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Blood's First Edition Papers: Last updated May 14, 2008 [View by section] To enable Blood's readers to learn about new scientific findings at the earliest possible moment, the Journal has decided to prepublish, in manuscript format, all accepted articles shortly after acceptance as "First Edition Papers." First Edition Papers have undergone full scientific review but none of the editorial preparation, such as copyediting, typesetting, and proofreading, which is mandatory for all articles published in the regular print and online issues of Blood. Disclaimer More about Blood's First Edition Papers: To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. 14 May 2008 Maria Dona, Gabrielle Fredman, Jan M. Schwab, Nan Chiang, Makoto Arita, Ahmad Goodarzi, Guiying Cheng, Ulrich H. von Andrian, and Charles N. Serhan Resolvin E1, an EPA-derived mediator in whole blood, selectively counterregulates leukocytes and platelets Blood First Edition Paper, prepublished online May 14, 2008; DOI 10.1182/blood-2007-11-122598 [Abstract] [PDF]   Raffaella Bonecchi, Elena M Borroni, Achille Anselmo, Andrea Doni, Benedetta Savino, Massimiliano Mirolo, Monica Fabbri, Venkatakrishna R Jala, Bodduluri Haribabu, Alberto Mantovani, and Massimo Locati Regulation of D6 chemokine scavenging activity by ligand and Rab11-dependent surface upregulation Blood First Edition Paper, prepublished online May 14, 2008; DOI 10.1182/blood-2007-08-108316 [Abstract] [PDF]   Ilaria V Libani, Ella C Guy, Luca Melchiori, Raffaella Schiro, Pedro Ramos, Laura Breda, Thomas Scholzen, Amy Chadburn, YiFang Liu, Margrit Kernbach, Bettina Baron-Luehr, Matteo Porotto, Maria de Sousa, Eliezer A Rachmilewitz, John D Hood, M. Domenica Cappellini, Patricia J Giardina, Robert W Grady, Johannes Gerdes, and Stefano Rivella Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in -thalassemia Blood First Edition Paper, prepublished online May 14, 2008; DOI 10.1182/blood-2007-12-126938 [Abstract] [PDF]   David E Gerber, Jodi B Segal, M. Yair Levy, Joyce Kane, Richard J. Jones, and Michael B Streiff The incidence of and risk factors for venous thromboembolism (VTE) and bleeding among 1,514 patients undergoing hematopoietic stem cell transplantation: implications for VTE prevention Blood First Edition Paper, prepublished online May 14, 2008; DOI 10.1182/blood-2007-10-117051 [Abstract] [PDF]   13 May 2008 Kimmo Porkka, Perttu Koskenvesa, Tuija Lundan, Johanna Rimpilainen, Satu Mustjoki, Richard Smykla, Robert Wild, Roger Luo, Montserrat Arnan, Benoit Brethon, Lydia Eccersley, Henrik Hjorth-Hansen, Martin Hoglund, Hana Klamova, Havar Knutsen, Suhag Parikh, Emmanuel Raffoux, Franz Gruber, Finella Brito-Babapulle, Herve Dombret, Rafael F. Duarte, Erkki Elonen, Ron Paquette, C Michel Zwaan, and Francis YF Lee Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia Blood First Edition Paper, prepublished online May 13, 2008; DOI 10.1182/blood-2008-02-140665 [Abstract] [PDF]   Mithun Vinod Shah, Ranran Zhang, Rosalyn Irby, Ravi Kothapalli, Xin Liu, Ty Arrington, Bryan Frank, Norman H. Lee, and Thomas P. Loughran Jr. Molecular profiling of LGL leukemia reveals role of sphingolipid signaling in survival of cytotoxic lymphocytes Blood First Edition Paper, prepublished online May 13, 2008; DOI 10.1182/blood-2007-11-121871 [Abstract] [PDF]   Anne C. Frei, YiHe Guo, Deron W. Jones, Kirkwood A. Pritchard Jr., Karen A. Fagan, Neil Hogg, and Nancy J Wandersee Vascular dysfunction in a murine model of severe hemolysis Blood First Edition Paper, prepublished online May 13, 2008; DOI 10.1182/blood-2007-12-126714 [Abstract] [PDF]   12 May 2008 Li Zhou, Aaron N Nguyen, Davendra Sohal, Jing Ying Ma, Perry Pahanish, Krishna Gundabolu, Josh Hayman, Adam Chubak, Yongkai Mo, Tushar Bhagat, Bhaskar Das, Ann M Kapoun, Tony A Navas, Simrit Parmar, Suman Kambhampati, Andrea Pellagatti, Ira Braunschweig, Ying Zhang, Amittha Wickrema, Satyanarayana Medicherla, Jacqueline Boultwood, Leonidas C Platanias, Linda S Higgins, Alan F List, Markus Bitzer, and Amit Verma Inhibition of the TGF- receptor I kinase promotes hematopoiesis in MDS Blood First Edition Paper, prepublished online May 12, 2008; DOI 10.1182/blood-2008-02-139824 [Abstract] [PDF] [Supplemental Table and Figures]   Irma Airoldi, Claudia Cocco, Nicola Giuliani, Marina Ferrarini, Simona Colla, Emanuela Ognio, Giuseppe Taverniti, Emma Di Carlo, Giovanna Cutrona, Vittorio Perfetti, Vittorio Rizzoli, Domenico Ribatti, and Vito Pistoia Constitutive expression of IL-12RB2 on human multiple myeloma cells delineates a novel therapeutic target Blood First Edition Paper, prepublished online May 12, 2008; DOI 10.1182/blood-2008-02-139378 [Abstract] [PDF]   Annelii Ny, Marta Koch, Wouter Vandevelde, Martin Schneider, Christian Fischer, Antonio Diez-Juan, Elke Neven, Ilse Geudens, Sunit Maity, Lieve Moons, Stephane Plaisance, Diether Lambrechts, Peter Carmeliet, and Mieke Dewerchin Role of VEGF-D and VEGFR-3 in developmental lymphangiogenesis, a chemicogenetic study in Xenopus tadpoles Blood First Edition Paper, prepublished online May 12, 2008; DOI 10.1182/blood-2007-08-106302 [Abstract] [PDF]   Mathias M Hauri-Hohl, Saulius Zuklys, Marcel P Keller, Lukas T Jeker, Thomas Barthlott, Anne M Moon, Jurgen Roes, and Georg A Hollander TGF- signaling in thymic epithelial cells regulates thymic involution and post-irradiation reconstitution Blood First Edition Paper, prepublished online May 12, 2008; DOI 10.1182/blood-2007-10-115618 [Abstract] [PDF] [Supplemental Table and Figures]   9 May 2008 Sebastien Lacroix-Desmazes, Ana-Maria Navarrete, Sebastien Andre, Jagadeesh Bayry, Srinivas V. Kaveri, and Suryasarathi Dasgupta Dynamics of factor VIII interactions determine its immunological fate in hemophilia A Blood First Edition Paper, prepublished online May 9, 2008; DOI 10.1182/blood-2008-02-124941 [Abstract] [PDF]   Faisal Khan, Teal S Hallstrand, Michelle N Geddes, William R Henderson Jr., and Jan Storek Is allergic disease curable or transferable with allogeneic hematopoietic cell transplantation? Blood First Edition Paper, prepublished online May 9, 2008; DOI 10.1182/blood-2008-01-128686 [Abstract] [PDF]   Inka Zschiedrich, Ulrike Hardeland, Anja Krones-Herzig, Mauricio Berriel Diaz, Alexandros Vegiopoulos, Johannes Muggenburg, Dirk Sombroek, Thomas G Hofmann, Rainer Zawatzky, Xiaolei Yu, Norbert Gretz, Mark Christian, Roger White, Malcolm G Parker, and Stephan Herzig Co-activator function of RIP140 for NFB/RelA-dependent cytokine gene expression Blood First Edition Paper, prepublished online May 9, 2008; DOI 10.1182/blood-2007-11-121699 [Abstract] [PDF]   8 May 2008 Tomonori Hidaka, Shingo Nakahata, Kinta Hatakeyama, Makoto Hamasaki, Kiyoshi Yamashita, Takashi Kohno, Yasuhito Arai, Tomohiko Taki, Kazuhiro Nishida, Akihiko Okayama, Yujiro Asada, Ryoji Yamaguchi, Hirohito Tsubouchi, Jun Yokota, Masafumi Taniwaki, Yujiro Higashi, and Kazuhiro Morishita Down-regulation of TCF8 is involved in the leukemogenesis of adult-T cell leukemia/lymphoma Blood First Edition Paper, prepublished online May 8, 2008; DOI 10.1182/blood-2008-01-131185 [Abstract] [PDF]   7 May 2008 Massimo Franchini and Giuseppe Lippi How I treat acquired factor VIII inhibitors Blood First Edition Paper, prepublished online May 7, 2008; DOI 10.1182/blood-2008-03-143586 [Abstract] [PDF]   Bertrand Godeau, Raphael Porcher, Olivier Fain, Francois Lefrere, Pierre Fenaux, Stephane Cheze, Anne Vekhoff, Marie-Paule Chauveheid, Jerome Stirnemann, Lionel Galicier, Emmanuelle Bourgeois, Stephanie Haiat, Bruno Varet, Michel Leporrier, Thomas Papo, Mehdi Khellaf, Marc Michel, and Philippe Bierling Rituximab efficacy and safety in adult splenectomy candidates with chronic immune thrombocytopenic purpura - results of a prospective multicenter phase 2 study Blood First Edition Paper, prepublished online May 7, 2008; DOI 10.1182/blood-2008-01-131029 [Abstract] [PDF]   6 May 2008 Annarita Zeoli, Patrizia Dentelli, Arturo Rosso, Gabriele Togliatto, Antonella Trombetta, Laura Damiano, Paola Francia di Celle, Luigi Pegoraro, Fiorella Altruda, and Maria Felice Brizzi Interleukin-3 (IL-3) promotes expansion of hemopoietic-derived CD45+ angiogenic cells and their arterial commitment via STAT5 activation Blood First Edition Paper, prepublished online May 6, 2008; DOI 10.1182/blood-2007-12-128215 [Abstract] [PDF] [Supplemental Methods and Figures]   2 May 2008 Shane R Mayack and Amy J Wagers Osteolineage niche cells initiate hematopoietic stem cell mobilization Blood First Edition Paper, prepublished online May 2, 2008; DOI 10.1182/blood-2008-01-133710 [Abstract] [PDF] [Supplemental Figures]   Dimitrios I. Zonios, Judith Falloon, John E. Bennett, Pamela A. Shaw, Doreen Chaitt, Michael W. Baseler, Joseph W. Adelsberger, Julia A. Metcalf, Michael A. Polis, Stephen J Kovacs, Joseph A. Kovacs, Richard T. Davey, H. Clifford Lane, Henry Masur, and Irini Sereti Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors Blood First Edition Paper, prepublished online May 2, 2008; DOI 10.1182/blood-2007-12-127878 [Abstract] [PDF]   1 May 2008 Philip A Beer, Peter J Campbell, Linda M Scott, Anthony J Bench, Wendy N Erber, David Bareford, Bridget S Wilkins, John T Reilly, Hans C Hasselbalch, Richard Bowman, Keith Wheatley, Georgina Buck, Claire N Harrison, and Anthony R Green MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort Blood First Edition Paper, prepublished online May 1, 2008; DOI 10.1182/blood-2008-01-131664 [Abstract] [PDF] [Supplemental Figure]   Ola Landgren, Lynn R. Goldin, Sigurdur Y Kristinsson, Elin A Helgadottir, Jan Samuelsson, and Magnus Bjorkholm Increased risks of polycythemia vera, essential thrombocythemia, and myelofibrosis among 24577 first-degree relatives of 11039 patients with myeloproliferative neoplasms in Sweden Blood First Edition Paper, prepublished online May 1, 2008; DOI 10.1182/blood-2008-03-143602 [Abstract] [PDF]   Olga V. Oskolkova, Taras Afonyushkin, Alexander Leitner, Elena von Schlieffen, Peter S. Gargalovic, Aldons J. Lusis, Bernd R. Binder, and Valery N. Bochkov ATF4-dependent transcription is a key mechanism in VEGF upregulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response Blood First Edition Paper, prepublished online May 1, 2008; DOI 10.1182/blood-2007-09-112870 [Abstract] [PDF] [Supplemental Results and Figures]   Toshiharu Yamashita, Osamu Ohneda, Ai Sakiyama, Fumiko Iwata, Kinuko Ohneda, and Yoshiaki Fujii-Kuriyama The microenvironment for erythropoiesis is regulated by HIF-2 through VCAM-1 in endothelial cells Blood First Edition Paper, prepublished online May 1, 2008; DOI 10.1182/blood-2007-11-122648 [Abstract] [PDF]   Reinhard Marks, Karin Potthoff, Joachim Hahn, Gabriele Ihorst, Hartmut Bertz, Alexandros Spyridonidis, Ernst Holler, and Jurgen Finke Reduced-toxicity conditioning with fludarabine, BCNU and melphalan in allogeneic hematopoietic cell transplantation: particular activity against advanced hematological malignancies Blood First Edition Paper, prepublished online May 1, 2008; DOI 10.1182/blood-2007-08-104745 [Abstract] [PDF]   30 April 2008 Hai T. Ngo, Xavier Leleu, Jack Lee, Xiaoying Jia, Molly Melhem, Judith Runnels, Anne-Sophie Moreau, Nicholas Burwick, Abdel Kareem Azab, Aldo Roccaro, Feda Azab, Antonio Sacco, Mena Farag, Robert Sackstein, and Irene M. Ghobrial SDF-1/CXCR4 and VLA-4 interaction regulates homing in Waldenstrom Macroglobulinemia Blood First Edition Paper, prepublished online April 30, 2008; DOI 10.1182/blood-2007-12-129395 [Abstract] [PDF]   29 April 2008 Raquel Malumbres, Jun Chen, Rob Tibshirani, Nathalie A Johnson, Laurie H Sehn, Yaso Natkunam, Javier Briones, Ranjana Advani, Joseph M Connors, Gerald E Byrne, Ronald Levy, Randy D Gascoyne, and Izidore S Lossos Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP Blood First Edition Paper, prepublished online April 29, 2008; DOI 10.1182/blood-2008-02-136374 [Abstract] [PDF] [Supplemental Figure]   Thomas Korff, Jennifer Braun, Dennis Pfaff, Hellmut G Augustin, and Markus Hecker Role of ephrinB2 expression in endothelial cells during arteriogenesis: Impact on smooth muscle cell migration and monocyte recruitment Blood First Edition Paper, prepublished online April 29, 2008; DOI 10.1182/blood-2007-12-128835 [Abstract] [PDF] [Supplemental Methods and Figures]   Helen Karlsson, Sujith Samarasinghe, Lynne M Ball, Berit Sundberg, Arjan C Lankester, Francesco Dazzi, Mehmet Uzunel, Kanchan Rao, Paul Veys, Katarina Le Blanc, Olle Ringden, and Persis J. Amrolia Mesenchymal stem cells exert differential effects on alloantigen and virus-specific T cell responses Blood First Edition Paper, prepublished online April 29, 2008; DOI 10.1182/blood-2007-10-119370 [Abstract] [PDF]   28 April 2008 Dana E Rollison, Nadia Howlader, Martyn T Smith, Sara S Strom, William D Merritt, Lynn A Ries, Brenda K Edwards, and Alan F List Epidemiology of Myelodysplastic Syndromes and Chronic Myeloproliferative Disorders in the United States, 2001-2004: Utilizing Data from the NAACCR and SEER Programs Blood First Edition Paper, prepublished online April 28, 2008; DOI 10.1182/blood-2008-01-134858 [Abstract] [PDF]   25 April 2008 Bence Rethi, Nancy Vivar, Stefano Sammicheli, Caroline Fluur, Nicolas Ruffin, Ann Atlas, Eva Rajnavolgyi, and Francesca Chiodi Priming of T cells to Fas-mediated proliferative signals by Interleukin-7 Blood First Edition Paper, prepublished online April 25, 2008; DOI 10.1182/blood-2007-12-126698 [Abstract] [PDF]   Tomoyuki Sawado, Jessica Halow, Hogune Im, Tobias Ragoczy, Emery H. Bresnick, M. A. Bender, and Mark Groudine H3K79 di-methylation marks developmental activation of the -globin gene but is reduced upon LCR-mediated high-level transcription Blood First Edition Paper, prepublished online April 25, 2008; DOI 10.1182/blood-2007-12-128983 [Abstract] [PDF] [Supplemental Methods and Tables]   24 April 2008 Lisa Kujawski, Peter Ouillette, Harry Erba, Chris Saddler, Andrzej Jakubowiak, Mark Kaminski, Kerby Shedden, and Sami N Malek Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia Blood First Edition Paper, prepublished online April 24, 2008; DOI 10.1182/blood-2007-07-099432 [Abstract] [PDF] [Supplemental Tables and Figures]   Xin Li, Angela Pennisi, and Shmuel Yaccoby Role of decorin in the antimyeloma effects of osteoblasts Blood First Edition Paper, prepublished online April 24, 2008; DOI 10.1182/blood-2007-11-124164 [Abstract] [PDF]   Bernard Lagane, Ken Y. C. Chow, Karl Balabanian, Angelique Levoye, Julie Harriague, Thierry Planchenault, Francoise Baleux, Nathalie Gunera-saad, Fernando Arenzana-Seisdedos, and Francoise Bachelerie CXCR4 dimerization and -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome Blood First Edition Paper, prepublished online April 24, 2008; DOI 10.1182/blood-2007-07-102103 [Abstract] [PDF]   23 April 2008 Fumiko Marttila-Ichihara, Raisa Turja, Mari Miiluniemi, Marika Karikoski, Mikael Maksimow, Jussi Niemela, Luisa Martinez-Pomares, Marko Salmi, and Sirpa Jalkanen Macrophage mannose receptor on lymphatics controls cell trafficking Blood First Edition Paper, prepublished online April 23, 2008; DOI 10.1182/blood-2007-10-118984 [Abstract] [PDF] [Supplemental Figure]   Rodrigo Proto-Siqueira, Rodrigo A Panepucci, Francisco P Careta, Abigail Lee, Andrew Clear, Kelly Morris, Carolyn Owen, Edgar G Rizzatti, Wilson A Silva-Jr, Roberto Passetto Falcao, Marco A Zago, and John G. Gribben SAGE analysis demonstrates increased expression of TOSO contributing to Fas mediated resistance in CLL Blood First Edition Paper, prepublished online April 23, 2008; DOI 10.1182/blood-2007-11-124065 [Abstract] [PDF] [Supplemental Tables and Figures]   21 April 2008 Steven M Devine, Ravi Vij, Michael Rettig, Laura Todt, Kiley McGlauchlen, Nicholas Fisher, Hollie Devine, Daniel C Link, Gary Calandra, Gary Bridger, Peter Westervelt, and John F DiPersio Rapid mobilization of functional donor hematopoietic cells without G-CSF using plerixafor, an antagonist of the CXCR4/SDF-1 interaction Blood First Edition Paper, prepublished online April 21, 2008; DOI 10.1182/blood-2007-12-130179 [Abstract] [PDF]   Nathan A Ellis, Dezheng Huo, Ozlem Yildiz, Lisa J Worrillow, Mekhala Banerjee, Michelle M Le Beau, Richard A Larson, James M Allan, and Kenan Onel MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility Blood First Edition Paper, prepublished online April 21, 2008; DOI 10.1182/blood-2007-11-126508 [Abstract] [PDF] [Supplemental Tables]   18 April 2008 Sarah M Burke, Thomas B Issekutz, Karkada Mohan, Patrick W K Lee, Maya Shmulevitz, and Jean S Marshall Human mast cell activation with virus associated stimuli leads to the selective chemotaxis of natural killer cells by a CXCL8 dependent mechanism Blood First Edition Paper, prepublished online April 18, 2008; DOI 10.1182/blood-2007-10-118547 [Abstract] [PDF]   Semra Aydin, Davide Rossi, Luciana Bergui, Giovanni D'Arena, Enza Ferrero, Lisa Bonello, Paola Omede, Domenico Novero, Fortunato Morabito, Antonino Carbone, Gianluca Gaidano, Fabio Malavasi, and Silvia Deaglio CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter's syndrome? Blood First Edition Paper, prepublished online April 18, 2008; DOI 10.1182/blood-2008-01-129726 [Abstract] [PDF]   Holger Karsunky, Matthew A Inlay, Thomas Serwold, Deepta Bhattacharya, and Irving L Weissman Flk2+ common lymphoid progenitors possess equivalent differentiation potential for the B and T lineages Blood First Edition Paper, prepublished online April 18, 2008; DOI 10.1182/blood-2007-11-126219 [Abstract] [PDF] [Supplemental Figures]   Dalemari Crowther, Ruth Wild, Gabrielle Sellick, Martin J. S. Dyer, Francesca R Mauro, Robert J.G Cuthbert, Viggo Jonsson, Estella Matutes, Claire Dearden, James Wiley, Stephen Fuller, Daniel Catovsky, and Richard S Houlston Insight into the pathogenesis of chronic lymphocytic leukemia (CLL) through analysis of IgVH gene usage and mutation status in familial CLL Blood First Edition Paper, prepublished online April 18, 2008; DOI 10.1182/blood-2008-03-142349 [Abstract] [PDF]   Claudia Schollkopf, Mads Melbye, Lars Munksgaard, Karin Ekstrom Smedby, Klaus Rostgaard, Bengt Glimelius, Ellen T. Chang, Goran Roos, Mads Hansen, Hans-Olov Adami, and Henrik Hjalgrim Borrelia infection and risk of non-Hodgkin lymphoma Blood First Edition Paper, prepublished online April 18, 2008; DOI 10.1182/blood-2007-08-109611 [Abstract] [PDF]   17 April 2008 Jin Yu, Susanne Heck, Vivek Patel, Jared Levan, Yu Yu, James B. Bussel, and Karina Yazdanbakhsh Defective circulating CD25 regulatory T cells in patients with chronic immune thrombocytopenic purpura Blood First Edition Paper, prepublished online April 17, 2008; DOI 10.1182/blood-2008-01-135335 [Abstract] [PDF]   So Youn Kim, Hyun Sik Jun, Paul A. Mead, Brian C. Mansfield, and Janice Y. Chou Neutrophil stress and apoptosis underlie myeloid dysfunction in glycogen storage disease type Ib Blood First Edition Paper, prepublished online April 17, 2008; DOI 10.1182/blood-2007-12-129114 [Abstract] [PDF]   16 April 2008 Mariska G Rondaij, Ruben Bierings, Ellen L van Agtmaal, Karina A Gijzen, Erica Sellink, Astrid Kragt, Stephen S.G. Ferguson, Koen Mertens, Matthew J Hannah, Jan A van Mourik, Mar Fernandez-Borja, and Jan Voorberg Guanine exchange factor RalGDS mediates exocytosis of Weibel-Palade bodies from endothelial cells Blood First Edition Paper, prepublished online April 16, 2008; DOI 10.1182/blood-2007-07-099309 [Abstract] [PDF] [Supplemental Figure]   Gourapura J. Renukaradhya, Masood A. Khan, Marcus Vieira, Wenjun Du, Jacquelyn Gervay-Hague, and Randy R. Brutkiewicz Type I NKT cells protect (and Type II NKT cells suppress) the host's innate antitumor immune response to a B cell lymphoma Blood First Edition Paper, prepublished online April 16, 2008; DOI 10.1182/blood-2007-05-092866 [Abstract]