785[Abstract][PDF][Supplemental Appendix and Tables]  Stefania Mitola, Cosetta Ravelli, Emanuela Moroni, Valentina Salvi, Daria Leali, Kurt Ballmer-Hofer, Luca Zammataro, and Marco Presta Gremlin is a novel agonist of the major pro-angiogenic receptor VEGFR2 Blood First Edition Paper, prepublished online July 21, 2010;DOI 10.1182/blood-2010-06-291930[Abstract][PDF][Supplemental Methods and Figures]  Leila R. Martins, Paulo Lúcio, Milene C. Silva, Kenna L. Anderes, Paula Gameiro, Maria G. Silva, and João T. Barata Targeting CK2 overexpression and hyperactivation as a novel therapeutic tool in chronic lymphocytic leukemia Blood First Edition Paper, prepublished online July 21, 2010;DOI 10.1182/blood-2010-04-277947[Abstract][PDF][Supplemental Table and Figures]  20 July 2010 Kimberly A. Bertrand, Brenda M. Birmann, Ellen T. Chang, Donna Spiegelman, Jon C. Aster, Shumin M. Zhang, and Francine Laden A prospective study of Epstein-Barr virus antibodies and risk of non-Hodgkin lymphoma Blood First Edition Paper, prepublished online July 20, 2010;DOI 10.1182/blood-2010-05-282715[Abstract][PDF]  Rens de Groot, David A. Lane, and James T.B. Crawley The ADAMTS13 metalloprotease domain: roles of subsites in enzyme activity and specificity Blood First Edition Paper, prepublished online July 20, 2010;DOI 10.1182/blood-2009-12-258780[Abstract][PDF][Supplemental Figure]  Petra S. Bachmann, Rocco G. Piazza, Mary E. Janes, Nicholas C. Wong, Carwyn Davies, Angela Mogavero, Vivek A. Bhadri, Barbara Szymanska, Greta Geninson, Vera Magistroni, Giovanni Cazzaniga, Andrea Biondi, Diego Miranda-Saavedra, Berthold Göttgens, Richard Saffery, Jeffrey M. Craig, Glenn M. Marshall, Carlo Gambacorti-Passerini, John E. Pimanda, and Richard B. Lock Epigenetic silencing of BIM in glucocorticoid poor-responsive pediatric acute lymphoblastic leukemia, and its reversal by histone deacetylase inhibition Blood First Edition Paper, prepublished online July 20, 2010;DOI 10.1182/blood-2010-05-284968[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Geoffrey L. Uy, Andrew A. Lane, John S. Welch, Nicole R. Grieselhuber, Jacqueline E. Payton, and Timothy J. Ley A protease-resistant PML-RAR has increased leukemogenic potential in a murine model of acute promyelocytic leukemia Blood First Edition Paper, prepublished online July 20, 2010;DOI 10.1182/blood-2008-11-189282[Abstract][PDF][Supplemental Methods, Table, and Figures]  Valerio W. Valeri, Anna Hryniewicz, Vibeke Andresen, Kathy Jones, Claudio Fenizia, Izabela Bialuk, Hye Kyung Chung, Risaku Fukumoto, Robyn Washington Parks, Maria Grazia Ferrari, Christophe Nicot, Valentina Cecchinato, Frank Ruscetti, and Genoveffa Franchini Requirement of the human T-cell leukemia virus p12 and p30 genes for infectivity of human dendritic cells and macaques but not rabbits Blood First Edition Paper, prepublished online July 20, 2010;DOI 10.1182/blood-2010-05-284141[Abstract][PDF]  Pingguo Chen, Conglei Li, Sean Lang, Guangheng Zhu, Adili Reheman, Christopher M. Spring, John Freedman, and Heyu Ni Animal model of fetal and neonatal immune thrombocytopenia: role of neonatal Fc receptor in the pathogenesis and therapy Blood First Edition Paper, prepublished online July 20, 2010;DOI 10.1182/blood-2010-05-284919[Abstract][PDF]  Tomoiku Takaku, Daniela Malide, Jichun Chen, Rodrigo T. Calado, Sachiko Kajigaya, and Neal S. Young Hematopoiesis in three dimensions: human and murine bone marrow architecture visualized by confocal microscopy Blood First Edition Paper, prepublished online July 20, 2010;DOI 10.1182/blood-2010-02-268466[Abstract][PDF][Supplemental Tables, Figures, and Videos]  19 July 2010 Ross M. Fasano, Alessandro Monaco, Emily Riehm Meier, Philippe Pary, A. Hallie Lee-Stroka, John Otridge, Harvey G. Klein, Francesco M. Marincola, Naynesh R. Kamani, Naomi L. C. Luban, David Stroncek, and Willy A. Flegel RH genotyping in a sickle cell disease patient contributing to hematopoetic stem cell transplantation donor selection and management Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-04-279372[Abstract][PDF][Supplemental Methods and Tables]  Roxane Lemoine, Florence Velge-Roussel, Florence Herr, Romain Felix, Hubert Nivet, Yvon Lebranchu, and Christophe Baron Interferon gamma licensing of human dendritic cells in T helper-independent CD8+ alloimmunity Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-02-268623[Abstract][PDF]  Giovanni Palladini, Alessandra Barassi, Catherine Klersy, Rosana Pacciolla, Paolo Milani, Gabriele Sarais, Stefano Perlini, Riccardo Albertini, Paola Russo, Andrea Foli, Letizia Zenone Bragotti, Laura Obici, Remigio Moratti, Gian Vico Melzi d'Eril, and Giampaolo Merlini The combination of high-sensitivity cardiac troponin T (hs-cTnT) at presentation and changes in N-terminal natriuretic peptide type B (NT-proBNP) after chemotherapy best predicts survival in AL amyloidosis Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-05-286567[Abstract][PDF][Supplemental Table and Figure]  Ganesan Keerthivasan, Sara Small, Hui Liu, Amittha Wickrema, and John D. Crispino Vesicle trafficking plays a novel role in erythroblast enucleation Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-03-277426[Abstract][PDF][Supplemental Table, Figures, and Video]  Soken-Nakazawa J. Song, Naohisa Tomosugi, Hiroshi Kawabata, Takayuki Ishikawa, Teppei Nishikawa, and Kazuyuki Yoshizaki Downregulation of hepcidin resulting from long-term treatment with an anti-IL-6 receptor antibody (tocilizumab) improves anemia of inflammation in multicentric Castleman's disease (MCD) Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-03-271791[Abstract][PDF][Supplemental Figure]  Markus Bender, Sebastian Hofmann, David Stegner, Athena Chalaris, Michael Bösl, Attila Braun, Jürgen Scheller, Stefan Rose-John, and Bernhard Nieswandt Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-06-289108[Abstract][PDF]  Sumaiya Sharmeen, Marko Skrtic, Mahadeo A. Sukhai, Rose Hurren, Marcela Gronda, Xiaoming Wang, Sonali B. Fonseca, Hong Sun, Tabitha E. Wood, Richard Ward, Mark D. Minden, Robert A. Batey, Alessandro Datti, Jeff Wrana, Shana O. Kelley, and Aaron D. Schimmer The anti-parasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-01-262675[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Jing Huang, David G. Motto, David R. Bundle, and J. Evan Sadler Shiga toxin B subunits induce VWF secretion by human endothelial cells and thrombotic microangiopathy in ADAMTS13-deficient mice Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-02-271957[Abstract][PDF][Supplemental Figures]  Ales Janda, Petr Sedlacek, Manfred Hönig, Wilhelm Friedrich, Martin Champagne, Tadashi Matsumoto, Alain Fischer, Benedicte Neven, Audrey Contet, Daniele Bensoussan, Pierre Bordigoni, David Loeb, William Savage, Nada Jabado, Francisco A. Bonilla, Mary A. Slatter, E. Graham Davies, and Andrew R. Gennery Multicenter survey on the outcome of transplantation of hematopoietic cells in patients with the complete form of DiGeorge anomaly Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-03-275966[Abstract][PDF][Supplemental Table]  Andrew D. Hislop, Umaimainthan Palendira, Alison M. Leese, Peter D. Arkwright, Pierre S. Rohrlich, Stuart G. Tangye, H. Bobby Gaspar, Arjan C. Lankester, Alessandro Moretta, and Alan B. Rickinson Impaired Epstein-Barr virus-specific CD8+ T cell function in X-linked lymphoproliferative disease is restricted to SLAM family positive B cell targets Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2009-09-238832[Abstract][PDF][Supplemental Figures]  Friederike Gieseke, Judith Böhringer, Rita Bussolari, Massimo Dominici, Rupert Handgretinger, and Ingo Müller Human multipotent mesenchymal stromal cells employ galectin-1 to inhibit immune effector cells Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-02-270777[Abstract][PDF]  Philippe Chadebech, Marc Michel, Daniel Janvier, Kazunori Yamada, Christiane Copie-Bergman, Gwellaouen Bodivit, Armand Bensussan, Jean-Jacques Fournie, Bertrand Godeau, Philippe Bierling, Shozo Izui, and France Noizat-Pirenne IgA-mediated human autoimmune hemolytic anemia as a result of hemagglutination in the spleen, but independently of complement activation and FcRI Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-03-276162[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Jayesh Mehta, Michele Cavo, and Seema Singhal How I treat elderly patients with myeloma Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2009-10-163329[Abstract][PDF][Supplemental Figures]  Francesco Lo-Coco, Giuseppe Avvisati, Marco Vignetti, Massimo Breccia, Eugenio Gallo, Alessandro Rambaldi, Francesca Paoloni, Giuseppe Fioritoni, Felicetto Ferrara, Giorgina Specchia, Giuseppe Cimino, Daniela Diverio, Erika Borlenghi, Giovanni Martinelli, Francesco Di Raimondo, Eros Di Bona, Paola Fazi, Antonio Peta, Alberto Bosi, Angelo M. Carella, Francesco Fabbiano, Enrico M. Pogliani, Maria C. Petti, Sergio Amadori, and Franco Mandelli Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults patients younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group Blood First Edition Paper, prepublished online July 19, 2010;DOI 10.1182/blood-2010-03-276196[Abstract][PDF][Supplemental Appendix]  16 July 2010 Yuliang Wu, Joshua A. Sommers, Avvaru N. Suhasini, Thomas Leonard, Julianna S. Deakyne, Alexander V. Mazin, Kazuo Shin-ya, Hiroyuki Kitao, and Robert M. Brosh Jr. Fanconi anemia Group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes Blood First Edition Paper, prepublished online July 16, 2010;DOI 10.1182/blood-2009-11-256016[Abstract][PDF][Supplemental Methods, Table, and Figures]  Pankaj Gupta, David M. Goldenberg, Edmund A. Rossi, and Chien-Hsing Chang Multiple signaling pathways induced by hexavalent, monospecific, anti-CD20 and hexavalent, bispecific, anti-CD20/CD22 humanized antibodies correlate with enhanced toxicity to B-cell lymphomas and leukemias Blood First Edition Paper, prepublished online July 16, 2010;DOI 10.1182/blood-2010-03-276857[Abstract][PDF]  15 July 2010 Sigbjørn Berentsen, Ulla Randen, Anne Marita Vågan, Henrik Hjorth-Hansen, Anders Vik, Jakob Dalgaard, Eva-Marie Jacobsen, Aud S. Thoresen, Klaus Beiske, and Geir E. Tjønnfjord High response rate and durable remissions following fludarabine and rituximab combination therapy for chronic cold agglutinin disease Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2010-06-288647[Abstract][PDF]  Sagarika Chakrabarty, James T. Snyder, Jijia Shen, Hooman Azmi, Paul Q. Hu, Qian Chen, and Jack A. Ragheb Human CD14hi monocytes and myeloid dendritic cells provide a cell contact-dependent costimulatory signal for early CD40 ligand expression Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2008-01-130252[Abstract][PDF]  Alexei V. Tumanov, Sergei I. Grivennikov, Andrei A. Kruglov, Yuriy V. Shebzukhov, Ekaterina P. Koroleva, Yulan Piao, Chang-Yi Cui, Dmitry V. Kuprash, and Sergei A. Nedospasov Cellular source and molecular form of TNF specify its distinct functions in organization of secondary lymphoid organs Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2009-10-249177[Abstract][PDF][Supplemental Table and Figures]  Maria Paola Martelli, Valentina Pettirossi, Christian Thiede, Elisabetta Bonifacio, Federica Mezzasoma, Debora Cecchini, Roberta Pacini, Alessia Tabarrini, Raffaella Ciurnelli, Ilaria Gionfriddo, Nicla Manes, Roberta Rossi, Linda Giunchi, Uta Oelschlägel, Lorenzo Brunetti, Marica Gemei, Mario Delia, Giorgina Specchia, Arcangelo Liso, Mauro Di Ianni, Francesco Di Raimondo, Franca Falzetti, Luigi del Vecchio, Massimo F. Martelli, and Brunangelo Falini CD34+ cells from AML with mutated NPM1 harbor cytoplasmic mutated nucleophosmin and generate leukemia in immunocompromised mice Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2009-08-238899[Abstract][PDF][Supplemental Tables and Figures]  Alison Y Swaims, Francesca Khani, Yingyu Zhang, Arthur I Roberts, Satish Devadas, Yufang Shi, and Arnold B Rabson Immune activation induces immortalization of HTLV-1 LTR-Tax transgenic CD4+ T-cells Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2009-07-231050[Abstract][PDF][Supplemental Tables and Figures]  Daniel B. Graham, Holly M. Akilesh, Grzegorz B. Gmyrek, Laura Piccio, Susan Gilfillan, Julia Sim, Roger Belizaire, Javier A. Carrero, Yinan Wang, Gregory S. Blaufuss, Gabriel Sandoval, Keiko Fujikawa, Anne H. Cross, John H. Russell, Marina Cella, and Wojciech Swat ITAM signaling in dendritic cells controls T helper cell priming by regulating MHC class II recycling Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2009-10-250415[Abstract][PDF][Supplemental Figures]  Jane R. Engler, Amity Frede, Verity Saunders, Andrew Zannettino, Deborah L. White, and Timothy P. Hughes The poor response to imatinib observed in CML patients with low OCT-1 activity is not attributable to lower uptake of imatinib into their CD34+ cells Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2010-01-267013[Abstract][PDF]  Darren S. Sigal, Heather J. Miller, Ethan D. Schram, and Alan Saven Beyond hairy cell: the activity of cladribine in other hematologic malignancies Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2010-02-246140[Abstract][PDF]  Qiufang Cheng, Erik I. Tucker, Meghann S. Pine, India Sisler, Anton Matafonov, Mao-fu Sun, Tara C. White-Adams, Stephanie A. Smith, Stephen R. Hanson, Owen J. T. McCarty, Thomas Renné, András Gruber, and David Gailani A role for factor XIIa-mediated factor XI activation in thrombus formation in vivo Blood First Edition Paper, prepublished online July 15, 2010;DOI 10.1182/blood-2010-02-270918[Abstract][PDF][Supplemental Figures]  14 July 2010 Hagop M. Kantarjian, Francis J. Giles, Peter L. Greenberg, Ron L. Paquette, Eunice S. Wang, Janice L. Gabrilove, Guillermo Garcia-Manero, Kuolung Hu, Janet L. Franklin, and Dietmar P. Berger Phase II study of romiplostim in patients with low- or intermediate-risk myelodysplastic syndrome receiving azacitidine therapy Blood First Edition Paper, prepublished online July 14, 2010;DOI 10.1182/blood-2010-03-274753[Abstract][PDF]  Karlien Hermans, Filip Claes, Wouter Vandevelde, Wei Zheng, Ilse Geudens, Fabrizio Orsenigo, Frederik De Smet, Evisa Gjini, Kristof Anthonis, Bin Ren, Dontscho Kerjaschki, Monica Autiero, Annelii Ny, Michael Simons, Mieke Dewerchin, Stefan Schulte-Merker, Elisabetta Dejana, Kari Alitalo, and Peter Carmeliet Role of synectin in lymphatic development in zebrafish and frogs Blood First Edition Paper, prepublished online July 14, 2010;DOI 10.1182/blood-2009-11-254557[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Oren Z. Lerman, Matthew R. Greives, Sunil P. Singh, Vishal D. Thanik, Christopher C. Chang, Natalie Seiser, Daniel J. Brown, Denis Knobel, Robert J. Schneider, Silvia C. Formenti, Pierre B. Saadeh, and Jamie P. Levine Low-dose radiation augments vasculogenesis signaling through HIF-1 dependent and independent SDF-1 induction Blood First Edition Paper, prepublished online July 14, 2010;DOI 10.1182/blood-2009-03-213629[Abstract][PDF]  Jochen Grassinger, David N. Haylock, Brenda Williams, Gemma H. Olsen, and Susan K. Nilsson Phenotypically identical hemopoietic stem cells isolated from different regions of bone marrow have different biological potential Blood First Edition Paper, prepublished online July 14, 2010;DOI 10.1182/blood-2009-12-260703[Abstract][PDF][Supplemental Tables and Figures]  James N. Kochenderfer, Zhiya Yu, Dorina Frasheri, Nicholas P. Restifo, and Steven A. Rosenberg Adoptive transfer of syngeneic T cells transduced with a chimeric antigen receptor that recognizes murine CD19 can eradicate lymphoma and normal B cells Blood First Edition Paper, prepublished online July 14, 2010;DOI 10.1182/blood-2010-01-265041[Abstract][PDF][Supplemental Methods and Figures]  Kirsteen J Campbell, Mary L Bath, Marian L Turner, Cassandra J Vandenberg, Philippe Bouillet, Donald Metcalf, Clare L Scott, and Suzanne Cory Elevated Mcl-1 perturbs lymphopoiesis, promotes transformation of hematopoietic stem/progenitor cells and enhances drug-resistance Blood First Edition Paper, prepublished online July 14, 2010;DOI 10.1182/blood-2010-04-281071[Abstract][PDF][Supplemental Tables and Figures]  Enrico Lugli, Carolyn K. Goldman, Liyanage P. Perera, Jeremy Smedley, Rhonda Pung, Jason L. Yovandich, Stephen P. Creekmore, Thomas A. Waldmann, and Mario Roederer Transient and persistent effects of IL15 on lymphocyte homeostasis in nonhuman primates Blood First Edition Paper, prepublished online July 14, 2010;DOI 10.1182/blood-2010-03-275438[Abstract][PDF][Supplemental Table and Figures]  13 July 2010 Michael R. Green, Stefano Monti, Scott J. Rodig, Przemyslaw Juszczynski, Treeve Currie, Evan O'Donnell, Bjoern Chapuy, Kunihiko Takeyama, Donna Neuberg, Todd R. Golub, Jeffery L. Kutok, and Margaret A. Shipp Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2010-05-282780[Abstract][PDF][Supplemental Methods, Table, and Figures]  Hilary S. Gammill, Katherine A. Guthrie, Tessa M. Aydelotte, Kristina M. Adams Waldorf, and J. Lee Nelson Effect of parity on fetal and maternal microchimerism: interaction of grafts within a host? Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2010-02-270942[Abstract][PDF]  Ben Van Handel, Sacha L. Prashad, Nargess Hassanzadeh-Kiabi, Andy Huang, Mattias Magnusson, Boriana Atanassova, Angela Chen, Eija I. Hamalainen, and Hanna K.A. Mikkola The first trimester human placenta is a site for terminal maturation of primitive erythroid cells Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2010-04-279489[Abstract][PDF][Supplemental Figures]  Emanuela Rosati, Rita Sabatini, Giuliana Rampino, Filomena De Falco, Mauro Di Ianni, Franca Falzetti, Katia Fettucciari, Andrea Bartoli, Isabella Screpanti, and Pierfrancesco Marconi Novel targets for endoplasmic reticulum stress-induced apoptosis in B-CLL Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2010-03-275628[Abstract][PDF]  Loems Ziegler-Heitbrock, Petronela Ancuta, Suzanne Crowe, Marc Dalod, Veronika Grau, Derek N. Hart, Pieter J.M. Leenen, Yong-Jun Liu, Gordon MacPherson, Gwendalyn J. Randolph, Juergen Scherberich, Juergen Schmitz, Ken Shortman, Silvano Sozzani, Herbert Strobl, Marek Zembala, Jonathan M. Austyn, and Manfred B. Lutz Nomenclature of monocytes and dendritic cells in blood Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2010-02-258558[Abstract][PDF]  Pinelopi P. Kapitsinou, Qingdu Liu, Travis L. Unger, Jennifer Rha, Olena Davidoff, Brian Keith, Jonathan A. Epstein, Sheri L. Moores, Connie L. Erickson-Miller, and Volker H. Haase Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2010-02-270322[Abstract][PDF][Supplemental Tables and Figures]  Minoko Takanashi, Yoshiko Atsuta, Koki Fujiwara, Hideki Kodo, Shunro Kai, Hiroyuki Sato, Masatoshi Kohsaki, Hiroshi Azuma, Hidenori Tanaka, Atsuko Ogawa, Kazunori Nakajima, and Shunichi Kato The impact of anti-HLA antibodies on unrelated cord blood transplantations Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2009-10-249219[Abstract][PDF]  Jean-Luc Harousseau, Antonio Palumbo, Paul G. Richardson, Rudolf Schlag, Meletios A. Dimopoulos, Ofer Shpilberg, Martin Kropff, Alain Kentos, Michele Cavo, Anatoly Golenkov, Mieczyslaw Komarnicki, Maria-Victoria Mateos, Dixie-Lee Esseltine, Andrew Cakana, Kevin Liu, William Deraedt, Helgi van de Velde, and Jesús F. San Miguel Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with non-intensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisone Blood First Edition Paper, prepublished online July 13, 2010;DOI 10.1182/blood-2010-03-275800[Abstract][PDF][Supplemental Tables]  12 July 2010 Tobias Feuchtinger, Kathrin Opherk, Wolfgang A. Bethge, Max S. Topp, Friedhelm R. Schuster, Eva M. Weissinger, Mohamad Mohty, Reuven Or, Michael Maschan, Michael Schumm, Klaus Hamprecht, Rupert Handgretinger, Peter Lang, and Hermann Einsele Adoptive transfer of pp-65 specific T-cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation Blood First Edition Paper, prepublished online July 12, 2010;DOI 10.1182/blood-2010-01-262089[Abstract][PDF]  Silke Huber, Reinhard Hoffmann, Femke Muskens, and David Voehringer Alternatively activated macrophages inhibit T cell proliferation by STAT6-dependent expression of PD-L2 Blood First Edition Paper, prepublished online July 12, 2010;DOI 10.1182/blood-2010-02-271981[Abstract][PDF][Supplemental Figures]  Lucía Comellas-Kirkerup, Gabriela Hernández-Molina, and Antonio R. Cabral Antiphospholipid-associated thrombocytopenia or autoimmune hemolytic anemia in patients with or without definite primary antiphospholipid syndrome according to the Sapporo revised classification criteria: a 6-year follow-up study Blood First Edition Paper, prepublished online July 12, 2010;DOI 10.1182/blood-2010-05-283507[Abstract][PDF]  Jorge J. Castillo, Samir Dalia, and Sheila Pascual The association between red blood cell transfusions and the development of non-Hodgkin lymphoma: a meta-analysis of observational studies Blood First Edition Paper, prepublished online July 12, 2010;DOI 10.1182/blood-2010-03-276683[Abstract][PDF]  Harald F. Langer, Kyoung-Jin Chung, Valeria V. Orlova, Eun Young Choi, Sunil Kaul, Michael J. Kruhlak, Markella Alatsatianos, Robert A. DeAngelis, Paul A. Roche, Paola Magotti, Xuri Li, Matina Economopoulou, Stavros Rafail, John D. Lambris, and Triantafyllos Chavakis Complement-mediated inhibition of neovascularization reveals a point of convergence between innate immunity and angiogenesis Blood First Edition Paper, prepublished online July 12, 2010;DOI 10.1182/blood-2010-01-261503[Abstract][PDF][Supplemental Figures]  Min Lu, Jiapeng Wang, Yan Li, Dmitriy Berenzon, Xiaoli Wang, John Mascarenhas, Mingjiang Xu, and Ronald Hoffman Treatment with the Bcl-xL inhibitor ABT-737 in combination with interferon specifically targets JAK2V617F positive polycythemia vera hematopoietic progenitor cells Blood First Edition Paper, prepublished online July 12, 2010;DOI 10.1182/blood-2010-04-279125[Abstract][PDF][Supplemental Methods]  8 July 2010 Holly M. Horton, Matthew J. Bernett, Matthias Peipp, Erik Pong, Sher Karki, Seung Y. Chu, John O. Richards, Hsing Chen, Roland Repp, John R. Desjarlais, and Eugene A. Zhukovsky Fc-engineered anti-CD40 antibody enhances multiple effector functions and exhibits potent in vitro and in vivo antitumor activity against hematological malignancie Blood First Edition Paper, prepublished online July 8, 2010;DOI 10.1182/blood-2010-01-265280[Abstract][PDF]  Myung Eun Shin, Yuan He, Dong Li, Sungsoo Na, Farhan Chowdhury, Yeh-Chuin Poh, Olivier Collin, Pei Su, Primal de Lanerolle, Martin A. Schwartz, Ning Wang, and Fei Wang Spatiotemporal organization, regulation and functions of tractions during neutrophil chemotaxis Blood First Edition Paper, prepublished online July 8, 2010;DOI 10.1182/blood-2009-12-260851[Abstract][PDF][Supplemental Methods, Figures, and Videos][Additional Supplemental Videos]  Zhuoxiao Cao, Xinghui Sun, Basak Icli, Akm Khyrul Wara, and Mark W. Feinberg Role of Kruppel-like factors in leukocyte development, function, and disease Blood First Edition Paper, prepublished online July 8, 2010;DOI 10.1182/blood-2010-05-285353[Abstract][PDF]  Brian A. Walker, Paola E. Leone, Laura Chiecchio, Nicholas J. Dickens, Matthew W. Jenner, Kevin D. Boyd, David C. Johnson, David Gonzalez, Gian Paolo Dagrada, Rebecca K.M. Protheroe, Zoe J. Konn, David M. Stockley, Walter M. Gregory, Faith E. Davies, Fiona M. Ross, and Gareth J. Morgan A compendium of myeloma associated chromosomal copy number abnormalities and their prognostic value Blood First Edition Paper, prepublished online July 8, 2010;DOI 10.1182/blood-2010-04-279596[Abstract][PDF][Supplemental Figures]  David H. McDermott, Suk See De Ravin, Hyun Sik Jun, Qian Liu, Debra A. Long Priel, Pierre Noel, Clifford M. Takemoto, Teresa Ojode, Scott M. Paul, Kimberly P. Dunsmore, Dianne Hilligoss, Martha Marquesen, Jean Ulrick, Douglas B. Kuhns, Janice Y. Chou, Harry L. Malech, and Philip M. Murphy Severe congenital neutropenia due to G6PC3 deficiency with increased neutrophil CXCR4 expression and myelokathexis Blood First Edition Paper, prepublished online July 8, 2010;DOI 10.1182/blood-2010-01-265942[Abstract][PDF]  Yoke Lin Fung, Michael Kim, Arata Tabuchi, Rukhsana Aslam, Edwin R. Speck, Leola Chow, Wolfgang M. Kuebler, John Freedman, and John W. Semple Recipient T lymphocytes modulate the severity of antibody-mediated transfusion-related acute lung injury (TRALI) Blood First Edition Paper, prepublished online July 8, 2010;DOI 10.1182/blood-2010-05-284570[Abstract][PDF][Supplemental Figures]  Alevtina D. Domashenko, Gwenn Danet-Desnoyers, Alissa Aron, Martin P. Carroll, and Stephen G. Emerson TAT-mediated transduction of NF-Ya peptide induces the ex vivo proliferation and engraftment potential of human hematopoietic progenitor cells Blood First Edition Paper, prepublished online July 8, 2010;DOI 10.1182/blood-2010-03-273441[Abstract][PDF]  7 July 2010 Samantha M. Jaglowski, Lapo Alinari, Rosa Lapalombella, Natarajan Muthusamy, and John C. Byrd The clinical application of monoclonal antibodies in chronic lymphocytic leukemia Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2010-04-001230[Abstract][PDF]  Thomas J. Kunicki and Diane J. Nugent The genetics of normal platelet reactivity Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2010-04-262048[Abstract][PDF]  Sigurdur Y Kristinsson, Min Tang, Ruth M Pfeiffer, Magnus Björkholm, Cecilie Blimark, Ulf-Henrik Mellqvist, Anders Wahlin, Ingemar Turesson, and Ola Landgren Monoclonal gammopathy of undetermined significance and risk of skeletal fractures: a population-based study Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2010-04-282848[Abstract][PDF]  Rita Shaknovich, Huimin Geng, Nathalie A. Johnson, Lucas Tsikitas, Leandro Cerchietti, John M. Greally, Randy D. Gascoyne, Olivier Elemento, and Ari Melnick DNA methylation signatures define molecular subtypes of diffuse large B cell lymphoma Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2010-05-285320[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Peter Papathanasiou, Robert Tunningley, Diwakar R. Pattabiraman, Ping Ye, Thomas J. Gonda, Belinda Whittle, Adam E. Hamilton, Simon O. Cridland, Rohan Lourie, and Andrew C. Perkins A recessive screen for genes regulating hematopoietic stem cells Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2010-04-269951[Abstract][PDF][Supplemental Methods, Table, and Figures]  Takashi Yokoyama, Yohei Kanno, Yukari Yamazaki, Tomoko Takahara, Satoshi Miyata, and Takuro Nakamura Trib1 links the MEK1/ERK pathway in myeloid leukemogenesis Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2009-10-246264[Abstract][PDF][Supplemental Methods and Figures]  Raul Alba, Angela C Bradshaw, Lynda Coughlan, Laura Denby, Robert A McDonald, Simon N Waddington, Suzanne M K Buckley, Jenny A Greig, Alan L Parker, Ashley M Miller, Hongjie Wang, Andre Lieber, Nico van Rooijen, John H McVey, Stuart A Nicklin, and Andrew H Baker Biodistribution and retargeting of FX-binding ablated adenovirus serotype 5 vectors Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2009-12-260026[Abstract][PDF][Supplemental Methods, Table, and Figures]  Anthony G. Pajerowski, Michael J. Shapiro, Kimberly Gwin, Rhianna Sundsbak, Molly Nelson-Holte, Kay Medina, and Virginia Smith Shapiro Adult hematopoietic stem cells require NKAP for maintenance and survival Blood First Edition Paper, prepublished online July 7, 2010;DOI 10.1182/blood-2010-02-268391[Abstract][PDF]  6 July 2010 Wei Ding, Traci R. Knox, Renee C. Tschumper, Wenting Wu, Susan M. Schwager, Justin C. Boysen, Diane F. Jelinek, and Neil E. Kay Platelet derived growth factor (PDGF) - PDGF receptor interaction activates bone marrow derived mesenchymal stromal cells derived from chronic lymphocytic leukemia: implications for an angiogenic switch Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2010-02-269894[Abstract][PDF][Supplemental Tables and Figures]  Qizhen Shi, Scot A. Fahs, Erin L. Kuether, Brian C. Cooley, Hartmut Weiler, and Robert R. Montgomery Targeting FVIII expression to endothelial cells regenerates a releasable pool of FVIII and restores hemostasis in a mouse model of hemophilia A Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2010-03-272419[Abstract][PDF]  Emily E. Devlin, Lydie DaCosta, Narla Mohandas, Gene Elliott, and David M. Bodine A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2010-03-275776[Abstract][PDF][Supplemental Table]  Melanie J. Stables, Justine Newson, Samir S. Ayoub, Jeremy Brown, Catherine J. Hyams, and Derek W. Gilroy Priming innate immune responses to infection by cyclooxygenase inhibition kills antibiotic susceptible and resistant bacteria Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2010-05-284844[Abstract][PDF][Supplemental Figure]  Masashi Narazaki, Marta Segarra, Xu Hou, Toshio Tanaka, Xuri Li, and Giovanna Tosato Oligo-guanosinenucleotide induces neuropilin-1 internalization in endothelial cells and inhibits angiogenesis Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2010-01-265801[Abstract][PDF]  Zhuo Sun, Yuemei Zhang, Keith R. Brunt, Jun Wu, Shu-Hong Li, Shafie Fazel, Richard D. Weisel, Armand Keating, and Ren-Ke Li An adult uterine hemangioblast: evidence for extramedullary self-renewal and clonal bilineage potential Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2010-01-266882[Abstract][PDF]  Anna C. Pulliam-Leath, Samantha L. Ciccone, Grzegorz Nalepa, Xiaxin Li, Yue Si, Leticia Miravalle, Danielle Smith, Jin Yuan, Jingling Li, Praveen Anur, Attilio Orazi, Gail H. Vance, Feng-Chun Yang, Helmut Hanenberg, Grover C. Bagby, and D. Wade Clapp Genetic disruption of both Fancc and Fancg in mice recapitulates the hematopoietic manifestations of Fanconi anemia Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2009-08-240747[Abstract][PDF][Supplemental Tables and Figures]  Karel Otero, Annunciata Vecchi, Emilio Hirsch, Jennifer Kearley, William Vermi, Annalisa Del Prete, Safiyè Gonzalvo-Feo, Cecilia Garlanda, Ornella Azzolino, Laura Salogni, Clare M. Lloyd, Fabio Facchetti, Alberto Mantovani, and Silvano Sozzani Non-redundant role of CCRL2 in lung dendritic cell trafficking Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2009-12-259903[Abstract][PDF][Supplemental Figures]  Sai Mun Leong, Ban Xiong Tan, Baidah Bte Ahmad, Tie Yan, Lai Yuen Chee, Liang Piu Koh, Allen Eng Juh Yeoh, Evelyn Siew-Chuan Koay, Yu-Keung Mok, and Tit Meng Lim Mutant nucleophosmin deregulates cell death and myeloid differentiation through excessive caspase-6 and -8 inhibition Blood First Edition Paper, prepublished online July 6, 2010;DOI 10.1182/blood-2009-12-256149[Abstract][PDF][Supplemental Methods and Figures]  1 July 2010 Ande Satyanarayana, Kristbjorn Orri Gudmundsson, Xiu Chen, Vincenzo Coppola, Lino Tessarollo, Jonathan R. Keller, and Steven X Hou RapGEF2 is essential for embryonic hematopoiesis but dispensable for adult hematopoiesis Blood First Edition Paper, prepublished online July 1, 2010;DOI 10.1182/blood-2010-01-262964[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Albert Gutierrez Jr., Renee C. Tschumper, Xiaosheng Wu, Tait D. Shanafelt, Jeanette Eckel-Passow, Paul M. Huddleston III, Susan L. Slager, Neil E. Kay, and Diane F. Jelinek LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B cell lymphocytosis Blood First Edition Paper, prepublished online July 1, 2010;DOI 10.1182/blood-2010-02-269878[Abstract][PDF][Supplemental Table]  Zane Orinska, Niko Föger, Michael Huber, Julia Marschall, Farhad Mirghomizadeh, Xin Du, Marina Scheller, Philip Rosenstiel, Torsten Goldmann, Annalena Bollinger, Bruce A. Beutler, and Silvia Bulfone-Paus I787 provides signals for c-Kit receptor internalization and functionality that control mast cell survival and development Blood First Edition Paper, prepublished online July 1, 2010;DOI 10.1182/blood-2009-06-228460[Abstract][PDF][Supplemental Methods, Table, and Figures]  Jeffrey J. Swensen, Archana M. Agarwal, Jose M. Esquilin, Sabina Swierczek, Ajay Perumbeti, Dottie Hussey, Clinton H. Joiner, Genevieve Pont-Kingdon, Elaine Lyon, and Josef T. Prchal Sickle cell disease due to uniparental disomy in a child who inherited sickle cell trait Blood First Edition Paper, prepublished online July 1, 2010;DOI 10.1182/blood-2010-05-284331[Abstract][PDF]  Peter Dreger, Hartmut Döhner, Matthias Ritgen, Sebastian Böttcher, Raymonde Busch, Sascha Dietrich, Donald Bunjes, Sandra Cohen, Jörg Schubert, Ute Hegenbart, Dietrich Beelen, Matthias Zeis, Michael Stadler, Justin Hasenkamp, Lutz Uharek, Christof Scheid, Andreas Humpe, Thorsten Zenz, Dirk Winkler, Michael Hallek, Michael Kneba, Norbert Schmitz, and Stephan Stilgenbauer Allogeneic stem cell transplantation provides durable disease control in poor-risk chronic lymphocytic leukemia:long-term clinical and MRD results of the GCLLSG CLL3X trial Blood First Edition Paper, prepublished online July 1, 2010;DOI 10.1182/blood-2010-03-275420[Abstract][PDF][Supplemental Tables]  Marie-Madeleine Dolmans, Cristina Marinescu, Pascale Saussoy, Anne Van Langendonckt, Christiani Amorim, and Jacques Donnez Reimplantation of cryopreserved ovarian tissue from patients with acute lymphoblastic leukemia is potentially unsafe Blood First Edition Paper, prepublished online July 1, 2010;DOI 10.1182/blood-2010-01-265751[Abstract][PDF][Supplemental Figures]  Sten Myrehaug, Melania Pintilie, Lingsong Yun, Michael Crump, Richard W. Tsang, Ralph M. Meyer, Jonathan Sussman, Eric Yu, and David C. Hodgson A population-based study of cardiac morbidity among Hodgkin lymphoma patients with pre-existing heart disease Blood First Edition Paper, prepublished online July 1, 2010;DOI 10.1182/blood-2010-01-263764[Abstract][PDF]  30 June 2010 Georg Mann, Andishe Attarbaschi, Martin Schrappe, Paola De Lorenzo, Christina Peters, Ian Hann, Giulio De Rossi, Maria Felice, Birgitte Lausen, Thierry LeBlanc, Tomasz Szczepanski, Alina Ferster, Gritta Janka-Schaub, Jeffrey Rubnitz, Lewis B. Silverman, Jan Stary, Myriam Campbell, Chi Kong Li, Ram Suppiah, Andrea Biondi, Ajay Vora, Maria Grazia Valsecchi, and Rob Pieters Improved outcome with hematopoietic stem cell transplantation in a poor prognostic subgroup of infants with mixed-lineage-leukemia (MLL)-rearranged acute lymphoblastic leukaemia: results from the Interfant-99 Study Blood First Edition Paper, prepublished online June 30, 2010;DOI 10.1182/blood-2010-03-273532[Abstract][PDF]  Kevin B. Walters, Julie M. Green, Jill C. Surfus, Sa Kan Yoo, and Anna Huttenlocher Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome Blood First Edition Paper, prepublished online June 30, 2010;DOI 10.1182/blood-2010-03-276972[Abstract][PDF][Supplemental Methods, Figures, and Videos][Additional Supplemental Videos]  Costa Bachas, Gerrit Jan Schuurhuis, Iris H.I.M. Hollink, Zinia J. Kwidama, Bianca F. Goemans, C. Michel Zwaan, Marry M. van den Heuvel-Eibrink, Eveline S.J.M. de Bont, Dirk Reinhardt, Ursula Creutzig, Valerie de Haas, Yehuda G. Assaraf, Gertjan J.L. Kaspers, and Jacqueline Cloos High frequency type I/II mutational shifts between diagnosis and relapse are associated with outcome in pediatric AML: implications for personalized medicine Blood First Edition Paper, prepublished online June 30, 2010;DOI 10.1182/blood-2010-03-276519[Abstract][PDF][Supplemental Tables and Figures]  Yves Lepelletier, Raphaël Zollinger, Cristina Ghirelli, Françoise Raynaud, Réda Hadj-Slimane, Antonio Cappuccio, Olivier Hermine, Yong-Jun Liu, and Vassili Soumelis Toll-like receptor control of glucocorticoid-induced apoptosis in human plasmacytoid pre-dendritic cells (pDC) Blood First Edition Paper, prepublished online June 30, 2010;DOI 10.1182/blood-2010-05-282913[Abstract][PDF][Supplemental Figures]  29 June 2010 Lamis K. Eldjerou, Sonali Chaudhury, Ada Baisre-de Leon, Mai He, Maria E. Arcila, Glenn Heller, Richard J. O'Reilly, Juliet N. Barker, and Malcolm A. Moore An in vivo model of double unit cord blood transplantation that correlates with clinical engraftment Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2010-03-276212[Abstract][PDF]  Daniel W Bougie, Dhirendra Nayak, Brian Boylan, Peter J Newman, and Richard H Aster Drug-dependent clearance of human platelets in the NOD/scid mouse by antibodies from patients with drug-induced immune thrombocytopenia Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2010-03-277764[Abstract][PDF]  Dafydd H. Thomas, Todd M. Getz, Tiffanny N. Newman, Carol A. Dangelmaier, Nick Carpino, Satya P. Kunapuli, Alexander Y. Tsygankov, and James L. Daniel A novel histidine tyrosine phosphatase, TULA-2, associates with Syk and negatively regulates GPVI signaling in platelets Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2010-02-268136[Abstract][PDF][Supplemental Figure]  Philippe V. Afonso, Mourad Mekaouche, Franck Mortreux, Frédéric Toulza, Antoine Moriceau, Eric Wattel, Antoine Gessain, Charles R. M. Bangham, Guy Dubreuil, Yves Plumelle, Olivier Hermine, Jérome Estaquier, and Renaud Mahieux Highly active antiretroviral treatment against STLV-1 infection combining reverse transcriptase and HDAC inhibitors Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2010-02-270751[Abstract][PDF][Supplemental Figures]  Oonagh Shannon, Victoria Rydengård, Artur Schmidtchen, Matthias Mörgelin, Per Alm, Ole E. Sørensen, and Lars Björck Histidine-rich glycoprotein promotes bacterial entrapment in clots and decreases mortality in a mouse model of sepsis Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2010-02-271858[Abstract][PDF]  Ronjon Chakraverty, Guillermo Orti, Michael Roughton, Jun Shen, Adele Fielding, Panagiotis Kottaridis, Donald Milligan, Matthew Collin, Charles Crawley, Peter Johnson, Andrew Clark, Anne Parker, Adrian Bloor, Ruth Pettengell, John Snowden, Andrew Pettitt, Richard Clark, Geoff Hale, Karl Peggs, Kirsty Thomson, Emma Morris, and Stephen Mackinnon Impact of in vivo alemtuzumab dose before reduced intensity conditioning and HLA-identical sibling stem cell transplantation: pharmacokinetics, GVHD and immune reconstitution Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2010-05-286856[Abstract][PDF]  Lilach Agemy, Kazuki N. Sugahara, Venkata Ramana Kotamraju, Kunal Gujraty, Olivier M. Girard, Yuko Kono, Robert F. Mattrey, Ji-Ho Park, Michael J. Sailor, Ana I. Jimenez, Carlos Cativiela, David Zanuy, Francisco J. Sayago, Carlos Aleman, Ruth Nussinov, and Erkki Ruoslahti Nanoparticle-induced vascular blockade in human prostate cancer Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2010-03-274258[Abstract][PDF][Supplemental Figures]  Alexander M. de Bruin, Miranda Buitenhuis, Koenraad F. van der Sluijs, Klaas P.J.M. van Gisbergen, Louis Boon, and Martijn A. Nolte Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN Blood First Edition Paper, prepublished online June 29, 2010;DOI 10.1182/blood-2009-12-261339[Abstract][PDF]  28 June 2010 Seung-Hee Jo, Jonathan Schatz, Jaime Acquaviva, Harinder Singh, and Ruibao Ren Cooperation between deficiencies of IRF-4 and IRF-8 promotes both myeloid and lymphoid tumorigenesis Blood First Edition Paper, prepublished online June 28, 2010;DOI 10.1182/blood-2009-07-234559[Abstract][PDF][Supplemental Methods and Figures]  Catherine Korsgren and Samuel E. Lux MD The carboxyterminal EF-domain of erythroid alpha spectrin are necessary for optimal spectrin-actin binding Blood First Edition Paper, prepublished online June 28, 2010;DOI 10.1182/blood-2009-12-260612[Abstract][PDF]  Jeannette D. Moyer, Roberta B Nowak, Nancy E. Kim, Sandra K. Larkin, Luanne L. Peters, John Hartwig, Frans A. Kuypers, and Velia M. Fowler Tropomodulin1-null mice have a mild spherocytic elliptocytosis with appearance of Tropomodulin3 in red blood cells and disruption of the membrane skeleton Blood First Edition Paper, prepublished online June 28, 2010;DOI 10.1182/blood-2010-02-268458[Abstract][PDF][Supplemental Figure]  Fabiana Perna, Nadia Gurvich, Ruben Hoya-Arias, Omar Abdel-Wahab, Ross L. Levine, Takashi Asai, Francesca Voza, Silvia Menendez, Lan Wang, Fan Liu, Xinyang Zhao, and Stephen D. Nimer Depletion of L3MBTL1 promotes the erythroid differentiation of human hematopoietic progenitor cells: possible role in 20q- polycythemia vera Blood First Edition Paper, prepublished online June 28, 2010;DOI 10.1182/blood-2010-02-270611[Abstract][PDF][Supplemental Figures]  Melania Tesio, Karin Golan, Simona Corso, Silvia Giordano, Amir Schajnovitz, Yaron Vagima, Shoham Shivtiel, Alexander Kalinkovich, Luisa Caione, Loretta Gammaitoni, Elisa Laurenti, Eike C. Buss, Elias Shezen, Tomer Itkin, Orit Kollet, Isabelle Petit, Andreas Trumpp, James Christensen, Massimo Aglietta, Wanda Piacibello, and Tsvee Lapidot Enhanced c-Met activity promotes G-CSF induced mobilization of hematopoietic progenitor cells via ROS signaling Blood First Edition Paper, prepublished online June 28, 2010;DOI 10.1182/blood-2009-06-230359[Abstract][PDF][Supplemental Tables and Figures]  25 June 2010 Miriam Miesner, Claudia Haferlach, Ulrike Bacher, Tamara Weiss, Katja Macijewski, Alexander Kohlmann, Hans-Ulrich Klein, Martin Dugas, Wolfgang Kern, Susanne Schnittger, and Torsten Haferlach Multilineage dysplasia (MLD) in acute myeloid leukemia (AML) correlates with MDS-related cytogenetic abnormalities and a prior history of MDS or MDS/MPN but has no independent prognostic relevance: a comparison of 408 cases classified as "AML not otherwise specified" (AML-NOS) or "AML with myelodysplasia-related changes" (AML-MRC) Blood First Edition Paper, prepublished online June 25, 2010;DOI 10.1182/blood-2010-04-279794[Abstract][PDF][Supplemental Table]  Federica Toffalini and Jean-Baptiste Demoulin New insights into the mechanisms of hematopoietic cell transformation by activated receptor tyrosine kinases Blood First Edition Paper, prepublished online June 25, 2010;DOI 10.1182/blood-2010-04-279752[Abstract][PDF][Supplemental Tables]  Huiyuan Zhang, Hoainam Nguyen-Jackson, Athanasia D. Panopoulos, Haiyan S. Li, Peter J. Murray, and Stephanie S. Watowich STAT3 controls myeloid progenitor growth during emergency granulopoiesis Blood First Edition Paper, prepublished online June 25, 2010;DOI 10.1182/blood-2009-12-259630[Abstract][PDF]  Arnt V. Kristen, Evangelos Giannitsis, Stephanie Lehrke, Ute Hegenbart, Matthias Konstandin, David Lindenmaier, Corina Merkle, Stefan Hardt, Philipp A. Schnabel, Christoph Röcken, Stefan O. Schonland, Anthony D. Ho, Thomas J. Dengler, and Hugo A. Katus Assessment of disease severity and outcome in patients with systemic light-chain amyloidosis by the high-sensitivity troponin-T assay Blood First Edition Paper, prepublished online June 25, 2010;DOI 10.1182/blood-2010-02-267708[Abstract][PDF]  Sarah Cooley, Daniel J. Weisdorf, Lisbeth A. Guethlein, John P. Klein, Tao Wang, Chap T. Le, Steven G.E. Marsh, Daniel Geraghty, Stephen Spellman, Michael D. Haagenson, Martha Ladner, Elizabeth Trachtenberg, Peter Parham, and Jeffery S. Miller Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia Blood First Edition Paper, prepublished online June 25, 2010;DOI 10.1182/blood-2010-05-283051[Abstract][PDF]  Eliseo F. Castillo, Luis F. Acero, Spencer W. Stonier, Dapeng Zhou, and Kimberly S. Schluns Thymic and peripheral microenvironments differentially mediate development and maturation of iNKT cells by IL-15 transpresentation Blood First Edition Paper, prepublished online June 25, 2010;DOI 10.1182/blood-2010-03-277103[Abstract][PDF][Supplemental Figures]  24 June 2010 Sherrie J. Divito, Zhiliang Wang, William J. Shufesky, Quan Liu, Olga A. Tkacheva, Angela Montecalvo, Geza Erdos, Adriana T. Larregina, and Adrian E. Morelli Endogenous dendritic cells mediate the effects of intravenously injected therapeutic immunosuppressive dendritic cells in transplantation Blood First Edition Paper, prepublished online June 24, 2010;DOI 10.1182/blood-2009-10-251058[Abstract][PDF][Supplemental Methods and Figures]  Medhat Shehata, Susanne Schnabl, Dita Demirtas, Martin Hilgarth, Rainer Hubmann, Elena Ponath, Sigrun Badrnya, Claudia Lehner, Andrea Hoelbl, Markus Duechler, Alexander Gaiger, Christoph Zielinski, Josef D. Schwarzmeier, and Ulrich Jaeger Reconstitution of PTEN activity by CK2 inhibitors and interference with the PI3-K/Akt cascade counteract the anti-apoptotic effect of human stromal cells in chronic lymphocytic leukemia Blood First Edition Paper, prepublished online June 24, 2010;DOI 10.1182/blood-2009-10-248054[Abstract][PDF][Supplemental Methods and Figures]  Andrea Knight, Alejandro J. Madrigal, Sarah Grace, Janani Sivakumaran, Panagiotis Kottaridis, Stephen Mackinnon, Paul J. Travers, and Mark W. Lowdell The role of Vdelta2-negative gamma-delta T cells during cytomegalovirus reactivation in recipients of allogeneic stem cell transplants Blood First Edition Paper, prepublished online June 24, 2010;DOI 10.1182/blood-2010-01-255166[Abstract][PDF]  23 June 2010 Xiaoyan Jiang, Donna Forrest, Franck Nicolini, Ali Turhan, Joelle Guilhot, Calvin Yip, Tessa Holyoake, Heather Jorgensen, Karen Lambie, Kyi Min Saw, Emily Pang, Ranko Vukovic, Paeta Lehn, Ashley Ringrose, Miao Yu, Ryan R. Brinkman, Clay Smith, Allen Eaves, and Connie Eaves Properties of CD34+ CML stem/progenitor cells that correlate with different clinical responses to imatinib mesylate Blood First Edition Paper, prepublished online June 23, 2010;DOI 10.1182/blood-2009-05-222471[Abstract][PDF][Supplemental Table]  Tomohiro Fukaya, Hideaki Takagi, Yumiko Sato, Kaori Sato, Kawori Eizumi, Honami Taya, Tahiro Shin, Lieping Chen, Chen Dong, Miyuki Azuma, Hideo Yagita, Bernard Malissen, and Katsuaki Sato Crucial roles of B7-H1 and B7-DC expressed on mesenteric lymph node dendritic cells in the generation of antigen-specific CD4+Foxp3+ regulatory T cells in the establishment of oral tolerance Blood First Edition Paper, prepublished online June 23, 2010;DOI 10.1182/blood-2009-10-250472[Abstract][PDF][Supplemental Figures]  Pauline Isakson, Magnar Bjørås, Stig Ove Bøe, and Anne Simonsen Autophagy contributes to therapy-induced degradation of the PML/RARA oncoprotein Blood First Edition Paper, prepublished online June 23, 2010;DOI 10.1182/blood-2010-01-261040[Abstract][PDF][Supplemental Methods and Figures]  Erin Hertlein, Georgia Triantafillou, Ellen J. Sass, Joshua D. Hessler, Xiaoli Zhang, David Jarjoura, David M. Lucas, Natarajan Muthusamy, David M. Goldenberg, Robert J. Lee, and John C. Byrd Milatuzumab immunoliposomes induce cell death in CLL by promoting accumulation of CD74 on the surface of B cells Blood First Edition Paper, prepublished online June 23, 2010;DOI 10.1182/blood-2009-11-253203[Abstract][PDF][Supplemental Methods, Table, and Figures]  Annemiek Broyl, Dirk Hose, Henk Lokhorst, Yvonne de Knegt, Justine Peeters, Anna Jauch, Uta Bertsch, Arjan Buijs, Marjan Stevens-Kroef, H. Berna Beverloo, Edo Vellenga, Sonja Zweegman, Marie-Josée Kersten, Bronno van der Holt, Laila el Jarari, George Mulligan, Hartmut Goldschmidt, Mark van Duin, and Pieter Sonneveld Gene expression profiling for molecular classification of multiple myeloma in newly diagnosed patients Blood First Edition Paper, prepublished online June 23, 2010;DOI 10.1182/blood-2009-12-261032[Abstract][PDF][Supplemental Methods, Tables, and Figures]  22 June 2010 Sarah K. Brennan, Brooke Meade, Qiuju Wang, Akil A. Merchant, Jeanne Kowalski, and William Matsui Mantle cell lymphoma activation enhances bortezomib sensitivity Blood First Edition Paper, prepublished online June 22, 2010;DOI 10.1182/blood-2010-02-268375[Abstract][PDF]  Qing Zhou, Meghan E. Munger, Steven L. Highfill, Jakub Tolar, Brenda J. Weigel, Megan Riddle, Arlene H. Sharpe, Daniel A. Vallera, Miyuki Azuma, Bruce L. Levine, Carl H. June, William J. Murphy, David H. Munn, and Bruce R. Blazar Program death-1 (PD-1) signaling and regulatory T cells (Tregs) collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes (CTLs) in advanced acute myeloid leukemia (AML) Blood First Edition Paper, prepublished online June 22, 2010;DOI 10.1182/blood-2010-03-275446[Abstract][PDF][Supplemental Figures]  Alexandre Fort, Christelle Borel, Eugenia Migliavacca, Stylianos E. Antonarakis, Richard J. Fish, and Marguerite Neerman-Arbez Regulation of fibrinogen production by microRNAs Blood First Edition Paper, prepublished online June 22, 2010;DOI 10.1182/blood-2010-02-268011[Abstract][PDF][Supplemental Tables and Figures]  Andreas Hofmann, Bertran Gerrits, Alexander Schmidt, Thomas Bock, Damaris Bausch-Fluck, Rudolf Aebersold, and Bernd Wollscheid Proteomic cell surface phenotyping of differentiating acute myeloid leukemia cells Blood First Edition Paper, prepublished online June 22, 2010;DOI 10.1182/blood-2010-02-271270[Abstract][PDF][Supplemental Methods and Tables]  Jose A. Richter-Larrea, Eloy F. Robles, Vicente Fresquet, Elena Beltran, Antonio J. Rullan, Xabier Agirre, Maria José Calasanz, Carlos Panizo, Jose A. Richter, Jesus M. Hernandez, Jose Roman-Gomez, Felipe Prosper, and Jose A. Martinez-Climent Reversion of epigenetically-mediated BIM silencing overcomes chemoresistance in Burkitt lymphoma Blood First Edition Paper, prepublished online June 22, 2010;DOI 10.1182/blood-2010-02-268003[Abstract][PDF][Supplemental Tables and Figures]  Joshua D. Milner, Tatyana Orekov, Jerrold M. Ward, Lily Cheng, Fernando Torres-Velez, Ilkka Junttila, Guangping Sun, Mark Buller, Suzanne C. Morris, Fred D. Finkelman, and William E. Paul Sustained IL-4 exposure leads to a novel pathway for hemophagocytosis, inflammation and tissue macrophage accumulation Blood First Edition Paper, prepublished online June 22, 2010;DOI 10.1182/blood-2009-11-255174[Abstract][PDF][Supplemental Figures]  Sang-Hyun Song, AeRi Kim, Tobias Ragoczy, M. A. Bender, Mark Groudine, and Ann Dean Multiple functions of Ldb1 required for β-globin activation during erythroid differentiation Blood First Edition Paper, prepublished online June 22, 2010;DOI 10.1182/blood-2010-03-272252[Abstract][PDF][Supplemental Figures]  21 June 2010 Katrin Birkholz, Michael Schwenkert, Christian Kellner, Stefanie Gross, Georg Fey, Beatrice Schuler-Thurner, Gerold Schuler, Niels Schaft, and Jan Dörrie Targeting of DEC-205 on human dendritic cells results in efficient MHC class II-restricted antigen presentation Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2010-02-268425[Abstract][PDF][Supplemental Methods and Figures]  Miranda Buitenhuis, Edwin van der Linden, Laurien H. Ulfman, Frans M. Hofhuis, Marc B. Bierings, and Paul J. Coffer Protein kinase B (PKB/c-akt) regulates homing of hematopoietic progenitors through modulation of their adhesive and migratory properties Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2009-10-250258[Abstract][PDF][Supplemental Figure]  Pablo Bartolucci, Vicky Chaar, Julien Picot, Dora Bachir, Anoosha Habibi, Christine Fauroux, Frédéric Galactéros, Yves Colin, Caroline Le Van Kim, and Wassim El Nemer Decreased sickle red blood cell adhesion to laminin by hydroxyurea is associated with inhibition of Lu/BCAM protein phosphorylation Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2009-12-257444[Abstract][PDF]  Jong Wook Lee, Sung-Soo Yoon, Zhi Xiang Shen, Arnold Ganser, Hui-Chi Hsu, Dany Habr, Gabor Domokos, Bernard Roubert, and John B. Porter Iron chelation therapy with deferasirox in patients with aplastic anemia: a subgroup analysis of 116 patients from the EPIC trial Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2010-01-261289[Abstract][PDF][Supplemental Appendix]  Yumin Hu, Weiqin Lu, Gang Chen, Hui Zhang, Yu Jia, Yue Wei, Hui Yang, Wan Zhang, Warren Fiskus, Kapil Bhalla, Michael Keating, Peng Huang, and Guillermo Garcia-Manero Overcoming resistance to histone deacetylase inhibitors in human leukemia with the redox modulating compound β-phenylethyl isothiocyanate Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2009-11-256354[Abstract][PDF][Supplemental Figure]  Rawad H. Mounzer, Oyvind S. Svendsen, Peter Baluk, Cheryl M. Bergman, Timothy P. Padera, Helge Wiig, Rakesh K. Jain, Donald M. McDonald, and Nancy H. Ruddle Lymphotoxin alpha contributes to lymphangiogenesis Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2009-12-256065[Abstract][PDF][Supplemental Figures]  Phillip A. Evans, Karl Hawkins, Roger H.K. Morris, Naresh Thirumalai, Roger Munro, Lisa Wakeman, Matthew J. Lawrence, and P. Rhodri Williams Gel point and fractal microstructure of incipient blood clots are significant new markers of haemostasis for healthy and anticoagulated blood Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2010-02-269324[Abstract][PDF]  Simon X Liang, Mykola Pinkevych, Levon M Khachigian, Christopher R Parish, Miles P Davenport, and Beng H Chong Drug-induced thrombocytopenia: development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets by drug-dependent antibodies and the efficacy of IVIG Blood First Edition Paper, prepublished online June 21, 2010;DOI 10.1182/blood-2010-02-268326[Abstract][PDF][Supplemental Methods, Tables, and Figures]  18 June 2010 Robert A.J. Signer, Encarnacion Montecino-Rodriguez, Owen N. Witte, and Kenneth Dorshkind Immature B cell progenitors survive oncogenic stress and efficiently initiate Ph+ B-acute lymphoblastic leukemia Blood First Edition Paper, prepublished online June 18, 2010;DOI 10.1182/blood-2010-01-264093[Abstract][PDF][Supplemental Figures]  Ian H Gabriel, Ruhena Sergeant, Richard Szydlo, Jane F Apperley, Hugues de Lavallade, Abdullah Alsuliman, Ahmad Khoder, David Marin, Edward Kanfer, Nichola Cooper, John Davis, Donald MacDonald, Marco Bua, Letizia Foroni, Chrissy Giles, Dragana Milojkovic, Amin Rahemtulla, and Katayoun Rezvani Interaction between KIR3DS1 and HLA-Bw4 predicts for progression-free survival following autologous stem cell transplantation in patients with multiple myeloma Blood First Edition Paper, prepublished online June 18, 2010;DOI 10.1182/blood-2010-03-273706[Abstract][PDF]  Bruno C. Medeiros, Megan Othus, Min Fang, Diane Roulston, and Frederick R. Appelbaum Prognostic impact of monosomal karyotype in young adult and elderly acute myeloid leukemia: the Southwest Oncology Group experience Blood First Edition Paper, prepublished online June 18, 2010;DOI 10.1182/blood-2010-02-270330[Abstract][PDF][Supplemental Tables and Figure]  Iain Comerford, Robert JB Nibbs, Wendel Litchfield, Mark Bunting, Yuka Harata-Lee, Sarah Haylock-Jacobs, Stephen Forrow, Heinrich Korner, and Shaun R McColl The atypical chemokine receptor CCX-CKR scavenges homeostatic chemokines in circulation and tissues and suppresses Th17 responses Blood First Edition Paper, prepublished online June 18, 2010;DOI 10.1182/blood-2010-01-264390[Abstract][PDF][Supplemental Figure]  Kimberley Jones, Jamie P. Nourse, Leanne Morrison, Do Nguyen-Van, Denis J. Moss, Scott R. Burrows, and Maher K. Gandhi Expansion of EBNA1-specific effector T cells in post-transplant lymphoproliferative disorders Blood First Edition Paper, prepublished online June 18, 2010;DOI 10.1182/blood-2010-03-274076[Abstract][PDF]  Xiang Li, A. Mario Marcondes, Theodore A. Gooley, and H. Joachim Deeg The helix-loop-helix transcription factor TWIST is dysregulated in myelodysplastic syndromes Blood First Edition Paper, prepublished online June 18, 2010;DOI 10.1182/blood-2009-09-242313[Abstract][PDF][Supplemental Figures]  Batoul Pourgheysari, Rachel Bruton, Helen Parry, Lucinda Billingham, Chris Fegan, Jim Murray, and Paul Moss Levels of cytomegalovirus-specific CD4+ T cells are markedly expanded in patients with B-cell chronic lymphocytic leukaemia and determine the total CD4+ T cell repertoire Blood First Edition Paper, prepublished online June 18, 2010;DOI 10.1182/blood-2009-12-257147[Abstract][PDF]  17 June 2010 Marie Meeths, Miriam Entesarian, Waleed Al-Herz, Samuel C. C. Chiang, Stephanie M. Wood, Wafa Al-Ateeqi, Francisco Almazan, Jaap J. Boelens, Henrik Hasle, Marianne Ifversen, Bendik Lund, J. Merlijn van den Berg, Britt Gustafsson, Hans Hjelmqvist, Magnus Nordenskjöld, Yenan T. Bryceson, and Jan-Inge Henter Spectrum of clinical presentations in familial hemophagocytic lymphohistiocytosis (FHL) type 5 patients with mutations in STXBP2 Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2010-05-282541[Abstract][PDF]  Jacob M. Rowe and Martin S. Tallman How I treat acute myeloid leukemia Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2010-05-260117[Abstract][PDF]  Voahanginirina Randriamboavonjy, Johann Isaak, Timo Frömel, Benoit Viollet, Beate Fisslthaler, Klaus T. Preissner, and Ingrid Fleming The AMP-activated protein kinase (AMPK) 2 subunit is involved in platelet signaling, clot retraction and thrombus stability Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2010-04-279612[Abstract][PDF][Supplemental Figures and Videos]  Matthew B. Lanktree, Christopher T. Johansen, Sonia S. Anand, A. Darlene Davis, Ruby Miller, Salim Yusuf, and Robert A. Hegele Genetic variation in hyaluronan metabolism loci is associated with plasma plasminogen activator inhibitor-1 concentration Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2010-02-269902[Abstract][PDF][Supplemental Table and Figures]  Helen Sheldon, Emily Heikamp, Helen Turley, Rebecca Dragovic, Peter Thomas, Chern Ein Oon, Russell Leek, Mariola Edelmann, Benedikt Kessler, Richard C. A. Sainson, Ian Sargent, Ji-Liang Li, and Adrian L. Harris New mechanism for notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2009-08-239228[Abstract][PDF][Supplemental Tables and Figures]  Nikolaus G. Oberprieler, Simone Lemeer, Maria E. Kalland, Knut M. Torgersen, Albert J.R. Heck, and Kjetil Taskén High-resolution mapping of prostaglandin E2-dependent signaling networks identifies a constitutively active PKA signaling node in CD8+CD45RO+ T cells Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2010-01-266650[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Thomas Prebet, Anne-Catherine Lhoumeau, Christine Arnoulet, Anaïs Aulas, Sylvie Marchetto, Stéphane Audebert, Francesca Puppo, Christian Chabannon, Danielle Sainty, Marie Josée Santoni, Michael Sebbagh, Virginia Summerour, Yannick Huon, Won-Sik Shin, Seung-Taek Lee, Benjamin Esterni, Norbert Vey, and Jean-Paul Borg The cell polarity PTK7 receptor acts as a modulator of the chemotherapeutic response in acute myeloid leukaemia and impairs clinical outcome Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2010-01-262352[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Jan Kazenwadel, Michael Z. Michael, and Natasha L. Harvey Prox1 expression is negatively regulated by miR-181 in endothelial cells Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2009-12-256297[Abstract][PDF][Supplemental Figures]  Sophie Kaltenbach, Gwendoline Soler, Carole Barin, Carine Gervais, Olivier A Bernard, Virginie Penard-Lacronique, and Serge P Romana A NUP98-MLL fusion in human acute myeloblastic leukemia Blood First Edition Paper, prepublished online June 17, 2010;DOI 10.1182/blood-2010-04-277806[Abstract][PDF]  16 June 2010 Jaime Tsay, Zheiwei Yang, F. Patrick Ross, Susanna Cunningham-Rundles, Hong Lin, Rhima Coleman, Philip Mayer-Kuckuk, Stephen B. Doty, Robert W. Grady, Patricia J. Giardina, Adele L. Boskey, and Maria G. Vogiatzi Bone loss due to iron overload in a murine model: importance of oxidative stress Blood First Edition Paper, prepublished online June 16, 2010;DOI 10.1182/blood-2009-12-260083[Abstract][PDF][Supplemental Figures]  Helena Ågerstam, Marcus Järås, Anna Andersson, Petra Johnels, Nils Hansen, Carin Lassen, Marianne Rissler, David Gisselsson, Tor Olofsson, Johan Richter, Xiaolong Fan, Mats Ehinger, and Thoas Fioretos Modeling the human 8p11-myeloproliferative syndrome in immuno-deficient mice Blood First Edition Paper, prepublished online June 16, 2010;DOI 10.1182/blood-2009-05-217182[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Benjamin Drogat, Joanna Kalucka, Laura Gutiérrez, Hamida Hammad, Steven Goossens, Morvarid Farhang Ghahremani, Sonia Bartunkova, Katharina Haigh, Kim Deswarte, Omar Nyabi, Michael Naessens, Napoleone Ferrara, Ursula Klingmüller, Bart Lambrecht, Andras Nagy, Sjaak Philipsen, and Jody J. Haigh VEGF regulates embryonic erythroid development through GATA1 modulation Blood First Edition Paper, prepublished online June 16, 2010;DOI 10.1182/blood-2010-01-264143[Abstract][PDF][Supplemental Tables and Figures]  Zhen Weng, Ding Li, Lin Zhang, Jian Chen, Changgeng Ruan, Guoqiang Chen, T. Kent Gartner, and Junling Liu PTEN regulates collagen-induced platelet activation Blood First Edition Paper, prepublished online June 16, 2010;DOI 10.1182/blood-2010-03-277236[Abstract][PDF][Supplemental Figures]  Laura E. Hays, Winifred W. Keeble, Jane E. Yates, R. Keaney Rathbun, Tara Koretsky, Susan B. Olson, Zejin Sun, D. Wade Clapp, and Grover C. Bagby Jr Human FANCC is hypomorphic in murine Fancc-deficient cells Blood First Edition Paper, prepublished online June 16, 2010;DOI 10.1182/blood-2010-02-266411[Abstract][PDF][Supplemental Methods and Figures]  15 June 2010 Thierry Bonnefoix and Mary Callanan Accurate hematopoietic stem cell frequency estimates by fitting multi-cell Poisson models substituting to the single-hit Poisson model in limiting dilution transplantation assays Blood First Edition Paper, prepublished online June 15, 2010;DOI 10.1182/blood-2009-10-251546[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Hendrik B. Feys, Jan Roodt, Nele Vandeputte, Inge Pareyn, Seb Lamprecht, Walter J. van Rensburg, Patricia J. Anderson, Ulrich Budde, Vernon J. Louw, Philip N. Badenhorst, Hans Deckmyn, and Karen Vanhoorelbeke Thrombotic thrombocytopenic purpura directly linked with ADAMTS13 inhibition in the baboon (Papio ursinus) Blood First Edition Paper, prepublished online June 15, 2010;DOI 10.1182/blood-2010-04-280479[Abstract][PDF][Supplemental Tables and Figures]  Teresa V. Halbsguth, Lucia Nogová, Horst Mueller, Michal Sieniawski, Dennis A. Eichenauer, Thomas Schober, Hiltrud Nisters-Backes, Peter Borchmann, Volker Diehl, Andreas Engert, and Andreas Josting Phase II study of BACOPP (Bleomycin, Adriamycin, Cyclophosphamide, Vincristine, Procarbazine and Prednisone) in older patients with Hodgkin lymphoma: a report from the German Hodgkin Study Group (GHSG) Blood First Edition Paper, prepublished online June 15, 2010;DOI 10.1182/blood-2009-11-253211[Abstract][PDF][Supplemental Appendix]  Chih-Wen Ni, Haiwei Qiu, Amir Rezvan, Kihwan Kwon, Douglas Nam, Dong Ju Son, Jane E. Visvader, and Hanjoong Jo Discovery of novel mechanosensitive genes in vivo using mouse carotid artery endothelium exposed to disturbed flow Blood First Edition Paper, prepublished online June 15, 2010;DOI 10.1182/blood-2010-04-278192[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Vito Di Marco, Marcello Capra, Emanuele Angelucci, Caterina Borgna-Pignatti, Paul Telfer, Paul Harmatz, Antonis Kattamis, Luciano Prossamariti, Aldo Filosa, Deborah Rund, Maria Rita Gamberini, Paolo Cianciulli, Marianne De Montalembert, Francesco Gagliardotto, Graham Foster, Jean Didier Grangè, Filippo Cassarà, Angela Iacono, Maria Domenica Cappellini, Gary M. Brittenham, Daniele Prati, Antonello Pietrangelo, Antonio Craxi, and Aurelio Maggio Management of chronic viral hepatitis in patients with thalassemia: an international panel's recommendations Blood First Edition Paper, prepublished online June 15, 2010;DOI 10.1182/blood-2009-11-248724[Abstract][PDF]  Yiannis Ioannou, Jing-Yun Zhang, Freda H Passam, Soheila Rahgozar, Jian Cheng Qi, Bill Giannakopoulos, Miao Qi, Pei Yu, Demin M Yu, Philip J Hogg, and Steven A Krilis Naturally occurring free thiols within β2-glycoprotein I in vivo: nitrosylation, redox modification by endothelial cells and regulation of oxidative stress induced cell injury Blood First Edition Paper, prepublished online June 15, 2010;DOI 10.1182/blood-2009-04-215335[Abstract][PDF][Supplemental Methods and Table]  14 June 2010 Faisal M. Khan, Sarah Sy, Polly Louie, Alejandra Ugarte-Torres, Noureddine Berka, Gary Sinclair, Douglas A. Stewart, James A. Russell, and Jan Storek Genomic instability after allogeneic hematopoietic cell transplantation is frequent in oral mucosa, particularly in patients with history of chronic graft-vs-host disease, and rare in nasal mucosa Blood First Edition Paper, prepublished online June 14, 2010;DOI 10.1182/blood-2009-10-249201[Abstract][PDF][Supplemental Tables and Figure]  Klaus Lechner and Ulrich Jäger How I treat autoimmune hemolytic anemias in adults Blood First Edition Paper, prepublished online June 14, 2010;DOI 10.1182/blood-2010-03-259325[Abstract][PDF]  Ruriko Tanaka, Matthew S. Squires, Shinya Kimura, Asumi Yokota, Rina Nagao, Takahiro Yamauchi, Miki Takeuchi, Hisayuki Yao, Matthias Reule, Tomoko Smyth, John F Lyons, Neil T Thompson, Eishi Ashihara, Oliver G. Ottmann, and Taira Maekawa Activity of the multi-targeted kinase inhibitor, AT9283, in imatinib-resistant BCR-ABL positive leukemic cells Blood First Edition Paper, prepublished online June 14, 2010;DOI 10.1182/blood-2009-03-211466[Abstract][PDF][Supplemental Table and Figures]  Francesco Buccisano, Luca Maurillo, Alessandra Spagnoli, Maria Ilaria Del Principe, Daniela Fraboni, Paola Panetta, Tiziana Ottone, Maria Irno Consalvo, Serena Lavorgna, Pietro Bulian, Emanuele Ammatuna, Daniela F. Angelini, Adamo Diamantini, Selenia Campagna, Licia Ottaviani, Chiara Sarlo, Valter Gattei, Giovanni Del Poeta, William Arcese, Sergio Amadori, Francesco Lo Coco, and Adriano Venditti Cytogenetic and molecular diagnostic characterization combined to post-consolidation minimal residual disease assessment by flow-cytometry improves risk stratification in adult acute myeloid leukemia Blood First Edition Paper, prepublished online June 14, 2010;DOI 10.1182/blood-2009-12-258178[Abstract][PDF][Supplemental Table and Figures]  Bertrand Coiffier, Catherine Thieblemont, Eric Van Den Neste, Gérard Lepeu, Isabelle Plantier, Sylvie Castaigne, Sophie Lefort, Gérald Marit, Margaret Macro, Catherine Sebban, Karim Belhadj, Dominique Bordessoule, Christophe Fermé, and Hervé Tilly Long-term outcome of patients in the LNH-98.5 trial, the first randomized study comparing rituximab-CHOP to standard CHOP chemotherapy in DLBCL patients: a study by the Groupe d'Etudes des Lymphomes de l'Adulte Blood First Edition Paper, prepublished online June 14, 2010;DOI 10.1182/blood-2010-03-276246[Abstract][PDF][Supplemental Appendix and Figures]  Larissa Lordier, Yunhua Chang, Abdelali Jalil, Frédéric Aurade, Loïc Garçon, Yann Lécluse, Frédéric Larbret, Toshiyuki Kawashima, Toshio Kitamura, Jérôme Larghero, Najet Debili, and William Vainchenker Aurora B is dispensable for megakaryocyte polyploidization, but contributes to the endomitotic process Blood First Edition Paper, prepublished online June 14, 2010;DOI 10.1182/blood-2010-01-265785[Abstract][PDF]  10 June 2010 Maria R. Kamstrup, Lise Mette Rahbek Gjerdrum, Edyta Biskup, Britt Thyssing Lauenborg, Elisabeth Ralfkiaer, Anders Woetmann, Niels Ødum, and Robert Gniadecki Notch 1 as a potential therapeutic target in cutaneous T-cell lymphoma Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2009-12-260216[Abstract][PDF][Supplemental Figures]  Alicja M. Gruszka, Serena Lavorgna, Maria Irno Consalvo, Tiziana Ottone, Chiara Martinelli, Mario Cinquanta, Giuseppe Ossolengo, Giancarlo Pruneri, Francesco Buccisano, Mariadomenica Divona, Michele Cedrone, Emanuele Ammatuna, Adriano Venditti, Ario de Marco, Francesco Lo-Coco, and Pier Giuseppe Pelicci A monoclonal antibody against mutated nucleophosmin1 for the molecular diagnosis of acute myeloid leukemias Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-01-266908[Abstract][PDF][Supplemental Figures]  Joao B. Oliveira, Jack J. Bleesing, Umberto Dianzani, Thomas A. Fleisher, Elaine S. Jaffe, Michael J. Lenardo, Frederic Rieux-Laucat, Richard M. Siegel, Helen C. Su, David T. Teachey, and V. Koneti Rao Revised diagnostic criteria and classification for the autoimmune lymphoproliferative syndrome: report from the 2009 NIH International Workshop Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-04-280347[Abstract][PDF][Supplemental Methods]  Thet Thet Lin, Boitelo T. Letsolo, Rhiannon E. Jones, Jan Rowson, Guy Pratt, Saman Hewamana, Chris Fegan, Chris Pepper, and Duncan M. Baird Telomere dysfunction and fusion during the progression of chronic lymphocytic leukaemia: evidence for a telomere crisis Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-02-272104[Abstract][PDF][Supplemental Table and Figures]  Shaun P. Jackson and Simone M. Schoenwaelder Procoagulant platelets: are they necrotic? Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-01-261669[Abstract][PDF]  Christian Lood, Stefan Amisten, Birgitta Gullstrand, Andreas Jönsen, Maria Allhorn, Lennart Truedsson, Gunnar Sturfelt, David Erlinge, and Anders A Bengtsson Platelet transcriptional profile and protein expression in patients with systemic lupus erythematosus: up-regulation of the type I interferon system is strongly associated with vascular disease Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-03-274605[Abstract][PDF][Supplemental Table]  Pei-Fen Guo, Mei-Rong Du, Hai-Xia Wu, Yi Lin, Li-Ping Jin, and Da-Jin Li Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2009-11-252940[Abstract][PDF]  Andrée-Laure Herr, Nabil Kabbara, Carmem M. S. Bonfim, Pierre Teira, Franco Locatelli, Karin Tiedemann, Arjan Lankester, Jean-Pierre Jouet, Chiara Messina, Yves Bertrand, Cristina Díaz de Heredia, Christina Peters, Wagnara Chaves, Samir K. Nabhan, Irina Ionescu, Eliane Gluckman, and Vanderson Rocha Long-term follow-up and factors influencing outcomes after related HLA-identical cord blood transplantation for patients with malignancies: an analysis on behalf of Eurocord-EBMT Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-02-271692[Abstract][PDF][Supplemental Appendix]  Christine Schirmer, Claudia Klein, Martin von Bergen, Jan C. Simon, and Anja Saalbach Human fibroblasts support the expansion of IL-17 producing T-cells via up-regulation of IL-23 production by dendritic cells Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-01-263509[Abstract][PDF][Supplemental Figures]  Patrizia Nigro, Jun-ichi Abe, Chang-Hoon Woo, Kimio Satoh, Carolyn McClain, Michael R. O'Dell, Hakjoo Lee, Jae-Hyang Lim, Jian-Dong Li, Kyung-Sun Heo, Keigi Fujiwara, and Bradford C. Berk PKC decreases eNOS protein stability via inhibitory phosphorylation of ERK5 Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-02-269134[Abstract][PDF][Supplemental Figures]  Saman Abbas, Sanne Lugthart, Francois G. Kavelaars, Anita Schelen, Jasper Koenders, Annelieke Zeilemaker, Wim J.L. van Putten, Anita Rijneveld, Bob Löwenberg, and Peter J.M. Valk Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia (AML): prevalence and prognostic value Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2009-11-250878[Abstract][PDF][Supplemental Table]  Laura Knipe, Athinoula Meli, Lindsay Hewlett, Ruben Bierings, John Dempster, Paul Skehel, Matthew J. Hannah, and Tom Carter A revised model for the secretion of tPA and cytokines from cultured endothelial cells Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-03-276170[Abstract][PDF][Supplemental Figures]  Roland B. Walter, Frederick R. Appelbaum, Martin S. Tallman, Noel S. Weiss, Richard A. Larson, and Elihu H. Estey Shortcomings in the clinical evaluation of new drugs: acute myeloid leukemia as paradigm Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-05-285387[Abstract][PDF]  Denise Niewerth, Ursula Creutzig, Marc B. Bierings, and Gertjan J. L. Kaspers A review on allogeneic stem cell transplantation for newly diagnosed pediatric acute myeloid leukemia Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-01-261800[Abstract][PDF]  Vikas Gupta, Martin S. Tallman, Wensheng He, Brent R. Logan, Edward Copelan, Robert Peter Gale, Hanna J Khoury, Thomas Klumpp, John Koreth, Hillard M. Lazarus, David I. Marks, Rodrigo Martino, David A. Rizzieri, Jacob M. Rowe, Mitchell Sabloff, Edmund Waller, John F. DiPersio, Donald W. Bunjes, and Daniel J. Weisdorf Comparable survival after HLA–well-matched unrelated or matched sibling donor transplantation for acute myeloid leukemia in first remission with unfavorable cytogenetics at diagnosis Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-04-278317[Abstract][PDF]  Monika Edelbauer, Dipak Datta, Ingrid HC Vos, Aninda Basu, Maria P. Stack, Marlies EJ Reinders, Masayuki Sho, Katiana Calzadilla, Peter Ganz, and David M. Briscoe Effect of vascular endothelial growth factor and its receptor KDR on the transendothelial migration and local trafficking of human T cells in vitro and in vivo Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2009-11-252460[Abstract][PDF][Supplemental Methods and Figures]  Christelle Vincent-Fabert, Remi Fiancette, Eric Pinaud, Véronique Truffinet, Nadine Cogné, Michel Cogné, and Yves Denizot Genomic deletion of the whole IgH 3' regulatory region (hs3a, hs1,2, hs3b, hs4) dramatically affects class switch recombination and Ig secretion to all isotypes Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2010-01-264689[Abstract][PDF][Supplemental Methods and Figures]  Oliver Winter, Katrin Moser, Elodie Mohr, Dimitra Zotos, Henriette Kaminski, Martin Szyska, Katrin Roth, David M. Wong, Christof Dame, David M. Tarlinton, Harald Schulze, Ian C. M. MacLennan, and Rudolf A. Manz Megakaryocytes constitute a functional component of a plasma cell niche in the bone marrow Blood First Edition Paper, prepublished online June 10, 2010;DOI 10.1182/blood-2009-12-259457[Abstract][PDF][Supplemental Figures]  8 June 2010 Sandra Balkow, Stefanie Heinz, Patricia Schmidbauer, Waldemar Kolanus, Bernhard Holzmann, Stephan Grabbe, and Melanie Laschinger LFA-1 activity state on dendritic cells regulates contact duration with T cells and promotes T-cell priming Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2009-05-224428[Abstract][PDF][Supplemental Methods and Figures]  Markus Moll, Sofia K. Andersson, Anna Smed-Sörensen, and Johan K. Sandberg Inhibition of lipid antigen presentation in dendritic cells by HIV-1 Vpu interference with CD1d recycling from endosomal compartments Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2009-09-243667[Abstract][PDF][Supplemental Figure]  Jessica A. Reese, Xiaoning Li, Manfred Hauben, Richard H. Aster, Daniel W. Bougie, Brian R. Curtis, James N. George, and Sara K. Vesely Identifying drugs that cause acute thrombocytopenia: an analysis using three distinct methods Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2010-03-276691[Abstract][PDF][Supplemental Table]  Cristina Scielzo, Maria T. S. Bertilaccio, Giorgia Simonetti, Antonis Dagklis, Elisa ten Hacken, Claudia Fazi, Marta Muzio, Valeria Caiolfa, Umberto Restuccia, Angela Bachi, Martina Rocchi, Maurilio Ponzoni, Paolo Ghia, and Federico Caligaris-Cappio HS1 has a central role in the trafficking and homing of leukemic B cells Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2009-12-258814[Abstract][PDF][Supplemental Methods, Figures, and Videos]  Rocio Aguado, Nadia Martin-Blanco, Michael Caraballo, and Matilde Canelles The endocytic adaptor Numb regulates thymus size by modulating pre-TCR signaling during asymmetric division Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2009-10-246777[Abstract][PDF][Supplemental Figures]  Oliver Goodyear, Angelo Agathanggelou, Igor Novitzky-Basso, Shamyla Siddique, Tina McSkeane, Gordon Ryan, Paresh Vyas, Jamie Cavenagh, Tanja Stankovic, Paul Moss, and Charles Craddock Induction of a CD8+ T-cell response to the MAGE cancer testis antigen by combined treatment with azacitidine and sodium valproate in patients with acute myeloid leukemia and myelodysplasia Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2009-11-249474[Abstract][PDF][Supplemental Tables]  Charlotte F McAuley, Clare Webb, Julie Makani, Alexander Macharia, Sophie Uyoga, Daniel H Opi, Carolyne Ndila, Anthony Ngatia, John Anthony G Scott, Kevin Marsh, and Thomas N Williams High mortality from P. falciparum malaria in children living with sickle cell anemia on the coast of Kenya Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2010-01-265249[Abstract][PDF]  Sara Massena, Gustaf Christoffersson, Elina Hjertström, Eyal Zcharia, Israel Vlodavsky, Nora Ausmees, Charlotte Rolny, Jin-Ping Li, and Mia Phillipson A chemotactic gradient sequestered on endothelial heparan sulfate induces directional intraluminal crawling of neutrophils Blood First Edition Paper, prepublished online June 8, 2010;DOI 10.1182/blood-2010-01-266072[Abstract][PDF][Supplemental Video]  7 June 2010 Markus Bender, Anita Eckly, John H. Hartwig, Margitta Elvers, Irina Pleines, Shuchi Gupta, Georg Krohne, Elisabeth Jeanclos, Antje Gohla, Christine Gurniak, Christian Gachet, Walter Witke, and Bernhard Nieswandt ADF/n-cofilin-dependent actin turnover determines platelet formation and sizing Blood First Edition Paper, prepublished online June 7, 2010;DOI 10.1182/blood-2010-03-274340[Abstract][PDF][Supplemental Methods, Figures, and Videos]  Wolfgang A. Bethge, Thoralf Lange, Christoph Meisner, Stephanie von Harsdorf, Martin Bornhaeuser, Birgit Federmann, Michael Stadler, Lutz Uharek, Matthias Stelljes, Stefan Knop, Gerald Wulf, Rudolf Trenschel, Vladan Vucinic, Helmut Dittmann, Christoph Faul, Wichard Vogel, Lothar Kanz, and Donald Bunjes Radioimmunotherapy with yttrium-90-ibritumomab tiuxetan as part of a reduced intensity conditioning regimen for allogeneic hematopoietic cell transplantation in patients with advanced non-Hodgkin lymphoma: results of a phase II study Blood First Edition Paper, prepublished online June 7, 2010;DOI 10.1182/blood-2010-02-270538[Abstract][PDF]  Eynav Klechevsky, Anne-Laure Flamar, Yanying Cao, Jean-Philippe Blanck, Maochang Liu, Amy O'Bar, Olivier Agouna-Deciat, Peter Klucar, LuAnn Thompson-Snipes, Sandra Zurawski, Yoram Reiter, Karolina Palucka, Gerard Zurawski, and Jacques Banchereau Cross-priming CD8+ T cells by targeting antigens to human dendritic cells through DCIR Blood First Edition Paper, prepublished online June 7, 2010;DOI 10.1182/blood-2010-01-264960[Abstract][PDF][Supplemental Methods, Table, and Figures]  Mark R. Dowling, Emma C. Josefsson, Katya J. Henley, Philip D. Hodgkin, and Benjamin T. Kile Platelet senescence is regulated by an internal timer, not damage inflicted by hits Blood First Edition Paper, prepublished online June 7, 2010;DOI 10.1182/blood-2009-12-259663[Abstract][PDF][Supplemental Methods, Tables, and Figures]  4 June 2010 Wei Zhang, Yong-Sheng Li, Michael A. Nardi, Suying Dang, Jing Yang, Yong Ji, Zongdong Li, Simon Karpatkin, and Thomas Wisniewski Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus Blood First Edition Paper, prepublished online June 4, 2010;DOI 10.1182/blood-2010-01-264358[Abstract][PDF][Supplemental Figures]  Stephanie Halene, Yuan Gao, Katherine Hahn, Stephanie Massaro, Joseph E. Italiano Jr., Vincent Schulz, Sharon Lin, Gary M. Kupfer, and Diane S. Krause Serum response factor is an essential transcription factor in megakaryocytic maturation Blood First Edition Paper, prepublished online June 4, 2010;DOI 10.1182/blood-2010-01-261743[Abstract][PDF][Supplemental Tables and Figures]  3 June 2010 Sarah E. M. Herman, Amber L. Gordon, Amy J. Wagner, Nyla A. Heerema, Weiqiang Zhao, Joseph M. Flynn, Jeffrey Jones, Leslie Andritsos, Kamal D. Puri, Brian J. Lannutti, Neill A. Giese, Xiaoli Zhang, Lai Wei, John C. Byrd, and Amy J. Johnson The phosphatidylinositol 3-kinase- inhibitor CAL-101 demonstrates promising pre-clinical activity in chronic lymphocytic leukemia by antagonizing intrinsic and extrinsic cellular survival signals Blood First Edition Paper, prepublished online June 3, 2010;DOI 10.1182/blood-2010-02-271171[Abstract][PDF]  Anna-Maria Strothmeyer, Dimitrios Papaioannou, Marcus Dühren-von Minden, Marcelo Navarrete, Katja Zirlik, Kristina Heining-Mikesch, and Hendrik Veelken Comparative analysis of predicted HLA binding of immunoglobulin idiotype sequences indicates T-cell–mediated immunosurveillance in follicular lymphoma Blood First Edition Paper, prepublished online June 3, 2010;DOI 10.1182/blood-2010-02-270199[Abstract][PDF][Supplemental Table]  Jonathan S. Wall, Stephen J. Kennel, Alan C. Stuckey, Misty J. Long, David W. Townsend, Gary T. Smith, Karen J. Wells, Yitong Fu, Michael G. Stabin, Deborah T. Weiss, and Alan Solomon Radioimmunodetection of amyloid deposits in patients with AL amyloidosis Blood First Edition Paper, prepublished online June 3, 2010;DOI 10.1182/blood-2010-03-273797[Abstract][PDF]  Hendrik J.M. de Jonge, Peter J.M. Valk, Nic J.G.M. Veeger, Arja ter Elst, Monique L. den Boer, Jacqueline Cloos, Valérie de Haas, Marry M. van den Heuvel-Eibrink, Gertjan J.L. Kaspers, Christian M. Zwaan, Willem A. Kamps, Bob Löwenberg, and Eveline S.J.M. de Bont High VEGFC expression is associated with unique gene expression profiles and predicts adverse prognosis in pediatric and adult acute myeloid leukemia Blood First Edition Paper, prepublished online June 3, 2010;DOI 10.1182/blood-2010-03-270991[Abstract][PDF][Supplemental Tables and Figures]  Jana Krosl, Aline Mamo, Jalila Chagraoui, Brian T. Wilhelm, Simon Girard, Isabelle Louis, Julie Lessard, Claude Perreault, and Guy Sauvageau A mutant allele of the Swi/Snf member BAF250a determines the pool size of fetal liver hemopoietic stem cell populations Blood First Edition Paper, prepublished online June 3, 2010;DOI 10.1182/blood-2010-03-273862[Abstract][PDF]  2 June 2010 Amudhan Maniar, Xiaoyu Zhang, Wei Lin, Brian R. Gastman, C. David Pauza, Scott E. Strome, and Andrei I. Chapoval Human T lymphocytes induce robust NK cell mediated antitumor cytotoxicity through CD137 engagement Blood First Edition Paper, prepublished online June 2, 2010;DOI 10.1182/blood-2009-07-234211[Abstract][PDF][Supplemental Figures]  Gayane Badalian-Very, Jo-Anne Vergilio, Barbara A. Degar, Laura E. MacConaill, Barbara Brandner, Monica L. Calicchio, Frank C. Kuo, Azra H. Ligon, Kristen E. Stevenson, Sarah M. Kehoe, Levi A. Garraway, William C. Hahn, Matthew Meyerson, Mark D. Fleming, and Barrett J. Rollins Recurrent BRAF mutations in Langerhans cell histiocytosis Blood First Edition Paper, prepublished online June 2, 2010;DOI 10.1182/blood-2010-04-279083[Abstract][PDF][Supplemental Methods, Tables, and Figures]  Daniel W. Sherbenou, Oliver Hantschel, Ines Kaupe, Stephanie Willis, Thomas Bumm, Lalita P. Turaga, Thoralf Lange, Kim-Hien Dao, Richard D. Press, Brian J. Druker, Giulio Superti-Furga, and Michael W. Deininger BCR-ABL SH3-SH2 domain mutations in chronic myeloid leukemia patients on imatinib Blood First Edition Paper, prepublished online June 2, 2010;DOI 10.1182/blood-2008-10-183665[Abstract][PDF][Supplemental Table and Figures]  1 June 2010 Jean-François Séïté, Divi Cornec, Yves Renaudineau, Pierre Youinou, Rizgar A Mageed, and Sophie Hillion IVIg modulates BCR-signaling through CD22 and promotes apoptosis in mature human B lymphocytes Blood First Edition Paper, prepublished online June 1, 2010;DOI 10.1182/blood-2009-12-261461[Abstract][PDF][Supplemental Figures]  Thomas A. White, Tucker Johnson, Natalia Zarzhevsky, Cindy Tom, Sinny Delacroix, Eric W. Holroyd, Susan A. Maroney, Ripudamanjit Singh, Shuchong Pan, William P. Fay, Jan van Deursen, Alan E. Mast, Gurpreet S. Sandhu, and Robert D. Simari Endothelial-derived tissue factor pathway inhibitor regulates arterial thrombosis but is not required for development or hemostasis Blood First Edition Paper, prepublished online June 1, 2010;DOI 10.1182/blood-2009-10-250910[Abstract][PDF][Supplemental Figures]  28 May 2010 Ilaria Visigalli, Silvia Ungari, Sabata Martino, Hyejung Park, Martina Cesani, Bernhard Gentner, Lucia Sergi Sergi, Aldo Orlacchio, Luigi Naldini, and Alessandra Biffi The galactocerebrosidase enzyme contributes to the maintenance of a functional hematopoietic stem cell niche Blood First Edition Paper, prepublished online May 28, 2010;DOI 10.1182/blood-2009-12-256461[Abstract][PDF][Supplemental Table]  Il-Kang Na, John C. Markley, Jennifer J. Tsai, Nury L. Yim, Bradley J. Beattie, Alexander D. Klose, Amanda M. Holland, Arnab Ghosh, Uttam K. Rao, Matthias T. Stephan, Inna Serganova, Elmer B. Santos, Renier J. Brentjens, Ronald G. Blasberg, Michel Sadelain, and Marcel R.M. van den Brink Concurrent visualization of trafficking, expansion and activation of T lymphocytes and T-cell precursors in vivo Blood First Edition Paper, prepublished online May 28, 2010;DOI 10.1182/blood-2009-12-259432[Abstract][PDF][Supplemental Figures]  Sergey S. Seregin, Yasser A. Aldhamen, Daniel M. Appledorn, Zachary C. Hartman, Nathaniel J. Schuldt, Jeannine Scott, Sarah Godbehere, Haixiang Jiang, Michael M. Frank, and Andrea Amalfitano Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad-vector triggered immune responses in vitro and in vivo Blood First Edition Paper, prepublished online May 28, 2010;DOI 10.1182/blood-2010-03-276949[Abstract][PDF][Supplemental Methods, Table, and Figures]  Suk See De Ravin, Kol A. Zarember, Debra Long-Priel, King C. Chan, Stephen D. Fox, John I. Gallin, Douglas B. Kuhns, and Harry L. Malech Tryptophan/kynurenine metabolism in human leukocytes is independent of superoxide and is fully maintained in chronic granulomatous disease Blood First Edition Paper, prepublished online May 28, 2010;DOI 10.1182/blood-2009-07-233734[Abstract][PDF]  Jonathan M. Rowlinson and Martin Gering Hey2 acts upstream of Notch in hematopoietic stem cell specification in zebrafish embryos Blood First Edition Paper, prepublished online May 28, 2010;DOI 10.1182/blood-2009-11-252635[Abstract][PDF][Supplemental Table and Figure]  27 May 2010 Nicole L. Whitlatch, David F. Kong, Ara D. Metjian, Gowthami M. Arepally, and Thomas L. Ortel Validation of the high-heparin confirmatory step for the diagnosis of heparin-induced thrombocytopenia Blood First Edition Paper, prepublished online May 27, 2010;DOI 10.1182/blood-2010-01-262659[Abstract][PDF]  Jan W. Gratama, Michael Boeckh, Ryotaro Nakamura, Jan J. Cornelissen, Rik A. Brooimans, John A. Zaia, Stephen J. Forman, Karl Gaal, Kurtis R. Bray, Gail H. Gasior, Christopher S. Boyce, Linda A. Sullivan, and Paula C. Southwick Immune monitoring with iTAgTM MHC tetramers for prediction of recurrent or persistent cytomegalovirus (CMV) infection or disease in allogeneic hematopoietic stem cell transplant (HCT) recipients: a prospective multicenter study Blood First Edition Paper, prepublished online May 27, 2010;DOI 10.1182/blood-2010-03-273508[Abstract][PDF]  Yi Ma, Mohammad Z. Ashraf, and Eugene A. Podrez Scavenger receptor BI modulates platelet reactivity and thrombosis in dyslipidemia Blood First Edition Paper, prepublished online May 27, 2010;DOI 10.1182/blood-2010-02-268508[Abstract][PDF][Supplemental Methods and Figure]  Jungshan Chang, John T. Patton, Arun Sarkar, Beat Ernst, John L. Magnani, and Paul S. Frenette GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice Blood First Edition Paper, prepublished online May 27, 2010;DOI 10.1182/blood-2009-12-260513[Abstract][PDF]  24 May 2010 Hyun Sik Jun, Young Mok Lee, Yuk Yin Cheung, David H. McDermott, Philip M. Murphy, Suk See De Ravin, Brian C. Mansfield, and Janice Y. Chou Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-beta-deficient neutrophils in a congenital neutropenia syndrome Blood First Edition Paper, prepublished online May 24, 2010;DOI 10.1182/blood-2009-12-258491[Abstract][PDF]  Carsten Müller-Tidow, Hans-Ulrich Klein, Antje Hascher, Fabienne Isken, Lara Tickenbrock, Nils Thoennissen, Shuchi Agrawal-Singh, Petra Tschanter, Christine Disselhoff, Yipeng Wang, Anke Becker, Christian Thiede, Gerhard Ehninger, Udo zur Stadt, Steffen Koschmieder, Matthias Seidl, Frank U. Müller, Wilhelm Schmitz, Peter Schlenke, Michael McClelland, Wolfgang E. Berdel, Martin Dugas, and Hubert Serve Profiling of histone H3 lysine 9 trimethylation levels predicts transcription factor activity and survival in acute myeloid leukemia Blood First Edition Paper, prepublished online May 24, 2010;DOI 10.1182/blood-2009-09-240978[Abstract][PDF][Supplemental Appendix, Methods, Tables, and Figure]  21 May 2010 Giada Bianchi, Robert A. Kyle, Colin L. Colby, Dirk R. Larson, Shaji Kumar, Jerry A. Katzmann, Angela Dispenzieri, Terry M. Therneau, James R. Cerhan, L. Joseph Melton III, and S. Vincent Rajkumar Impact of optimal follow-up of Monoclonal Gammopathy of Undetermined Significance (MGUS) on early diagnosis and prevention of myeloma-related complications Blood First Edition Paper, prepublished online May 21, 2010;DOI 10.1182/blood-2010-04-277566[Abstract][PDF][Supplemental Tables]  20 May 2010 Haefaa Alchalby, Anita Badbaran, Tatjana Zabelina, Guido Kobbe, Joachim Hahn, Daniel Wolff, Martin Bornhäuser, Christian Thiede, Herrad Baurmann, Wolfgang Bethge, York Hildebrandt, Ulrike Bacher, Boris Fehse, Axel R. Zander, and Nicolaus Kröger Impact of JAK2V617F-mutation status, allele burden and clearance after allogeneic stem cell transplantation for myelofibrosis Blood First Edition Paper, prepublished online May 20, 2010;DOI 10.1182/blood-2009-12-260588[Abstract][PDF]  17 May 2010 Xiaojun Liu, Yaqing Wang, Sherri Benaissa, Akira Matsuda, Hagop Kantarjian, Zeev Estrov, and William Plunkett Homologous recombination as a resistance mechanism to replication-induced double-strand breaks caused by the anti-leukemia agent, CNDAC Blood First Edition Paper, prepublished online May 17, 2010;DOI 10.1182/blood-2009-05-220376[Abstract][PDF][Supplemental Methods, Table, and Figures]  Norbert Claude Gorin, Myriam Labopin, Josy Reiffers, Noel Milpied, Didier Blaise, Francis Witz, Theo de Witte, Giovanna Meloni, Michel Attal, Teresa Bernal, and Vanderson Rocha Higher incidence of relapse for acute myelocytic leukemia patients infused with higher doses of CD34+ cells from leukapheresis products autografted during the first remission Blood First Edition Paper, prepublished online May 17, 2010;DOI 10.1182/blood-2009-11-252197[Abstract][PDF][Supplemental Appendix]  13 May 2010 Farhad Ravandi, Susan O'Brien, Deborah Thomas, Stefan Faderl, Dan Jones, Rebecca Garris, Samuel Dara, Jeffrey Jorgensen, Partow Kebriaei, Richard Champlin, Gautam Borthakur, Jan Burger, Alessandra Ferrajoli, Guillermo Garcia-Manero, William Wierda, Jorge Cortes, and Hagop Kantarjian First report of phase II study of dasatinib with hyperCVAD for the frontline treatment of patients with Philadelphia chromosome positive (Ph+) acute lymphoblastic leukemia Blood First Edition Paper, prepublished online May 13, 2010;DOI 10.1182/blood-2009-12-261586[Abstract][PDF]  11 May 2010 Don M. Benson Jr., Courtney E. Bakan, Anjali Mishra, Craig C. Hofmeister, Yvonne Efebera, Brian Becknell, Robert A. Baiocchi, Jianying Zhang, Jianhua Yu, Megan K. Smith, Carli N. Greenfield, Pierluigi Porcu, Steven M. Devine, Rinat Rotem-Yehudar, Gerard Lozanski, John C. Byrd, and Michael A. Caligiuri The PD-1 / PD-L1 axis modulates the natural killer cell versus multiple myeloma effect: a therapeutic target for CT-011, a novel, monoclonal anti-PD-1 antibody Blood First Edition Paper, prepublished online May 11, 2010;DOI 10.1182/blood-2010-02-271874[Abstract][PDF][Supplemental Figure]  7 May 2010 Andrew C. Dudley, Taturo Udagawa, Juan M. Melero-Martin, Shou-Ching Shih, Adam Curatolo, Marsha A. Moses, and Michael Klagsbrun Bone marrow is a reservoir for pro-angiogenic myelomonocytic cells but not endothelial cells in spontaneous tumors Blood First Edition Paper, prepublished online May 7, 2010;DOI 10.1182/blood-2010-02-271122[Abstract][PDF][Supplemental Methods and Figure]  6 May 2010 Karine M. Valentijn, Linda F. van Driel, Marjon J. Mourik, Gert-Jan Hendriks, Tom J. Arends, Abraham J. Koster, and Jack A. Valentijn Multigranular exocytosis of Weibel Palade bodies in vascular endothelial cells Blood First Edition Paper, prepublished online May 6, 2010;DOI 10.1182/blood-2010-03-274209[Abstract][PDF][Supplemental Figures and Videos]  4 May 2010 Horace M. DeLisser How I conduct the family meeting to discuss the limitation of life-sustaining interventions: a recipe for success Blood First Edition Paper, prepublished online May 4, 2010;DOI 10.1182/blood-2010-03-277343[Abstract][PDF]  28 April 2010 Chen Yu, Yanxia Liu, Zhenchuan Miao, Ming Yin, Wei Lu, Yaxin Lv, Mingxiao Ding, and Hongkui Deng Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors Blood First Edition Paper, prepublished online April 28, 2010;DOI 10.1182/blood-2010-01-263335[Abstract][PDF][Supplemental Methods, Tables, and Figures]  10 February 2010 Simona Sivori, Michela Falco, Simona Carlomagno, Elisa Romeo, Cristiana Soldani, Armand Bensussan, Antonella Viola, Lorenzo Moretta, and Alessandro Moretta A novel KIR-associated function: evidence that CpG DNA uptake and shuttling to early endosomes is mediated by KIR3DL2 Blood First Edition Paper, prepublished online February 10, 2010;DOI 10.1182/blood-2009-12-256586[Abstract][PDF][Supplemental Methods, Tables, and Figures]  13 January 2010 To see an article, click its [PDF] link. 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