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Blood's First Edition Papers: Last updated July 9, 2009 [View by section] To enable Blood's readers to learn about new scientific findings at the earliest possible moment, the Journal has decided to prepublish, in manuscript format, all accepted articles shortly after acceptance as "First Edition Papers." First Edition Papers have undergone full scientific review but none of the editorial preparation, such as copyediting, typesetting, and proofreading, which is mandatory for all articles published in the regular print and online issues of Blood. Disclaimer More about Blood's First Edition Papers: To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. 9 July 2009 Matteo Bianchi, Abdul Hakkim, Volker Brinkmann, Ulrich Siler, Reinhard A. Seger, Arturo Zychlinsky, and Janine Reichenbach Restoration of NET formation by gene therapy in CGD controls aspergillosis Blood First Edition Paper, prepublished online July 9, 2009; DOI 10.1182/blood-2009-05-221606 [Abstract] [PDF] [Supplemental Methods and Figures]   Yanina Eberhard, Sean McDermott, Xiaoming Wang, Marcela Gronda, Amudha Venugopal, Tabitha E. Wood, Rose Hurren, Alessandro Datti, Robert A. Batey, Jeffrey Wrana, William E. Antholine, John Dick, and Aaron D. Schimmer Chelation of intracellular iron with the anti-fungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells Blood First Edition Paper, prepublished online July 9, 2009; DOI 10.1182/blood-2009-03-209965 [Abstract] [PDF] [Supplemental Figures]   William R. Burns, Zhili Zheng, Steven A. Rosenberg, and Richard A. Morgan Lack of specific -retroviral vector LTR promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation Blood First Edition Paper, prepublished online July 9, 2009; DOI 10.1182/blood-2009-01-199216 [Abstract] [PDF]   Simona Soverini, Alessandra Gnani, Sabrina Colarossi, Fausto Castagnetti, Elisabetta Abruzzese, Stefania Paolini, Serena Merante, Ester Orlandi, Silvia de Matteis, Antonella Gozzini, Ilaria Iacobucci, Francesca Palandri, Gabriele Gugliotta, Cristina Papayannidis, Angela Poerio, Marilina Amabile, Daniela Cilloni, Gianantonio Rosti, Michele Baccarani, and Giovanni Martinelli Philadelphia-positive patients who already harbour imatinib-resistant Bcr-Abl kinase domain mutations have a higher likelihood of developing additional mutations associated with resistance to second- or third-line tyrosine kinase inhibitors Blood First Edition Paper, prepublished online July 9, 2009; DOI 10.1182/blood-2009-01-197186 [Abstract] [PDF] [Supplemental Figures]   Abire Jedidi, Caroline Marty, Charleen Oligo, Laurence Jeanson-Leh, Jean-Antoine Ribeil, Nicole Casadevall, Anne Galy, William Vainchenker, and Jean-Luc Villeval Selective reduction of JAK2V617F-dependent cell growth by siRNA / shRNA and its reversal by cytokines Blood First Edition Paper, prepublished online July 9, 2009; DOI 10.1182/blood-2008-09-176875 [Abstract] [PDF]   Ilaria Iacobucci, Clelia Tiziana Storlazzi, Daniela Cilloni, Annalisa Lonetti, Emanuela Ottaviani, Simona Soverini, Annalisa Astolfi, Sabina Chiaretti, Antonella Vitale, Francesca Messa, Luciana Impera, Carmen Baldazzi, Pietro D'Addabbo, Cristina Papayannidis, Angelo Lonoce, Sabrina Colarossi, Marco Vignetti, Pier Paolo Piccaluga, Stefania Paolini, Domenico Russo, Fabrizio Pane, Giuseppe Saglio, Michele Baccarani, Robin Foa, and Giovanni Martinelli Identification and molecular characterisation of recurrent genomic deletions on 7p12 in the IKZF1 gene in a large cohort of BCR-ABL1-positive acute lymphoblastic leukaemia patients: on behalf of GIMEMA AL WP Blood First Edition Paper, prepublished online July 9, 2009; DOI 10.1182/blood-2008-08-173963 [Abstract] [PDF] [Supplemental Tables] [Additional Supplemental Tables and Supplemental Figures]   8 July 2009 Sara Zanardelli, Alain C.K. Chion, Evelyn Groot, Peter J. Lenting, Thomas A.J. McKinnon, Mike A. Laffan, Michelle Tseng, and David A. Lane A novel binding site for ADAMTS13 constitutively exposed on the surface of globular VWF Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-05-224915 [Abstract] [PDF]   Bill Giannakopoulos and Steven A. Krilis How we treat the antiphospholipid syndrome Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-05-220756 [Abstract] [PDF] [Supplemental Methods]   Susanne Schnittger, Wolfgang Kern, Claudia Tschulik, Tamara Weiss, Frank Dicker, Brunangelo Falini, Claudia Haferlach, and Torsten Haferlach Minimal residual disease levels assessed by NPM1 mutation specific RQ-PCR provide important prognostic information in AML Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-03-213389 [Abstract] [PDF]   Curry L. Koening, Jennifer C. Miller, Jenifer M. Nelson, Diane M. Ward, James P. Kushner, Linda K. Bockenstedt, Janis J. Weis, Jerry Kaplan, and Ivana De Domenico Toll-like receptors mediate induction of hepcidin in mice infected with Borrelia burgdorferi Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-03-209577 [Abstract] [PDF]   Philippe M. Campeau, Moutih Rafei, Marie-Noelle Boivin, Ying Sun, Gregory A. Grabowski, and Jacques Galipeau Characterization of Gaucher disease bone marrow mesenchymal stromal cells reveals an altered inflammatory secretome Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-02-205708 [Abstract] [PDF] [Supplemental Methods, Table, and Figure]   Simona Blotta, Pierfrancesco Tassone, Rao H. Prabhala, Piersandro Tagliaferri, David Cervi, Samir Amin, Jana Jakubikova, Yu-Tzu Tai, Klaus Podar, Constantine S. Mitsiades, Alessandro Zullo, Brunella Franco, Kenneth C. Anderson, and Nikhil C. Munshi Identification of novel antigens with induced immune response in monoclonal gammopathy of undetermined significance Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-04-219436 [Abstract] [PDF]   Susanne Wilde, Daniel Sommermeyer, Bernhard Frankenberger, Matthias Schiemann, Slavoljub Milosevic, Stefani Spranger, Heike Pohla, Wolfgang Uckert, Dirk H. Busch, and Dolores J. Schendel Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior anti-tumor activity and higher TCR functional avidity Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-03-209387 [Abstract] [PDF]   Ramesh C. Nayak, Prosenjit Sen, Samit Ghosh, Ramakrishnan Gopalakrishnan, Charles T. Esmon, Usha R. Pendurthi, and L. Vijaya Mohan Rao Endothelial cell protein C receptor cellular localization and trafficking Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2009-03-208900 [Abstract] [PDF] [Supplemental Methods and Figures]   Graham D. Jack, Li Zhang, and Alan D. Friedman M-CSF elevates c-Fos and phospho-C/EBP(S21) via ERK whereas G-CSF stimulates SHP2 phosphorylation in marrow progenitors to contribute to myeloid lineage specification Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2008-11-191536 [Abstract] [PDF] [Supplemental Figures]   Ramya Chari, Soochong Kim, Swaminathan Murugappan, Archana Sanjay, James L. Daniel, and Satya P. Kunapuli Lyn, PKC delta, SHIP-1 interactions regulate GPVI-mediated platelet dense granule secretion Blood First Edition Paper, prepublished online July 8, 2009; DOI 10.1182/blood-2008-11-188516 [Abstract] [PDF]   7 July 2009 Mieke Delvaeye and Edward M. Conway Coagulation and innate immune responses: can we view them separately? Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2009-05-199208 [Abstract] [PDF]   Andre L. Samson, Rachael J. Borg, Be'eri Niego, Connie H.Y. Wong, Peter J. Crack, Tang Yongqing, and Robert L. Medcalf A non-fibrin macromolecular cofactor for tPA-mediated plasmin generation following cellular injury Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2009-02-203448 [Abstract] [PDF]   Timothy A. Morris, James J. Marsh, Peter G. Chiles, Marisa M. Magana, Ni-Cheng Liang, Xavier Soler, Daniel J. DeSantis, Debby Ngo, and Virgil L. Woods Jr. High prevalence of dysfibrinogenemia among patients with chronic thromboembolic pulmonary hypertension Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2009-03-208264 [Abstract] [PDF] [Supplemental Figures]   Francisco Navarro, David Gutman, Eti Meire, Mario Caceres, Isidore Rigoutsos, Zvi Bentwich, and Judy Lieberman miR-34a contributes to megakaryocytic differentiation of K562 cells independently of p53 Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2009-02-205062 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures]   Lubka T. Roumenina, Mathieu Jablonski, Christophe Hue, Jacques Blouin, Jordan D. Dimitrov, Marie-Agnes Dragon-Durey, Mathieu Cayla, Wolf H. Fridman, Marie-Alice Macher, David Ribes, Luc Moulonguet, Lionel Rostaing, Simon C. Satchell, Peter W. Mathieson, Catherine Sautes-Fridman, Chantal Loirat, Catherine H. Regnier, Lise Halbwachs-Mecarelli, and Veronique Fremeaux-Bacchi Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2009-01-197640 [Abstract] [PDF] [Supplemental Methods and Figures]   Cindy L. Schwartz, Louis S. Constine, Doojduen Villaluna, Wendy B. London, Robert E. Hutchison, Richard Sposto, Steven E. Lipshultz, Charles S. Turner, Pedro A. deAlarcon, and Allen Chauvenet A risk-adapted, response-based approach using ABVE-PC for children and adolescents with intermediate and high risk Hodgkin lymphoma: the results of P9425 from the Children's Oncology Group Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2008-10-184143 [Abstract] [PDF] [Supplemental Appendix]   Tatiana Usenko, You-Jun Li, Mehran Haeri, Yanmei Li, Laura M. Vecchiarelli-Federico, Xiaojun Zhao, Josef T Prchal, and Yaacov Ben-David Enrichment of SCA1 positive hematopoietic progenitors in polycythemic mice inhibits leukemogenesis Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2008-11-187419 [Abstract] [PDF] [Supplemental Results and Figure]   Jumpei Yamazaki, Takuo Mizukami, Kazuya Takizawa, Madoka Kuramitsu, Haruka Momose, Atsuko Masumi, Yasushi Ami, Hideki Hasegawa, William W. Hall, Hajime Tsujimoto, Isao Hamaguchi, and Kazunari Yamaguchi Identification of cancer stem cells in a Tax-transgenic (Tax-Tg) mouse model of adult T- cell leukemia / lymphoma (ATL) Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2008-08-174425 [Abstract] [PDF]   Maike Schwieger, Andrea Schuler, Martin Forster, Afra Engelmann, Michael A. Arnold, Ruud Delwel, Peter J. Valk, Jurgen Lohler, Robert K. Slany, Eric N. Olson, and Carol Stocking Homing and invasiveness of MLL/ENL leukemic cells is regulated by MEF2C Blood First Edition Paper, prepublished online July 7, 2009; DOI 10.1182/blood-2008-05-158196 [Abstract] [PDF]   1 July 2009 Geerte L. Van Sluis, Tatjana M.H. Niers, Charles T. Esmon, Wikky Tigchelaar, Dick J. Richel, Harry R. Buller, Cornelis J.F. Van Noorden, and C. Arnold Spek Endogenous activated protein C limits cancer cell extravasation through sphingosine-1-phosphate receptor 1 mediated vascular endothelial barrier enhancement Blood First Edition Paper, prepublished online July 1, 2009; DOI 10.1182/blood-2009-04-217679 [Abstract] [PDF]   Willem M. Lijfering, Nic J.G.M. Veeger, Saskia Middeldorp, Karly Hamulyak, Martin H. Prins, Harry R. Buller, and Jan van der Meer A lower risk of recurrent venous thrombosis in women compared to men is explained by sex-specific risk factors at time of first venous thrombosis in thrombophilic families Blood First Edition Paper, prepublished online July 1, 2009; DOI 10.1182/blood-2009-04-215418 [Abstract] [PDF]   Anna Rita Migliaccio, Fabrizio Martelli, Maria Verrucci, Massimo Sanchez, Mauro Valeri, Giovanni Migliaccio, Alessandro Maria Vannucchi, Maria Zingariello, Angela Di Baldassarre, Barbara Ghinassi, Rosa Alba Rana, Yvette van Hensbergen, and Willem E Fibbe GATA1 expression driven by the alternative HS2 enhancer in the spleen rescues the hematopoietic failure induced by the hypomorphic GATA1low mutation Blood First Edition Paper, prepublished online July 1, 2009; DOI 10.1182/blood-2009-03-211680 [Abstract] [PDF] [Supplemental Tables and Figures]   Andrew D. Wood, Edwin Chen, Ian J. Donaldson, Shilpa Hattangadi, Karly A. Burke, Mark A. Dawson, Diego Miranda-Saavedra, Harvey F. Lodish, Anthony R. Green, and Berthold Gottgens Id1 promotes expansion and survival of primary erythroid cells and is a target of JAK2V617F-STAT5 signalling Blood First Edition Paper, prepublished online July 1, 2009; DOI 10.1182/blood-2009-02-206573 [Abstract] [PDF] [Supplemental Figures]   Mignon L. Loh, Debbie S. Sakai, Christian Flotho, Michelle Kang, Manfred Fliegauf, Sophie Archambeault, Charles G. Mullighan, Leslie Chen, Eva Bergstraesser, Carlos E. Bueso-Ramos, Peter D. Emanuel, Henrik Hasle, Jean-Pierre Issa, Marry M. van den Heuvel-Eibrink, Franco Locatelli, Jan Stary, Monica Trebo, Marcin Wlodarski, Marco Zecca, Kevin M. Shannon, and Charlotte M. Niemeyer Mutations in CBL occur frequently in juvenile myelomonocytic leukemia Blood First Edition Paper, prepublished online July 1, 2009; DOI 10.1182/blood-2009-01-198416 [Abstract] [PDF] [Supplemental Tables and Figure]   Pablo Ramirez, Michael P Rettig, Geoffrey L Uy, Elena Deych, Matthew S Holt, Julie K Ritchey, and John F DiPersio BIO5192, a small molecule inhibitor of VLA-4, mobilizes hematopoietic stem and progenitor cells Blood First Edition Paper, prepublished online July 1, 2009; DOI 10.1182/blood-2008-10-184721 [Abstract] [PDF] [Supplemental Figures]   Margret S. Fernandes, Mamatha M. Reddy, Jeffrey R. Gonneville, Scott C. DeRoo, Klaus Podar, James D. Griffin, David M. Weinstock, and Martin Sattler BCR-ABL promotes the frequency of mutagenic single strand annealing DNA repair Blood First Edition Paper, prepublished online July 1, 2009; DOI 10.1182/blood-2008-07-172148 [Abstract] [PDF] [Supplemental Figure]   30 June 2009 Elias Jabbour, Daniel Jones, Hagop M. Kantarjian, Susan O'Brien, Constantine Tam, Charles Koller, Jan A. Burger, Gautam Borthakur, William G. Wierda, and Jorge Cortes Long-term outcome of patients with chronic myeloid leukemia treated with second generation tyrosine kinase inhibitors after imatinib failure is predicted by the in vitro sensitivity of BCR-ABL kinase domain mutations Blood First Edition Paper, prepublished online June 30, 2009; DOI 10.1182/blood-2009-01-197715 [Abstract] [PDF]   Makoto Ishii, Haitao Wen, Callie A.S. Corsa, Tianju Liu, Ana L. Coelho, Ronald M. Allen, William F. Carson IV, Karen A. Cavassani, Xiangzhi Li, Nicholas W. Lukacs, Cory M. Hogaboam, Yali Dou, and Steven L. Kunkel Epigenetic regulation of the alternatively activated macrophage phenotype Blood First Edition Paper, prepublished online June 30, 2009; DOI 10.1182/blood-2009-04-217620 [Abstract] [PDF] [Supplemental Figures]   Yoshinori Katayama, Miho Sekai, Masakazu Hattori, Ichiro Miyoshi, Yoko Hamazaki, and Nagahiro Minato Rap signaling is crucial for the competence of IL-7 response and the development of B-lineage cells Blood First Edition Paper, prepublished online June 30, 2009; DOI 10.1182/blood-2009-03-213371 [Abstract] [PDF]   Francois Saller, Anne C. Brisset, Svetlana N. Tchaikovski, Monica Azevedo, Roman Chrast, Jose A. Fernandez, Marc Schapira, Tilman M. Hackeng, John H. Griffin, and Anne Angelillo-Scherrer Generation and phenotypic analysis of protein S-deficient mice Blood First Edition Paper, prepublished online June 30, 2009; DOI 10.1182/blood-2009-03-209031 [Abstract] [PDF]   William A. Anong, Taina Franco, Haiyan Chu, Tahlia L. Weis, Emily E. Devlin, David M. Bodine, Xiuli An, Narla Mohandas, and Philip S. Low Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion Blood First Edition Paper, prepublished online June 30, 2009; DOI 10.1182/blood-2009-02-203216 [Abstract] [PDF] [Supplemental Table and Figures]   29 June 2009 Motohito Okabe, Makoto Otsu, Dong Hyuck Ahn, Toshihiro Kobayashi, Yohei Morita, Yukiko Wakiyama, Masafumi Onodera, Koji Eto, Hideo Ema, and Hiromitsu Nakauchi Definitive proof for direct reprogramming of hematopoietic cells to pluripotency Blood First Edition Paper, prepublished online June 29, 2009; DOI 10.1182/blood-2009-02-203695 [Abstract] [PDF] [Supplemental Methods, Table, and Figures]   Peter L. Greenberg, Zhuoxin Sun, Kenneth B. Miller, John M. Bennett, Martin S. Tallman, Gordon Dewald, Elisabeth Paietta, Richard van der Jagt, Jessie Houston, Mary L. Thomas, David Cella, and Jacob M. Rowe Treatment of myelodysplastic syndromes patients with erythropoietin with or without granulocyte colony-stimulating factor: results of a prospective randomized phase III trial by the Eastern Cooperative Oncology Group (E1996) Blood First Edition Paper, prepublished online June 29, 2009; DOI 10.1182/blood-2009-03-211797 [Abstract] [PDF] [Supplemental Appendix]   Cecile Saint-Martin, Gwendoline Leroy, Francois Delhommeau, Gerard Panelatti, Sabrina Dupont, Chloe James, Isabelle Plo, Dominique Bordessoule, Christine Chomienne, Andre Delannoy, Alain Devidas, Martine Gardembas-Pain, Francoise Isnard, Yves Plumelle, Olivier Bernard, William Vainchenker, Albert Najman, and Christine Bellanne-Chantelot Analysis of the Ten-Eleven Translocation (TET)2 gene in familial myeloproliferative neoplasms Blood First Edition Paper, prepublished online June 29, 2009; DOI 10.1182/blood-2009-01-197525 [Abstract] [PDF] [Supplemental Appendix and Tables]   Malika Oubaha and Jean-Philippe Gratton Phosphorylation of endothelial nitric oxide synthase by atypical PKC contributes to angiopoietin-1-dependent inhibition of VEGF-induced endothelial permeability in vitro Blood First Edition Paper, prepublished online June 29, 2009; DOI 10.1182/blood-2008-12-196584 [Abstract] [PDF] [Supplemental Figures]   Kate Hsu, Naiwen Chi, Marjan Gucek, Jennifer E. Van Eyk, Robert N. Cole, Marie Lin, and D. Brian Foster Miltenberger blood group antigen type III (Mi.III) enhances the expression of band 3 Blood First Edition Paper, prepublished online June 29, 2009; DOI 10.1182/blood-2008-12-195180 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures]   26 June 2009 Shaji Kumar, Sergio Giralt, Edward A. Stadtmauer, Jean L. Harousseau, Antonio Palumbo, William Bensinger, Raymond L. Comenzo, Suzanne Lentzsch, Nikhil Munshi, Ruben Niesvizky, Jesus San Miguel, Heinz Ludwig, Leif Bergsagel, Joan Blade, Sagar Lonial, Kenneth C. Anderson, Patrizia Tosi, Pieter Sonneveld, Orhan Sezer, David Vesole, Michele Cavo, Hermann Einsele, Paul G. Richardson, Brian G.M. Durie, and S. Vincent Rajkumar Mobilization in myeloma revisited: IMWG consensus perspectives on stem cell collection following initial therapy with thalidomide, lenalidomide or bortezomib- containing regimens Blood First Edition Paper, prepublished online June 26, 2009; DOI 10.1182/blood-2009-04-205013 [Abstract] [PDF] [Supplemental Appendix]   Ayten Kandilci and Gerard C. Grosveld Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyper proliferation and restores myeloid differentiation Blood First Edition Paper, prepublished online June 26, 2009; DOI 10.1182/blood-2009-02-205443 [Abstract] [PDF]   Christopher A. Klebanoff, Zhiya Yu, Leroy N. Hwang, Douglas C. Palmer, Luca Gattinoni, and Nicholas P. Restifo Programming tumor-reactive effector memory CD8+ T cells in vitro obviates the requirement for in vivo vaccination Blood First Edition Paper, prepublished online June 26, 2009; DOI 10.1182/blood-2008-12-192419 [Abstract] [PDF] [Supplemental Figure]   Armelle Le Campion, Marie-Claude Gagnerault, Cedric Auffray, Chantal Becourt, Maud Poitrasson-Riviere, Eliette Lallemand, Boris Bienvenu, Bruno Martin, Francoise Lepault, and Bruno Lucas Lymphopenia-induced spontaneous T-cell proliferation as a cofactor for autoimmune disease development Blood First Edition Paper, prepublished online June 26, 2009; DOI 10.1182/blood-2008-12-192120 [Abstract] [PDF] [Supplemental Figures]   Rodrigo T. Calado, William T. Yewdell, Keisha L. Wilkerson, Joshua A. Regal, Sachiko Kajigaya, Constantine A. Stratakis, and Neal S. Young Sex hormones, acting on the TERT gene, increase telomerase activity in human primary hematopoietic cells Blood First Edition Paper, prepublished online June 26, 2009; DOI 10.1182/blood-2008-09-178871 [Abstract] [PDF]   25 June 2009 Aleksandra Rizo, Sandra Olthof, Lina Han, Edo Vellenga, Gerald de Haan, and Jan Jacob Schuringa Repression of BMI1 in normal and leukemic human CD34+ cells impairs self-renewal and induces apoptosis Blood First Edition Paper, prepublished online June 25, 2009; DOI 10.1182/blood-2009-03-209734 [Abstract] [PDF]   Teresa Greenwell-Wild, Nancy Vazquez, Wenwen Jin, Zoila Rangel, Peter Munson, and Sharon M. Wahl IL-27 inhibition of HIV-1 involves an intermediate induction of type I IFN Blood First Edition Paper, prepublished online June 25, 2009; DOI 10.1182/blood-2009-03-211540 [Abstract] [PDF] [Supplemental Table]   Ivan M. Borrello, Hyam I. Levitsky, Wendy Stock, Dorie Sher, Lu Qin, Daniel J. DeAngelo, Edwin P. Alyea, Richard M. Stone, Lloyd E. Damon, Charles A. Linker, Daniel J. Maslyar, and Kristen M. Hege GM-CSF secreting cellular immunotherapy in combination with autologous stem cell transplant (ASCT) as post-remission therapy for acute myeloid leukemia (AML) Blood First Edition Paper, prepublished online June 25, 2009; DOI 10.1182/blood-2009-02-205278 [Abstract] [PDF] [Supplemental Methods, Table, and Figure]   Michele Ghielmini and Emanuele Zucca How I treat mantle cell lymphoma Blood First Edition Paper, prepublished online June 25, 2009; DOI 10.1182/blood-2009-02-179739 [Abstract] [PDF]   24 June 2009 Claudio Graziano, Simona Carone, Emanuele Panza, Flora Marino, Pamela Magini, Giovanni Romeo, Andrea Pession, and Marco Seri Association of hereditary thrombocythemia and distal limb defects with a thrombopoietin gene mutation Blood First Edition Paper, prepublished online June 24, 2009; DOI 10.1182/blood-2009-04-217851 [Abstract] [PDF] [Supplemental Table]   Jeremy Di Domizio, Ariane Blum, Maighread Gallagher-Gambarelli, Jean-Paul Molens, Laurence Chaperot, and Joel Plumas TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN Blood First Edition Paper, prepublished online June 24, 2009; DOI 10.1182/blood-2009-04-216770 [Abstract] [PDF] [Supplemental Figure]   Pau Abrisqueta, Arturo Pereira, Ciril Rozman, Marta Aymerich, Eva Gine, Carol Moreno, Ana Muntanola, Maria Rozman, Neus Villamor, Kate Hodgson, Elias Campo, Francesc Bosch, and Emili Montserrat Improving survival in patients with chronic lymphocytic leukemia (1980-2008): the Hospital Clinic of Barcelona experience Blood First Edition Paper, prepublished online June 24, 2009; DOI 10.1182/blood-2009-04-214346 [Abstract] [PDF] [Supplemental Tables]   Francois Romagne, Pascale Andre, Pieter Spee, Stefan Zahn, Nicolas Anfossi, Laurent Gauthier, Marusca Capanni, Loredana Ruggeri, Don M. Benson Jr., Bradley W. Blaser, Mariella Della Chiesa, Alessandro Moretta, Eric Vivier, Michael A. Caligiuri, Andrea Velardi, and Nicolai Wagtmann Pre-clinical characterization of 1-7F9, a novel human anti-KIR therapeutic antibody that augments NK-mediated killing of tumor cells Blood First Edition Paper, prepublished online June 24, 2009; DOI 10.1182/blood-2009-02-206532 [Abstract] [PDF] [Supplemental Figures]   23 June 2009 Ruth A. Ettinger, Eddie A. James, William W. Kwok, Arthur R. Thompson, and Kathleen P. Pratt Lineages of human T-cell clones, including TH17/TH1 cells, isolated at different stages of anti-factor VIII immune responses Blood First Edition Paper, prepublished online June 23, 2009; DOI 10.1182/blood-2009-01-200725 [Abstract] [PDF] [Supplemental Methods]   Frederikus A. Klok, Inge C.M. Mos, Lisette Broek, Jouke T. Tamsma, Frits R. Rosendaal, Albert de Roos, and Menno V. Huisman Risk of arterial cardiovascular events in patients after pulmonary embolism Blood First Edition Paper, prepublished online June 23, 2009; DOI 10.1182/blood-2009-05-220491 [Abstract] [PDF]   Paola Guglielmelli, Giovanni Barosi, Giorgina Specchia, Alessandro Rambaldi, Francesco Lo Coco, Elisabetta Antonioli, Lisa Pieri, Alessandro Pancrazzi, Vanessa Ponziani, Federica Delaini, Giovanni Longo, Emanuele Ammatuna, Vincenzo Liso, Alberto Bosi, Tiziano Barbui, and Alessandro M. Vannucchi Identification of patients with poorer survival in primary myelofibrosis based on the burden of JAK2V617F mutated allele Blood First Edition Paper, prepublished online June 23, 2009; DOI 10.1182/blood-2009-04-216044 [Abstract] [PDF]   Benedicte Dumont, Dominique Lasne, Chantal Rothschild, Maxime Bouabdelli, Veronique Ollivier, Claire Oudin, Nadine Ajzenberg, Bernard Grandchamp, and Martine Jandrot-Perrus Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations Blood First Edition Paper, prepublished online June 23, 2009; DOI 10.1182/blood-2009-03-213504 [Abstract] [PDF] [Supplemental Methods and Figures]   Barbara Herr, Jie Zhou, Christian Werno, Heidi Menrad, Dmitry Namgaladze, Andreas Weigert, Nathalie Dehne, and Bernhard Brune The supernatant of apoptotic cells causes transcriptional activation of HIF-1 in macrophages via sphingosine-1-phosphate and transforming growth factor- Blood First Edition Paper, prepublished online June 23, 2009; DOI 10.1182/blood-2009-01-201889 [Abstract] [PDF]   22 June 2009 Tamer E. Fandy, James G. Herman, Patrick Kerns, Anchalee Jiemjit, Elizabeth A. Sugar, Si-Ho Choi, Allen S. Yang, Timothy Aucott, Tianna Dauses, Rosalie Odchimar-Reissig, Jonathan Licht, Melanie J. McConnell, Chris Nasrallah, Marianne K.H. Kim, Weijia Zhang, Yezou Sun, Anthony Murgo, Igor Espinoza-Delgado, Katharine Oteiza, Ibitayo Owoeye, Lewis R. Silverman, Steven D. Gore, and Hetty E. Carraway Early epigenetic changes and DNA damage do not predict clinical response in an overlapping schedule of 5-azacytidine and entinostat in patients with myeloid malignancies Blood First Edition Paper, prepublished online June 22, 2009; DOI 10.1182/blood-2009-02-203547 [Abstract] [PDF] [Supplemental Tables and Figure]   Nina S. Kadan-Lottick, Pim Brouwers, David Breiger, Thomas Kaleita, James Dziura, Haibei Liu, Lu Chen, Megan Nicoletti, Linda Stork, Bruce Bostrom, and Joseph P. Neglia A comparison of neurocognitive functioning in children previously randomized to dexamethasone or prednisone in the treatment of childhood acute lymphoblastic leukemia Blood First Edition Paper, prepublished online June 22, 2009; DOI 10.1182/blood-2008-12-186502 [Abstract] [PDF] [Supplemental Appendix]   Manfred Kneilling, Reinhard Mailhammer, Lothar Hultner, Tanja Schonberger, Kerstin Fuchs, Martin Schaller, Daniel Bukala, Steffen Massberg, Christian A. Sander, Heidi Braumuller, Martin Eichner, Konrad L. Maier, Rupert Hallmann, Bernd J. Pichler, Roland Haubner, Meinrad Gawaz, Klaus Pfeffer, Tilo Biedermann, and Martin Rocken Direct crosstalk between mast cell-TNF and TNFR1-expressing endothelia mediates local tissue inflammation Blood First Edition Paper, prepublished online June 22, 2009; DOI 10.1182/blood-2008-11-187682 [Abstract] [PDF] [Supplemental Methods, Figures, and Videos]   Arpita Chakravarti, Marie-Astrid Raquil, Philippe Tessier, and Patrice E. Poubelle Surface RANKL of toll-like receptor 4-stimulated human neutrophils activates osteoclastic bone resorption Blood First Edition Paper, prepublished online June 22, 2009; DOI 10.1182/blood-2008-09-178301 [Abstract] [PDF]   19 June 2009 Christof Geldmacher, Ian S. Metzler, Sodsai Tovanabutra, Tedi E. Asher, Emma Gostick, David R. Ambrozak, Constantinos Petrovas, Alexandra Schuetz, Njabulo Ngwenyama, Gustavo Kijak, Leonard Maboko, Michael Hoelscher, Francine McCutchan, David A. Price, Daniel C. Douek, and Richard A. Koup Minor viral and host genetic polymorphisms can dramatically impact the biological outcome of an epitope-specific CD8 T cell response Blood First Edition Paper, prepublished online June 19, 2009; DOI 10.1182/blood-2009-02-206193 [Abstract] [PDF] [Supplemental Figures]   Chao Niu, Jiwang Zhang, Peter Breslin, Mihaela Onciu, Zhigui Ma, and Stephan Wade Morris c-Myc is a target of Rbm15 in the regulation of adult hematopoietic stem cell and megakaryocyte development Blood First Edition Paper, prepublished online June 19, 2009; DOI 10.1182/blood-2009-01-197921 [Abstract] [PDF] [Supplemental Tables and Figures]   Linda Marie Starnes, Antonio Sorrentino, Elvira Pelosi, Monica Ballarino, Ornella Morsilli, Mauro Biffoni, Simona Santoro, Nadia Felli, Germana Castelli, Maria Laura De Marchis, Gianfranco Mastroberardino, Marco Gabbianelli, Alessandro Fatica, Irene Bozzoni, Clara Nervi, and Cesare Peschle NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls -globin and G-CSF receptor expression Blood First Edition Paper, prepublished online June 19, 2009; DOI 10.1182/blood-2008-12-196196 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures]   18 June 2009 Thomas J. Raife, Wenjing Cao, Bonnie S. Atkinson, Bruce Bedell, Robert R. Montgomery, Steven R. Lentz, George F. Johnson, and X. Long Zheng Leukocyte proteases cleave von Willebrand factor at or near the ADAMTS13 cleavage site Blood First Edition Paper, prepublished online June 18, 2009; DOI 10.1182/blood-2009-01-195461 [Abstract] [PDF]   Jonathan R Lambert, Tamara Everington, David C Linch, and Rosemary E Gale In essential thrombocythemia, multiple JAK2-V617F clones are present in most mutant-positive patients: a new disease paradigm Blood First Edition Paper, prepublished online June 18, 2009; DOI 10.1182/blood-2009-03-209916 [Abstract] [PDF] [Supplemental Methods and Table]   Roberto Alonso, Monica Lopez-Guerra, Ramanda Upshaw, Shanta Bantia, Caroline Smal, Francoise Bontemps, Chantal Manz, Thomas Mehrling, Neus Villamor, Elias Campo, Emili Montserrat, and Dolors Colomer Forodesine has high anti-tumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis via induction of p73 and BIM Blood First Edition Paper, prepublished online June 18, 2009; DOI 10.1182/blood-2009-02-207654 [Abstract] [PDF] [Supplemental Figures]   Yukimasa Shiotsu, Hitoshi Kiyoi, Yuichi Ishikawa, Ryohei Tanizaki, Makiko Shimizu, Hiroshi Umehara, Kenichi Ishii, Yumiko Mori, Kazutaka Ozeki, Yosuke Minami, Akihiro Abe, Hiroshi Maeda, Tadakazu Akiyama, Yutaka Kanda, Yuko Sato, Shiro Akinaga, and Tomoki Naoe KW-2449, a novel multi-kinase inhibitor, suppresses the growth of leukemia cells with FLT3 mutations or T315I-mutated BCR/ABL translocation Blood First Edition Paper, prepublished online June 18, 2009; DOI 10.1182/blood-2009-01-199307 [Abstract] [PDF]   17 June 2009 Surya V. Seshan, Claus-Werner Franzke, Patricia Redecha, Marc Monestier, Nigel Mackman, and Guillermina Girardi Role of tissue factor in a mouse model of thrombotic microangiopathy induced by antiphospholipid (aPL) antibodies Blood First Edition Paper, prepublished online June 17, 2009; DOI 10.1182/blood-2009-01-199117 [Abstract] [PDF]   Naofumi Matsuno, Atsushi Wake, Naoyuki Uchida, Kazuya Ishiwata, Hideki Araoka, Shinsuke Takagi, Masanori Tsuji, Hisashi Yamamoto, Daisuke Kato, Yoshiko Matsuhashi, Sachiko Seo, Kazuhiro Masuoka, Shigesaburo Miyakoshi, Shigeyoshi Makino, Akiko Yoneyama, Yoshinobu Kanda, and Shuichi Taniguchi Impact of HLA disparity in the graft-versus-host direction on engraftment in adult patients receiving reduced-intensity cord blood transplantation Blood First Edition Paper, prepublished online June 17, 2009; DOI 10.1182/blood-2008-12-194696 [Abstract] [PDF]   Martin Stanulla, Elke Schaeffeler, Anja Moricke, Sally A. Coulthard, Gunnar Cario, Andre Schrauder, Peter Kaatsch, Michael Dordelmann, Karl Welte, Martin Zimmermann, Alfred Reiter, Michel Eichelbaum, Hansjorg Riehm, Martin Schrappe, and Matthias Schwab Thiopurine methyltransferase genetics is not a major risk factor for secondary malignant neoplasms after treatment of childhood acute lymphoblastic leukemia on Berlin-Frankfurt-Munster protocols Blood First Edition Paper, prepublished online June 17, 2009; DOI 10.1182/blood-2008-12-193250 [Abstract] [PDF]   16 June 2009 Fionnuala Ni Ainle, Roger J.S. Preston, P. Vincent Jenkins, Hendrik J. Nel, Jennifer A. Johnson, Owen P. Smith, Barry White, Padraic G. Fallon, and James S. O'Donnell Protamine sulphate downregulates thrombin generation by inhibiting factor V activation Blood First Edition Paper, prepublished online June 16, 2009; DOI 10.1182/blood-2009-05-222109 [Abstract] [PDF]   Megan S. Lim, Mary L. Carlson, David K. Crockett, G. Chris Fillmore, David R. Abbott, Olaotan F. Elenitoba-Johnson, Sheryl R. Tripp, George Z. Rassidakis, L. Jeffrey Medeiros, Philippe Szankasi, and Kojo S.J. Elenitoba-Johnson The proteomic signature of NPM/ALK reveals deregulation of multiple cellular pathways Blood First Edition Paper, prepublished online June 16, 2009; DOI 10.1182/blood-2009-02-204735 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures]   Dushyant Verma, Hagop M. Kantarjian, Dan Jones, Rajyalakshmi Luthra, Gautam Borthakur, Srdan Verstovsek, Mary Beth Rios, and Jorge Cortes Chronic myeloid leukemia (CML) with P190BCR-ABL - analysis of characteristics, outcomes and prognostic significance Blood First Edition Paper, prepublished online June 16, 2009; DOI 10.1182/blood-2009-02-204693 [Abstract] [PDF]   Jui-Hung Yen and Doina Ganea Interferon beta induces mature dendritic cell apoptosis through caspase-11 / caspase-3 activation Blood First Edition Paper, prepublished online June 16, 2009; DOI 10.1182/blood-2008-12-196592 [Abstract] [PDF] [Supplemental Methods and Figures]   15 June 2009 Brian V. Balgobind, Susana C. Raimondi, Jochen Harbott, Martin Zimmermann, Todd A. Alonzo, Anne Auvrignon, H. Berna Beverloo, Myron Chang, Ursula Creutzig, Michael N. Dworzak, Erik Forestier, Brenda Gibson, Henrik Hasle, Christine J. Harrison, Nyla A. Heerema, Gertjan J.L. Kaspers, Anna Leszl, Nathalia Litvinko, Luca Lo Nigro, Akira Morimoto, Christine Perot, Rob Pieters, Dirk Reinhardt, Jeffrey E. Rubnitz, Franklin O. Smith, Jan Stary, Irina Stasevich, Sabine Strehl, Takashi Taga, Daisuke Tomizawa, David Webb, Zuzana Zemanova, C. Michel Zwaan, and Marry M. van den Heuvel-Eibrink Novel prognostic subgroups in childhood 11q23/MLL-rearranged acute myeloid leukemia: results of an international retrospective study Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2009-04-215152 [Abstract] [PDF] [Supplemental Appendices and Tables]   Zhenquan Wei, Yahui Yan, Robin W Carrell, and Aiwu Zhou Crystal structure of protein Z-dependent inhibitor complex shows how protein Z functions as a cofactor in the membrane inhibition of factor X Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2009-04-210021 [Abstract] [PDF] [Supplemental Figures]   Karin Wahlberg, Jie Jiang, Helen Rooks, Kiran Jawaid, Fumihiko Matsuda, Masao Yamaguchi, Mark Lathrop, Swee Lay Thein, and Steve Best The HBS1L-MYB intergenic interval associated with elevated HbF levels shows characteristics of a distal regulatory region in erythroid cells Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2009-03-210146 [Abstract] [PDF] [Supplemental Methods, Table, and Figures]   Stefan Heinen, Andrea Hartmann, Nadine Lauer, Ulrike Wiehl, Hans-Martin Dahse, Sylvia Schirmer, Katharina Gropp, Tina Enghardt, Reinhard Wallich, Steffi Halbich, Michael Mihlan, Ursula Schlotzer-Schrehardt, Peter F. Zipfel, and Christine Skerka Factor H related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2009-02-205641 [Abstract] [PDF] [Supplemental Methods and Figures]   Michael A. Pulsipher, Kenneth M. Boucher, Donna Wall, Haydar Frangoul, Michel Duval, Rakesh K. Goyal, Peter J. Shaw, Ann E. Haight, Michael Grimley, Stephan A. Grupp, Morris Kletzel, and Richard Kadota Reduced intensity allogeneic transplantation in pediatric patients ineligible for myeloablative therapy: results of the Pediatric Blood and Marrow Transplant Consortium (PBMTC) study ONC0313 Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2009-01-196303 [Abstract] [PDF] [Supplemental Appendix]   Mariko Yoshizaki, Aya Tazawa, Eiji Kasumi, Shigemi Sasawatari, Kenji Itoh, Taeko Dohi, Takehiko Sasazuki, Kayo Inaba, Andrew P. Makrigiannis, and Noriko Toyama-Sorimachi Spatiotemporal regulation of intracellular trafficking of TLR9 by an inhibitory receptor, Ly49Q Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2008-12-192344 [Abstract] [PDF] [Supplemental Figures]   Shella Saint Fleur, Akemi Hoshino, Kimie Kondo, Takeshi Egawa, and Hodaka Fujii Regulation of Fas-mediated immune homeostasis by an activation-induced protein, Cyclon Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2008-11-189118 [Abstract] [PDF] [Supplemental Methods and Figures] [Additional Supplemental Figures]   Olga Neumuller, Meike Hoffmeister, Jan Babica, Carola Prelle, Kristina Gegenbauer, and Albert P. Smolenski Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets Blood First Edition Paper, prepublished online June 15, 2009; DOI 10.1182/blood-2008-05-155234 [Abstract] [PDF]   12 June 2009 Anders Malarstig, Alfonso Buil, Juan Carlos Souto, Robert Clarke, Francisco Blanco-Vaca, Jordi Fontcuberta, John Peden, Malin Andersen, Angela Silveira, Simona Barlera, Udo Seedorf, Hugh Watkins, Laura Almasy, Anders Hamsten, and Jose Manuel Soria Identification of ZNF366 and PTPRD as novel determinants of plasma homocysteine in a family-based genome-wide association study Blood First Edition Paper, prepublished online June 12, 2009; DOI 10.1182/blood-2009-04-215269 [Abstract] [PDF] [Supplemental Appendices and Tables]   Maxime Desmarets, Chantel M. Cadwell, Kenneth R. Peterson, Renee Neades, and James C. Zimring Minor histocompatibility antigens on transfused leukoreduced units of red blood cells induce bone marrow transplant rejection in a mouse model Blood First Edition Paper, prepublished online June 12, 2009; DOI 10.1182/blood-2009-04-214387 [Abstract] [PDF]   Claire Dunois-Larde, Claude Capron, Serge Fichelson, Thomas Bauer, Elisabeth Cramer-Borde, and Dominique Baruch Exposure of human megakaryocytes to high shear rates accelerates platelet production Blood First Edition Paper, prepublished online June 12, 2009; DOI 10.1182/blood-2009-03-209205 [Abstract] [PDF] [Supplemental Videos]   11 June 2009 Antje Hoering, John Crowley, John D. Shaughnessy Jr, Klaus Hollmig, Yazan Alsayed, Jackie Szymonifka, Sarah Waheed, Bijay Nair, Frits van Rhee, Elias Anaissie, and Bart Barlogie Complete remission in multiple myeloma examined as time-dependent variable in terms of both onset and duration in total therapy protocols Blood First Edition Paper, prepublished online June 11, 2009; DOI 10.1182/blood-2009-03-211953 [Abstract] [PDF]   Stefan Costinean, Sukhinder K. Sandhu, Irene M. Pedersen, Esmerina Tili, Rossana Trotta, Danilo Perrotti, David Ciarlariello, Paolo Neviani, Jason Harb, Lauren Rachel Kauffman, Aaditya Shidham, and Carlo Maria Croce Ship and C/ebp are targeted by miR-155 in B cells of Eµ-miR-155 transgenic mice Blood First Edition Paper, prepublished online June 11, 2009; DOI 10.1182/blood-2009-05-220814 [Abstract] [PDF] [Supplemental Figures]   Anne Louise Sorensen, Viktoria Rumjantseva, Sara Nayeb-Hashemi, Henrik Clausen, John H. Hartwig, Hans H. Wandall, and Karin M. Hoffmeister Role of sialic acid for platelet lifespan: exposure of galactose results in the rapid clearance of platelets from the circulation by asialoglycoprotein receptor-expressing liver macrophages and hepatocytes Blood First Edition Paper, prepublished online June 11, 2009; DOI 10.1182/blood-2009-01-199414 [Abstract] [PDF]   Jean-Luc Harousseau, Giovanni Martinelli, Wieslaw W. Jedrzejczak, Joseph M. Brandwein, Dominique Bordessoule, Tamas Masszi, Gert J. Ossenkoppele, Julia A. Alexeeva, Gernot Beutel, Johan Maertens, Maria-Belen Vidriales, Herve Dombret, Xavier Thomas, Alan K. Burnett, Tadeusz Robak, Nuriet K. Khuageva, Anatoly K. Golenkov, Elena Tothova, Lars Mollgard, Youn C. Park, Annick Bessems, Peter De Porre, and Angela J. Howes A randomized phase 3 study of tipifarnib compared to best supportive care, including hydroxyurea, in the treatment of newly diagnosed acute myeloid leukemia (AML) in patients 70 years or older Blood First Edition Paper, prepublished online June 11, 2009; DOI 10.1182/blood-2009-01-198093 [Abstract] [PDF] [Supplemental Appendix]   Manik C. Ghosh, Gary D. Collins, Bolormaa Vandanmagsar, Kalpesh Patel, Margaret Brill, Arnell Carter, Ana Lustig, Kevin G. Becker, William W. Wood III, Chineye D. Emeche, Amanda D. French, Michael P. O'Connell, Mai Xu, Ashani T. Weeraratna, and Dennis D. Taub Activation of Wnt5A signaling is required for CXCL12-mediated T-cell migration Blood First Edition Paper, prepublished online June 11, 2009; DOI 10.1182/blood-2008-08-175869 [Abstract] [PDF] [Supplemental Figure]   10 June 2009 Andrew J. Steele, Archibald G. Prentice, A. Victor Hoffbrand, Birunthini C. Yogashangary, Stephen M. Hart, Mark W. Lowdell, Edward R. Samuel, Janet M. North, Elisabeth P. Nacheva, Anastasios Chanalaris, Panagiotis Kottaridis, Kate Cwynarski, and R. Gitendra Wickremasinghe 2-phenylacetylenesulfonamide (PAS) induces p53-independent apoptotic killing of B-chronic lymphocytic leukemia (CLL) cells Blood First Edition Paper, prepublished online June 10, 2009; DOI 10.1182/blood-2008-11-190587 [Abstract] [PDF] [Supplemental Table and Figures]   Ulrike Nowak-Gottl, Hartmut Weiler, Irene Hernandez, Sabine Thedieck, Tanja Seehafer, Thomas Schulte, and Monika Stoll Fibrinogen alpha and gamma genes and factor VLeiden in children with thromboembolism: results from two family-based association studies Blood First Edition Paper, prepublished online June 10, 2009; DOI 10.1182/blood-2009-04-218727 [Abstract] [PDF]   Damian J. Green, John M. Pagel, Eneida R. Nemecek, Yukang Lin, Aimee Kenoyer, Anastasia Pantelias, Donald K. Hamlin, D. Scott Wilbur, Darrell R. Fisher, Joseph G. Rajendran, Ajay K. Gopal, Steven I. Park, and Oliver W. Press Pretargeting CD45 enhances the selective delivery of radiation to hematolymphoid tissues in nonhuman primates Blood First Edition Paper, prepublished online June 10, 2009; DOI 10.1182/blood-2009-03-210344 [Abstract] [PDF]   Ilaria Canobbio, Lucia Stefanini, Lina Cipolla, Elisa Ciraolo, Cristian Gruppi, Cesare Balduini, Emilio Hirsch, and Mauro Torti Genetic evidence for a predominant role of PI3K catalytic activity in ITAM- and integrin-mediated signaling in platelets Blood First Edition Paper, prepublished online June 10, 2009; DOI 10.1182/blood-2009-03-208074 [Abstract] [PDF] [Supplemental Figure]   Roberto Crocchiolo, Elisabetta Zino, Luca Vago, Rosi Oneto, Barbara Bruno, Simona Pollichieni, Nicoletta Sacchi, Maria Pia Sormani, Jessica Marcon, Teresa Lamparelli, Renato Fanin, Lucia Garbarino, Valeria Miotti, Giuseppe Bandini, Alberto Bosi, Fabio Ciceri, Andrea Bacigalupo, and Katharina Fleischhauer Non-permissive HLA-DPB1 disparity is a significant independent risk factor for mortality after unrelated hematopoietic stem cell transplantation Blood First Edition Paper, prepublished online June 10, 2009; DOI 10.1182/blood-2009-01-200378 [Abstract] [PDF] [Supplemental Appendix]   Marc Ansari, Geraldine Sauty, Malgorzata Labuda, Vincent Gagne, Caroline Laverdiere, Albert Moghrabi, Daniel Sinnett, and Maja Krajinovic Polymorphisms in multidrug resistance-associated protein gene 4 is associated with outcome in childhood acute lymphoblastic leukemia Blood First Edition Paper, prepublished online June 10, 2009; DOI 10.1182/blood-2008-11-191098 [Abstract] [PDF] [Supplemental Tables and Figures]   8 June 2009 Kimberly Syres, Frank Harrison, Matthew Tadlock, James V. Jester, Jennifer Simpson, Subhojit Roy, Daniel R. Salomon, and Stephanie Cherqui Successful treatment of the murine model of cystinosis using bone marrow cell transplantation Blood First Edition Paper, prepublished online June 8, 2009; DOI 10.1182/blood-2009-03-213934 [Abstract] [PDF]   Mingqiang Ren, Xiurong Li, and John K Cowell Genetic fingerprinting of the development and progression of T-cell lymphoma in a murine model of atypical myeloproliferative disorder initiated by the ZNF198-FGFR1 chimeric tyrosine kinase Blood First Edition Paper, prepublished online June 8, 2009; DOI 10.1182/blood-2009-03-212704 [Abstract] [PDF] [Supplemental Tables and Figure]   Astrid G.S. van Halteren, Ewa Jankowska-Gan, Antoinette Joosten, Els Blokland, Jos Pool, Anneke Brand, William J. Burlingham, and Els Goulmy Naturally acquired tolerance and sensitization to minor histocompatibility antigens in healthy family members Blood First Edition Paper, prepublished online June 8, 2009; DOI 10.1182/blood-2009-01-200410 [Abstract] [PDF]   Esther S. Shao, Laura Lin, Yucheng Yao, and Kristina I. Bostrom Expression of vascular endothelial growth factor is coordinately regulated by the activin-like kinase receptors 1 and 5 in endothelial cells Blood First Edition Paper, prepublished online June 8, 2009; DOI 10.1182/blood-2009-01-199166 [Abstract] [PDF] [Supplemental Figures]   Pengcheng Zhu, Denis Martinvalet, Dipanjan Chowdhury, Dong Zhang, Ann Schlesinger, and Judy Lieberman The CTL protease granzyme A cleaves and inactivates PARP-1 Blood First Edition Paper, prepublished online June 8, 2009; DOI 10.1182/blood-2008-12-195768 [Abstract] [PDF] [Supplemental Methods and Figures]   Federico Mingozzi, Janneke J. Meulenberg, Daniel J. Hui, Etiena Basner-Tschakarjan, Nicole C. Hasbrouck, Shyrie A. Edmonson, Natalie A. Hutnick, Michael R. Betts, John J. Kastelein, Erik S. Stroes, and Katherine A. High AAV-1-mediated gene transfer to skeletal muscle in humans results in dose-dependent activation of capsid-specific T cells Blood First Edition Paper, prepublished online June 8, 2009; DOI 10.1182/blood-2008-07-167510 [Abstract] [PDF] [Supplemental Tables and Figures]   4 June 2009 Donna E. Reece, Vaishali Sanchorawala, Ute Hegenbart, Giampaolo Merlini, Giovanni Palladini, Jean-Paul Fermand, Robert A. Vescio, Xiangyang Liu, Yusri A. Elsayed, Andrew Cakana, and Raymond L. Comenzo Weekly and twice-weekly bortezomib in patients with systemic AL-amyloidosis: results of a phase 1 dose-escalation study Blood First Edition Paper, prepublished online June 4, 2009; DOI 10.1182/blood-2009-02-203398 [Abstract] [PDF] [Supplemental Appendix]   Bhawna Poonia, Maria S. Salvato, Hideo Yagita, Toshihiro Maeda, Ko Okumura, and C. David Pauza Treatment with anti-FasL antibody preserves memory lymphocytes and virus-specific cellular immunity in macaques challenged with simian immunodeficiency virus Blood First Edition Paper, prepublished online June 4, 2009; DOI 10.1182/blood-2009-02-202655 [Abstract] [PDF]   Alexander Claviez, Carme Canals, Daan Dierickx, Jerry Stein, Isabel Badell, Andrea Pession, Stephen Mackinnon, Shimon Slavin, Jean-Hugues Dalle, Manuel Jurado Chacon, Mahmoud Sarhan, Robert Francis Wynn, Meinolf Suttorp, Giorgio Dini, Anna Sureda, and Norbert Schmitz Allogeneic hematopoietic stem cell transplantation in children and adolescents with recurrent and refractory Hodgkin's lymphoma: an analysis of the European Group for Blood and Marrow Transplantation Blood First Edition Paper, prepublished online June 4, 2009; DOI 10.1182/blood-2008-11-189399 [Abstract] [PDF] [Supplemental Appendix]   3 June 2009 Francesco Annunziato and Sergio Romagnani Do studies in humans better depict Th17 cells? Blood First Edition Paper, prepublished online June 3, 2009; DOI 10.1182/blood-2009-03-209189 [Abstract] [PDF]   Gregg L. Semenza Involvement of oxygen-sensing pathways in physiological and pathological erythropoiesis Blood First Edition Paper, prepublished online June 3, 2009; DOI 10.1182/blood-2009-05-189985 [Abstract] [PDF]   Gholamreza Anani Sarab, Michael Moss, Robert N. Barker, and Stanislaw J. Urbaniak Naturally processed peptides spanning the HPA-1a polymorphism are efficiently generated and displayed from platelet glycoprotein by HLA-DRB3*0101 positive antigen presenting cells Blood First Edition Paper, prepublished online June 3, 2009; DOI 10.1182/blood-2009-04-211839 [Abstract] [PDF]   Marie-Pierre Gratacap, Valerie Martin, Marie-Cecile Valera, Sophie Allart, Cedric Garcia, Pierre Sie, Christian Recher, and Bernard Payrastre The new tyrosine-kinase inhibitor and anti-cancer drug dasatinib reversibly affects platelet activation in vitro and in vivo Blood First Edition Paper, prepublished online June 3, 2009; DOI 10.1182/blood-2009-02-205328 [Abstract] [PDF] [Supplemental Figures]   Valeria Tosello, Marc R. Mansour, Kelly Barnes, Maddalena Paganin, Maria Luisa Sulis, Sarah Jenkinson, Christopher G. Allen, Rosemary E. Gale, David C. Linch, Teresa Palomero, Pedro Real, Vundavalli Murty, Xiaopan Yao, Susan M. Richards, Anthony Goldstone, Jacob Rowe, Giuseppe Basso, Peter H. Wiernik, Elisabeth Paietta, Rob Pieters, Martin Horstmann, Jules P.P. Meijerink, and Adolfo Ferrando WT1 mutations in T-ALL Blood First Edition Paper, prepublished online June 3, 2009; DOI 10.1182/blood-2008-12-192039 [Abstract] [PDF] [Supplemental Appendices and Tables]   Mohamed Nejmeddine, Veera S. Negi, Sohini Mukherjee, Yuetsu Tanaka, Kim Orth, Graham P. Taylor, and Charles R.M. Bangham HTLV-1-Tax and ICAM-1 act on T-cell signal pathways to polarize the MTOC at the virological synapse Blood First Edition Paper, prepublished online June 3, 2009; DOI 10.1182/blood-2008-03-136770 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures]   2 June 2009 Maite P. Quiroga, Kumudha Balakrishnan, Antonina V. Kurtova, Mariela Sivina, Michael J. Keating, William G. Wierda, Varsha Gandhi, and Jan A. Burger B cell antigen receptor signaling enhances chronic lymphocytic leukemia cell migration and survival: specific targeting with a novel Syk inhibitor, R406 Blood First Edition Paper, prepublished online June 2, 2009; DOI 10.1182/blood-2009-03-212837 [Abstract] [PDF] [Supplemental Tables and Figures]   Stella T. Chou, Eugene Khandros, L. Charles Bailey, Kim E. Nichols, Christopher Vakoc, Yu Yao, Zan Huang, John D. Crispino, Ross C. Hardison, Gerd A. Blobel, and Mitchell J. Weiss Graded repression of PU.1/Sfpi1 gene transcription by GATA factors regulates hematopoietic cell fate Blood First Edition Paper, prepublished online June 2, 2009; DOI 10.1182/blood-2009-03-207944 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures]   Chongyun Fang, Xinhua Zhang, Takashi Miwa, and Wen-Chao Song Complement promotes the development of inflammatory Th17 cells through synergistic interaction with TLR signaling and IL-6 production Blood First Edition Paper, prepublished online June 2, 2009; DOI 10.1182/blood-2009-01-198283 [Abstract] [PDF]   Xiao Chen, Rupali Das, Richard Komorowski, Amy Beres, Martin J. Hessner, Masahiko Mihara, and William R. Drobyski Blockade of interleukin-6 signaling augments regulatory T cell reconstitution and attenuates the severity of graft versus host disease Blood First Edition Paper, prepublished online June 2, 2009; DOI 10.1182/blood-2009-01-197178 [Abstract] [PDF]   Patrick W. Oakes, Dipan C. Patel, Nicole A. Morin, Daniel P. Zitterbart, Ben Fabry, Jonathan S. Reichner, and Jay X. Tang Neutrophil morphology and migration are affected by substrate elasticity Blood First Edition Paper, prepublished online June 2, 2009; DOI 10.1182/blood-2008-11-191445 [Abstract] [PDF] [Supplemental Methods, Table, Figure, and Videos]   Geneve Awong, Elaine Herer, Charles D. Surh, John E. Dick, Ross N. La Motte-Mohs, and Juan Carlos Zuniga-Pflucker Characterization in vitro and engraftment potential in vivo of human progenitor T-cells generated from hematopoietic stem cells Blood First Edition Paper, prepublished online June 2, 2009; DOI 10.1182/blood-2008-10-187013 [Abstract] [PDF] [Supplemental Methods and Figures]   1 June 2009 Jeffrey McCullough, David McKenna, Diane Kadidlo, David Maurer, Harriett J. Noreen, Kathy French, Claudio Brunstein, and John E. Wagner Mislabeled units of umbilical cord blood detected by a quality assurance program at the transplant center Blood First Edition Paper, prepublished online June 1, 2009; DOI 10.1182/blood-2009-02-205047 [Abstract] [PDF]   29 May 2009 Sarah L. Siggins, Nhu-Y N. Nguyen, Matthew P. McCormack, Sumitha Vasudevan, Rehan Villani, Stephen M. Jane, Brandon J. Wainwright, and David J. Curtis The hedgehog receptor Patched1 regulates myeloid and lymphoid progenitors by distinct cell-extrinsic mechanisms Blood First Edition Paper, prepublished online May 29, 2009; DOI 10.1182/blood-2009-03-208330 [Abstract] [PDF] [Supplemental Table and Figures]   Jianmin Ding, Hirokazu Komatsu, Shinsuke Iida, Hiroki Yano, Shigeru Kusumoto, Atsushi Inagaki, Fumiko Mori, Masaki Ri, Asahi Ito, Atsushi Wakita, Takashi Ishida, Masakazu Nitta, and Ryuzo Ueda The Asn505 mutation of c-MPL gene, which causes familial essential thrombocythemia, induces autonomous homodimerization of the c-Mpl protein due to strong amino acid polarity Blood First Edition Paper, prepublished online May 29, 2009; DOI 10.1182/blood-2008-04-149047 [Abstract] [PDF] [Supplemental Table]   28 May 2009 Roland E. Kalin, Nadja E. Banziger-Tobler, Michael Detmar, and Andre W. Brandli An in vivo chemical library screen in Xenopus tadpoles reveals novel pathways involved in angiogenesis and lymphangiogenesis Blood First Edition Paper, prepublished online May 28, 2009; DOI 10.1182/blood-2009-03-211771 [Abstract] [PDF] [Supplemental Methods, Tables, and Figure]   Ahmad Zaheen, Bryant Boulianne, Jahan-Yar Parsa, Shaliny Ramachandran, Jennifer L. Gommerman, and Alberto Martin AID constrains germinal center size by rendering B cells susceptible to apoptosis Blood First Edition Paper, prepublished online May 28, 2009; DOI 10.1182/blood-2009-03-211763 [Abstract] [PDF] [Supplemental Figure]   Hyung Chan Suh, Ming Ji, John Gooya, Michael Lee, Kimberly D. Klarmann, and Jonathan R. Keller Cell non-autonomous function of Id1 in the hematopoietic progenitor cell niche Blood First Edition Paper, prepublished online May 28, 2009; DOI 10.1182/blood-2008-09-179788 [Abstract] [PDF]   Olena Klimchenko, Marcella Mori, Antonio DiStefano, Thierry Langlois, Frederic Larbret, Yann Lecluse, Olivier Feraud, William Vainchenker, Francoise Norol, and Najet Debili A common bipotent progenitor generates the erythroid and megakaryocyte lineages in embryonic stem cell- derived primitive hematopoiesis Blood First Edition Paper, prepublished online May 28, 2009; DOI 10.1182/blood-2008-09-178863 [Abstract] [PDF] [Supplemental Table and Figures]   27 May 2009 Ajay Perumbeti, Tomoyasu Higashimoto, Fabrizia Urbinati, Robert Franco, Herbert J. Meiselman, David Witte, and Punam Malik A novel human gamma-globin gene vector for genetic correction of sickle cell anemia in a humanized sickle mouse model: critical determinants for successful correction Blood First Edition Paper, prepublished online May 27, 2009; DOI 10.1182/blood-2009-01-201863 [Abstract] [PDF]   Francesco Rodeghiero, Giancarlo Castaman, and Alberto Tosetto How we treat von Willebrand disease Blood First Edition Paper, prepublished online May 27, 2009; DOI 10.1182/blood-2009-01-153296 [Abstract] [PDF]   26 May 2009 Thierry VandenDriessche, Zoltan Ivics, Zsuzsanna Izsvak, and Marinee K.L. Chuah Emerging potential of transposons for gene therapy and generation of induced pluripotent stem cells Blood First Edition Paper, prepublished online May 26, 2009; DOI 10.1182/blood-2009-04-210427 [Abstract] [PDF]   Christian S. Hinrichs, Andrew Kaiser, Chrystal M. Paulos, Lydie Cassard, Luis Sanchez-Perez, Bianca Heemskerk, Claudia Wrzesinski, Zachary A. Borman, Pawel Muranski, and Nicholas P. Restifo Type 17 CD8+ T cells display enhanced anti-tumor immunity Blood First Edition Paper, prepublished online May 26, 2009; DOI 10.1182/blood-2009-02-203935 [Abstract] [PDF]   Ellen Leich, Itziar Salaverria, Silvia Bea, Andreas Zettl, George Wright, Victor Moreno, Randy D. Gascoyne, Wing-Chung Chan, Rita M. Braziel, Lisa M. Rimsza, Dennis D. Weisenburger, Jan Delabie, Elaine S. Jaffe, Andrew Lister, Jude Fitzgibbon, Louis M. Staudt, Elena M. Hartmann, Hans-Konrad Mueller-Hermelink, Elias Campo, German Ott, and Andreas Rosenwald Follicular lymphomas with and without translocation t(14;18) differ in gene expression profiles and genetic alterations Blood First Edition Paper, prepublished online May 26, 2009; DOI 10.1182/blood-2009-01-198580 [Abstract] [PDF]   Paul Richardson, Sundar Jagannath, Mohamad Hussein, James Berenson, Seema Singhal, David Irwin, Stephanie F. Williams, William Bensinger, Ashraf Z. Badros, Robert Vescio, Laurie Kenvin, Zhinuan Yu, Marta Olesnyckyj, Jerome Zeldis, Robert Knight, and Kenneth C. Anderson Safety and efficacy of single-agent lenalidomide in patients with relapsed and refractory multiple myeloma Blood First Edition Paper, prepublished online May 26, 2009; DOI 10.1182/blood-2008-12-196238 [Abstract] [PDF]   Donald J. McCrann, Alexia Eliades, Maria Makitalo, Kuniharu Matsuno, and Katya Ravid Differential expression of NADPH oxidases in megakaryocytes and their role in polyploidy Blood First Edition Paper, prepublished online May 26, 2009; DOI 10.1182/blood-2008-12-195883 [Abstract] [PDF] [Supplemental Table and Figures]   22 May 2009 Elisabetta Trifiro, Shirley A. Williams, Yann Cheli, Kenichi Furihata, Fabio M. Pulcinelli, Diane J. Nugent, and Thomas J. Kunicki The low frequency isoform of platelet GPVI (GPVIb) attenuates ligand-mediated signal transduction but not receptor expression or ligand binding Blood First Edition Paper, prepublished online May 22, 2009; DOI 10.1182/blood-2009-03-209510 [Abstract] [PDF]   Dior Kingston, Michael A. Schmid, Nobuyuki Onai, Aya Obata-Onai, Dirk Baumjohann, and Markus G. Manz The concerted action of GM-CSF and Flt3-ligand on in vivo dendritic cell homeostasis Blood First Edition Paper, prepublished online May 22, 2009; DOI 10.1182/blood-2009-02-206318 [Abstract] [PDF] [Supplemental Tables and Figures]   Manuela Del Corno, Alessandro Michienzi, Andrea Masotti, Letizia Da Sacco, Gian Franco Bottazzo, Filippo Belardelli, and Sandra Gessani CCL2 down-modulation by selected TLR agonist combinations contributes to Th1 polarization in human dendritic cells Blood First Edition Paper, prepublished online May 22, 2009; DOI 10.1182/blood-2009-01-199406 [Abstract] [PDF]   Tong-Young Lee, Stefan Muschal, Elke A. Pravda, Judah Folkman, Amir Abdollahi, and Kashi Javaherian Angiostatin regulates the expression of antiangiogenic and pro-apoptotic pathways via targeted inhibition of mitochondrial proteins Blood First Edition Paper, prepublished online May 22, 2009; DOI 10.1182/blood-2008-12-197236 [Abstract] [PDF]   David J. Chung, Marco Rossi, Emanuela Romano, Jennifer Ghith, Jianda Yuan, David H. Munn, and James W. Young Indoleamine 2,3-dioxygenase-expressing mature human monocyte-derived dendritic cells expand potent autologous regulatory T cells Blood First Edition Paper, prepublished online May 22, 2009; DOI 10.1182/blood-2008-11-191197 [Abstract] [PDF]   21 May 2009 Afonso C. Vigorito, Paulo V. Campregher, Barry E. Storer, Paul A. Carpenter, Carina K. Moravec, Hans-Peter Kiem, Matthew L. Fero, Edus H. Warren, Stephanie J. Lee, Frederick R. Appelbaum, Paul J. Martin, and Mary E.D. Flowers Evaluation of NIH consensus criteria for classification of late acute and chronic GVHD Blood First Edition Paper, prepublished online May 21, 2009; DOI 10.1182/blood-2009-03-208983 [Abstract] [PDF]   Ilona Kryczek, Mousumi Banerjee, Pui Cheng, Linhua Vatan, Wojciech Szeliga, Shuang Wei, Emina Huang, Emily Finlayson, Diane Simeone, Theodore H. Welling, Alfred Chang, George Coukos, Rebecca Liu, and Weiping Zou Phenotype, distribution, generation, functional and clinical relevance of Th17 cells in the human tumor environments Blood First Edition Paper, prepublished online May 21, 2009; DOI 10.1182/blood-2009-03-208249 [Abstract] [PDF] [Supplemental Table and Figures] [Additional Supplemental Figures]   Ali Ramezani and Robert G. Hawley Correction of murine hemophilia A following nonmyeloablative transplantation of hematopoietic stem cells engineered to encode an enhanced human factor VIII variant using a safety-augmented retroviral vector Blood First Edition Paper, prepublished online May 21, 2009; DOI 10.1182/blood-2009-01-199653 [Abstract] [PDF] [Supplemental Methods and Figures]   20 May 2009 Steven L. Highfill, Ryan M. Kelly, Matthew J. O'Shaughnessy, Qing Zhou, Lily Xia, Angela Panoskaltsis-Mortari, Patricia A. Taylor, Jakub Tolar, and Bruce R. Blazar Multipotent adult progenitor cells (MAPC) can suppress graft-versus-host disease via prostaglandin E2 synthesis and only if localized to sites of allopriming Blood First Edition Paper, prepublished online May 20, 2009; DOI 10.1182/blood-2009-03-213850 [Abstract] [PDF] [Supplemental Figures]   Hideto Matsui, Masaru Shibata, Brian Brown, Andrea Labelle, Carol Hegadorn, Chandler Andrews, Marinee Chuah, Thierry VandenDriessche, Carol H Miao, Christine Hough, and David Lillicrap A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells Blood First Edition Paper, prepublished online May 20, 2009; DOI 10.1182/blood-2009-03-202267 [Abstract] [PDF]   Alejandro Gutierrez, Takaomi Sanda, Ruta Grebliunaite, Arkaitz Carracedo, Leonardo Salmena, Yebin Ahn, Suzanne Dahlberg, Donna Neuberg, Lisa A. Moreau, Stuart S. Winter, Richard Larson, Jianhua Zhang, Alexei Protopopov, Lynda Chin, Pier Paolo Pandolfi, Lewis B. Silverman, Stephen P. Hunger, Stephen E. Sallan, and A. Thomas Look High frequency of PTEN, PI3K and AKT abnormalities in T cell acute lymphoblastic leukemia Blood First Edition Paper, prepublished online May 20, 2009; DOI 10.1182/blood-2009-02-206722 [Abstract] [PDF] [Supplemental Methods, Appendices, and Table]   Siqing Wang, Guido Tricot, Lei Shi, Wei Xiong, Zhaoyang Zeng, Hongwei Xu, Maurizio Zangari, Bart Barlogie, John D. Shaughnessy Jr, and Fenghuang Zhan RAR2 expression is associated with disease progression and plays a crucial role in efficacy of ATRA treatment in myeloma Blood First Edition Paper, prepublished online May 20, 2009; DOI 10.1182/blood-2008-12-194126 [Abstract] [PDF] [Supplemental Tables]   Annelies G Renner, Cedric Dos Santos, Christian Recher, Christian Bailly, Laurent Creancier, Anna Kruczynski, Bernard Payrastre, and Stephane Manenti Polo-like kinase 1 is over-expressed in acute myeloid leukemia and its inhibition preferentially targets the proliferation of leukemic cells Blood First Edition Paper, prepublished online May 20, 2009; DOI 10.1182/blood-2008-12-195867 [Abstract] [PDF] [Supplemental Table and Figures]   Jerome Tamburini, Alexa S. Green, Valerie Bardet, Nicolas Chapuis, Sophie Park, Lise Willems, Madalina Uzunov, Norbert Ifrah, Francois Dreyfus, Catherine Lacombe, Patrick Mayeux, and Didier Bouscary Protein synthesis is resistant to rapamycin and constitutes a promising therapeutic target in acute myeloid leukemia Blood First Edition Paper, prepublished online May 20, 2009; DOI 10.1182/blood-2008-10-184515 [Abstract] [PDF] [Supplemental Appendix and Figures]   Justin Wray, Elizabeth A. Williamson, Sheema Sheema, Suk-Hee Lee, Edward Libby, Cheryl L. Willman, Jac A. Nickoloff, and Robert Hromas Metnase mediates chromosome decatenation in acute leukemia cells Blood First Edition Paper, prepublished online May 20, 2009; DOI 10.1182/blood-2008-08-175760 [Abstract] [PDF] [Supplemental Figures]   19 May 2009 Hsin-Yu Fang, Russell Hughes, Craig Murdoch, Seth B. Coffelt, Subhra K. Biswas, Adrian L. Harris, Randall S. Johnson, Hongxia Z. Imityaz, M. Celeste Simon, Erik Fredlund, Florian R. Greten, Jordi Rius, and Claire E. Lewis Hypoxia inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia Blood First Edition Paper, prepublished online May 19, 2009; DOI 10.1182/blood-2008-12-195941 [Abstract] [PDF]   18 May 2009 Laura A Johnson, Richard A Morgan, Mark E Dudley, Lydie Cassard, James C Yang, Marybeth S Hughes, Udai S Kammula, Richard E Royal, Richard M Sherry, John R Wunderlich, Chyi-Chia R Lee, Nicholas P Restifo, Susan L Schwarz, Alexandria P Cogdill, Rachel J Bishop, Hung Kim, Carmen C Brewer, Susan F Rudy, Carter VanWaes, Jeremy L Davis, Aarti Mathur, Robert T Ripley, Debbie A Nathan, Carolyn M Laurencot, and Steven A Rosenberg Gene therapy with human and mouse T cell receptors mediates cancer regression and targets normal tissues expressing cognate antigen Blood First Edition Paper, prepublished online May 18, 2009; DOI 10.1182/blood-2009-03-211714 [Abstract] [PDF]   Elin Hallan Naderi, Harry W Findley, Ellen Ruud, Heidi Kiil Blomhoff, and Soheil Naderi Activation of cAMP signalling inhibits DNA damage-induced apoptosis in BCP-ALL cells through abrogation of p53 accumulation Blood First Edition Paper, prepublished online May 18, 2009; DOI 10.1182/blood-2009-02-204883 [Abstract] [PDF]   Alessandro Re, Mariagrazia Michieli, Salvatore Casari, Bernardino Allione, Chiara Cattaneo, Maurizio Rupolo, Michele Spina, Rosa Manuele, Emanuela Vaccher, Mario Mazzucato, Luciano Abbruzzese, Pierino Ferremi, Giampiero Carosi, Umberto Tirelli, and Giuseppe Rossi High dose therapy and autologous peripheral blood stem cell transplantation as salvage treatment for AIDS-related lymphoma: long term results of the GICAT study with analysis of prognostic factors Blood First Edition Paper, prepublished online May 18, 2009; DOI 10.1182/blood-2009-02-202762 [Abstract] [PDF] [Supplemental Appendix]   Kathrin Gollmer, Francois Asperti-Boursin, Yoshihiko Tanaka, Klaus Okkenhaug, Bart Vanhaesebroeck, Jeffrey R. Peterson, Yoshinori Fukui, Emmanuel Donnadieu, and Jens V. Stein CCL21 mediates CD4+ T cell costimulation via a DOCK2/Rac-dependent pathway Blood First Edition Paper, prepublished online May 18, 2009; DOI 10.1182/blood-2009-01-200923 [Abstract] [PDF] [Supplemental Methods, Table, Figures, and Videos]   14 May 2009 Patrick J. Hanley, Conrad Russell Young Cruz, Barbara Savoldo, Ann M Leen, Maja Stanojevic, Mariam Khalil, William Decker, Jeffrey J Molldrem, Hao Liu, Adrian P Gee, Cliona M Rooney, Helen E Heslop, Gianpietro Dotti, Malcolm K Brenner, Elizabeth J Shpall, and Catherine M Bollard Functionally active virus-specific T-cells that target CMV, adenovirus and EBV can be expanded from naive T-cell populations in cord blood and will target a range of viral epitopes Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2009-03-213256 [Abstract] [PDF]   Twyla B. Bartel, Jeff Haessler, Tracy LY Brown, John D Shaughnessy Jr, Frits van Rhee, Elias Anaissie, Terri Alpe, Edgardo Angtuaco, Ronald Walker, Joshua Epstein, John Crowley, and Bart Barlogie F18-fluorodeoxyglucose positron emission tomography in the context of other imaging techniques and prognostic factors in multiple myeloma Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2009-03-213280 [Abstract] [PDF]   Yi-Hui Lin, Purvi M. Kakadia, Ying Chen, Ya-Qiang Li, Aniruddha J. Deshpande, Christian Buske, Kang-Ling Zhang, Yi Zhang, Guo-Liang Xu, and Stefan K. Bohlander Global reduction of the epigenetic H3K79 methylation mark and increased chromosomal instability in CALM-AF10 positive leukemias Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2009-03-209395 [Abstract] [PDF]   Amin M. Alousi, Daniel J. Weisdorf, Brent R. Logan, Javier Bolanos-Meade, Shelly Carter, Nancy DiFronzo, Marcelo Pasquini, Steven C. Goldstein, Vincent T Ho, Brandon Hayes-Lattin, John R. Wingard, Mary M. Horowitz, and John E. Levine Etanercept, mycophenolate, denileukin or pentostatin plus corticosteroids for acute graft vs. host disease: a randomized phase II trial from the BMT CTN Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2009-03-212290 [Abstract] [PDF]   Marina T. van Leeuwen, Andrew E. Grulich, Angela C. Webster, Margaret R.E. McCredie, John H. Stewart, Stephen P. McDonald, Janaki Amin, John M. Kaldor, Jeremy R. Chapman, and Claire M. Vajdic Immunosuppression and other risk factors for early and late non-Hodgkin lymphoma after kidney transplantation Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2009-02-202507 [Abstract] [PDF]   Abdel Kareem Azab, Feda Azab, Simona Blotta, Costas M. Pitsillides, Brian Thompson, Judith M. Runnels, Aldo M. Roccaro, Hai T. Ngo, Molly R. Melhem, Antonio Sacco, Xiaoying Jia, Kenneth C. Anderson, Charles P. Lin, Barrett J. Rollins, and Irene M. Ghobrial Rho-A and Rac-1 GTPases play major and differential roles in SDF1-induced cell adhesion and chemotaxis in multiple myeloma Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2009-01-199281 [Abstract] [PDF]   Qian Qi, Mingcan Xia, Jianfang Hu, Elizabeth Hicks, Archana Iyer, Na Xiong, and Avery August Enhanced development of CD4+ T cells in the absence of Itk results in elevated IgE production Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2008-12-196345 [Abstract] [PDF]   Ken I. Mills, Alexander Kohlmann, P. Mickey Williams, Lothar Wieczorek, Wei-min Liu, Rachel Li, Wen Wei, David T. Bowen, Helmut Loeffler, Jesus M. Hernandez, Wolf-Karsten Hofmann, and Torsten Haferlach Microarray-based classifiers and prognosis models identify subgroups with distinct clinical outcomes and high risk of AML transformation of myelodysplastic syndrome (MDS) Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2008-10-187203 [Abstract] [PDF]   Heather M. Long, Jianmin Zuo, Alison M. Leese, Nancy H. Gudgeon, Hui Jia, Graham S. Taylor, and Alan B. Rickinson CD4+ T cell clones recognising human lymphoma-associated antigens: generation by in vitro stimulation with autologous Epstein-Barr virus-transformed B cells Blood First Edition Paper, prepublished online May 14, 2009; DOI 10.1182/blood-2008-12-194043 [Abstract] [PDF]   13 May 2009 Daniel M. Witt, Thomas Delate, Nathan P. Clark, Chad Martell, Thu Tran, Mark A. Crowther, David A. Garcia, Walter Ageno, and Elaine M. Hylek Outcomes and predictors of very stable INR control during chronic anticoagulation therapy Blood First Edition Paper, prepublished online May 13, 2009; DOI 10.1182/blood-2009-02-207928 [Abstract] [PDF]   Christian Becker, Christian Taube, Tobias Bopp, Christoph Becker, Kai Michel, Jan Kubach, Sebastian Reuter, Nina Dehzad, Markus F. Neurath, Kurt Reifenberg, Franz-Joseph Schneider, Edgar Schmitt, and Helmut Jonuleit Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells Blood First Edition Paper, prepublished online May 13, 2009; DOI 10.1182/blood-2009-02-206730 [Abstract] [PDF]   Nana Ueffing, Kusum K. Singh, Andrea Christians, Christoph Thorns, Alfred C. Feller, Florian Nagl, Falko Fend, Sebastian Heikaus, Alexander Marx, Rainer B. Zotz, Joachim Brade, Wolfgang A. Schulz, Klaus Schulze-Osthoff, Ingo Schmitz, and Christian Schwerk A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein Blood First Edition Paper, prepublished online May 13, 2009; DOI 10.1182/blood-2009-02-204230 [Abstract] [PDF] [Supplemental Tables and Figures]   12 May 2009 Teru Hideshima, Hiroshi Ikeda, Dharminder Chauhan, Yutaka Okawa, Noopur Raje, Klaus Podar, Constantine Mitsiades, Nikhil C. Munshi, Paul G. Richardson, Ruben D. Carrasco, and Kenneth C. Anderson Bortezomib induces canonical NF-B activation in multiple myeloma cells Blood First Edition Paper, prepublished online May 12, 2009; DOI 10.1182/blood-2009-01-199604 [Abstract] [PDF]   Erin G. Brooks, Winifred Trotman, Marilyn P. Wadsworth, Douglas J. Taatjes, Mark F. Evans, Frank P. Ittleman, Peter W. Callas, Charles T. Esmon, and Edwin G. Bovill Valves of the deep venous system: an overlooked risk factor Blood First Edition Paper, prepublished online May 12, 2009; DOI 10.1182/blood-2009-03-209981 [Abstract] [PDF]   Timothy R Hercus, Daniel Thomas, Mark A Guthridge, Paul G Ekert, Jack King-Scott, Michael W Parker, and Angel F Lopez The GM-CSF receptor: linking its structure to cell signaling and its role in disease Blood First Edition Paper, prepublished online May 12, 2009; DOI 10.1182/blood-2008-12-164004 [Abstract] [PDF]   11 May 2009 Kori L. Wallace, Melissa A. Marshall, Susan I. Ramos, Joanne A. Lannigan, Joshua J. Field, Robert M. Strieter, and Joel Linden NKT cells mediate pulmonary inflammation and dysfunction in murine sickle cell disease through production of IFN- and CXCR3 chemokines Blood First Edition Paper, prepublished online May 11, 2009; DOI 10.1182/blood-2009-02-205492 [Abstract] [PDF] [Supplemental Figures]   Marcella Sarzotti-Kelsoe, Chan M. Win, Roberta E. Parrott, Myriah Cooney, Barry K. Moser, Joseph L. Roberts, Gregory D. Sempowski, and Rebecca H. Buckley Thymic output, T cell diversity and T cell function in long-term human SCID chimeras Blood First Edition Paper, prepublished online May 11, 2009; DOI 10.1182/blood-2009-01-199323 [Abstract] [PDF] [Supplemental Figures]   Massimo Dominici, Valeria Rasini, Rita Bussolari, Xiaohua Chen, Ted J. Hofmann, Carlotta Spano, Daniela Bernabei, Elena Veronesi, Filippo Bertoni, Paolo Paolucci, PierFranco Conte, and Edwin M. Horwitz Restoration and reversible expansion of the osteoblastic hematopoietic stem cell niche after marrow radioablation Blood First Edition Paper, prepublished online May 11, 2009; DOI 10.1182/blood-2008-10-183459 [Abstract] [PDF]   8 May 2009 Yu Yu, Cristina Iclozan, Tomohide Yamazaki, Xuexian Yang, Claudio Anasetti, Chen Dong, and Xue-Zhong Yu Abundant c-FLIP expression determines resistance of Th17 cells to activation-induced cell death Blood First Edition Paper, prepublished online May 8, 2009; DOI 10.1182/blood-2009-03-210153 [Abstract] [PDF]   Raul Alba, Angela C Bradshaw, Alan L Parker, David Bhella, Simon N Waddington, Stuart A Nicklin, Nico van Rooijen, Jerome Custers, Jaap Goudsmit, Dan H Barouch, John H McVey, and Andrew H Baker Identification of coagulation factor (F)X binding sites on the adenovirus serotype 5 hexon: effect of mutagenesis on FX interactions and gene transfer Blood First Edition Paper, prepublished online May 8, 2009; DOI 10.1182/blood-2009-03-208835 [Abstract] [PDF] [Supplemental Table and Figures]   Andreas Greinacher, Birgitt Fuerll, Heike Zinke, Bernd Mullejans, William Kruger, Noemi Michetti, Wolfgang Motz, and Hansjorg Schwertz Megakaryocyte impairment by eptifibatide-induced antibodies causes prolonged thrombocytopenia Blood First Edition Paper, prepublished online May 8, 2009; DOI 10.1182/blood-2009-02-203034 [Abstract] [PDF]   Chris I Jones, Sarah Bray, Stephen F Garner, Jonathan Stephens, Bernard de Bono, Will GJ Angenent, David Bentley, Philippa Burns, Alison Coffey, Panos Deloukas, Mark Earthrowl, Richard W Farndale, Marc F Hoylaerts, Kerstin Koch, Angela Rankin, Catherine M Rice, Jane Rogers, Nilesh J Samani, Michael Steward, Adam Walker, Nicholas A Watkins, Jan-Willem Akkerman, Frank Dudbridge, Alison H Goodall, and Willem H Ouwehand A functional genomics approach reveals novel quantitative trait loci associated with platelet signalling pathways Blood First Edition Paper, prepublished online May 8, 2009; DOI 10.1182/blood-2009-02-202614 [Abstract] [PDF]   Claudia Haferlach, Cristina Mecucci, Susanne Schnittger, Alexander Kohlmann, Marco Mancini, Antonio Cuneo, Nicoletta Testoni, Giovanna Rege-Cambrin, Antonella Santucci, Marco Vignetti, Paola Fazi, Maria Paola Martelli, Torsten Haferlach, and Brunangelo Falini AML with mutated NPM1 carrying a normal or aberrant karyotype show overlapping biological, pathological, immunophenotypic, and prognostic features Blood First Edition Paper, prepublished online May 8, 2009; DOI 10.1182/blood-2009-01-197871 [Abstract] [PDF] [Supplemental Table and Figures]   Raffaella Molteni, Carolina Lage Crespo, Sara Feigelson, Christian Moser, Monica Fabbri, Valentin Grabovsky, Fritz Krombach, Carlo Laudanna, Ronen Alon, and Ruggero Pardi -arrestin 2 is required for the induction and strengthening of integrin-mediated leukocyte adhesion during CXCR2-driven extravasation Blood First Edition Paper, prepublished online May 8, 2009; DOI 10.1182/blood-2008-10-183699 [Abstract] [PDF]   7 May 2009 Holbrook E Kohrt, Brit B Turnbull, Kartoosh Heydari, Judith A Shizuru, Ginna G Laport, David B Miklos, Laura J Johnston, Sally Arai, Wen-Kai Weng, Richard T Hoppe, Philip W Lavori, Karl G Blume, Robert S Negrin, Samuel Strober, and Robert Lowsky TLI and ATG conditioning with low risk of graft-versus-host disease retains anti-tumor reactions after allogeneic hematopoietic cell transplantation from related and unrelated donors Blood First Edition Paper, prepublished online May 7, 2009; DOI 10.1182/blood-2009-03-211441 [Abstract] [PDF]   Olga Ritz, Chrystelle Guiter, Flavia Castellano, Karola Dorsch, Julia Melzner, Jean-Philippe Jais, Gwendoline Dubois, Philippe Gaulard, Peter Moller, and Karen Leroy Recurrent mutations of the STAT6 DNA binding domain in primary mediastinal B-cell lymphoma Blood First Edition Paper, prepublished online May 7, 2009; DOI 10.1182/blood-2009-03-209759 [Abstract] [PDF]   Mojgan Ahmadzadeh, Laura A. Johnson, Bianca Heemskerk, John R. Wunderlich, Mark E. Dudley, Donald E. White, and Steven A. Rosenberg Tumor antigen-specific CD8 T cells infiltrating the tumor express high levels of PD-1 and are functionally impaired Blood First Edition Paper, prepublished online May 7, 2009; DOI 10.1182/blood-2008-12-195792 [Abstract] [PDF]   6 May 2009 Sabine Mumprecht, Christian Schurch, Juerg Schwaller, Max Solenthaler, and Adrian F. Ochsenbein PD-1 signaling on chronic myeloid leukemia-specific T cells results in T cell exhaustion and disease progression Blood First Edition Paper, prepublished online May 6, 2009; DOI 10.1182/blood-2008-09-179697 [Abstract] [PDF]   5 May 2009 Long Zhang, Thomas F. Gajewski, and Justin Kline PD-1/PD-L1 interactions inhibit anti-tumor immune responses in a murine acute myeloid leukemia model Blood First Edition Paper, prepublished online May 5, 2009; DOI 10.1182/blood-2009-03-206672 [Abstract] [PDF]   4 May 2009 Constantine S Tam, Tait D Shanafelt, William G Wierda, Lynne V Abruzzo, Daniel L Van Dyke, Susan O'Brien, Alessandra Ferrajoli, Susan A Lerner, Alice Lynn, Neil E Kay, and Michael J Keating De novo deletion 17p13.1 chronic lymphocytic leukemia shows significant clinical heterogeneity: the MD Anderson and Mayo Clinic experience Blood First Edition Paper, prepublished online May 4, 2009; DOI 10.1182/blood-2009-03-210591 [Abstract] [PDF]   Xingkui Xue, Xin Huang, Sonja E. Nodland, Lajos Mates, Linan Ma, Zsuzsanna Izsvak, Zoltan Ivics, Tucker W. LeBien, R. Scott McIvor, John E. Wagner, and Xianzheng Zhou Stable gene transfer and expression in cord blood-derived CD34+ hematopoietic stem and progenitor cells by a hyperactive Sleeping Beauty transposon system Blood First Edition Paper, prepublished online May 4, 2009; DOI 10.1182/blood-2009-03-210005 [Abstract] [PDF]   Yang Buyue and John P. Sheehan Fucosylated chondroitin sulfate inhibits plasma thrombin generation via targeting of the factor IXa heparin-binding exosite Blood First Edition Paper, prepublished online May 4, 2009; DOI 10.1182/blood-2009-02-203661 [Abstract] [PDF]   1 May 2009 Guo Wei, Ruchika Srinivasan, Carmen Z. Cantemir-Stone, Sudarshana M. Sharma, Ramasamy Santhanam, Michael Weinstein, Natarajan Muthusamy, Albert K. Man, Robert G. Oshima, Gustavo Leone, and Michael C. Ostrowski Ets1 and Ets2 are required for endothelial cell survival during embryonic angiogenesis Blood First Edition Paper, prepublished online May 1, 2009; DOI 10.1182/blood-2009-03-211391 [Abstract] [PDF]   Mohammad Qadura, Braden Waters, Erin Burnett, Rouzbeh Chegeni, Scott Bradshaw, Christine Hough, Maha Othman, and David Lillicrap Recombinant and plasma-derived factor VIII products induce distinct splenic cytokine microenvironments in hemophilia A mice Blood First Edition Paper, prepublished online May 1, 2009; DOI 10.1182/blood-2008-09-174649 [Abstract] [PDF]   Ombretta Salvucci, Dragan Maric, Matina Economopoulou, Shuhei Sakakibara, Simone Merlin, Antonia Follenzi, and Giovanna Tosato EphrinB reverse signaling contributes to endothelial and mural cell assembly into vascular structures Blood First Edition Paper, prepublished online May 1, 2009; DOI 10.1182/blood-2008-12-192294 [Abstract] [PDF]   30 April 2009 Marc Remke, Stefan Pfister, Corinne Kox, Grischa Toedt, Natalia Becker, Axel Benner, Wiebke Werft, Stephen Breit, Shuangyou Liu, Felix Engel, Andrea Wittmann, Martin Zimmermann, Martin Stanulla, Martin Schrappe, Wolf-Dieter Ludwig, Claus R. Bartram, Bernhard Radlwimmer, Martina U. Muckenthaler, Peter Lichter, and Andreas E. Kulozik High-resolution genomic profiling of childhood T-ALL reveals frequent copy-number alterations affecting the TGF- and PI3K-AKT pathways and deletions at 6q15-16.1 as a genomic marker for unfavorable early treatment response Blood First Edition Paper, prepublished online April 30, 2009; DOI 10.1182/blood-2008-10-186536 [Abstract] [PDF]   29 April 2009 Attilio Olivieri, Franco Locatelli, Marco Zecca, Adele Sanna, Michele Cimminiello, Roberto Raimondi, Guido Gini, Nicola Mordini, Adriana Balduzzi, Pietro Leoni, Armando Gabrielli, and Andrea Bacigalupo Imatinib for refractory chronic graft-versus-host-disease with fibrotic features Blood First Edition Paper, prepublished online April 29, 2009; DOI 10.1182/blood-2009-02-204156 [Abstract] [PDF]   28 April 2009 Steven W. Lane, David T. Scadden, and D. Gary Gilliland The leukemic stem cell niche - current concepts and therapeutic opportunities Blood First Edition Paper, prepublished online April 28, 2009; DOI 10.1182/blood-2009-01-202606 [Abstract] [PDF]   Simone Cunha Maradei, Angelo Maiolino, Alexandre Mello de Azevedo, Marta Colares, Luis Fernando Bouzas, and Marcio Nucci Serum ferritin as risk factor for sinusoidal obstruction syndrome of the liver in patients undergoing hematopoietic stem cell transplantation Blood First Edition Paper, prepublished online April 28, 2009; DOI 10.1182/blood-2009-03-212282 [Abstract] [PDF]   27 April 2009 Denise Stenzel, Emma Nye, Maya Nisancioglu, Ralf H. Adams, Yu Yamaguchi, and Holger Gerhardt Peripheral mural cell recruitment requires cell-autonomous heparan-sulfate Blood First Edition Paper, prepublished online April 27, 2009; DOI 10.1182/blood-2008-10-186239 [Abstract] [PDF]   Young-Jun Park, Gang Liu, Yuko Tsuruta, Emmanuel Lorne, and Edward Abraham Participation of the urokinase receptor in neutrophil efferocytosis Blood First Edition Paper, prepublished online April 27, 2009; DOI 10.1182/blood-2008-12-193524 [Abstract] [PDF]   24 April 2009 Gwenda J. Graham, Qiansheng Ren, James R. Dilks, Price Blair, Sidney W. Whiteheart, and Robert Flaumenhaft Endobrevin/VAMP-8-dependent dense granule release mediates thrombus formation in vivo Blood First Edition Paper, prepublished online April 24, 2009; DOI 10.1182/blood-2009-03-210211 [Abstract] [PDF]   22 April 2009 Simone M. Schoenwaelder, Yuping Yuan, Emma C Josefsson, Michael J. White, Yu Yao, Kylie D. Mason, Lorraine A. O'Reilly, Katya J. Henley, Akiko Ono, Sarah Hsiao, Abbey Willcox, Andrew W. Roberts, David C.S. Huang, Hatem H. Salem, Benjamin T. Kile, and Shaun P. Jackson Two distinct pathways regulate platelet phosphatidylserine exposure and procoagulant function Blood First Edition Paper, prepublished online April 22, 2009; DOI 10.1182/blood-2009-01-200345 [Abstract] [PDF]   Ilaria Del Giudice, Sabina Chiaretti, Simona Tavolaro, Maria Stefania De Propris, Roberta Maggio, Francesca Mancini, Nadia Peragine, Simona Santangelo, Marilisa Marinelli, Francesca Romana Mauro, Anna Guarini, and Robin Foa Spontaneous regression of chronic lymphocytic leukemia: clinical and biologic features of 9 cases Blood First Edition Paper, prepublished online April 22, 2009; DOI 10.1182/blood-2008-12-196568 [Abstract] [PDF]   21 April 2009 Atsuhiko Hasegawa, Huining Liu, Binhua Ling, Juan T. Borda, Xavier Alvarez, Chie Sugimoto, Heather Vinet-Oliphant, Woong-Ki Kim, Kenneth C. Williams, Ruy M. Ribeiro, Andrew A. Lackner, Ronald S. Veazey, and Marcelo J. Kuroda The level of monocyte turnover predicts disease progression in the macaque model of AIDS Blood First Edition Paper, prepublished online April 21, 2009; DOI 10.1182/blood-2009-02-204263 [Abstract] [PDF]   Ferdinando Pucci, Mary Anna Venneri, Daniela Biziato, Alessandro Nonis, Davide Moi, Antonio Sica, Clelia Di Serio, Luigi Naldini, and Michele De Palma A distinguishing gene signature shared by tumor-infiltrating Tie2-expressing monocytes (TEMs), blood "resident" monocytes and embryonic macrophages suggests common functions and developmental relationships Blood First Edition Paper, prepublished online April 21, 2009; DOI 10.1182/blood-2009-01-200931 [Abstract] [PDF]   20 April 2009 Marianne Jensby Nielsen and Soren Kragh Moestrup Receptor-targeting of hemoglobin mediated by the haptoglobins: roles beyond heme scavenging Blood First Edition Paper, prepublished online April 20, 2009; DOI 10.1182/blood-2009-01-198309 [Abstract] [PDF]   16 April 2009 Tiziano Barbui, Alessandra Carobbio, Alessandro Rambaldi, and Guido Finazzi Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor? Blood First Edition Paper, prepublished online April 16, 2009; DOI 10.1182/blood-2009-02-206797 [Abstract] [PDF]   Yinshi Guo, Chao Niu, Peter Breslin, Minghui Tang, Shubin Zhang, Wei Wei, Ameet R. Kini, Gladell P. Paner, Serhan Alkan, Stephan W. Morris, Manuel Diaz, Patrick J. Stiff, and Jiwang Zhang c-Myc-mediated control of cell fate in megakaryocyte-erythrocyte progenitors Blood First Edition Paper, prepublished online April 16, 2009; DOI 10.1182/blood-2009-01-197947 [Abstract] [PDF] [Supplemental Appendix, Tables, and Figures]   Paola E.J. van der Meijden, Imke C.A. Munnix, Jocelyn M. Auger, Jose W.P. Govers-Riemslag, Judith M.E.M. Cosemans, Marijke J.E. Kuijpers, Henri M. Spronk, Steve P. Watson, Thomas Renne, and Johan W.M. Heemskerk Dual role of collagen in factor XII-dependent thrombus formation Blood First Edition Paper, prepublished online April 16, 2009; DOI 10.1182/blood-2008-07-171066 [Abstract] [PDF] [Supplemental Figures]   Alexandra Stefanovic and Izidore S Lossos Extranodal marginal zone lymphoma of the ocular adnexa Blood First Edition Paper, prepublished online April 16, 2009; DOI 10.1182/blood-2008-12-195453 [Abstract] [PDF]   Megan S. Sutherland, Anthony M. Cumming, Mackenzie Bowman, Paula H.B. Bolton-Maggs, Derrick J. Bowen, Peter W. Collins, Charles R.M. Hay, Andrew M. Will, and Stephen Keeney A novel deletion mutation is recurrent in von Willebrand disease types 1 and 3 Blood First Edition Paper, prepublished online April 16, 2009; DOI 10.1182/blood-2008-08-173278 [Abstract] [PDF]   15 April 2009 Marianna Prokopi, Giordano Pula, Ursula Mayr, Cecile Devue, Joy Gallagher, Qingzhong Xiao, Chantal M. Boulanger, Nigel Westwood, Carmen Urbich, Johann Willeit, Marianne Steiner, Johannes Breuss, Qingbo Xu, Stefan Kiechl, and Manuel Mayr Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultures Blood First Edition Paper, prepublished online April 15, 2009; DOI 10.1182/blood-2009-02-205930 [Abstract] [PDF]   13 April 2009 Mettine H.A. Bos, Michael Boltz, Liam St. Pierre, Paul P. Masci, John de Jersey, Martin F. Lavin, and Rodney M. Camire Venom factor V from the common brown snake escapes hemostatic regulation through procoagulant adaptations Blood First Edition Paper, prepublished online April 13, 2009; DOI 10.1182/blood-2009-02-202663 [Abstract] [PDF]   9 April 2009 Gerard Hernandez Mir, Jari Helin, Kari-Pekka Skarp, Richard D. Cummings, Antti Makitie, Risto Renkonen, and Anne Leppanen Glycoforms of human endothelial CD34 that bind L-selectin carry sulfated sialyl Lewis x capped O- and N-glycans Blood First Edition Paper, prepublished online April 9, 2009; DOI 10.1182/blood-2009-03-210237 [Abstract] [PDF]   8 April 2009 James W. Vardiman, Juergen Thiele, Daniel A. Arber, Richard D. Brunning, Michael J. Borowitz, Anna Porwit, Nancy Lee Harris, Michelle M. Le Beau, Eva Hellstrom-Lindberg, Ayalew Tefferi, and Clara D. Bloomfield The 2008 revision of the WHO classification of myeloid neoplasms and acute leukemia: rationale and important changes Blood First Edition Paper, prepublished online April 8, 2009; DOI 10.1182/blood-2009-03-209262 [Abstract] [PDF]   Giuseppe Tagariello, Alfonso Iorio, Elena Santagostino, Massimo Morfini, Ruggero Bisson, Massimo Innocenti, Maria Elisa Mancuso, Maria Gabriella Mazzucconi, Gian Luigi Pasta, Paolo Radossi, Giuseppina Rodorigo, Cristina Santoro, Roberto Sartori, Antonio Scaraggi, Luigi Pier Solimeno, and Pier Mannuccio Mannucci Comparison of the rates of joint arthroplasty in patients with severe factor VIII and IX deficiency: an index of different clinical severity of the two coagulation disorders Blood First Edition Paper, prepublished online April 8, 2009; DOI 10.1182/blood-2009-01-195313 [Abstract] [PDF] [Supplemental Appendix]   7 April 2009 Stephanie Beq, Sandra Rozlan, David Gautier, Raphaelle Parker, Veronique Mersseman, Clementine Schilte, Brigitte Assouline, Iann Rance, Pascal Lavedan, Michel Morre, and Remi Cheynier Injection of glycosylated recombinant simian IL-7 provokes rapid and massive T-cell homing in rhesus macaques Blood First Edition Paper, prepublished online April 7, 2009; DOI 10.1182/blood-2008-11-191288 [Abstract] [PDF] [Supplemental Figures]   6 April 2009 Youjin Lee, Sogyong L. Auh, Yugang Wang, Byron Burnette, Yang Wang, Yuru Meng, Michael Beckett, Rohit Sharma, Robert Chin, Tony Tu, Ralph R. Weichselbaum, and Yang-Xin Fu Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment Blood First Edition Paper, prepublished online April 6, 2009; DOI 10.1182/blood-2009-02-206870 [Abstract] [PDF]   30 March 2009 Donna Reece, Kevin W. Song, Tommy Fu, Birgitte Roland, Hong Chang, Douglas E. Horsman, Adnan Mansoor, Christine Chen, Esther Masih-Khan, Young Trieu, Helene Bruyere, Douglas A. Stewart, and Nizar J. Bahlis Influence of cytogenetics in patients with relapsed or refractory multiple myeloma treated with lenalidomide plus dexamethasone: adverse effect of deletion 17p13 Blood First Edition Paper, prepublished online March 30, 2009; DOI 10.1182/blood-2008-12-193458 [Abstract] [PDF]   26 March 2009 Prashant Kapoor, Shaji Kumar, Rafael Fonseca, Martha Q. Lacy, Thomas E. Witzig, Suzanne R. Hayman, Angela Dispenzieri, Francis Buadi, P. Leif Bergsagel, Morie A. Gertz, Robert J. Dalton, Joseph R. Mikhael, David Dingli, Craig B. Reeder, John A. Lust, Stephen J. Russell, Vivek Roy, Steven R. Zeldenrust, A. Keith Stewart, Robert A. Kyle, Philip R. Greipp, and S. Vincent Rajkumar Impact of risk stratification on outcome among patients with multiple myeloma receiving initial therapy with lenalidomide and dexamethasone Blood First Edition Paper, prepublished online March 26, 2009; DOI 10.1182/blood-2009-01-202010 [Abstract] [PDF]   16 March 2009 Leonardo Magro, Mohamad Mohty, Benoit Catteau, Valerie Coiteux, Patrice Chevallier, Louis Terriou, Jean-Pierre Jouet, and Ibrahim Yakoub-Agha Imatinib mesylate as salvage therapy for refractory sclerotic chronic graft-versus-host disease Blood First Edition Paper, prepublished online March 16, 2009; DOI 10.1182/blood-2009-02-204750 [Abstract] [PDF]   30 January 2009 Ola Landgren, Sigurdur Y. Kristinsson, Lynn R. Goldin, Neil E. Caporaso, Cecilie Blimark, Ulf-Henrik Mellqvist, Anders Wahlin, Magnus Bjorkholm, and Ingemar Turesson Risk of plasma-cell and lymphoproliferative disorders among 14,621 first-degree relatives of 4,458 patients with monoclonal gammopathy of undetermined significance (MGUS) in Sweden Blood First Edition Paper, prepublished online January 30, 2009; DOI 10.1182/blood-2008-12-191676 [Abstract] [PDF]   29 January 2009 Celine M. Vachon, Robert A. Kyle, Terry M. Therneau, Barbara J. Foreman, Dirk R. Larson, Colin L. Colby, Tara K. Phelps, Angela Dispenzieri, Shaji K. Kumar, Jerry A. Katzmann, and S. Vincent Rajkumar Increased risk of monoclonal gammopathy in first-degree relatives of patients with multiple myeloma or monoclonal gammopathy of undetermined significance Blood First Edition Paper, prepublished online January 29, 2009; DOI 10.1182/blood-2008-12-192575 [Abstract] [PDF]   13 January 2009 Matthew J. Christopher, Fulu Liu, Matthew J. Hilton, Fanxin Long, and Daniel C. Link Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization Blood First Edition Paper, prepublished online January 13, 2009; DOI 10.1182/blood-2008-10-184754 [Abstract] [PDF] [Supplemental Table and Figures]   To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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