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Blood's First Edition Papers: Last updated February 4, 2010 [View by section] To enable Blood's readers to learn about new scientific findings at the earliest possible moment, the Journal has decided to prepublish, in manuscript format, all accepted articles shortly after acceptance as "First Edition Papers." First Edition Papers have undergone full scientific review but none of the editorial preparation, such as copyediting, typesetting, and proofreading, which is mandatory for all articles published in the regular print and online issues of Blood. Disclaimer More about Blood's First Edition Papers: To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. 4 February 2010 Richard C. Harvey, Charles G. Mullighan, I-Ming Chen, Walker Wharton, Fady M. Mikhail, Andrew J. Carroll, Huining Kang, Wei Liu, Kevin K. Dobbin, Malcolm A. Smith, William L. Carroll, Meenakshi Devidas, W. Paul Bowman, Bruce M. Camitta, Gregory H. Reaman, Stephen P. Hunger, James R. Downing, and Cheryl L. Willman Rearrangement of CRLF2 is associated with mutation of JAK kinases, alteration of IKZF1, Hispanic/Latino ethnicity, and a poor outcome in pediatric B-progenitor acute lymphoblastic leukemia Blood First Edition Paper, prepublished online February 4, 2010; DOI 10.1182/blood-2009-09-245944 [Abstract] [PDF]   Laurent Burnier, François Saller, Linda Kadi, Anne C. Brisset, Rocco Sugamele, Lucie Baudino, Françoise Bono, Jean-Marc Herbert, Peter Carmeliet, Marc Schapira, Shozo Izui, and Anne Angelillo-Scherrer Gas6 deficiency in recipient mice ofallogeneic transplantation alleviates hepatic graft-versus-host disease Blood First Edition Paper, prepublished online February 4, 2010; DOI 10.1182/blood-2009-02-206920 [Abstract] [PDF]   Caiyun Xuan, Kristopher K. Steward, John M. Timmerman, and Sherie L. Morrison Targeted delivery of interferon alpha via fusion to anti-CD20 results in potent antitumor activity against B-cell lymphoma Blood First Edition Paper, prepublished online February 4, 2010; DOI 10.1182/blood-2009-10-250555 [Abstract] [PDF]   Joanne Shaw, Yui-Hsi Wang, Tomoki Ito, Kazuhiko Arima, and Yong-Jun Liu Plasmacytoid dendritic cells regulate B cell growth and differentiation via CD70 Blood First Edition Paper, prepublished online February 4, 2010; DOI 10.1182/blood-2009-08-239145 [Abstract] [PDF]   Irina Pleines, Anita Eckly, Margitta Elvers, Ina Hagedorn, Sandra Eliautou, Markus Bender, Xunwei Wu, Francois Lanza, Christian Gachet, Cord Brakebusch, and Bernhard Nieswandt Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets Blood First Edition Paper, prepublished online February 4, 2010; DOI 10.1182/blood-2009-09-242271 [Abstract] [PDF]   Douglas W. White, Catherine R. Keppel, Stephanie E. Schneider, Tiffany A. Reese, James Coder, Jacqueline E. Payton, Timothy J. Ley, Herbert W. Virgin, and Todd A. Fehniger Latent herpesvirus infection arms NK cells Blood First Edition Paper, prepublished online February 4, 2010; DOI 10.1182/blood-2009-09-245464 [Abstract] [PDF]   Thomas Bee, Gemma Swiers, Sawako Muroi, Amir Pozner, Wade Nottingham, Ana Cristina Santos, Pik-Shan Li, Ichiro Taniuchi, and Marella F.T.R. de Bruijn Non-redundant roles for Runx1 alternative promoters reflect their activity at discrete stages of developmental hematopoiesis Blood First Edition Paper, prepublished online February 4, 2010; DOI 10.1182/blood-2009-08-238626 [Abstract] [PDF]   3 February 2010 Karen A Cavassani, William Carson IV, Ana Paula Moreira, Haitao Wen, Matthew A Schaller, Makoto Ishii, Dennis M Lindell, Yali Dou, Nicholas N Lukacs, Venkateshwar G Keshamouni, Cory M Hogaboam, and Steven L Kunkel The post sepsis-induced expansion and enhanced function of regulatory T cells creates an environment to potentiate tumor growth Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-09-241083 [Abstract] [PDF]   Kylie T Greig, Carolyn A de Graaf, James M Murphy, Marina R Carpinelli, Swee Heng Milon Pang, Jon Frampton, Benjamin T Kile, Douglas J Hilton, and Stephen L Nutt Critical roles for c-Myb in lymphoid priming and early B-cell development Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-08-239210 [Abstract] [PDF]   Christian Bach, Sebastian Buhl, Dorothée Mueller, Maria-Paz Garcia-Cuéllar, Emanuel Maethner, and Robert K. Slany Leukemogenic transformation by HOXA-cluster genes Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-04-216606 [Abstract] [PDF]   Helena Stabile, Claudia Carlino, Cinzia Mazza, Silvia Giliani, Stefania Morrone, Lucia D. Notarangelo, Luigi D. Notarangelo, Angela Santoni, and Angela Gismondi Impaired NK cell migration in WAS/XLT patients: role of Cdc42/WASp pathway in the control of chemokine-induced β2 integrin high-affinity state Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-07-235804 [Abstract] [PDF]   Francesco Zaja, Michele Baccarani, Patrizio Mazza, Monica Bocchia, Luigi Gugliotta, Alfonso Zaccaria, Nicola Vianelli, Marzia Defina, Alessia Tieghi, Sergio Amadori, Selenia Campagna, Felicetto Ferrara, Emanuele Angelucci, Emilio Usala, Silvia Cantoni, Giuseppe Visani, Antonella Fornaro, Rita Rizzi, Valerio De Stefano, Francesco Casulli, Marta Lisa Battista, Miriam Isola, Franca Soldano, Enrica Gamba, and Renato Fanin Dexamethasone plus rituximab yields higher sustained response rates than dexamethasone monotherapy in adults with primary immune thrombocytopenia Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-07-229815 [Abstract] [PDF]   Olivier Adotévi, Karine Mollier, Christine Neuveut, Magalie Dosset, Patrice Ravel, Wolf-Hervé Fridman, Eric Tartour, Pierre Charneau, Simon Wain-Hobson, and Pierre Langlade-Demoyen Targeting human telomerase reverse transcriptase (hTERT) with recombinant lentivector is highly effective to stimulate antitumor CD8 T-cell immunity in vivo Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-11-253641 [Abstract] [PDF]   Alfonso Quintás-Cardama, Kris Vaddi, Phillip Liu, Taghi Manshouri, Jun Li, Peggy A. Scherle, Eian Caulder, Xiaoming Wen, Yanlong Li, Paul Waeltz, Mark Rupar, Timothy Burn, Yvonne Lo, Jennifer Kelley, Maryanne Covington, Stacey Shepard, James D. Rodgers, Patrick Haley, Hagop Kantarjian, Jordan S. Fridman, and Srdan Verstovsek Preclinical characterization of the selective JAK1/2 inhibitor INCB018424: implications for the treatment of myeloproliferative neoplasms Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-04-214957 [Abstract] [PDF]   Kieron Dunleavy, Richard F. Little, Stefania Pittaluga, Nicole Grant, Alan S. Wayne, Jorge A. Carrasquillo, Seth M. Steinberg, Robert Yarchoan, Elaine S. Jaffe, and Wyndham H. Wilson The role of tumor histogenesis, FDG-PET, and short course EPOCH with dose-dense rituximab (SC-EPOCH-RR) in HIV-associated diffuse large B-cell lymphoma Blood First Edition Paper, prepublished online February 3, 2010; DOI 10.1182/blood-2009-11-253039 [Abstract] [PDF]   2 February 2010 Bijay Nair, Frits van Rhee, John D Shaughnessy Jr, Elias Anaissie, Jackie Szymonifka, Antje Hoering, Yazan Alsayed, Sarah Waheed, John Crowley, and Bart Barlogie Superior results of Total Therapy 3 (2003-33) in gene expression profiling-defined low-risk multiple myeloma confirmed in subsequent trial 2006-66 with bortezomib, lenalidomide and dexamethasone (VRD) maintenance Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-11-255620 [Abstract] [PDF]   Jonathan R Lambert, Jamshed B Bomanji, Karl S Peggs, Kirsty J Thomson, Ronjon K Chakraverty, Adele K Fielding, Panagiotis D Kottaridis, Michael Roughton, Emma C Morris, Anthony H Goldstone, David C Linch, Peter J Ell, and Stephen Mackinnon Prognostic role of PET scanning before and after reduced intensity allogeneic stem cell transplant for lymphoma Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-11-255182 [Abstract] [PDF]   Leo Luznik, Javier Bolaños-Meade, Marianna Zahurak, Allen R. Chen, B. Douglas Smith, Robert Brodsky, Carol Ann Huff, Ivan Borrello, William Matsui, Jonathan D. Powell, Yvette Kasamon, Steven N. Goodman, Allan Hess, Hyam I. Levitsky, Richard F. Ambinder, Richard J. Jones, and Ephraim J. Fuchs High-dose cyclophosphamide as single agent, short-course prophylaxis of graft-versus-host disease Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-11-251595 [Abstract] [PDF]   Jingying Xu, Melissa Millard, Xiuhai Ren, Orla T. Cox, and Anat Erdreich-Epstein c-Abl mediates endothelial apoptosis induced by inhibition of integrins vβ3 and vβ5 and by disruption of actin Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-05-223776 [Abstract] [PDF] [Supplemental Methods and Figures]   Angus M. Sinclair, Angela Coxon, Ian McCaffery, Stephen Kaufman, Katherine Paweletz, Liqin Liu, Leigh Busse, Susan Swift, Steven Elliott, and C. Glenn Begley Functional erythropoietin receptor is undetectable in endothelial, cardiac, neuronal, and renal cells Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-10-248666 [Abstract] [PDF]   Susan Swift, Aaron R. Ellison, Paul Kassner, Ian McCaffery, John Rossi, Angus M. Sinclair, C. Glenn Begley, and Steven Elliott Absence of functional EpoR expression in human tumor cell lines Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-10-248674 [Abstract] [PDF]   Voahangy Randrianarison-Huetz, Benoit Laurent, Valérie Bardet, Gerard C. Blobe, François Huetz, and Dominique Duménil Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGFβ signaling at the bipotent erythro-megakaryocytic progenitor stage Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-09-241752 [Abstract] [PDF]   Ivana De Domenico, Eric Lo, Diane M. Ward, and Jerry Kaplan Human mutation D157G in ferroportin leads to hepcidin-independent binding of Jak2 and ferroportin downregulation Blood First Edition Paper, prepublished online February 2, 2010; DOI 10.1182/blood-2009-10-251306 [Abstract] [PDF]   1 February 2010 Jeffrey M. Venstrom, Ted A. Gooley, Stephen Spellman, James Pring, Mari Malkki, Bo Dupont, Effie Petersdorf, and Katharine C. Hsu Donor activating KIR3DS1 is associated with decreased acute GvHD in unrelated allogeneic hematopoietic stem cell transplantation Blood First Edition Paper, prepublished online February 1, 2010; DOI 10.1182/blood-2009-08-236943 [Abstract] [PDF]   Itzel Bustos Villalobos, Yoshiyuki Takahashi, Yoshiki Akatsuka, Hideki Muramatsu, Nobuhiro Nishio, Asahito Hama, Hiroshi Yagasaki, Hiroh Saji, Motohiro Kato, Seishi Ogawa, and Seiji Kojima Relapse of leukemia with loss of mismatched HLA due to uniparental disomy following haploidentical hematopoietic stem cell transplantation Blood First Edition Paper, prepublished online February 1, 2010; DOI 10.1182/blood-2009-11-254284 [Abstract] [PDF]   Linda C. Stork, Yousif Matloub, Emmett Broxson, Mei La, Rochelle Yanofsky, Harland Sather, Ray Hutchison, Nyla A. Heerema, April D. Sorrell, Margaret Masterson, Archie Bleyer, and Paul S. Gaynon Oral 6-mercaptopurine vs. Oral 6-thioguanine and veno-occlusive disease in children with standard risk acute lymphoblastic leukemia: report of the Children's Oncology Group CCG-1952 clinical trial Blood First Edition Paper, prepublished online February 1, 2010; DOI 10.1182/blood-2009-07-230656 [Abstract] [PDF]   Prabal Banerjee, Adam Tripp, Michael D. Lairmore, Lindsey Crawford, Michelle Sieburg, JC Ramos, William Harrington Jr, Mark A. Beilke, and Gerold Feuer Adult T cell leukemia/lymphoma development in HTLV-1-infected humanized SCID mice Blood First Edition Paper, prepublished online February 1, 2010; DOI 10.1182/blood-2009-10-246959 [Abstract] [PDF]   Alejandro Gutierrez, Takaomi Sanda, Wenxue Ma, Jianhua Zhang, Ruta Grebliunaite, Suzanne Dahlberg, Donna Neuberg, Alexei Protopopov, Stuart S. Winter, Richard S. Larson, Michael J. Borowitz, Lewis B. Silverman, Lynda Chin, Stephen P. Hunger, Catriona Jamieson, Stephen E. Sallan, and A. Thomas Look Inactivation of LEF1 in T-cell acute lymphoblastic leukemia Blood First Edition Paper, prepublished online February 1, 2010; DOI 10.1182/blood-2009-07-234377 [Abstract] [PDF]   29 January 2010 Paquita Nurden, Giuliana Gobbi, Alan Nurden, Jocelyne Enouf, Ibtissam Youlyouz-Marfak, Cecilia Carubbi, Silvia La Marca, Margherita Punzo, Luciano Baronciani, Luigi De Marco, Marco Vitale, and Augusto B. Federici Abnormal VWF modifies megakaryocytopoiesis: studies of platelets and megakaryocyte cultures from von Willebrand disease type 2B patients Blood First Edition Paper, prepublished online January 29, 2010; DOI 10.1182/blood-2009-07-231886 [Abstract] [PDF]   Zhi-Chun Ding, Bruce R. Blazar, Andrew L. Mellor, David H. Munn, and Gang Zhou Chemotherapy rescues tumor-driven aberrant CD4+ T-cell differentiation and restores an activated polyfunctional helper phenotype Blood First Edition Paper, prepublished online January 29, 2010; DOI 10.1182/blood-2009-11-253336 [Abstract] [PDF]   28 January 2010 Aldo M. Roccaro, Antontio Sacco, Monette Aujay, Hai T. Ngo, Abdel Kareem Azab, Feda Azab, Phong Quang, Patricia Maiso, Judith Runnels, Kenneth C. Anderson, Susan Demo, and Irene M. Ghobrial Selective inhibition of chymotrypsin-like activity of the immunoproteasome and constitutive proteasome in Waldenstrom macroglobulinemia Blood First Edition Paper, prepublished online January 28, 2010; DOI 10.1182/blood-2009-09-243402 [Abstract] [PDF] [Supplemental Figure]   Makiko Ohki, Yuichi Ohki, Makoto Ishihara, Chiemi Nishida, Yoshihiko Tashiro, Haruyo Akiyama, Hiromitsu Komiyama, Leif R. Lund, Atsumi Nitta, Kiyofumi Yamada, Zhenping Zhu, Hideoki Ogawa, Hideo Yagita, Ko Okumura, Hiromitsu Nakauchi, Zena Werb, Beate Heissig, and Koichi Hattori Tissue type plasminogen activator regulates myeloid-cell dependent neoangiogenesis during tissue regeneration Blood First Edition Paper, prepublished online January 28, 2010; DOI 10.1182/blood-2009-08-236851 [Abstract] [PDF] [Supplemental Tables and Figure]   Charles C. Chu, Rosa Catera, Lu Zhang, Sebastien Didier, Briana M. Agagnina, Rajendra N. Damle, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, and Nicholas Chiorazzi Many chronic lymphocytic leukemia antibodies recognize apoptotic cells with exposed non-muscle myosin heavy chain IIA: implications for patient outcome and cell of origin Blood First Edition Paper, prepublished online January 28, 2010; DOI 10.1182/blood-2009-09-244251 [Abstract] [PDF] [Supplemental Figure]   Kenneth P. Micklethwaite, Barbara Savoldo, Patrick J. Hanley, Ann M. Leen, Gail J. Demmler-Harrison, Laurence J.N. Cooper, Hao Liu, Adrian P. Gee, Elizabeth J. Shpall, Cliona M. Rooney, Helen E. Heslop, Malcolm K. Brenner, Catherine M. Bollard, and Gianpietro Dotti Derivation of human T-lymphocytes from cord blood and peripheral blood with antiviral and antileukemic specificity from a single culture as protection against infection and relapse after stem cell transplantation Blood First Edition Paper, prepublished online January 28, 2010; DOI 10.1182/blood-2009-09-242263 [Abstract] [PDF]   Jonas Emsley, Paul A. McEwan, and David Gailani Structure and function of factor XI Blood First Edition Paper, prepublished online January 28, 2010; DOI 10.1182/blood-2009-09-199182 [Abstract] [PDF]   Pavel Uhrin, Jan Zaujec, Joannes M. Breuss, Damla Olcaydu, Peter Chrenek, Hannes Stockinger, Elke Fuertbauer, Markus Moser, Paula Haiko, Reinhard Fässler, Kari Alitalo, Bernd R. Binder, and Dontscho Kerjaschki Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation Blood First Edition Paper, prepublished online January 28, 2010; DOI 10.1182/blood-2009-04-216069 [Abstract] [PDF]   Junhui Song, Mark J. Kiel, Zhuo Wang, Jingcheng Wang, Russell S. Taichman, Sean J. Morrison, and Paul H. Krebsbach An in vivo model to study and manipulate the hematopoietic stem cell niche Blood First Edition Paper, prepublished online January 28, 2010; DOI 10.1182/blood-2009-01-200071 [Abstract] [PDF]   27 January 2010 Julia A. Brown, Kristen Stevenson, Haesook T. Kim, Corey Cutler, Karen Ballen, Sean McDonough, Carol Reynolds, Maria Herrera, Deborah Liney, Vincent Ho, Grace Kao, Philippe Armand, John Koreth, Edwin Alyea, Steve McAfee, Eyal Attar, Bimalangshu Dey, Thomas Spitzer, Robert Soiffer, Jerome Ritz, Joseph H. Antin, and Vassiliki A. Boussiotis Clearance of CMV viremia and survival after double umbilical cord blood transplantation in adults depends on reconstitution of thymopoiesis Blood First Edition Paper, prepublished online January 27, 2010; DOI 10.1182/blood-2009-09-244145 [Abstract] [PDF]   Christine O'Keefe, Michael A. McDevitt, and Jaroslaw P. Maciejewski Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies Blood First Edition Paper, prepublished online January 27, 2010; DOI 10.1182/blood-2009-10-201848 [Abstract] [PDF]   Akil Merchant, Giselle Joseph, Qiuju Wang, Sarah Brennan, and William Matsui Gli1 regulates the proliferation and differentiation of HSC and myeloid progenitors Blood First Edition Paper, prepublished online January 27, 2010; DOI 10.1182/blood-2009-09-241703 [Abstract] [PDF]   Julien Y. Bertrand, Jennifer L. Cisson, David L. Stachura, and David Traver Notch signaling distinguishes two waves of definitive hematopoiesis in the zebrafish embryo Blood First Edition Paper, prepublished online January 27, 2010; DOI 10.1182/blood-2009-09-244590 [Abstract] [PDF]   Christian Schulz, Nina V. Leuschen, Thomas Fröhlich, Michael Lorenz, Susanne Pfeiler, Christian A. Gleissner, Elisabeth Kremmer, Mirjam Kessler, Alexander G. Khandoga, Bernd Engelmann, Klaus Ley, Steffen Massberg, and Georg J. Arnold Identification of novel downstream targets of platelet glycoprotein VI activation by differential proteome analysis: implications for thrombus formation Blood First Edition Paper, prepublished online January 27, 2010; DOI 10.1182/blood-2009-07-230268 [Abstract] [PDF]   26 January 2010 Zakary L. Whichard, Casim A. Sarkar, Marek Kimmel, and Seth J. Corey Hematopoiesis and its disorders: a systems biology approach Blood First Edition Paper, prepublished online January 26, 2010; DOI 10.1182/blood-2009-08-215798 [Abstract] [PDF]   Andreas Moosmann, Iris Bigalke, Johanna Tischer, Leah Schirrmann, Julitta Kasten, Stefanie Tippmer, Marina Leeping, Dusan Prevalsek, Gundula Jaeger, Georg Ledderose, Josef Mautner, Wolfgang Hammerschmidt, Dolores J. Schendel, and Hans-Jochem Kolb Effective and long-term control of EBV PTLD after transfer of peptide-selected T cells Blood First Edition Paper, prepublished online January 26, 2010; DOI 10.1182/blood-2009-08-236356 [Abstract] [PDF]   Natascha Hermann-Kleiter and Gottfried Baier NFAT pulls the strings during CD4+ T helper cell effector functions Blood First Edition Paper, prepublished online January 26, 2010; DOI 10.1182/blood-2009-10-233585 [Abstract] [PDF]   B. Löwenberg, J. Beck, C. Graux, W. van Putten, H. C. Schouten, L. F. Verdonck, A. Ferrant, P. Sonneveld, M. Jongen-Lavrencic, M. von Lilienfeld-Toal, B. J. Biemond, E. Vellenga, D. Breems, H. de Muijnck, M. R. Schaafsma, G. Verhoef, H. Döhner, A. Gratwohl, Th Pabst, G. J. Ossenkoppele, and J. Maertens Gemtuzumab ozogamicin as postremission treatment in AML at 60 years of age or more: results of a multicenter phase III study Blood First Edition Paper, prepublished online January 26, 2010; DOI 10.1182/blood-2009-10-246470 [Abstract] [PDF]   25 January 2010 Rhona Stein, Pankaj Gupta, Xiaochuan Chen, Thomas M. Cardillo, Richard R. Furman, Susan Chen, Chien-Hsing Chang, and David M. Goldenberg Therapy of B-cell malignancies by anti-HLA-DR humanized monoclonal antibody, IMMU-114, is mediated through hyper-activation of ERK and JNK MAP kinase signaling pathways Blood First Edition Paper, prepublished online January 25, 2010; DOI 10.1182/blood-2009-06-228288 [Abstract] [PDF] [Supplemental Figures]   S. Merluzzi, B. Frossi, G. Gri, S. Parusso, C. Tripodo, and C. Pucillo Mast cells enhance proliferation of B lymphocytes and drive their differentiation towards IgA-secreting plasma cells Blood First Edition Paper, prepublished online January 25, 2010; DOI 10.1182/blood-2009-10-250126 [Abstract] [PDF] [Supplemental Figures]   Telma Lança, Daniel V. Correia, Catarina F. Moita, Helena Raquel, Ana Neves-Costa, Cristina Ferreira, José S. Ramalho, João T. Barata, Luis F. Moita, Anita Q. Gomes, and Bruno Silva-Santos The MHC class Ib protein ULBP1 is a non-redundant determinant of leukemia/ lymphoma susceptibility to T-cell cytotoxicity Blood First Edition Paper, prepublished online January 25, 2010; DOI 10.1182/blood-2009-08-237123 [Abstract] [PDF]   Tracy J Lightfoot, W Thomas Johnston, Dan Painter, Jill Simpson, Eve Roman, Chris F Skibola, Martyn T Smith, James M Allan, and G Malcolm Taylor Genetic variation in the folate metabolic pathway and risk of childhood leukemia Blood First Edition Paper, prepublished online January 25, 2010; DOI 10.1182/blood-2009-10-249722 [Abstract] [PDF]   Yuh-Ching Twu, Chuang-Yi Hsieh, Marie Lin, Cheng-Hwai Tzeng, Chien-Feng Sun, and Lung-Chih Yu Phosphorylation status of transcription factor C/EBP determines cell surface poly-LacNAc branching (I antigen) formation in erythropoiesis and granulopoiesis Blood First Edition Paper, prepublished online January 25, 2010; DOI 10.1182/blood-2009-07-231993 [Abstract] [PDF]   Jonathan J. Ipsaro and Alfonso Mondragón Structural basis for spectrin recognition by ankyrin Blood First Edition Paper, prepublished online January 25, 2010; DOI 10.1182/blood-2009-11-255604 [Abstract] [PDF]   22 January 2010 Jeng-Jung Yeh, Sharon Tsai, Deng-Chyang Wu, Jeng-Yih Wu, Ta-Chih Liu, and Angela Chen P-selectin dependent platelet aggregation and apoptosis may explain the decrease in platelet count during H. pylori infection Blood First Edition Paper, prepublished online January 22, 2010; DOI 10.1182/blood-2009-09-241166 [Abstract] [PDF]   Wen-Chien Chou, Hsin-An Hou, Chien-Yuan Chen, Jih-Luh Tang, Ming Yao, Woei Tsay, Bor-Sheng Ko, Shang-Ju Wu, Shang-Yi Huang, Szu Chun Hsu, Yao-Chang Chen, Yen-Ning Huang, Yi-Chang Chang, Fen-Yu Lee, Ming-Chi Liu, Chia-Wen Liu, Mei-Hsuan Tseng, Chi-Fei Huang, and Hwei-Fang Tien Distinct clinical and biological characteristics in adult acute myeloid leukemia bearing isocitrate dehydrogenase 1 (IDH1) mutation Blood First Edition Paper, prepublished online January 22, 2010; DOI 10.1182/blood-2009-11-253070 [Abstract] [PDF]   Anurag Purushothaman, Toru Uyama, Fumi Kobayashi, Shuhei Yamada, Kazuyuki Sugahara, Alan C. Rapraeger, and Ralph D. Sanderson Heparanase enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis Blood First Edition Paper, prepublished online January 22, 2010; DOI 10.1182/blood-2009-07-234757 [Abstract] [PDF]   Andreas T. Björklund, Marie Schaffer, Cyril Fauriat, Olle Ringdén, Mats Remberger, Christina Hammarstedt, A. John Barrett, Per Ljungman, Hans-Gustaf Ljunggren, and Karl-Johan Malmberg NK cells expressing inhibitory KIR for non-self ligands remain tolerant in HLA-matched sibling stem cell transplantation Blood First Edition Paper, prepublished online January 22, 2010; DOI 10.1182/blood-2009-07-229740 [Abstract] [PDF]   21 January 2010 Ankush Vaid, Ravikant Ranjan, Wynand A. Smythe, Heinrich C. Hoppe, and Pushkar Sharma PfPI3K, a Phosphatidylinositol-3 kinase from Plasmodium falciparum, is exported to the host erythrocyte and is involved in hemoglobin trafficking Blood First Edition Paper, prepublished online January 21, 2010; DOI 10.1182/blood-2009-08-238972 [Abstract] [PDF]   Alice Gerrits, Brad Dykstra, Olga J. Kalmykowa, Karin Klauke, Evgenia Verovskaya, Mathilde J.C. Broekhuis, Gerald de Haan, and Leonid V. Bystrykh Cellular barcoding tool for clonal analysis in the hematopoietic system Blood First Edition Paper, prepublished online January 21, 2010; DOI 10.1182/blood-2009-06-229757 [Abstract] [PDF]   Xiao-Tong Hu, Yun-Wen Chen, Anthony C.T. Liang, Wing-Yan Au, Kai-Yau Wong, Thomas S.K. Wan, Michelle L.Y. Wong, Lijun Shen, Ka-Kui Chan, Tianhuan Guo, Kent-Man Chu, Qian Tao, Chor-Sang Chim, Florence Loong, William W.L. Choi, Liwei Lu, Chi-Chiu So, Li Chong Chan, Yok-Lam Kwong, Raymond H.S. Liang, and Gopesh Srivastava CD44 activation in mature B-cell malignancies by a novel recurrent IGH translocation Blood First Edition Paper, prepublished online January 21, 2010; DOI 10.1182/blood-2009-09-238782 [Abstract] [PDF]   Marcia Bellon, Hicham H. Baydoun, Yuan Yao, and Christophe Nicot HTLV-I Tax-dependent and independent events associated with immortalization of human primary T-lymphocytes Blood First Edition Paper, prepublished online January 21, 2010; DOI 10.1182/blood-2009-08-241117 [Abstract] [PDF]   Hannah M. Kerns, Byoung Y. Ryu, Brigid V. Stirling, Blythe D. Sather, Alexander Astrakhan, Stephanie Humblet-Baron, Denny Liggitt, and David J. Rawlings B-cell-specific lentiviral gene therapy leads to sustained B cell functional recovery in a murine model of X-linked agammaglobulinemia Blood First Edition Paper, prepublished online January 21, 2010; DOI 10.1182/blood-2009-09-241869 [Abstract] [PDF]   20 January 2010 Haytham Khoury, Fernando Suarez-Saiz, Samantha Wu, and Mark D. Minden An upstream insulator regulates DLK1 imprinting in AML Blood First Edition Paper, prepublished online January 20, 2010; DOI 10.1182/blood-2009-03-212746 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures] [Additional Supplemental Figures]   F. Lennie Wong, Liton Francisco, Kayo Togawa, Alysia Bosworth, Mitzi Gonzales, Cara Hanby, Melanie Sabado, Marcia Grant, Stephen J. Forman, and Smita Bhatia Long-term recovery after hematopoietic cell transplantation: predictors of quality of life concerns Blood First Edition Paper, prepublished online January 20, 2010; DOI 10.1182/blood-2009-06-225631 [Abstract] [PDF]   Stephen Spellman, Robert Bray, Sandra Rosen-Bronson, Michael Haagenson, John Klein, Susan Flesch, Cynthia Vierra-Green, and Claudio Anasetti The detection of donor-directed, HLA-specific alloantibodies in recipients of unrelated hematopoietic cell transplantation is predictive of graft failure Blood First Edition Paper, prepublished online January 20, 2010; DOI 10.1182/blood-2009-09-244525 [Abstract] [PDF]   Asmin Tulpule, M. William Lensch, Justine D. Miller, Karyn Austin, Alan D'Andrea, Thorsten M. Schlaeger, Akiko Shimamura, and George Q. Daley Knockdown of Fanconi anemia genes in human embryonic stem cells reveals early developmental defects in the hematopoietic lineage Blood First Edition Paper, prepublished online January 20, 2010; DOI 10.1182/blood-2009-10-246694 [Abstract] [PDF]   Daniela Asslaber, Josefina D Piñón, Irina Seyfried, Petra Desch, Markus Stöcher, Inge Tinhofer, Alexander Egle, Olaf Merkel, and Richard Greil MicroRNA-34a expression correlates with MDM2 SNP309 polymorphism and treatment-free survival in chronic lymphocytic leukemia Blood First Edition Paper, prepublished online January 20, 2010; DOI 10.1182/blood-2009-07-234823 [Abstract] [PDF]   Carole Henry, Marina Deschamps, Pierre-Simon Rohrlich, Jean-René Pallandre, Jean-Paul Rémy-Martin, Mary Callanan, Alexandra Traverse-Glehen, Camille GrandClément, Francine Garnache-Ottou, Remy Gressin, Eric Deconinck, Gilles Salles, Eric Robinet, Pierre Tiberghien, Christophe Borg, and Christophe Ferrand Identification of an alternative CD20 transcript variant in B cell malignancies coding for a novel protein associated to rituximab resistance Blood First Edition Paper, prepublished online January 20, 2010; DOI 10.1182/blood-2009-06-229112 [Abstract] [PDF]   Morie A. Gertz, Shaji Kumar, Martha Q. Lacy, Angela Dispenzieri, David Dingli, Suzanne R. Hayman, Francis K. Buadi, and William J. Hogan Stem cell transplant in multiple myeloma: impact of response failure with thalidomide or lenalidomide induction Blood First Edition Paper, prepublished online January 20, 2010; DOI 10.1182/blood-2009-07-235531 [Abstract] [PDF]   19 January 2010 Jian-Jun Zhao, Jianhong Lin, Tint Lwin, Hua Yang, Jianping Guo, William Kong, Sophie Dessureault, Lynn C. Moscinski, Dorna Rezania, William S. Dalton, Eduardo Sotomayor, Jianguo Tao, and Jin Q. Cheng microRNA expression profile and identification of miR-29 as a prognostic marker and pathogenetic factor by targeting CDK6 in mantle cell lymphoma Blood First Edition Paper, prepublished online January 19, 2010; DOI 10.1182/blood-2009-09-243147 [Abstract] [PDF]   Alexander Zaslavsky, Kwan-Hyuck Baek, Ryan C. Lynch, Sarah Short, Jenny Grillo, Judah Folkman, Joseph E. Italiano Jr., and Sandra Ryeom Platelet-derived thrombospondin-1 (TSP-1) is a critical negative regulator and potential biomarker of angiogenesis Blood First Edition Paper, prepublished online January 19, 2010; DOI 10.1182/blood-2009-09-242065 [Abstract] [PDF]   Paul A Cordell, Benjamin T Kile, Kristina F Standeven, Emma C Josefsson, Richard J Pease, and Peter J Grant Association of coagulation factor XIII-A with Golgi proteins within monocyte-macrophages: implications for subcellular trafficking and secretion Blood First Edition Paper, prepublished online January 19, 2010; DOI 10.1182/blood-2009-08-231316 [Abstract] [PDF] [Supplemental Methods and Figures]   Anjali Verma, Resham Bhattacharya, Indu Remadevi, Keguo Li, Kallal Pramanik, Ganesh V. Samant, Mark Horswill, Chang Z. Chun, Baofeng Zhao, Enfeng Wang, Robert Qing Miao, Debabrata Mukhopadhyay, Ramani Ramchandran, and George A. Wilkinson Endothelial cell-specific chemotaxis receptor (ecscr) promotes angioblast migration during vasculogenesis and enhances VEGF receptor sensitivity Blood First Edition Paper, prepublished online January 19, 2010; DOI 10.1182/blood-2009-10-248856 [Abstract] [PDF]   Krystalyn E. Hudson, Eugene Lin, Jeanne E. Hendrickson, Aron E. Lukacher, and James C. Zimring Regulation of primary alloantibody response through antecedent exposure to a microbial T cell epitope Blood First Edition Paper, prepublished online January 19, 2010; DOI 10.1182/blood-2009-08-238568 [Abstract] [PDF]   Elke De Bruyne, Tomas J. Bos, Frans Schuit, Els Van Valckenborgh, Eline Menu, Lieven Thorrez, Peter Atadja, Helena Jernberg-Wiklund, and Karin Vanderkerken IGF-1 suppresses Bim expression in multiple myeloma via epigenetic and posttranslational mechanisms Blood First Edition Paper, prepublished online January 19, 2010; DOI 10.1182/blood-2009-07-232801 [Abstract] [PDF]   Hansjörg Schwertz, Sarah Köster, Walter H.A. Kahr, Noemi Michetti, Bjoern F. Kraemer, David A. Weitz, Robert C. Blaylock, Larry W. Kraiss, Andreas Greinacher, Guy A. Zimmerman, and Andrew S. Weyrich Anucleate platelets generate progeny Blood First Edition Paper, prepublished online January 19, 2010; DOI 10.1182/blood-2009-08-239558 [Abstract] [PDF]   15 January 2010 Dalya R. Soond, Elisa Bjorgo, Kristine Moltu, Verity Q Dale, Daniel T Patton, Knut Martin Torgersen, Fiona Galleway, Breda Twomey, Jonathan Clark, JS Hill Gaston, Kjetil Tasken, Peter Bunyard, and Klaus Okkenhaug PI3K p110 regulates T cell cytokine production during primary and secondary immune responses in mice and humans Blood First Edition Paper, prepublished online January 15, 2010; DOI 10.1182/blood-2009-07-232330 [Abstract] [PDF]   Luigi Ferrucci, Richard D. Semba, Jack M. Guralnik, William B. Ershler, Stefania Bandinelli, Kushang V. Patel, Kai Sun, Richard C Woodman, Nancy C Andrews, Robert J Cotter, Tomas Ganz, Elizabeta Nemeth, and Dan L. Longo Proinflammatory state, hepcidin and anemia in older persons Blood First Edition Paper, prepublished online January 15, 2010; DOI 10.1182/blood-2009-02-201087 [Abstract] [PDF]   Cyrus Khandanpour, Christian Thiede, Peter J.M. Valk, Ehssan Sharif-Askari, Holger Nueckel, Dietmar Lohmann, Bernhard Horsthemke, Winfried Siffert, Andreas Neubauer, Karl-Heinz Grzeschik, Clara D. Bloomfield, Guido Marcucci, Kati Maharry, Marilyn L. Slovak, Bert A. van der Reijden, Joop H. Jansen, Hans K. Schackert, Khashyar Afshar, Susanne Schnittger, Justine K. Peeters, Frank Kroschinsky, Gerhard Ehninger, Bob Lowenberg, Ulrich Duehrsen, and Tarik Moroy A variant allele of Growth Factor Independence 1 (GFI1) is associated with acute myeloid leukemia Blood First Edition Paper, prepublished online January 15, 2010; DOI 10.1182/blood-2009-08-239822 [Abstract] [PDF]   14 January 2010 Patrick R. Hagner, Abraham Schneider, and Ronald B. Gartenhaus Targeting the translational machinery as a novel treatment strategy for hematologic malignancies Blood First Edition Paper, prepublished online January 14, 2010; DOI 10.1182/blood-2009-09-220020 [Abstract] [PDF]   Sheng-Yu Jin, Christopher G. Skipwith, and X. Long Zheng Amino acid residues Arg659, Arg660 and Tyr661 in the spacer domain of ADAMTS13 are critical for cleavage of von Willebrand factor Blood First Edition Paper, prepublished online January 14, 2010; DOI 10.1182/blood-2009-07-235101 [Abstract] [PDF]   Olga Ostrovsky, Avichai Shimoni, Avital Rand, Israel Vlodavsky, and Arnon Nagler Genetic variations in the heparanase gene (HPSE) associate with increased risk of GVHD following allogeneic stem cell transplantation: effect of discrepancy between recipients and donors Blood First Edition Paper, prepublished online January 14, 2010; DOI 10.1182/blood-2009-08-236455 [Abstract] [PDF]   Cristiana Lavazza, Carmelo Carlo-Stella, Arianna Giacomini, Loredana Cleris, Marco Righi, Daniela Sia, Massimo Di Nicola, Michele Magni, Paolo Longoni, Marco Milanesi, Maura Francolini, Annunziata Gloghini, Antonino Carbone, Franca Formelli, and Alessandro M. Gianni Human CD34+ cells engineered to express membrane-bound tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) target both tumor cells and tumor vasculature Blood First Edition Paper, prepublished online January 14, 2010; DOI 10.1182/blood-2009-08-239632 [Abstract] [PDF] [Supplemental Figure]   G. Wei Xu, Mohsin Ali, Tabitha E. Wood, Derek Wong, Neil Maclean, Xiaoming Wang, Marcela Gronda, Marko Skrtic, Xiaoming Li, Rose Hurren, Xinliang Mao, Meenakshi Venkatesan, Reza Beheshti Zavareh, Troy Ketela, John C. Reed, David Rose, Jason Moffat, Robert A. Batey, Sirano Dhe-Paganon, and Aaron D. Schimmer The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma Blood First Edition Paper, prepublished online January 14, 2010; DOI 10.1182/blood-2009-07-231191 [Abstract] [PDF] [Supplemental Figures]   Thilo Oelert, Maria Papatriantafyllou, Georg Pougialis, Gunter J. Hammerling, Bernd Arnold, and Thomas Schuler Irradiation and IL-15 promote loss of CD8 T cell tolerance in response to lymphopenia Blood First Edition Paper, prepublished online January 14, 2010; DOI 10.1182/blood-2009-06-227298 [Abstract] [PDF]   13 January 2010 Edus H. Warren, Nobuharu Fujii, Yoshiki Akatsuka, Colette N. Chaney, Jeffrey K. Mito, Keith R. Loeb, Ted A. Gooley, Michele L. Brown, Kevin K.W. Koo, Kellie V. Rosinski, Seishi Ogawa, Aiko Matsubara, Frederick R. Appelbaum, and Stanley R. Riddell Therapy of relapsed leukemia after allogeneic hematopoietic cell transplant with T cells specific for minor histocompatibility antigens Blood First Edition Paper, prepublished online January 13, 2010; DOI 10.1182/blood-2009-10-248997 [Abstract] [PDF] [Supplemental Tables and Figures]   Hidehiko Narazaki, Yuwen Zhu, Liqun Luo, Gefeng Zhu, and Lieping Chen CD137 agonist antibody prevents cancer recurrence: contribution of CD137 on both hematopoietic and non-hematopoietic cells Blood First Edition Paper, prepublished online January 13, 2010; DOI 10.1182/blood-2008-12-192591 [Abstract] [PDF]   Alexey Palamarchuk, Alexey Efanov, Natalya Nazaryan, Urmila Santanam, Hansjuerg Alder, Laura Rassenti, Thomas Kipps, Carlo M. Croce, and Yuri Pekarsky 13q14 deletions in CLL involve cooperating tumor suppressors Blood First Edition Paper, prepublished online January 13, 2010; DOI 10.1182/blood-2009-10-249367 [Abstract] [PDF]   Ivan K. H. Poon, Mark D. Hulett, and Christopher R. Parish Histidine-rich glycoprotein is a novel plasma pattern recognition molecule that recruits IgG to facilitate necrotic cell clearance via FcRI on phagocytes Blood First Edition Paper, prepublished online January 13, 2010; DOI 10.1182/blood-2009-07-234013 [Abstract] [PDF]   Hiroe Tanji, Chie Ishikawa, Shigeki Sawada, Sawako Nakachi, Reika Takamatsu, Takehiro Matsuda, Taeko Okudaira, Jun-Nosuke Uchihara, Kazuiku Ohshiro, Yuetsu Tanaka, Masachika Senba, Hiroshi Uezato, Koichi Ohshima, Madeleine Duc Dodon, Kou-Juey Wu, and Naoki Mori Aberrant expression of the transcription factor Twist in adult T-cell leukemia Blood First Edition Paper, prepublished online January 13, 2010; DOI 10.1182/blood-2009-07-232231 [Abstract] [PDF]   12 January 2010 David H. McDermott, Susan E. Conway, Tao Wang, Stacy M. Ricklefs, Manza A. Agovi, Steve F. Porcella, Huong Thi Bich Tran, Edgar Milford, Stephen Spellman, and Reza Abdi Donor and recipient chemokine receptor CCR5 genotype is associated with survival after bone marrow transplantation Blood First Edition Paper, prepublished online January 12, 2010; DOI 10.1182/blood-2009-08-237768 [Abstract] [PDF]   Xingguo Li, Xin Hu, Bhavita Patel, Zhuo Zhou, Shermi Liang, River Ybarra, Yi Qiu, Gary Felsenfeld, Jorg Bungert, and Suming Huang H4R3 methylation facilitates β-globin transcription by regulating histone acetyltransferase binding and H3 acetylation Blood First Edition Paper, prepublished online January 12, 2010; DOI 10.1182/blood-2009-07-236059 [Abstract] [PDF]   Margaret A. Lindorfer, Andrew W Pawluczkowycz, Elizabeth M. Peek, Kimberly Hickman, Ronald P. Taylor, and Charles J Parker A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement Blood First Edition Paper, prepublished online January 12, 2010; DOI 10.1182/blood-2009-09-244285 [Abstract] [PDF]   Martin Guilliams, Karine Crozat, Sandrine Henri, Samira Tamoutounour, Pierre Grenot, Elisabeth Devilard, Beatrice de Bovis, Lena Alexopoulou, Marc Dalod, and Bernard Malissen Skin-draining lymph nodes contain dermis-derived CD103- dendritic cells that constitutively produce retinoic acid and induce Foxp3+ regulatory T cells Blood First Edition Paper, prepublished online January 12, 2010; DOI 10.1182/blood-2009-09-245274 [Abstract] [PDF]   N B Heaney, F Pellicano, B Zhang, L Crawford, S Chu, S MA Kazmi, E K Allan, H G Jorgensen, A E Irvine, R Bhatia, and T L Holyoake Bortezomib induces apoptosis in primitive chronic myeloid leukemia cells including LTC-IC and NOD/SCID repopulating cells Blood First Edition Paper, prepublished online January 12, 2010; DOI 10.1182/blood-2008-06-164582 [Abstract] [PDF]   Alix E. Seif, Catherine S. Manno, Cecilia Sheen, Stephan A. Grupp, and David T. Teachey Identifying autoimmune lymphoproliferative syndrome (ALPS) in children with Evans syndrome: a multi-institutional study Blood First Edition Paper, prepublished online January 12, 2010; DOI 10.1182/blood-2009-08-239525 [Abstract] [PDF]   Nils H. Thoennissen, Utz O. Krug, Dhong Hyun Tony Lee, Norihiko Kawamata, Gabriela B. Iwanski, Terra Lasho, Tamara Weiss, Daniel Nowak, Maya Koren-Michowitz, Motohiro Kato, Masashi Sanada, Lee-Yung Shih, Arnon Nagler, Sophie D. Raynaud, Carsten Muller-Tidow, Ruben Mesa, Torsten Haferlach, D. Gary Gilliland, Ayalew Tefferi, Seishi Ogawa, and H. Phillip Koeffler Prevalence and prognostic impact of allelic imbalances associated with leukemic transformation of Philadelphia chromosome-negative myeloproliferative neoplasms Blood First Edition Paper, prepublished online January 12, 2010; DOI 10.1182/blood-2009-07-235119 [Abstract] [PDF]   11 January 2010 Gregory D. Gregory, Annarita Miccio, Alexey Bersenev, Yuhuan Wang, Wei Hong, Zhe Zhang, Mortimer Poncz, Wei Tong, and Gerd A. Blobel FOG1 requires NuRD to promote hematopoiesis and maintain lineage fidelity within the megakaryocytic-erythroid compartment Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-10-251280 [Abstract] [PDF]   D-H. Lee, L-J Zhou, Z. Zhou, J-X. Xie, J-U. Jung, Y. Liu, C-X. Xi, L. Mei, and W-C. Xiong Neogenin inhibits HJV secretion and regulates BMP induced hepcidin expression and iron homeostasis Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-11-251199 [Abstract] [PDF]   Jianghong Wang, Anthony A. Fernald, John Anastasi, Michelle M. Le Beau, and Zhijian Qian Haploinsufficiency of Apc leads to ineffective hematopoiesis Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-11-251835 [Abstract] [PDF]   Sandip Bhattacharyya, Christine K. Ratajczak, Sherri K. Vogt, Crystal Kelley, Marco Colonna, Robert D. Schreiber, and Louis J. Muglia TAK1 targeting by glucocorticoids determines JNK and IB regulation in Toll-like receptor-stimulated macrophages Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-06-224782 [Abstract] [PDF]   Andrea Kuehnl, Nicola Goekbuget, Andrea Stroux, Thomas Burmeister, Martin Neumann, Sandra Heesch, Torsten Haferlach, Dieter Hoelzer, Wolf-Karsten Hofmann, Eckhard Thiel, and Claudia D. Baldus High BAALC expression predicts chemoresistance in adult B-precursor acute lymphoblastic leukemia Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-09-241943 [Abstract] [PDF]   Deepa Rajagopal, Carine Paturel, Yannis Morel, Satoshi Uematsu, Shizuo Akira, and Sandra S. Diebold Plasmacytoid dendritic cell-derived type I interferon is crucial for the adjuvant activity of Toll-like receptor 7 agonists Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-08-238543 [Abstract] [PDF]   Agamemnon E. Grigoriadis, Marion Kennedy, Aline Bozec, Fiona Brunton, Gudrun Stenbeck, In-Hyun Park, Erwin F. Wagner, and Gordon M. Keller Directed differentiation of hematopoietic precursors and functional osteoclasts from human ES and iPS cells Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-07-234690 [Abstract] [PDF]   Valerie Martin, Julie Guillermet-Guibert, Gaetan Chicanne, Cendrine Cabou, Martine Jandrot-Perrus, Monique Plantavid, Bart Vanhaesebroeck, Bernard Payrastre, and Marie-Pierre Gratacap Deletion of the p110β isoform of phosphoinositide 3-kinase in platelets reveals its central role in Akt activation and thrombus formation in vitro and in vivo Blood First Edition Paper, prepublished online January 11, 2010; DOI 10.1182/blood-2009-04-217224 [Abstract] [PDF]   8 January 2010 Caroline M. Bateman, Susan M. Colman, Tracy Chaplin, Bryan D. Young, Tim O. Eden, Manoo Bhakta, Eric J. Gratias, Elisabeth R. van Wering, Gianni Cazzaniga, Christine J. Harrison, Richard Hain, Philip Ancliff, Anthony M. Ford, Lyndal Kearney, and Mel Greaves Acquisition of genome-wide copy number alterations in monozygotic twins with acute lymphoblastic leukaemia Blood First Edition Paper, prepublished online January 8, 2010; DOI 10.1182/blood-2009-10-251413 [Abstract] [PDF]   Shigeki Sawada, Chie Ishikawa, Hiroe Tanji, Sawako Nakachi, Masachika Senba, Taeko Okudaira, Jun-Nosuke Uchihara, Naoya Taira, Kazuiku Ohshiro, Yasuaki Yamada, Yuetsu Tanaka, Hiroshi Uezato, Koichi Ohshima, Ken Sasai, Boudewijn M. T. Burgering, Madeleine Duc Dodon, Masahiro Fujii, Hajime Sunakawa, and Naoki Mori Overexpression of caveolin-1 in adult T-cell leukemia Blood First Edition Paper, prepublished online January 8, 2010; DOI 10.1182/blood-2009-08-240044 [Abstract] [PDF]   A. Mario Marcondes, Xiang Li, Ted Gooley, Brian Milless, and H. Joachim Deeg Identification of DJ-1/Park-7 as a determinant of stroma-dependent and TNF-induced apoptosis in MDS by using mass spectrometry and phosphopetide analysis Blood First Edition Paper, prepublished online January 8, 2010; DOI 10.1182/blood-2009-08-236992 [Abstract] [PDF]   Franz X. Schaub, Renate Looser, Sai Li, Hui Hao-Shen, Thomas Lehmann, Andre Tichelli, and Radek C. Skoda Clonal analysis of TET2 and JAK2 mutations suggests that TET2 can be a late event in the progression of myeloproliferative neoplasms Blood First Edition Paper, prepublished online January 8, 2010; DOI 10.1182/blood-2009-09-245381 [Abstract] [PDF]   Shao-Qing Kuang, Hao Bai, Zhi-Hong Fang, Gonzalo Lopez, Hui Yang, Wei-Gang Tong, Zack Z. Wang, and Guillermo Garcia-Manero Aberrant DNA methylation and epigenetic inactivation of Eph receptor tyrosine kinases and ephrin ligands in acute lymphoblastic leukemia Blood First Edition Paper, prepublished online January 8, 2010; DOI 10.1182/blood-2009-05-222208 [Abstract] [PDF]   Nagaja Capitani, Orso Maria Lucherini, Elisa Sozzi, Micol Ferro, Nico Giommoni, Francesca Finetti, Giulia De Falco, Emanuele Cencini, Donatella Raspadori, Pier Giuseppe Pelicci, Francesco Lauria, Francesco Forconi, and Cosima T. Baldari Impaired expression of p66Shc, a novel regulator of B-cell survival, in chronic lymphocytic leukemia Blood First Edition Paper, prepublished online January 8, 2010; DOI 10.1182/blood-2009-08-239244 [Abstract] [PDF]   7 January 2010 Alexandra C.H. Smith, Aubrey R. Raimondi, Chris D. Salthouse, Myron S. Ignatius, Jessica S. Blackburn, Igor V. Mizgirev, Narie Y. Storer, Jill L.O. de Jong, Aye T. Chen, Yi Zhou, Sergei Revskoy, Leonard I. Zon, and David M. Langenau High-throughput cell transplantation establishes that tumor-initiating cells are abundant in zebrafish T-cell acute lymphoblastic leukemia Blood First Edition Paper, prepublished online January 7, 2010; DOI 10.1182/blood-2009-10-246488 [Abstract] [PDF]   Robert T. Peters, Susan C. Low, George D. Kamphaus, Jennifer A. Dumont, John V. Amari, Qi Lu, Greg Zarbis-Papastoitsis, Thomas J. Reidy, Elizabeth P. Merricks, Timothy C. Nichols, and Alan J. Bitonti Prolonged activity of factor IX as a monomeric Fc fusion protein Blood First Edition Paper, prepublished online January 7, 2010; DOI 10.1182/blood-2009-08-239665 [Abstract] [PDF]   Karsten Grote, Harald Schuett, Gustavo Salguero, Christina Grothusen, Joanna Jagielska, Helmut Drexler, Peter F Muhlradt, and Bernhard Schieffer Toll-like receptor 2/6 stimulation promotes angiogenesis via GM-CSF as a potential strategy for immune defense and tissue regeneration Blood First Edition Paper, prepublished online January 7, 2010; DOI 10.1182/blood-2009-05-224402 [Abstract] [PDF]   Raymond F. Robledo, Amy J. Lambert, Connie S. Birkenmeier, Marius V. Cirlan, Andreea Flavia M. Cirlan, Dean R. Campagna, Samuel E. Lux, and Luanne L. Peters Analysis of novel sph (spherocytosis) alleles in mice reveals allele-specific loss of band 3 and adducin in -spectrin deficient red cells Blood First Edition Paper, prepublished online January 7, 2010; DOI 10.1182/blood-2009-07-232199 [Abstract] [PDF]   Jessica A. Pollard, Todd A. Alonzo, Robert B. Gerbing, Phoenix A. Ho, Rong Zeng, Yaddanapudi Ravindranath, Gary Dahl, Norman J. Lacayo, David Becton, Myron Chang, Howard J. Weinstein, Betsy Hirsch, Susana C. Raimondi, Nyla A. Heerema, William G. Woods, Beverly J. Lange, Craig Hurwitz, Robert J. Arceci, Jerald P. Radich, Irwin D. Bernstein, Michael C. Heinrich, and Soheil Meshinchi Prevalence and prognostic significance of KIT mutations in pediatric core binding factor AML patients enrolled on serial pediatric cooperative trials for de novo AML Blood First Edition Paper, prepublished online January 7, 2010; DOI 10.1182/blood-2009-09-241075 [Abstract] [PDF]   Darren S. Sigal, Robert Sharpe, Carol Burian, and Alan Saven Very long-term eradication of minimal residual disease in patients with hairy cell leukemia following a single course of cladribine Blood First Edition Paper, prepublished online January 7, 2010; DOI 10.1182/blood-2009-10-251645 [Abstract] [PDF]   6 January 2010 Mirle Schemionek, Christian Elling, Ulrich Steidl, Nicole Baumer, Ashley Hamilton, Tilmann Spieker, Joachim R. Gothert, Martin Stehling, Amy Wagers, Claudia S. Huettner, Daniel G. Tenen, Lara Tickenbrock, Wolfgang E. Berdel, Hubert Serve, Tessa L. Holyoake, Carsten Muller-Tidow, and Steffen Koschmieder BCR-ABL enhances differentiation of long-term repopulating hematopoietic stem cells Blood First Edition Paper, prepublished online January 6, 2010; DOI 10.1182/blood-2009-04-215376 [Abstract] [PDF]   Persis P. Wadia, Marc Coram, Randall J. Armstrong, Michael Mindrinos, Atul J. Butte, and David B. Miklos Antibodies specifically target AML antigen NuSAP1 after allogeneic bone marrow transplantation Blood First Edition Paper, prepublished online January 6, 2010; DOI 10.1182/blood-2009-03-211375 [Abstract] [PDF]   Barbra J. Sasu, Keegan S. Cooke, Tara L. Arvedson, Cherylene Plewa, Aaron R. Ellison, Jackie Sheng, Aaron Winters, Todd Juan, Hongyan Li, C. Glenn Begley, and Graham Molineux Anti-hepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia Blood First Edition Paper, prepublished online January 6, 2010; DOI 10.1182/blood-2009-09-245977 [Abstract] [PDF]   Yulia N. Demchenko, Oleg K. Glebov, Adriana Zingone, Jonathan J. Keats, P. Leif Bergsagel, and W. Michael Kuehl Classical and/or alternative NFB pathway activation in multiple myeloma Blood First Edition Paper, prepublished online January 6, 2010; DOI 10.1182/blood-2009-09-243535 [Abstract] [PDF]   Venkatesh Kundumani-Sridharan, Jixiao Niu, Dong Wang, Dong Van Quyen, Qiuhua Zhang, Nikhlesh K. Singh, Jaganathan Subramani, Saradasri Karri, and Gadiparthi N. Rao 15(S)-hydroxyeicosatetraenoic acid-induced angiogenesis requires Src-mediated Egr-1-dependent rapid induction of FGF-2 expression Blood First Edition Paper, prepublished online January 6, 2010; DOI 10.1182/blood-2009-09-241802 [Abstract] [PDF]   David C. Taussig, Jacques Vargaftig, Farideh Miraki-Moud, Emmanuel Griessinger, Kirsty Sharrock, Tina Luke, Debra Lillington, Heather E. Oakervee, Jamie Cavenagh, Samir G. Agrawal, T. Andrew Lister, John G. Gribben, and Dominique Bonnet Leukemia initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34- fraction Blood First Edition Paper, prepublished online January 6, 2010; DOI 10.1182/blood-2009-02-206565 [Abstract] [PDF]   Robert P. Hebbel, Gregory M. Vercellotti, Betty S. Pace, Anna N. Solovey, Rahn Kollander, Chine F. Abanonu, Julia Nguyen, Julie V. Vineyard, John D. Belcher, Fuad Abdulla, Shade Osifuye, John W. Eaton, Robert J. Kelm Jr, and Arne Slungaard The HDAC inhibitors trichostatin A and suberoylanilide hydroxamic acid exhibit multiple modalities of benefit for the vascular pathobiology of sickle transgenic mice Blood First Edition Paper, prepublished online January 6, 2010; DOI 10.1182/blood-2009-02-204990 [Abstract] [PDF]   30 December 2009 Weiye Wang, Chang Hoon Ha, Bong Sook Jhun, Chelsea Wong, Mukesh K. Jain, and Zheng Gen Jin Fluid shear stress stimulates phosphorylation-dependent nuclear export of HDAC5 and mediates expression of KLF2 and eNOS Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-05-224824 [Abstract] [PDF]   Eran Ophir, Yaki Eidelstein, Ran Afik, Esther Bachar-Lustig, and Yair Reisner Induction of tolerance to BM allografts by donor derived host non-reactive ex vivo-induced central memory CD8 T cells Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-10-248716 [Abstract] [PDF]   Rosanna Asselta, Valeria Rimoldi, Ilaria Guella, Giulia Solda, Raimondo De Cristofaro, Flora Peyvandi, and Stefano Duga Molecular characterization of in-frame and out-of-frame alternative splicings in coagulation factor XI pre-mRNA Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-09-245092 [Abstract] [PDF]   Filippo Milano, Angela P. Campbell, Katherine A. Guthrie, Jane Kuypers, Janet A. Englund, Lawrence Corey, and Michael J. Boeckh Human rhinovirus and coronavirus detection among allogeneic hematopoietic stem cell transplantation recipients Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-09-244152 [Abstract] [PDF]   Nattawat Onlamoon, Sansanee Noisakran, Hui-Mien Hsiao, Alexander Duncan, Francois Villinger, Aftab A. Ansari, and Guey Chuen Perng Dengue virus induced hemorrhage in a nonhuman primate model Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-09-242990 [Abstract] [PDF]   Olaf Penack, Ernst Holler, and Marcel R M van den Brink Graft-versus-host disease: regulation by microbe-associated molecules and innate immune receptors Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-09-242784 [Abstract] [PDF]   Marco Calamito, Marisa M. Juntilla, Matthew Thomas, Daniel L. Northrup, Jeffrey Rathmell, Morris J. Birnbaum, Gary Koretzky, and David Allman Akt1 and Akt2 promote peripheral B cell maturation and survival Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-09-241638 [Abstract] [PDF]   Rashmi B Prasad, Fay J Hosking, Jayaram Vijayakrishnan, Elli Papaemmanuil, Rolf Kohler, Mel F Greaves, Eammon Sheridan, Andreas Gast, Sally E Kinsey, Tracy Lightfoot, Eve Roman, Graham Malcolm Taylor, Kathy Pritchard-Jones, Martin Stanulla, Martin Schrappe, Claus R Bartram, Richard S Houlston, Rajiv Kumar, and Kari Hemminki Verification of the susceptibility loci on 7p12.2, 10q21.2 and 14q11.2 in precursor B-cell acute lymphoblastic leukemia of childhood Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-09-241513 [Abstract] [PDF]   Martin J. S. Dyer, Takashi Akasaka, Melania Capasso, Palminder Dusanjh, Yin Fai Lee, E. Loraine Karran, Inga Nagel, Inga Vater, Gunnar Cario, and Reiner Siebert Immunoglobulin heavy chain (IGH) locus chromosomal translocations in B-cell precursor acute lymphoblastic leukemia (BCP-ALL): rare clinical curios or potent genetic drivers? Blood First Edition Paper, prepublished online December 30, 2009; DOI 10.1182/blood-2009-09-235986 [Abstract] [PDF]   29 December 2009 Andreas Krueger, Stefanie Willenzon, Marcin Lyszkiewicz, Elisabeth Kremmer, and Reinhold Forster CC chemokine receptor (CCR) 7 and 9 double-deficient hematopoietic progenitors are severely impaired in seeding the adult thymus Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-07-235721 [Abstract] [PDF]   Dennis Adeegbe, Robert B. Levy, and Thomas R. Malek Allogeneic T regulatory cell-mediated transplantation tolerance in adoptive therapy depends on dominant peripheral suppression and central tolerance Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-08-238584 [Abstract] [PDF]   Robert P. Hasserjian, Zhuang Zuo, Christine Garcia, Guilin Tang, Armen Kasyan, Rajyalakshmi Luthra, Lynne V. Abruzzo, Hagop M. Kantarjian, L. Jeffrey Medeiros, and Sa A. Wang Acute erythroid leukemia: a reassessment using criteria refined in the 2008 WHO classification Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-09-243964 [Abstract] [PDF]   Katarzyna Mleczko-Sanecka, Guillem Casanovas, Anan Ragab, Katja Breitkopf, Alexandra Muller, Michael Boutros, Steven Dooley, Matthias W. Hentze, and Martina U. Muckenthaler SMAD7 controls iron metabolism as a potent inhibitor of hepcidin expression Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-09-238105 [Abstract] [PDF] [Supplemental Tables]   Thomas Klingebiel, Jacqueline Cornish, Myriam Labopin, Franco Locatelli, Philippe Darbyshire, Rupert Handgretinger, Adriana Balduzzi, Joanna Owoc-Lempach, Franca Fagioli, Reuven Or, Christina Peters, Franco Aversa, Emmanuelle Polge, Giorgio Dini, and Vanderson Rocha Results and factors influencing outcome after fully haploidentical hematopoietic stem cell transplant in children with very-high risk acute lymphoblastic leukemia - impact of center size: an analysis on behalf of the Acute Leukemia and Pediatric Disease Working Parties of the European Blood and Marrow Transplant group Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-03-207001 [Abstract] [PDF]   Rita Vicente, Oumeya Adjali, Chantal Jacquet, Valerie S. Zimmermann, and Naomi Taylor Intrathymic transplantation of bone marrow derived progenitors provides long-term thymopoiesis Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-06-229724 [Abstract] [PDF]   Joseph A. Sparano, Jeannette Y. Lee, Lawrence D. Kaplan, Alexandra M. Levine, Juan Carlos Ramos, Richard F. Ambinder, William Wachsman, David Aboulafia, Ariela Noy, David H. Henry, Jamie Von Roenn, Bruce J. Dezube, Scot C. Remick, Manisha H. Shah, Lawrence Leichman, Lee Ratner, Ethel Cesarman, Amy Chadburn, and Ronald Mitsuyasu Rituximab plus concurrent infusional EPOCH chemotherapy is highly effective in HIV-associated, B-cell non-Hodgkin's lymphoma Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-08-231613 [Abstract] [PDF]   Jie Li, Wei Du, Suzette Maynard, Paul R. Andreassen, and Qishen Pang Oxidative-stress specific interaction between FANCD2 and FOXO3a Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-07-234385 [Abstract] [PDF]   Brian R. Curtis, Nancy J. Cox, Mia J. Sullivan, Anuar Konkashbaev, Krista Bowens, Kirk Hansen, and Richard H. Aster The neutrophil alloantigen HNA-3a (5b) is located on choline transporter-like protein 2 (CTL2) and appears to be encoded by an R>Q154 amino acid substitution Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-11-248336 [Abstract] [PDF]   Julia E. Brittain, Ben Hulkower, Susan K. Jones, Dell Strayhorn, Laura De Castro, Marilyn J. Telen, Eugene P. Orringer, Alan Hinderliter, and Kenneth I. Ataga Placenta growth factor in sickle cell disease: association with hemolysis and inflammation Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-04-217950 [Abstract] [PDF]   Donald C. Vinh, Smita Y. Patel, Gulbu Uzel, Victoria L. Anderson, Alexandra F. Freeman, Kenneth N. Olivier, Christine Spalding, Stephen Hughes, Stefania Pittaluga, Mark Raffeld, Lynn R. Sorbara, Houda Z. Elloumi, Douglas B. Kuhns, Maria L. Turner, Edward W. Cowen, Danielle Fink, Debra Long-Priel, Amy P. Hsu, Li Ding, Michelle L. Paulson, Adeline R. Whitney, Elizabeth P. Sampaio, David M. Frucht, Frank R. DeLeo, and Steven M. Holland Autosomal dominant and sporadic monocytopenia with susceptibility to mycobacteria, fungi, papillomaviruses, and myelodysplasia Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-03-208629 [Abstract] [PDF]   Renate B. Schnabel, Jens Baumert, Maja Barbalic, Josee Dupuis, Patrick T. Ellinor, Peter Durda, Abbas Dehghan, Joshua C. Bis, Thomas Illig, Alanna C. Morrison, Nancy S. Jenny, John F. Keaney Jr., Christian Gieger, Cathy Tilley, Jennifer F. Yamamoto, Natalie Khuseyinova, Gerardo Heiss, Margaret Doyle, Stefan Blankenberg, Christian Herder, Jeremy D. Walston, Yanyan Zhu, Ramachandran S. Vasan, Norman Klopp, Eric Boerwinkle, Martin G. Larson, Bruce M. Psaty, Annette Peters, Christie M. Ballantyne, Jacqueline C.M. Witteman, Ron C. Hoogeveen, Emelia J. Benjamin, Wolfgang Koenig, and Russell P. Tracy Duffy antigen receptor for chemokines (Darc) polymorphism regulates circulating concentrations of monocyte chemoattractant protein-1 and other inflammatory mediators Blood First Edition Paper, prepublished online December 29, 2009; DOI 10.1182/blood-2009-05-221382 [Abstract] [PDF] [Supplemental Methods, Appendix, Tables, and Figures]   28 December 2009 Jing Liu, Xinhua Guo, Narla Mohandas, Joel A Chasis, and Xiuli An Membrane remodeling during reticulocyte maturation Blood First Edition Paper, prepublished online December 28, 2009; DOI 10.1182/blood-2009-08-241182 [Abstract] [PDF]   Jerome Thiery, Dennis Keefe, Saviz Saffarian, Denis Martinvalet, Michael Walch, Emmanuel Boucrot, Tomas Kirchhausen, and Judy Lieberman Perforin activates clathrin and dynamin-dependent endocytosis, which is required for plasma membrane repair and delivery of granzyme B for granzyme-mediated apoptosis Blood First Edition Paper, prepublished online December 28, 2009; DOI 10.1182/blood-2009-10-246116 [Abstract] [PDF]   Daniel Scott-Algara, Karl Balabanian, Lisa A. Chakrabarti, Luc Mouthon, Francoise Dromer, Celine Didier, Fernando Arenzana-Seisdedos, and Olivier Lortholary Idiopathic CD4+ T-cell lymphocytopenia is associated with impaired membrane expression of the chemokine receptor CXCR4 Blood First Edition Paper, prepublished online December 28, 2009; DOI 10.1182/blood-2009-02-202796 [Abstract] [PDF]   Theresia M Westers, Canan Alhan, Martine ED Chamuleau, Maurice JDL van der Vorst, Corien Eeltink, Gert J Ossenkoppele, and Arjan A van de Loosdrecht Aberrant immunophenotype of blasts in myelodysplastic syndromes is a clinically relevant biomarker in predicting response to growth factor treatment Blood First Edition Paper, prepublished online December 28, 2009; DOI 10.1182/blood-2009-08-239749 [Abstract] [PDF]   23 December 2009 Reinier A. Boon, Thomas A. Leyen, Ruud D. Fontijn, Joost O. Fledderus, Josefien M.C. Baggen, Oscar L. Volger, Geerten P. van Nieuw Amerongen, and Anton J.G. Horrevoets KLF2-induced actin shear fibers control both alignment to flow and JNK signaling in vascular endothelium Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-06-228726 [Abstract] [PDF]   Christiane Pott, Eva Hoster, Marie-Helene Delfau-Larue, Kheira Beldjord, Sebastian Bottcher, Vahid Asnafi, Anne Plonquet, Reiner Siebert, Evelyne Callet-Bauchu, Niels Andersen, Jacques J M van Dongen, Wolfram Klapper, Francoise Berger, Vincent Ribrag, Achiel L. van Hoof, Marek Trneny, Jan Walewski, Peter Dreger, Michael Unterhalt, Wolfgang Hiddemann, Michael Kneba, Hanneke J. C. Kluin-Nelemans, Olivier Hermine, Elizabeth Macintyre, and Martin Dreyling Molecular remission is an independent predictor of clinical outcome in patients with mantle cell lymphoma after combined immunochemotherapy: a European MCL intergroup study Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-06-230250 [Abstract] [PDF]   Vanessa Morales-Tirado, Dorothy K. Sojka, Shoshana D. Katzman, Christopher A. Lazarski, Fred D. Finkelman, Joseph F. Urban, and Deborah J. Fowell Critical requirement for the Wiskott-Aldrich syndrome protein in Th2 effector function Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-07-235754 [Abstract] [PDF]   Yan Sun, Lijian Shao, Hao Bai, Zack Z. Wang, and Wen-Shu Wu Slug deficiency enhances self-renewal of hematopoietic stem cells during hematopoietic regeneration Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-07-232934 [Abstract] [PDF]   Karin Tarte, Julien Gaillard, Jean-Jacques Lataillade, Loic Fouillard, Martine Becker, Hossein Mossafa, Andrei Tchirkov, Helene Rouard, Catherine Henry, Marie Splingard, Joelle Dulong, Delphine Monnier, Patrick Gourmelon, Norbert-Claude Gorin, and Luc Sensebe Clinical-grade production of human mesenchymal stromal cells: occurrence of aneuploidy without transformation Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-05-219907 [Abstract] [PDF]   Wouter Pos, James T.B. Crawley, Rob Fijnheer, Jan Voorberg, David A. Lane, and Brenda M. Luken An autoantibody epitope comprising residues R660, Y661 and Y665 in the ADAMTS13 spacer domain identifies a binding site for the A2 domain of VWF Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-06-229203 [Abstract] [PDF]   Mark R. Litzow, Sergey Tarima, Waleska S. Perez, Brian J. Bolwell, Mitchell S. Cairo, Bruce M. Camitta, Corey S. Cutler, Marcos de Lima, John F. DiPersio, Robert Peter Gale, Armand Keating, Hillard M. Lazarus, Selina Luger, David I. Marks, Richard T. Maziarz, Philip L. McCarthy, Marcelo C. Pasquini, Gordon L. Phillips, J. Douglas Rizzo, Jorge Sierra, Martin S. Tallman, and Daniel J. Weisdorf Allogeneic transplantation for therapy-related myelodysplastic syndrome and acute myeloid leukemia Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-10-249128 [Abstract] [PDF]   Christian H. Geisler, Arne Kolstad, Anna Laurell, Riikka Raty, Mats Jerkeman, Mikael Eriksson, Marie Nordstrom, Eva Kimby, Anne Marie Boesen, Herman Nilsson-Ehle, Outi Kuittinen, Grete F. Lauritzsen, Elisabeth Ralfkiaer, Mats Ehinger, Christer Sundstrom, Jan Delabie, Marja-Liisa Karjalainen-Lindsberg, Peter Brown, and Erkki Elonen The Mantle Cell Lymphoma Prognostic Index (MIPI) is superior to the International Prognostic Index (IPI) in predicting survival following intensive 1st-line immunochemotherapy and autologous stem-cell transplantation (ASCT) Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-08-236570 [Abstract] [PDF]   Ronald W. Stam, Pauline Schneider, Jill A. P. Hagelstein, Marieke H. van der Linden, Dominique J.P.M. Stumpel, Renee X. de Menezes, Paola de Lorenzo, Maria G. Valsecchi, and Rob Pieters Gene expression profiling-based dissection of MLL translocated and MLL germline acute lymphoblastic leukemia in infants Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-07-233049 [Abstract] [PDF]   Johanna A. Kremer Hovinga, Sara K. Vesely, Deirdra R. Terrell, Bernhard Lammle, and James N. George Survival and relapse in patients with thrombotic thrombocytopenic purpura Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-09-243790 [Abstract] [PDF]   Ali T. Taher, Khaled M. Musallam, Mehran Karimi, Amal El-Beshlawy, Khawla Belhoul, Shahina Daar, Mohamed-SalahEldin Saned, Abdul-Hamid El-Chafic, Maria R. Fasulo, and Maria D. Cappellini Overview on Practices in Thalassemia Intermedia Management Aiming for Lowering Complication-rates Across a Region of Endemicity: the OPTIMAL CARE study Blood First Edition Paper, prepublished online December 23, 2009; DOI 10.1182/blood-2009-09-243154 [Abstract] [PDF]   22 December 2009 Gregory F. Sonnenberg, Paul R. Mangan, Natalie A. Bezman, Debora R. Sekiguchi, Eline T. Luning Prak, Jan Erikson, Jonathan S. Maltzman, Martha S. Jordan, and Gary A. Koretzky Mislocalization of SLP-76 leads to aberrant inflammatory cytokine and autoantibody production Blood First Edition Paper, prepublished online December 22, 2009; DOI 10.1182/blood-2009-08-237438 [Abstract] [PDF]   John A. Pulikkan, Viola Dengler, Philomina S. Paramangalam, Abdul A. Peer Zada, Carsten Muller-Tidow, Stefan K. Bohlander, Daniel G. Tenen, and Gerhard Behre Cell cycle regulator E2F1 and microRNA-223 comprise an autoregulatory negative feedback loop in acute myeloid leukemia Blood First Edition Paper, prepublished online December 22, 2009; DOI 10.1182/blood-2009-08-240101 [Abstract] [PDF]   Jin Zhou, Yingmei Zhang, Jinmei Li, Xiaoxia Li, Jinxiao Hou, Yanqiu Zhao, Xiuhua Liu, Xueying Han, Longhu Hu, Shuye Wang, Yanhong Zhao, Ying Zhang, Shengjin Fan, Chengfang Lv, Limin Li, and Lingling Zhu Single-agent arsenic trioxide in the treatment of children with newly diagnosed acute promyelocytic leukemia Blood First Edition Paper, prepublished online December 22, 2009; DOI 10.1182/blood-2009-07-230805 [Abstract] [PDF]   J. N. Barker, A. Scaradavou, and C. E. Stevens Combined effect of total nucleated cell dose and HLA-match on transplant outcome in 1061 cord blood recipients with hematological malignancies Blood First Edition Paper, prepublished online December 22, 2009; DOI 10.1182/blood-2009-07-231068 [Abstract] [PDF]   18 December 2009 Eun Jeong Park, Antonio Peixoto, Yoichi Imai, Ahmad Goodarzi, Guiying Cheng, Christopher V. Carman, Ulrich H. von Andrian, and Motomu Shimaoka Distinct roles for LFA-1 affinity regulation during T cell adhesion, diapedesis, and interstitial migration in lymph nodes Blood First Edition Paper, prepublished online December 18, 2009; DOI 10.1182/blood-2009-08-237917 [Abstract] [PDF] [Supplemental Methods, Table, Figures, and Videos]   Satoru Kase, Shikun He, Shozo Sonoda, Mizuki Kitamura, Christine Spee, Eric Wawrousek, Stephen J Ryan, Ram Kannan, and David R Hinton AlphaB crystallin regulation of angiogenesis by modulation of VEGF Blood First Edition Paper, prepublished online December 18, 2009; DOI 10.1182/blood-2009-01-197095 [Abstract] [PDF]   Mark K. Lafferty, Lingling Sun, Leon DeMasi, Wuyuan Lu, and Alfredo Garzino-Demo CCR6 ligands inhibit HIV by inducing APOBEC3G Blood First Edition Paper, prepublished online December 18, 2009; DOI 10.1182/blood-2009-06-226423 [Abstract] [PDF] [Supplemental Figures]   17 December 2009 Silvio Danese, Stefania Vetrano, Li Zhang, Victoria A. Ploplis, and Francis J. Castellino The protein C pathway in tissue inflammation and injury: pathogenic role and therapeutic implications Blood First Edition Paper, prepublished online December 17, 2009; DOI 10.1182/blood-2009-09-201616 [Abstract] [PDF]   Lionel Ades, Agnes Guerci, Emmanuel Raffoux, Miguel Sanz, Patrice Chevallier, Simona Lapusan, Christian Recher, Xavier Thomas, Consuelo Rayon, Sylvie Castaigne, Olivier Tournilhac, Stephane de Botton, Norbert Ifrah, Jean-Yves Cahn, Eric Solary, Claude Gardin, Nathalie Fegueux, Dominique Bordessoule, Augustin Ferrant, Sandrine Meyer-Monard, Norbert Vey, Herve Dombret, Laurent Degos, Sylvie Chevret, and Pierre Fenaux Very long-term outcome of acute promyelocytic leukemia after treatment wtih all trans retinoic acid and chemotherapy: the European APL Group experience Blood First Edition Paper, prepublished online December 17, 2009; DOI 10.1182/blood-2009-07-233387 [Abstract] [PDF]   Asish K. Ghosh, Charla R. Secreto, Traci R. Knox, Wei Ding, Debabrata Mukhopadhyay, and Neil E. Kay Circulating microvesicles in B cell chronic lymphocytic leukemia can stimulate marrow stromal cells: implications for disease progression Blood First Edition Paper, prepublished online December 17, 2009; DOI 10.1182/blood-2009-09-242719 [Abstract] [PDF]   Sebastian Rutsch, Vishala T. Neppalli, Dong-Mi Shin, Wendy DuBois, Herbert C. Morse III, Hartmut Goldschmidt, and Siegfried Janz IL-6 and MYC collaborate in plasma cell tumor formation in mice Blood First Edition Paper, prepublished online December 17, 2009; DOI 10.1182/blood-2009-08-237941 [Abstract] [PDF]   Saki Shimizu, Patrick Hong, Balamurugan Arumugam, Lauren Pokomo, Joshua Boyer, Naoya Koizumi, Panyamol Kittipongdaja, Angela Chen, Greg Bristol, Zoran Galic, Jerome A. Zack, Otto Yang, Irvin S. Y. Chen, Benhur Lee, and Dong Sung An A highly efficient short hairpin RNA potently down-regulates CCR5 expression in systemic lymphoid organs in the hu-BLT mouse model Blood First Edition Paper, prepublished online December 17, 2009; DOI 10.1182/blood-2009-04-215855 [Abstract] [PDF]   16 December 2009 Maria Teresa Sabrina Bertilaccio, Cristina Scielzo, Giorgia Simonetti, Maurilio Ponzoni, Benedetta Apollonio, Claudia Fazi, Lydia Scarfo, Martina Rocchi, Marta Muzio, Federico Caligaris-Cappio, and Paolo Ghia A novel rag2-/-c-/--xenograft model of human CLL Blood First Edition Paper, prepublished online December 16, 2009; DOI 10.1182/blood-2009-05-223586 [Abstract] [PDF]   Nadia Solovieff, Jacquline N. Milton, Stephen W. Hartley, Richard Sherva, Paola Sebastiani, Daniel A. Dworkis, Elizabeth S. Klings, Lindsay A. Farrer, Melanie E. Garrett, Allison Ashley-Koch, Marilyn J. Telen, Supan Fucharoen, Shau Yin Ha, Chi-Kong Li, David H.K. Chui, Clinton T. Baldwin, and Martin H. Steinberg Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster Blood First Edition Paper, prepublished online December 16, 2009; DOI 10.1182/blood-2009-08-239517 [Abstract] [PDF]   Robert A. Brodsky, Allen R. Chen, Donna Dorr, Ephraim J. Fuchs, Carol Ann Huff, Leo Luznik, B. Douglas Smith, William H. Matsui, Steven N. Goodman, Richard F. Ambinder, and Richard J. Jones High dose cyclophosphamide for severe aplastic anemia: long-term follow-up Blood First Edition Paper, prepublished online December 16, 2009; DOI 10.1182/blood-2009-06-225375 [Abstract] [PDF]   15 December 2009 Namita Saran, Marcin Lyszkiewicz, Jens Pommerencke, Katrin Witzlau, Ramin Vakilzadeh, Matthias Ballmaier, Harald von Boehmer, and Andreas Krueger Multiple extra-thymic precursors contribute to T cell development with different kinetics Blood First Edition Paper, prepublished online December 15, 2009; DOI 10.1182/blood-2009-07-230821 [Abstract] [PDF]   Stefania Parlato, Giulia Romagnoli, Francesca Spadaro, Irene Canini, Paolo Sirabella, Paola Borghi, Carlo Ramoni, Ilaria Filesi, Silvia Biocca, Lucia Gabriele, and Filippo Belardelli LOX-1 as natural IFN--mediated signal for apoptotic cell uptake and antigen presentation in dendritic cells Blood First Edition Paper, prepublished online December 15, 2009; DOI 10.1182/blood-2009-07-234468 [Abstract] [PDF]   Ana L. Gomes, Tania Carvalho, Jacinta Serpa, Cheila Torre, and Sergio Dias Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF1:CXCR4 axis Blood First Edition Paper, prepublished online December 15, 2009; DOI 10.1182/blood-2009-08-240580 [Abstract] [PDF]   Zhi Xu, Francis J. Castellino, and Victoria A. Ploplis Plasminogen activator inhibitor-1 (PAI-1) is cardioprotective in mice by maintaining microvascular integrity and cardiac architecture Blood First Edition Paper, prepublished online December 15, 2009; DOI 10.1182/blood-2009-09-244962 [Abstract] [PDF]   Corey Casper, Janet Englund, and Michael Boeckh How we treat influenza in patients with hematologic malignancies Blood First Edition Paper, prepublished online December 15, 2009; DOI 10.1182/blood-2009-11-255455 [Abstract] [PDF]   14 December 2009 Francesco Passamonti, Francisco Cervantes, Alessandro Maria Vannucchi, Enrica Morra, Elisa Rumi, Arturo Pereira, Paola Guglielmelli, Ester Pungolino, Marianna Caramella, Margherita Maffioli, Cristiana Pascutto, Mario Lazzarino, Mario Cazzola, and Ayalew Tefferi A dynamic prognostic model to predict survival in primary myelofibrosis: a study by the IWG-MRT (International Working Group for Myeloproliferative Neoplasms Research and Treatment) Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-09-245837 [Abstract] [PDF]   Maarten L Janmaat, Jasper LT Heerkens, Alexander M de Bruin, Anita Klous, Vivian de Waard, and Carlie JM de Vries Erythropoietin accelerates smooth muscle cell-rich vascular lesion formation in mouse through endothelial cell activation involving enhanced PDGF-BB release Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-07-230870 [Abstract] [PDF]   Michael G. Kharas, Rachel Okabe, Jared J. Ganis, Maricel Gozo, Tulasi Khandan, Mahnaz Paktinat, D. Gary Gilliland, and Kira Gritsman Constitutively active AKT depletes hematopoietic stem cells and induces leukemia in mice Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-06-229443 [Abstract] [PDF]   Jonathan Richard, Sardar Sindhu, Tram NQ Pham, Jean-Philippe Belzile, and Eric A. Cohen HIV-1 Vpr upregulates expression of ligands for the activating NKG2D receptor and promotes NK cell-mediated killing Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-08-237370 [Abstract] [PDF] [Supplemental Methods and Figures]   Van B.T. Ta, Marjolein J.W. de Bruijn, Petra J. ter Brugge, Jan Piet van Hamburg, Hans J.A. Diepstraten, Pieter Fokko van Loo, Rogier Kersseboom, and Rudi W. Hendriks Malignant transformation of Slp65-deficient pre-B cells involves disruption of the Arf-Mdm2-p53 tumor suppressor pathway Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-05-222166 [Abstract] [PDF]   Bindya Jacob, Motomi Osato, Namiko Yamashita, Chelsia Qiuxia Wang, Ichiro Taniuchi, Dan R. Littman, Norio Asou, and Yoshiaki Ito Stem cell exhaustion due to Runx1 deficiency is prevented by Evi5 activation in leukemogenesis Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-07-232249 [Abstract] [PDF]   Tina Baessler, Jean Enno Charton, Benjamin Joachim Schmiedel, Frank Grunebach, Matthias Krusch, Alexander Wacker, Hans-Georg Rammensee, and Helmut Rainer Salih CD137 ligand mediates opposite effects in human and mouse NK cells and impairs NK cell reactivity against human acute myeloid leukemia cells Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-06-227934 [Abstract] [PDF]   Geqiang Li, Kristy L. Miskimen, Zhengqi Wang, Xiu Yan Xie, Jennifer Brenzovich, John J. Ryan, William Tse, Richard Moriggl, and Kevin D. Bunting STAT5 requires the N-domain for suppression of miR15/16, induction of bcl-2, and survival signaling in myeloproliferative disease Blood First Edition Paper, prepublished online December 14, 2009; DOI 10.1182/blood-2009-07-234963 [Abstract] [PDF]   11 December 2009 Sasidhar Vemula, Jianjian Shi, Philip Hanneman, Lei Wei, and Reuben Kapur ROCK1 functions as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-08-237222 [Abstract] [PDF]   Fabio P S Santos, Hagop M Kantarjian, Nitin Jain, Taghi Manshouri, Deborah A Thomas, Guillermo Garcia-Manero, Debra Kennedy, Zeev Estrov, Jorge Cortes, and Srdan Verstovsek Phase II study of CEP-701, an orally available JAK2 inhibitor, in patients with primary or post polycythemia vera/essential thrombocythemia myelofibrosis Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-10-246363 [Abstract] [PDF]   Hideki Muramatsu, Hideki Makishima, Anna M. Jankowska, Heather Cazzolli, Christine O'Keefe, Nao Yoshida, Yinyan Xu, Nobuhiro Nishio, Asahito Hama, Hiroshi Yagasaki, Yoshiyuki Takahashi, Koji Kato, Atsushi Manabe, Seiji Kojima, and Jaroslaw P. Maciejewski Mutations of E3 ubiquitin ligase Cbl family members but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-06-226340 [Abstract] [PDF]   Philip A Beer, Francois Delhommeau, Jean-Pierre LeCouedic, Mark A Dawson, Edwin Chen, David Bareford, Rajko Kusec, Mary Frances McMullin, Claire N Harrison, Alessandro M Vannucchi, William Vainchenker, and Anthony R Green Two routes to leukemic transformation following a JAK2 mutation-positive myeloproliferative neoplasm Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-08-236596 [Abstract] [PDF]   Vito Racanelli, Patrizia Leone, Maria Antonia Frassanito, Claudia Brunetti, Federico Perosa, Soldano Ferrone, and Franco Dammacco Alterations in the antigen processing-presenting machinery of transformed plasma cells are associated with reduced recognition by CD8+ T cells and characterize the progression of MGUS to multiple myeloma Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-06-228676 [Abstract] [PDF] [Supplemental Methods and Figure]   Francesca Gay, Suzanne R. Hayman, Martha Q. Lacy, Francis Buadi, Morie A. Gertz, Shaji Kumar, Angela Dispenzieri, Joseph R. Mikhael, P. Leif Bergsagel, David Dingli, Craig B. Reeder, John A. Lust, Stephen J. Russell, Vivek Roy, Steven R. Zeldenrust, Thomas E. Witzig, Rafael Fonseca, Robert A. Kyle, Philip R. Greipp, A. Keith Stewart, and S. Vincent Rajkumar Lenalidomide plus dexamethasone versus thalidomide plus dexamethasone in newly diagnosed multiple myeloma: a comparative analysis of 411 patients Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-08-239046 [Abstract] [PDF]   Saul J. Priceman, James L. Sung, Zory Shaposhnik, Jeremy B. Burton, Antoni X. Torres-Collado, Diana L. Moughon, Mai Johnson, Aldons J. Lusis, Donald A. Cohen, M. Luisa Iruela-Arispe, and Lily Wu Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of anti-angiogenic therapy Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-08-237412 [Abstract] [PDF]   Hind Medyouf, Xiuhua Gao, Florence Armstrong, Samuel Gusscott, Qing Liu, Amanda Larson Gedman, Larry H. Matherly, Kirk R. Schultz, Francoise Pflumio, Mingjian James You, and Andrew P. Weng Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss Blood First Edition Paper, prepublished online December 11, 2009; DOI 10.1182/blood-2009-04-214718 [Abstract] [PDF]   10 December 2009 Keith W. Pratz, Takashi Sato, Kathleen M. Murphy, Adam Stine, Trivikram Rajkhowa, and Mark Levis FLT3 mutant allelic burden and clinical status are predictive of response to FLT3 inhibitors in AML Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-09-242859 [Abstract] [PDF]   Paul S. Hole, Lorna Pearn, Amanda J. Tonks, Philip E. James, Alan K. Burnett, Richard L. Darley, and Alex Tonks Ras-induced reactive oxygen species promote growth factor-independent proliferation in human CD34+ haematopoeitic progenitor cells Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-06-222869 [Abstract] [PDF]   Thomas Fehr, Carrie L. Lucas, Josef Kurtz, Takashi Onoe, Guiling Zhao, Timothy Hogan, Casey Vallot, Anjana Rao, and Megan Sykes A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-07-230680 [Abstract] [PDF]   Giovanni Riva, Mario Luppi, Patrizia Barozzi, Chiara Quadrelli, Sabrina Basso, Daniela Vallerini, Eleonora Zanetti, Monica Morselli, Fabio Forghieri, Monica Maccaferri, Francesco Volzone, Cinzia Del Giovane, Roberto D'Amico, Franco Locatelli, Giuseppe Torelli, Patrizia Comoli, and Leonardo Potenza Emergence of BCR-ABL-specific cytotoxic T cells in the bone marrow of patients with Ph+ acute lymphoblastic leukemia during long-term Imatinib mesylate treatment Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-06-230391 [Abstract] [PDF]   Renaud Colisson, Lucie Barblu, Christophe Gras, Francoise Raynaud, Reda Hadj-Slimane, Claudine Pique, Olivier Hermine, Yves Lepelletier, and Jean-Philippe Herbeuval Free HTLV-1 induces TLR7-dependent innate immune response and TRAIL relocalization in killer plasmacytoid dendritic cells Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-06-224741 [Abstract] [PDF]   Leola Chow, Rukhsana Aslam, Edwin R. Speck, Michael Kim, Norman Cridland, Michelle Lee Webster, Pingguo Chen, Kim Sahib, Heyu Ni, Alan H. Lazarus, M. Bernadette Garvey, John Freedman, and John W. Semple A murine model of severe immune thrombocytopenia is induced by antibody- and CD8+ T cell-mediated responses that are differentially sensitive to therapy Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-09-244772 [Abstract] [PDF] [Supplemental Figures]   Lewis B. Silverman, Jeffrey G. Supko, Kristen E. Stevenson, Christina Woodward, Lynda M. Vrooman, Donna S. Neuberg, Barbara L. Asselin, Uma H. Athale, Luis Clavell, Peter D. Cole, Kara M. Kelly, Caroline Laverdiere, Bruno Michon, Marshall Schorin, Cindy L. Schwartz, Jane E. O'Brien, Harvey J. Cohen, and Stephen E. Sallan Intravenous PEG-asparaginase during remission induction in children and adolescents with newly diagnosed acute lymphoblastic leukemia Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-09-245951 [Abstract] [PDF]   T. Harma C. Brondijk, Talitha de Ruiter, Joost Ballering, Hans Wienk, Robert Jan Lebbink, Hugo van Ingen, Rolf Boelens, Richard W. Farndale, Linde Meyaard, and Eric G. Huizinga Crystal structure and collagen-binding site of immune inhibitory receptor LAIR-1: unexpected implications for collagen binding by platelet receptor GPVI Blood First Edition Paper, prepublished online December 10, 2009; DOI 10.1182/blood-2009-10-246322 [Abstract] [PDF]   9 December 2009 Bart Keymeulen, Sophie Candon, Samira Fafi-Kremer, Anette Ziegler, Marianne Leruez-Ville, Chantal Mathieu, Evy Vandemeulebroucke, Markus Walter, Laurent Crenier, Eric Thervet, Christophe Legendre, Denis Pierard, Geoff Hale, Herman Waldmann, Jean-Francois Bach, Jean Marie Seigneurin, Daniel Pipeleers, and Lucienne Chatenoud Transient Epstein Barr virus reactivation in CD3 monoclonal antibody-treated patients Blood First Edition Paper, prepublished online December 9, 2009; DOI 10.1182/blood-2009-02-204875 [Abstract] [PDF]   Andrew D. Paterson, Johanna M. Rommens, Bhupinder Bharaj, Jessica Blavignac, Isidro Wong, Maria Diamandis, John S. Waye, Georges E. Rivard, and Catherine P. M. Hayward Individuals with Quebec platelet disorder have a tandem duplication of PLAU, the urokinase plasminogen activator gene Blood First Edition Paper, prepublished online December 9, 2009; DOI 10.1182/blood-2009-07-233965 [Abstract] [PDF]   Takaomi Sanda, Xiaoyu Li, Alejandro Gutierrez, Yebin Ahn, Donna S. Neuberg, Jennifer O'Neil, Peter R. Strack, Christopher G. Winter, Stuart S. Winter, Richard S. Larson, Harald von Boehmer, and A. Thomas Look Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia Blood First Edition Paper, prepublished online December 9, 2009; DOI 10.1182/blood-2009-07-235143 [Abstract] [PDF]   R. Katherine Hyde, Yasuhiko Kamikubo, Stacie Anderson, Martha Kirby, Lemlem Alemu, Ling Zhao, and P. Paul Liu Cbfb/Runx1-repression independent blockage of differentiation and accumulation of Csf2rb expressing cells by Cbfb-MYH11 Blood First Edition Paper, prepublished online December 9, 2009; DOI 10.1182/blood-2009-06-227413 [Abstract] [PDF]   Ben J. Gu, Bernadette M. Saunders, Claudia Jursik, and James S. Wiley The P2X7-nonmuscle myosin membrane complex regulates phagocytosis of non-opsonized particles and bacteria by a pathway attenuated by extracellular ATP Blood First Edition Paper, prepublished online December 9, 2009; DOI 10.1182/blood-2009-11-251744 [Abstract] [PDF]   Dave Caudell, David P. Harper, Rachel L. Novak, Rachel M. Pierce, Christopher Slape, Linda Wolff, and Peter D. Aplan Retroviral insertional mutagenesis identifies Zeb2 activation as a novel leukemogenic collaborating event in CALM-AF10 transgenic mice Blood First Edition Paper, prepublished online December 9, 2009; DOI 10.1182/blood-2009-04-216184 [Abstract] [PDF]   Ashley P. Ng, Craig D. Hyland, Donald Metcalf, Catherine L. Carmichael, Stephen J. Loughran, Ladina Di Rago, Benjamin T. Kile, and Warren S. Alexander Trisomy of Erg is required for myeloproliferation in a mouse model of Down syndrome Blood First Edition Paper, prepublished online December 9, 2009; DOI 10.1182/blood-2009-09-242107 [Abstract] [PDF]   8 December 2009 Dhananjay D. Marathe, Alexander Buffone Jr., E. V. Chandrasekaran, Jun Xue, Robert D. Locke, Mehrab Nasirikenari, Joseph T. Y. Lau, Khushi L. Matta, and Sriram Neelamegham Fluorinated per-acetylated GalNAc metabolically alters glycan structures on leukocyte PSGL-1 and reduces cell binding to selectins Blood First Edition Paper, prepublished online December 8, 2009; DOI 10.1182/blood-2009-07-231480 [Abstract] [PDF]   Dudley J. Pennell, John B. Porter, Maria Domenica Cappellini, Amal El-Beshlawy, Lee Lee Chan, Yesim Aydinok, Mohsen Saleh Elalfy, Pranee Sutcharitchan, Chi-Kong Li, Hishamshah Ibrahim, Vip Viprakasit, Antonis Kattamis, Gillian Smith, Dany Habr, Gabor Domokos, Bernard Roubert, and Ali Taher Efficacy of deferasirox in reducing and preventing cardiac iron overload in β-thalassemia Blood First Edition Paper, prepublished online December 8, 2009; DOI 10.1182/blood-2009-04-217455 [Abstract] [PDF]   Kohji Kasahara, Masayoshi Souri, Mizuho Kaneda, Toshiaki Miki, Naomasa Yamamoto, and Akitada Ichinose Impaired clot retraction in factor XIII A subunit-deficient mice Blood First Edition Paper, prepublished online December 8, 2009; DOI 10.1182/blood-2009-06-227645 [Abstract] [PDF]   Robert Mansson, Sasan Zandi, Eva Welinder, Panagiotis Tsapogas, Nobuo Sakaguchi, David Bryder, and Mikael Sigvardsson Single cell analysis of the common lymphoid progenitor compartment reveals functional and molecular heterogeneity Blood First Edition Paper, prepublished online December 8, 2009; DOI 10.1182/blood-2009-08-236398 [Abstract] [PDF]   7 December 2009 Tiphaine Dejouvencel, Loic Doeuvre, Romaric Lacroix, Laurent Plawinski, Francoise Dignat-Georges, H. Roger Lijnen, and Eduardo Angles-Cano Fibrinolytic cross-talk: a new mechanism for plasmin formation Blood First Edition Paper, prepublished online December 7, 2009; DOI 10.1182/blood-2009-06-228817 [Abstract] [PDF]   R. E. Tiedemann, Y.X. Zhu, J. Schmidt, H. Yin, C.X. Shi, Q. Que, G. Basu, D. Azorsa, L. M. Perkins, E. Braggio, R. Fonseca, P. L. Bergsagel, S. Mousses, and A. K. Stewart Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid restricted kinase, GRK6 Blood First Edition Paper, prepublished online December 7, 2009; DOI 10.1182/blood-2009-09-243980 [Abstract] [PDF]   Ana Kasirer-Friede, Zaverio M. Ruggeri, and Sanford J. Shattil Role for ADAP in shear flow-induced platelet mechanotransduction Blood First Edition Paper, prepublished online December 7, 2009; DOI 10.1182/blood-2009-08-238238 [Abstract] [PDF]   4 December 2009 Marcello Rotta, Barry E. Storer, Rainer F. Storb, Paul J. Martin, Shelly Heimfeld, Amanda Peffer, David G. Maloney, H. Joachim Deeg, Brenda M. Sandmaier, Frederick R. Appelbaum, and Marco Mielcarek Donor statin treatment protects against severe acute graft-versus-host disease after related allogeneic hematopoietic cell transplantation Blood First Edition Paper, prepublished online December 4, 2009; DOI 10.1182/blood-2009-08-240358 [Abstract] [PDF]   3 December 2009 Bernd Jahrsdorfer, Angelika Vollmer, Sue E. Blackwell, Julia Maier, Kai Sontheimer, Thamara Beyer, Birgit Mandel, Oleg Lunov, Kyrylo Tron, G. Ulrich Nienhaus, Thomas Simmet, Klaus-Michael Debatin, George J. Weiner, and Dorit Fabricius Granzyme B produced by human plasmacytoid dendritic cells suppresses T cell expansion Blood First Edition Paper, prepublished online December 3, 2009; DOI 10.1182/blood-2009-07-235382 [Abstract] [PDF]   2 December 2009 Farrukh T. Awan, Rosa Lapalombella, Rossana Trotta, Jonathan P. Butchar, Bo Yu, Don M. Benson Jr., Julie M. Roda, Carolyn Cheney, Xiaokui Mo, Amy Lehman, Jeffrey Jones, Joseph Flynn, David Jarjoura, John R. Desjarlais, Susheela Tridandapani, Michael A. Caligiuri, Natarajan Muthusamy, and John C. Byrd CD19 targeting of chronic lymphocytic leukemia with a novel Fc-domain engineered monoclonal antibody Blood First Edition Paper, prepublished online December 2, 2009; DOI 10.1182/blood-2009-06-229039 [Abstract] [PDF]   Zhangfa Song, Jianwei Wang, Luis Miguel Guachalla, Grzegorz Terszowskif, Hans-Reimer Rodewald, Zhenyu Ju, and K. Lenhard Rudolph Alterations of the systemic environment are the primary cause of impaired B- and T-lymphopoiesis in telomere dysfunctional mice Blood First Edition Paper, prepublished online December 2, 2009; DOI 10.1182/blood-2009-08-237230 [Abstract] [PDF]   1 December 2009 Daniel A. Zlotoff, Arivazhagan Sambandam, Theodore D. Logan, J. Jeremiah Bell, Benjamin A. Schwarz, and Avinash Bhandoola CCR7 and CCR9 together recruit hematopoietic progenitors to the adult thymus Blood First Edition Paper, prepublished online December 1, 2009; DOI 10.1182/blood-2009-08-237784 [Abstract] [PDF]   Cyril Fauriat, Eric O. Long, Hans-Gustaf Ljunggren, and Yenan T. Bryceson Regulation of human NK cell cytokine and chemokine productionby target cell recognition Blood First Edition Paper, prepublished online December 1, 2009; DOI 10.1182/blood-2009-08-238469 [Abstract] [PDF]   Francesca Pellicano, Daniela Cilloni, G. Vignir Helgason, Francesca Messa, Cristina Panuzzo, Francesca Arruga, Enrico Bracco, Elaine Allan, Brian J.P. Huntly, Tessa L. Holyoake, and Giuseppe Saglio FOXO transcription factor activity is partially retained in quiescent CML stem cells and induced by tyrosine kinase inhibitors in CML progenitor cells Blood First Edition Paper, prepublished online December 1, 2009; DOI 10.1182/blood-2009-06-226621 [Abstract] [PDF] [Notice of Concern]   Antonio Palumbo, Sara Bringhen, Benedetto Bruno, Antonietta Pia Falcone, Anna Marina Liberati, Mariella Grasso, Roberto Ria, Fancesco Pisani, Clotilde Cangialosi, Tommaso Caravita, Anna Levi, Giovanna Meloni, Andrea Nozza, Patrizia Pregno, Attilio Gabbas, Vincenzo Callea, Manuela Rizzo, Luciana Annino, Valerio De Stefano, Pellegrino Musto, Ileana Baldi, Federica Cavallo, Maria Teresa Petrucci, Massimo Massaia, and Mario Boccadoro Melphalan 200 mg/m2 versus Melphalan 100 mg/m2 in newly diagnosed myeloma patients: a prospective, multi-center phase III study Blood First Edition Paper, prepublished online December 1, 2009; DOI 10.1182/blood-2009-09-241737 [Abstract] [PDF]   30 November 2009 James J. Driscoll, Dheeraj Pelluru, Konstantinos Lefkimmiatis, Mariateresa Fulciniti, Rao H. Prabhala, Philip R. Greipp, Bart Barlogie, Yu-Tzu Tai, Kenneth C. Anderson, John D. Shaughnessy Jr., Christina M. Annunziata, and Nikhil C. Munshi The sumoylation pathway is dysregulated in multiple myeloma and is associated with adverse patient outcome Blood First Edition Paper, prepublished online November 30, 2009; DOI 10.1182/blood-2009-03-211045 [Abstract] [PDF] [Supplemental Table and Figure]   Matthias Canault, Daniel Duerschmied, Alexander Brill, Lucia Stefanini, Daphne Schatzberg, Stephen M. Cifuni, Wolfgang Bergmeier, and Denisa D. Wagner p38 mitogen-activated protein kinase activation during platelet storage: consequences for platelet recovery and hemostatic function in vivo Blood First Edition Paper, prepublished online November 30, 2009; DOI 10.1182/blood-2009-03-211706 [Abstract] [PDF]   Yenlin Huang, Aurelien de Reynies, Laurence de Leval, Bouchra Ghazi, Nadine Martin-Garcia, Marion Travert, Jacques Bosq, Josette Briere, Barbara Petit, Emilie Thomas, Paul Coppo, Teresa Marafioti, Jean-Francois Emile, Marie-Helene Delfau-Larue, Christian Schmitt, and Philippe Gaulard Gene expression profiling identifies emerging oncogenic pathways operating in extranodal NK/T-cell lymphoma, nasal-type Blood First Edition Paper, prepublished online November 30, 2009; DOI 10.1182/blood-2009-05-221275 [Abstract] [PDF]   Jacob H. Rand, Xiao-Xuan Wu, Anthony S. Quinn, Anthony W. Ashton, Pojen P. Chen, James J. Hathcock, Harry A.M. Andree, and Douglas J. Taatjes Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug Blood First Edition Paper, prepublished online November 30, 2009; DOI 10.1182/blood-2009-04-213520 [Abstract] [PDF]   Arie J Stangou, Nicholas R Banner, Bruce M Hendry, Mohamed Rela, Bernard Portmann, Julia Wendon, Mark Monaghan, Philip MacCarthy, Muriel Buxton-Thomas, Christopher J Mathias, Juris J Liepnieks, John O'Grady, Nigel D Heaton, and Merrill D Benson Hereditary fibrinogen A -chain amyloidosis: phenotypic characterization of a systemic disease and the role of liver transplantation Blood First Edition Paper, prepublished online November 30, 2009; DOI 10.1182/blood-2009-06-223792 [Abstract] [PDF]   25 November 2009 Lili Milani, Anders Lundmark, Anna Kiialainen, Jessica Nordlund, Trond Flaegstad, Erik Forestier, Mats Heyman, Gudmundur Jonmundsson, Jukka Kanerva, Kjeld Schmiegelow, Stefan Soderhall, Mats G Gustafsson, Gudmar Lonnerholm, and Ann-Christine Syvanen DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-04-214668 [Abstract] [PDF]   Eva Maria Murga Penas, Evelyne Callet-Bauchu, Hongtao Ye, Sophie Gazzo, Francoise Berger, Georgia Schilling, Nadine Albert-Konetzny, Eik Vettorazzi, Gilles Salles, Iwona Wlodarska, Ming-Qing Du, Carsten Bokemeyer, and Judith Dierlamm The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-08-236265 [Abstract] [PDF]   24 November 2009 Rachel T. McGrath, Thomas A.J. McKinnon, Barry Byrne, Richard O' Kennedy, Virginie Terraube, Emily McRae, Roger J.S. Preston, Mike A. Laffan, and James S. O'Donnell Expression of terminal 2-6 linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13 Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-09-241547 [Abstract] [PDF]   Ghyath Maarof, Laurence Bouchet-Delbos, Helene Gary-Gouy, Ingrid Durand-Gasselin, Roman Krzysiek, and Ali Dalloul Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-05-220251 [Abstract] [PDF] [Supplemental Figures]   Rosa Lapalombella, Leslie Andritsos, Qing Liu, Sarah E. May, Rebekah Browning, Lan V. Pham, Kristie A. Blum, William Blum, Asha Ramanunni, Chelsey A. Raymond, Lisa L. Smith, Amy Lehman, Xiaokui Mo, David Jarjoura, Ching-Shih Chen, Richard Ford Jr, Christoph Rader, Natarajan Muthusamy, Amy J. Johnson, and John C. Byrd Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B Cells through a PI3-kinase dependent pathway Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-09-242438 [Abstract] [PDF] [Supplemental Figures]   23 November 2009 Jun-ichi Suehiro, Takao Hamakubo, Tatsuhiko Kodama, William C. Aird, and Takashi Minami Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3 Blood First Edition Paper, prepublished online November 23, 2009; DOI 10.1182/blood-2009-07-233478 [Abstract] [PDF]   20 November 2009 Sonja Loges, Thomas Schmidt, Marc Tjwa, Katie Van Geyte, Dirk Lievens, Esther Lutgens, Davy Vanhoutte, Delphine Borgel, Stephane Plaisance, Marc Hoylaerts, Aernout Luttun, Mieke Dewerchin, Bart Jonckx, and Peter Carmeliet Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6 Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-06-228684 [Abstract] [PDF] [Supplemental Methods, Table, and Figures]   Norbert Lubenow, Peter Hinz, Simone Thomaschewski, Theresia Lietz, Michael Vogler, Andrea Ladwig, Michael Junger, Matthias Nauck, Sebastian Schellong, Kathrin Wander, Georg Engel, Axel Ekkernkamp, and Andreas Greinacher The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-07-231506 [Abstract] [PDF]   18 November 2009 Susanne Saussele, Michael Lauseker, Alois Gratwohl, Dietrich W. Beelen, Donald Bunjes, Rainer Schwerdtfeger, Hans-Jochem Kolb, Anthony D. Ho, Christiane Falge, Ernst Holler, Gunter Schlimok, Axel R. Zander, Renate Arnold, Lothar Kanz, Robert Dengler, Claudia Haferlach, Brigitte Schlegelberger, Markus Pfirrmann, Martin C Muller, Susanne Schnittger, Armin Leitner, Nadine Pletsch, Andreas Hochhaus, Joerg Hasford, and Ruediger Hehlmann Allogeneic hematopoietic stem cell transplantation (alloSCT) for chronic myeloid leukemia in the imatinib era; evaluation of its impact within a subgroup of the randomized German CML Study IV Blood First Edition Paper, prepublished online November 18, 2009; DOI 10.1182/blood-2009-08-237115 [Abstract] [PDF] [Supplemental Appendix and Table]   17 November 2009 Jonathan W. Friedberg, Jeff Sharman, John Sweetenham, Patrick B. Johnston, Julie M. Vose, Ann LaCasce, Julia Schaefer-Cutillo, Sven De Vos, Rajni Sinha, John P. Leonard, Larry D. Cripe, Stephanie A. Gregory, Michael P. Sterba, Ann M. Lowe, Ronald Levy, and Margaret A. Shipp Inhibition of Syk with fostamatinib disodium has significant clinical activity in non Hodgkin's lymphoma and chronic lymphocytic leukemia Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-08-236471 [Abstract] [PDF]   13 November 2009 Matthew Staron, Yi Yang, Bei Liu, Janet Li, Yuankai Shen, Juan Carlos Zuniga-Pflucker, Hector L. Aguila, Irving Goldschneider, and Zihai Li gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-07-233031 [Abstract] [PDF]   Eric Aubin, Real Lemieux, and Renee Bazin Indirect inhibition of in vivo and in vitro T cell responses by intravenous immunoglobulins due to impaired antigen presentation Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-06-225417 [Abstract] [PDF]   Sheng F. Cai, Xuefang Cao, Anjum Hassan, Todd A. Fehniger, and Timothy J. Ley Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-07-233676 [Abstract] [PDF]   Masayuki Fujioka, Kazuhide Hayakawa, Kenichi Mishima, Ai Kunizawa, Keiichi Irie, Sei Higuchi, Takafumi Nakano, Carl Muroi, Hidetada Fukushima, Mitsuhiko Sugimoto, Fumiaki Banno, Koichi Kokame, Toshiyuki Miyata, Michihiro Fujiwara, Kazuo Okuchi, and Kenji Nishio ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating post-ischemic hypoperfusion Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-06-230110 [Abstract] [PDF]   10 November 2009 Jeffrey D. Ahlers and Igor M. Belyakov Memories that last forever: strategies for optimizing vaccine T cell memory Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-06-227546 [Abstract] [PDF] [Supplemental Methods]   Kyle Niessen, Gu Zhang, John Brady Ridgway, Hao Chen, and Minhong Yan ALK1 signaling regulates early postnatal lymphatic vessel development Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-07-235655 [Abstract] [PDF]   Ersi Voskaridou, Dimitrios Christoulas, Antonios Bilalis, Eleni Plata, Konstantinos Varvagiannis, George Stamatopoulos, Klio Sinopoulou, Aggeliki Balassopoulou, Dimitris Loukopoulos, and Evangelos Terpos The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle-cell syndromes: results of a 17-year, single center trial (LaSHS) Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-05-221333 [Abstract] [PDF]   Cyril Fauriat, Martin A. Ivarsson, Hans-Gustaf Ljunggren, Karl-Johan Malmberg, and Jakob Michaelsson Education of human natural killer cells by activating killer cell immunoglobulin-like receptors Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-09-245746 [Abstract] [PDF]   Stefano Ugel, Elisa Scarselli, Manuela Iezzi, Carmela Mennuni, Tania Pannellini, Francesco Calvaruso, Barbara Cipriani, Raffaele De Palma, Lucia Ricci-Vitiani, Elisa Peranzoni, Piero Musiani, Paola Zanovello, and Vincenzo Bronte Autoimmune B cell lymphopenia following successful adoptive therapy with telomerase-specific T lymphocytes Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-07-233270 [Abstract] [PDF]   6 November 2009 Pietro Sodani, Antonella Isgro, Javid Gaziev, Paola Polchi, Katia Paciaroni, Marco Marziali, Maria Domenica Simone, Andrea Roveda, Aldo Montuoro, Cecilia Alfieri, Gioia De Angelis, Cristiano Gallucci, Buket Erer, Giancarlo Isacchi, Francesco Zinno, Gaspare Adorno, Alessandro Lanti, Lawrence Faulkner, Manuela Testi, Marco Andreani, and Guido Lucarelli Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-05-218982 [Abstract] [PDF]   Celine Cougoule, Veronique Le Cabec, Renaud Poincloux, Talal Al Saati, Jean-Louis Mege, Guillaume Tabouret, Clifford A. Lowell, Nathalie Laviolette-Malirat, and Isabelle Maridonneau-Parini Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-04-218735 [Abstract] [PDF]   R. Beedholm-Ebsen, K. van de Wetering, T. Hardlei, E. Nexo, P. Borst, and S. K. Moestrup Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-07-232587 [Abstract]