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Blood's First Edition Papers: Last updated November 25, 2009 [View by section] To enable Blood's readers to learn about new scientific findings at the earliest possible moment, the Journal has decided to prepublish, in manuscript format, all accepted articles shortly after acceptance as "First Edition Papers." First Edition Papers have undergone full scientific review but none of the editorial preparation, such as copyediting, typesetting, and proofreading, which is mandatory for all articles published in the regular print and online issues of Blood. Disclaimer More about Blood's First Edition Papers: To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link. 25 November 2009 Rekha Pal, Sara A. Monaghan, Andrea Cortese Hassett, Markus Y. Mapara, Peter Schafer, G. David Roodman, Margaret V. Ragni, Lynn Moscinski, Alan List, and Suzanne Lentzsch Immunomodulatory derivatives (IMiDs) induce PU.1 downregulation, myeloid maturation arrest, and neutropenia Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-05-221077 [Abstract] [PDF]   Kei Tamura, Shuuji Mawaribuchi, Shin Yoshimoto, Tadayoshi Shiba, Nobuhiko Takamatsu, and Michihiko Ito TNF-related apoptosis-inducing ligand1 (TRAIL1) enhances the transition of red blood cells from the larval to adult type during metamorphosis in Xenopus Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-04-218966 [Abstract] [PDF]   Lili Milani, Anders Lundmark, Anna Kiialainen, Jessica Nordlund, Trond Flaegstad, Erik Forestier, Mats Heyman, Gudmundur Jonmundsson, Jukka Kanerva, Kjeld Schmiegelow, Stefan Soderhall, Mats G Gustafsson, Gudmar Lonnerholm, and Ann-Christine Syvanen DNA methylation for subtype classification and prediction of treatment outcome in patients with childhood acute lymphoblastic leukemia Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-04-214668 [Abstract] [PDF]   Eva Maria Murga Penas, Evelyne Callet-Bauchu, Hongtao Ye, Sophie Gazzo, Francoise Berger, Georgia Schilling, Nadine Albert-Konetzny, Eik Vettorazzi, Gilles Salles, Iwona Wlodarska, Ming-Qing Du, Carsten Bokemeyer, and Judith Dierlamm The t(14;18)(q32;q21)/IGH-MALT1 translocation in MALT lymphomas contains templated nucleotide insertions and a major breakpoint region similar to follicular and mantle cell lymphoma Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-08-236265 [Abstract] [PDF]   Daniel R. Crooks, Manik C. Ghosh, Ronald G. Haller, Wing-Hang Tong, and Tracey A. Rouault Post-translational stability of the heme biosynthetic enzyme ferrochelatase is dependent on iron availability and intact iron-sulfur cluster assembly machinery Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-09-243105 [Abstract] [PDF]   Yukihiko Ebisuno, Koko Katagiri, Tomoya Katakai, Yoshihiro Ueda, Tomomi Nemoto, Hiroyuki Inada, Junichi Nabekura, Takaharu Okada, Reiji Kannagi, Toshiyuki Tanaka, Masayuki Miyasaka, Nancy Hogg, and Tatsuo Kinashi Rap1 controls lymphocyte adhesion cascades and interstitial migration within lymph nodes in RAPL-dependent and -independent manners Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-03-211979 [Abstract] [PDF]   Katrien Devreese, Kathelijne Peerlinck, and Marc F. Hoylaerts Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants Blood First Edition Paper, prepublished online November 25, 2009; DOI 10.1182/blood-2009-09-244426 [Abstract] [PDF]   24 November 2009 Ren Liu, Xiuqing Li, Anil Tulpule, Yue Zhou, Jeffrey S. Scehnet, Shaobing Zhang, Jong-Soo Lee, Preet M. Chaudhary, Jae Jung, and Parkash S. Gill KSHV induced notch components render endothelial and mural cell characteristics and cell survival Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-08-236745 [Abstract] [Full Text] [PDF]   David F. Bishop, Xiaoye Schneider-Yin, Sonia Clavero, Han-Wook Yoo, Elisabeth I. Minder, and Robert J. Desnick Congenital erythropoietic porphyria: a novel uroporphyrinogen III synthase branchpoint mutation reveals underlying wild-type alternatively-spliced transcripts Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-04-218016 [Abstract] [Full Text] [PDF]   B. Laurent, V. Randrianarison-Huetz, V. Marechal, P. Mayeux, I. Dusanter-Fourt, and D. Dumenil High Mobility Group protein HMGB2 regulates human erythroid differentiation through trans-activation of Gfi-1B transcription Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-06-230094 [Abstract] [Full Text] [PDF]   Rachel T. McGrath, Thomas A.J. McKinnon, Barry Byrne, Richard O' Kennedy, Virginie Terraube, Emily McRae, Roger J.S. Preston, Mike A. Laffan, and James S. O'Donnell Expression of terminal 2-6 linked sialic acid on von Willebrand factor specifically enhances proteolysis by ADAMTS13 Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-09-241547 [Abstract] [Full Text] [PDF]   Ghyath Maarof, Laurence Bouchet-Delbos, Helene Gary-Gouy, Ingrid Durand-Gasselin, Roman Krzysiek, and Ali Dalloul Interleukin-24 inhibits the plasma cell differentiation program in human germinal center B cells Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-05-220251 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Libi Hertzberg, Elena Vendramini, Ithamar Ganmore, Giovanni Cazzaniga, Maike Schmitz, Jane Chalker, Ruth Shiloh, Ilaria Iacobucci, Chen Shochat, Sharon Zeligson, Gunnar Cario, Martin Stanulla, Sabine Strehl, Lisa J Russell, Christine J Harrison, Beat Bornhauser, Akinori Yoda, Gideon Rechavi, Dani Bercovich, Arndt Borkhardt, Helena Kempski, Geertruy te Kronnie, Jean-Pierre Bourquin, Eytan Domany, and Shai Izraeli Down syndrome acute lymphoblastic leukemia: a highly heterogeneous disease in which aberrant expression of CRLF2 is associated with mutated JAK2: a report from the iBFM Study Group Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-08-235408 [Abstract] [Full Text] [PDF]   Rosa Lapalombella, Leslie Andritsos, Qing Liu, Sarah E. May, Rebekah Browning, Lan V. Pham, Kristie A. Blum, William Blum, Asha Ramanunni, Chelsey A. Raymond, Lisa L. Smith, Amy Lehman, Xiaokui Mo, David Jarjoura, Ching-Shih Chen, Richard Ford Jr, Christoph Rader, Natarajan Muthusamy, Amy J. Johnson, and John C. Byrd Lenalidomide treatment promotes CD154 expression on CLL cells and enhances production of antibodies by normal B Cells through a PI3-kinase dependent pathway Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-09-242438 [Abstract] [Full Text] [PDF]   James C. Mulloy, Jose A. Cancelas, Marie-Dominique Filippi, Theodosia A. Kalfa, Fukun Guo, and Yi Zheng Rho GTPases in hematopoiesis and hemopathies Blood First Edition Paper, prepublished online November 24, 2009; DOI 10.1182/blood-2009-09-198127 [Abstract] [Full Text] [PDF]   23 November 2009 Ying-Wei Lin, Zanna M. Beharry, Elizabeth G. Hill, Jin H. Song, Wenxue Wang, Zuping Xia, Zhenhua Zhang, Peter D. Aplan, Jon C. Aster, Charles D. Smith, and Andrew S. Kraft A small molecule inhibitor of Pim protein kinases blocks the growth of precursor T-cell lymphoblastic leukemia/lymphoma Blood First Edition Paper, prepublished online November 23, 2009; DOI 10.1182/blood-2009-07-233445 [Abstract] [Full Text] [PDF]   Jun-ichi Suehiro, Takao Hamakubo, Tatsuhiko Kodama, William C. Aird, and Takashi Minami Vascular endothelial growth factor activation of endothelial cells is mediated by early growth response-3 Blood First Edition Paper, prepublished online November 23, 2009; DOI 10.1182/blood-2009-07-233478 [Abstract] [Full Text] [PDF]   20 November 2009 Kristopher A. Sarosiek, Raquel Malumbres, Hovav Nechushtan, Andrew J. Gentles, Eli Avisar, and Izidore S. Lossos Novel IL-21 signaling pathway upregulates c-Myc and induces apoptosis of diffuse large B-cell lymphomas Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-08-239996 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Sonja Loges, Thomas Schmidt, Marc Tjwa, Katie Van Geyte, Dirk Lievens, Esther Lutgens, Davy Vanhoutte, Delphine Borgel, Stephane Plaisance, Marc Hoylaerts, Aernout Luttun, Mieke Dewerchin, Bart Jonckx, and Peter Carmeliet Malignant cells fuel tumor growth by educating infiltrating leukocytes to produce the mitogen Gas6 Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-06-228684 [Abstract] [Full Text] [PDF] [Supplemental Methods, Table, and Figures]   Tiziano Barbui, Alessandra Carobbio, Francisco Cervantes, Alessandro M. Vannucchi, Paola Guglielmelli, Elisabetta Antonioli, Alberto Alvarez-Larran, Alessandro Rambaldi, Guido Finazzi, and Giovanni Barosi Thrombosis in primary myelofibrosis: incidence and risk factors Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-08-238956 [Abstract] [Full Text] [PDF]   Larysa Sautina, Yuri Sautin, Elaine Beem, Zhuo Zhou, Anna Schuler, Jennafer Brennan, Sergey I. Zharikov, YanPeng Diao, Jorg Bungert, and Mark S. Segal Induction of nitric oxide by erythropoietin is mediated by the β common receptor and requires interaction with VEGF receptor 2 Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-04-216432 [Abstract] [Full Text] [PDF]   Norbert Lubenow, Peter Hinz, Simone Thomaschewski, Theresia Lietz, Michael Vogler, Andrea Ladwig, Michael Junger, Matthias Nauck, Sebastian Schellong, Kathrin Wander, Georg Engel, Axel Ekkernkamp, and Andreas Greinacher The severity of trauma determines the immune response to PF4/heparin and the frequency of heparin-induced thrombocytopenia Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-07-231506 [Abstract] [Full Text] [PDF]   Rashade A. H. Haynes II, Evan Ware, Christopher Premanandan, Bevin Zimmerman, Lianbo Yu, Andrew J. Phipps, and Michael D. Lairmore Cyclosporine-induced immune suppression alters establishment of HTLV-1 infection in a rabbit model Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-07-230912 [Abstract] [Full Text] [PDF]   Ulrich Y. Schaff, Neha Dixit, Emily Procyk, Itsukyo Yamayoshi, Tiffany Tse, and Scott I. Simon Orai1 regulates intracellular calcium, arrest, and shape polarization during neutrophil recruitment in shear flow Blood First Edition Paper, prepublished online November 20, 2009; DOI 10.1182/blood-2009-05-224659 [Abstract] [Full Text] [PDF]   19 November 2009 Aldo M. Roccaro, Antonio Sacco, Emanuel N. Husu, Costas Pitsillides, Steven Vesole, Abdel Kareem Azab, Feda Azab, Molly Melhem, Hai T. Ngo, Phong Quang, Patricia Maiso, Judith Runnels, Mei-Chih Liang, Kwok-Kin Wong, Charles Lin, and Irene M. Ghobrial Dual targeting of the PI3K/Akt/mTOR pathway as an anti-tumor strategy in Waldenstrom's macroglobulinemia Blood First Edition Paper, prepublished online November 19, 2009; DOI 10.1182/blood-2009-07-235747 [Abstract] [Full Text] [PDF]   Estefania Ugarte-Berzal, Javier Redondo-Munoz, Pilar Eroles, Mercedes Hernandez del Cerro, Jose A. Garcia-Marco, Maria Jose Terol, and Angeles Garcia-Pardo VEGF/VEGFR2 interaction downregulates matrix metalloproteinase-9 via STAT1 activation and inhibits B chronic lymphocytic leukemia cell migration Blood First Edition Paper, prepublished online November 19, 2009; DOI 10.1182/blood-2009-08-239426 [Abstract] [Full Text] [PDF]   Kouichi Furugaki, Katerina Pokorna, Carole le Pogam, Masayuki Aoki, Murielle Reboul, Veronique Bajzik, Patricia Krief, Anne Janin, Maria-Elena Noguera, Robert West, Dominique Charron, Christine Chomienne, Marika Pla, Helene Moins-Teisserenc, and Rose Ann Padua DNA vaccination with all-trans retinoic acid treatment induces long term survival and elicits specific immune responses requiring CD4+ and CD8+ T-cell activation in an acute promyelocytic leukemia mouse model Blood First Edition Paper, prepublished online November 19, 2009; DOI 10.1182/blood-2007-08-109009 [Abstract] [Full Text] [PDF]   Roberto Rodriguez, Ryotaro Nakamura, Joycelynne M. Palmer, Pablo Parker, Sepideh Shayani, Auyaporn Nademanee, David Snyder, Vinod Pullarkat, Neil Kogut, Joseph Rosenthal, Eileen Smith, Chatchada Karanes, Margaret O'Donnell, Amrita Y. Krishnan, David Senitzer, and Stephen J. Forman A phase II pilot study of tacrolimus/sirolimus GVHD prophylaxis for sibling donor hematopoietic stem cell transplant using three conditioning regimens Blood First Edition Paper, prepublished online November 19, 2009; DOI 10.1182/blood-2009-03-207563 [Abstract] [Full Text] [PDF]   Nicholas Di Bella, Raymond Taetle, Kathryn Kolibaba, Thomas Boyd, Robert Raju, David Barrera, Ernest W Cochran Jr., Philip Y Dien, Roger Lyons, Peter J Schlegel, Svetislava J Vukelja, Julie Boston, Kristi A Boehm, Yunfei Wang, and Lina Asmar Results of a phase II study of bortezomib in patients with relapsed or refractory indolent lymphoma Blood First Edition Paper, prepublished online November 19, 2009; DOI 10.1182/blood-2009-08-233155 [Abstract] [Full Text] [PDF]   18 November 2009 Susanne Saussele, Michael Lauseker, Alois Gratwohl, Dietrich W. Beelen, Donald Bunjes, Rainer Schwerdtfeger, Hans-Jochem Kolb, Anthony D. Ho, Christiane Falge, Ernst Holler, Gunter Schlimok, Axel R. Zander, Renate Arnold, Lothar Kanz, Robert Dengler, Claudia Haferlach, Brigitte Schlegelberger, Markus Pfirrmann, Martin C Muller, Susanne Schnittger, Armin Leitner, Nadine Pletsch, Andreas Hochhaus, Joerg Hasford, and Ruediger Hehlmann Allogeneic hematopoietic stem cell transplantation (alloSCT) for chronic myeloid leukemia in the imatinib era; evaluation of its impact within a subgroup of the randomized German CML Study IV Blood First Edition Paper, prepublished online November 18, 2009; DOI 10.1182/blood-2009-08-237115 [Abstract] [Full Text] [PDF]   Cong Peng, Yaoyu Chen, Zhongfa Yang, Haojian Zhang, Lori Osterby, Alan G. Rosmarin, and Shaoguang Li PTEN is a tumor suppressor in CML stem cells and BCR-ABL induced leukemias in mice Blood First Edition Paper, prepublished online November 18, 2009; DOI 10.1182/blood-2009-06-228130 [Abstract] [Full Text] [PDF]   Jildou Hoekstra, Ana H.C. Guimaraes, Frank W.G. Leebeek, Sarwa Darwish Murad, Joyce J.M.C. Malfliet, Aurelie Plessier, Manuel Hernandez-Guerra, Philippe Langlet, Elwyn Elias, Jonel Trebicka, Massimo Primignani, Juan-Carlos Garcia-Pagan, Dominique C. Valla, Dingeman C. Rijken, and Harry L.A. Janssen Impaired fibrinolysis as a risk factor for Budd-Chiari syndrome Blood First Edition Paper, prepublished online November 18, 2009; DOI 10.1182/blood-2009-03-211557 [Abstract] [Full Text] [PDF]   Tomomi Toubai, Chelsea Malter, Isao Tawara, Chen Liu, Evelyn Nieves, Kathleen Lowler, Yaping Sun, and Pavan Reddy Immunization with host type CD8+ dendritic cells reduces experimental acute GVHD in an IL-10 dependent manner Blood First Edition Paper, prepublished online November 18, 2009; DOI 10.1182/blood-2009-06-229708 [Abstract] [Full Text] [PDF]   Javeed Iqbal, Dennis D Weisenburger, Timothy C Greiner, Julie M Vose, Timothy McKeithan, Can Kucuk, Huimin Geng, Karen Deffenbacher, Lynette Smith, Karen Dybkaer, Shigeo Nakamura, Masao Seto, Jan Delabie, Francoise Berger, Florence Loong, Wing Y Au, Young-Hyeh Ko, Ivy Sng, James Olen Armitage, and Wing C Chan Molecular signatures to improve diagnosis in peripheral T-cell lymphoma and prognostication in angioimmunoblastic T-cell lymphoma Blood First Edition Paper, prepublished online November 18, 2009; DOI 10.1182/blood-2009-06-227579 [Abstract] [Full Text] [PDF]   17 November 2009 Jihui J. Qiu, Xiaoxi Lu, Bernd B. Zeisig, Zhigui Ma, Xun Cai, Saijuan Chen, Hinrich Gronemeyer, David J. Tweardy, Chi Wai Eric So, and Shuo Dong Leukemic transformation by the APL fusion protein PRKAR1A-RAR critically depends on recruitment of RXR Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-07-232652 [Abstract] [Full Text] [PDF]   Vanessa J. Craig, Isabelle Arnold, Christiane Gerke, Minh Q. Huynh, Thomas Wundisch, Andreas Neubauer, Christoph Renner, Stanley Falkow, and Anne Mueller Gastric MALT lymphoma B cells express polyreactive, somatically mutated immunoglobulins Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-06-228015 [Abstract] [Full Text] [PDF]   Jonathan W. Friedberg, Jeff Sharman, John Sweetenham, Patrick B. Johnston, Julie M. Vose, Ann LaCasce, Julia Schaefer-Cutillo, Sven De Vos, Rajni Sinha, John P. Leonard, Larry D. Cripe, Stephanie A. Gregory, Michael P. Sterba, Ann M. Lowe, Ronald Levy, and Margaret A. Shipp Inhibition of Syk with fostamatinib disodium has significant clinical activity in non Hodgkin's lymphoma and chronic lymphocytic leukemia Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-08-236471 [Abstract] [Full Text] [PDF]   Arpita S. Bharadwaj, Meagan Kelly, Dongsoo Kim, and Hengjun Chao Induction of immune tolerance to FIX by intramuscular AAV gene transfer is independent of the activation status of dendritic cells Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-08-239509 [Abstract] [Full Text] [PDF]   Samar Kheirallah, Pierre Caron, Emilie Gross, Anne Quillet-Mary, Justine Bertrand-Michel, Jean-Jacques Fournie, Guy Laurent, and Christine Bezombes Rituximab inhibits B-cell receptor signaling Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-08-237537 [Abstract] [Full Text] [PDF]   Anissa M Jabbour, Carmel P Daunt, Benjamin D Green, Sandra Vogel, Lavinia Gordon, Rachel S Lee, Natasha Silke, Richard B Pearson, Cassandra J Vandenberg, Priscilla N Kelly, Stephen L Nutt, Andreas Strasser, Christoph Borner, and Paul G Ekert Myeloid progenitor cells lacking p53 exhibit delayed upregulation of Puma and prolonged survival after cytokine deprivation Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-07-230730 [Abstract] [Full Text] [PDF]   Santi Suryani, David A Fulcher, Brigitte Santner-Nanan, Ralph Nanan, Melanie Wong, Peter J Shaw, John Gibson, Andrew Williams, and Stuart G Tangye Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells Blood First Edition Paper, prepublished online November 17, 2009; DOI 10.1182/blood-2009-07-234799 [Abstract] [Full Text] [PDF]   16 November 2009 Ion Cristobal, Francisco J. Blanco, Laura Garcia-Orti, Nerea Marcotegui, Carmen Vicente, Jose Rifon, Francisco J. Novo, Eva Bandres, Maria J. Calasanz, Carmelo Bernabeu, and Maria D. Odero SETBP1 overexpression is a novel leukemogenic mechanism that predicts adverse outcome in elderly patients with acute myeloid leukemia Blood First Edition Paper, prepublished online November 16, 2009; DOI 10.1182/blood-2009-06-227363 [Abstract] [Full Text] [PDF]   Benilde Cosmi, Cristina Legnani, Alberto Tosetto, Vittorio Pengo, Angelo Ghirarduzzi, Sophie Testa, Domenico Prisco, Daniela Poli, Armando Tripodi, Francesco Marongiu, and Gualtiero Palareti Usefulness of repeated D-dimer testing after stopping anticoagulation for a first episode of unprovoked venous thromboembolism: the PROLONG II prospective study Blood First Edition Paper, prepublished online November 16, 2009; DOI 10.1182/blood-2009-08-237354 [Abstract] [Full Text] [PDF]   13 November 2009 Matthew Staron, Yi Yang, Bei Liu, Janet Li, Yuankai Shen, Juan Carlos Zuniga-Pflucker, Hector L. Aguila, Irving Goldschneider, and Zihai Li gp96, an endoplasmic reticulum master chaperone for integrins and Toll-like receptors, selectively regulates early T and B lymphopoiesis Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-07-233031 [Abstract] [Full Text] [PDF]   Eric Aubin, Real Lemieux, and Renee Bazin Indirect inhibition of in vivo and in vitro T cell responses by intravenous immunoglobulins due to impaired antigen presentation Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-06-225417 [Abstract] [Full Text] [PDF]   Dharminder Chauhan, Ajita V. Singh, Bryan Ciccarelli, Paul G. Richardson, Michael A. Palladino, and Kenneth C. Anderson Combination of novel proteasome inhibitor NPI-0052 and lenalidomide trigger in vitro and in vivo synergistic cytotoxicity in multiple myeloma Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-03-213009 [Abstract] [Full Text] [PDF]   Sheng F. Cai, Xuefang Cao, Anjum Hassan, Todd A. Fehniger, and Timothy J. Ley Granzyme B is not required for regulatory T cell-mediated suppression of graft-versus-host disease Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-07-233676 [Abstract] [Full Text] [PDF]   Masayuki Fujioka, Kazuhide Hayakawa, Kenichi Mishima, Ai Kunizawa, Keiichi Irie, Sei Higuchi, Takafumi Nakano, Carl Muroi, Hidetada Fukushima, Mitsuhiko Sugimoto, Fumiaki Banno, Koichi Kokame, Toshiyuki Miyata, Michihiro Fujiwara, Kazuo Okuchi, and Kenji Nishio ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating post-ischemic hypoperfusion Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-06-230110 [Abstract] [Full Text] [PDF]   Rogier M. Reijmers, Richard W. J. Groen, Henk Rozemuller, Annemieke Kuil, Anneke de Haan-Kramer, Tamas Csikos, Anton C. M. Martens, Marcel Spaargaren, and Steven T. Pals Targeting EXT-1 reveals a crucial role for heparan sulfate in the growth of multiple myeloma Blood First Edition Paper, prepublished online November 13, 2009; DOI 10.1182/blood-2009-02-204396 [Abstract] [Full Text] [PDF]   12 November 2009 Alan K Burnett, Robert K Hills, Claire Green, Sarah Jenkinson, Kenneth Koo, Yashma Patel, Carol Guy, Amanda Gilkes, Donald W Milligan, Anthony H Goldstone, Archibald G Prentice, Keith Wheatley, David C Linch, and Rosemary E Gale The impact on outcome of the addition of all-trans retinoic acid to intensive chemotherapy in younger patients with non-acute promyelocytic acute myeloid leukemia: overall results and results in genotypic subgroups defined by mutations in NPM1, FLT3 and CEBPA Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2009-08-236588 [Abstract] [Full Text] [PDF]   Won-Woo Lee, Seong Wook Kang, Jihoon Choi, Seung-Hyun Lee, Kamini Shah, Elizabeth E. Eynon, Richard A. Flavell, and Insoo Kang Regulating human Th17 cells via differential expression of IL-1 receptor Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2009-08-236521 [Abstract] [Full Text] [PDF]   Molly A. Ingersoll, Rainer Spanbroek, Claudio Lottaz, Emmanuel L. Gautier, Marion Frankenberger, Reinhard Hoffmann, Roland Lang, Muzlifah Haniffa, Matthew Collin, Frank Tacke, Andreas J.R. Habenicht, Loems Ziegler-Heitbrock, and Gwendalyn J. Randolph Comparison of gene expression profiles between human and mouse monocyte subsets Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2009-07-235028 [Abstract] [Full Text] [PDF]   Maria Luigia Randi, Anna Maria Brunati, Margherita Scapin, Martina Frasson, Renzo Deana, Elisa Magrin, Fabrizio Fabris, and Arianna Donella-Deana Src tyrosine kinase pre-activation is associated with platelet hypersensitivity in essential thrombocythemia and polycythemia vera Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2008-12-196535 [Abstract] [Full Text] [PDF]   Graziella Curtale, Franca Citarella, Claudia Carissimi, Marina Goldoni, Nicoletta Carucci, Valerio Fulci, Debora Franceschini, Francesca Meloni, Vincenzo Barnaba, and Giuseppe Macino An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and AICD in T lymphocytes Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2009-06-225987 [Abstract] [Full Text] [PDF]   Hongjie Wang, Ying Liu, Zong-Yi Li, Xiaolong Fan, Akseli Hemminki, and Andre Lieber A recombinant adenovirus type 35 fiber knob protein sensitizes lymphoma cells to rituximab therapy Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2009-05-222463 [Abstract] [Full Text] [PDF]   Jennifer F. A. Swisher, Nicholas Burton, Silvia Bacot, Stefanie N. Vogel, and Gerald M. Feldman Annexin A2 tetramer activates human and murine macrophages through TLR4 Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2009-06-226944 [Abstract] [Full Text] [PDF]   Xiaoming Feng, Gregory C. Ippolito, Lifeng Tian, Karla Wiehagen, Soyoung Oh, Arivazhagan Sambandam, Jessica Willen, Ralph M. Bunte, Shanna D. Maika, June V. Harriss, Andrew J. Caton, Avinash Bhandoola, Philip W. Tucker, and Hui Hu Foxp1 is an essential transcriptional regulator for the generation of quiescent naive T cells during thymocyte development Blood First Edition Paper, prepublished online November 12, 2009; DOI 10.1182/blood-2009-07-232694 [Abstract] [Full Text] [PDF]   10 November 2009 Jeffrey D. Ahlers and Igor M. Belyakov Memories that last forever: strategies for optimizing vaccine T cell memory Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-06-227546 [Abstract] [Full Text] [PDF]   Kyle Niessen, Gu Zhang, John Brady Ridgway, Hao Chen, and Minhong Yan ALK1 signaling regulates early postnatal lymphatic vessel development Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-07-235655 [Abstract] [Full Text] [PDF]   Ersi Voskaridou, Dimitrios Christoulas, Antonios Bilalis, Eleni Plata, Konstantinos Varvagiannis, George Stamatopoulos, Klio Sinopoulou, Aggeliki Balassopoulou, Dimitris Loukopoulos, and Evangelos Terpos The effect of prolonged administration of hydroxyurea on morbidity and mortality in adult patients with sickle-cell syndromes: results of a 17-year, single center trial (LaSHS) Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-05-221333 [Abstract] [Full Text] [PDF]   Lars Bullinger, Mathias Ehrich, Konstanze Dohner, Richard F. Schlenk, Hartmut Dohner, Matthew R. Nelson, and Dirk van den Boom Quantitative DNA-methylation predicts survival in adult acute myeloid leukemia Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-03-211003 [Abstract] [Full Text] [PDF]   Celine Barres, Lionel Blanc, Pascale Bette-Bobillo, Sabine Andre, Robert Mamoun, Hans-Joachim Gabius, and Michel Vidal Galectin-5 is bound onto the surface of rat reticulocyte exosomes and modulates vesicle uptake by macrophages Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-07-231449 [Abstract] [Full Text] [PDF]   Cyril Fauriat, Martin A. Ivarsson, Hans-Gustaf Ljunggren, Karl-Johan Malmberg, and Jakob Michaelsson Education of human natural killer cells by activating killer cell immunoglobulin-like receptors Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-09-245746 [Abstract] [Full Text] [PDF]   Yong Tang, Marie J. Desierto, Jichun Chen, and Neal S. Young The role of the Th1 transcription factor T-bet in a mouse model of immune-mediated bone marrow failure Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-03-211383 [Abstract] [Full Text] [PDF]   Christoph Schliemann, Christoph Roesli, Haruhiko Kamada, Beatrice Borgia, Tim Fugmann, Wolfram Klapper, and Dario Neri In vivo biotinylation of the vasculature in B cell lymphomaidentifies BST-2 as a target for antibody-based therapy Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-08-239004 [Abstract] [Full Text] [PDF]   Stefano Ugel, Elisa Scarselli, Manuela Iezzi, Carmela Mennuni, Tania Pannellini, Francesco Calvaruso, Barbara Cipriani, Raffaele De Palma, Lucia Ricci-Vitiani, Elisa Peranzoni, Piero Musiani, Paola Zanovello, and Vincenzo Bronte Autoimmune B cell lymphopenia following successful adoptive therapy with telomerase-specific T lymphocytes Blood First Edition Paper, prepublished online November 10, 2009; DOI 10.1182/blood-2009-07-233270 [Abstract] [Full Text] [PDF]   9 November 2009 Pedro Farinha, Abdulwahab Al-Tourah, Karamjit Gill, Richard Klasa, Joseph M Connors, and Randy D Gascoyne The architectural pattern of FOXP3-positive T cells in follicular lymphoma is an independent predictor of survival and histologic transformation Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2009-07-235598 [Abstract] [Full Text] [PDF]   Hans Beier Ommen, Susanne Schnittger, Jelena V. Jovanovic, Ingrid Beier Ommen, Henrik Hasle, Mette Ostergaard, David Grimwade, and Peter Hokland Strikingly different molecular relapse kinetics in NPM1c, PML-RARA, RUNX1-RUNX1T1 and CBFB-MYH11 acute myeloid leukemias Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2009-04-212530 [Abstract] [Full Text] [PDF]   Michael J. Flister, Andrew Wilber, Kelly L. Hall, Caname Iwata, Kohei Miyazono, Riccardo E. Nisato, Michael S. Pepper, David C. Zawieja, and Sophia Ran Inflammation induces lymphangiogenesis through upregulation of VEGFR-3 mediated by NF-B and Prox1 Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2008-12-196840 [Abstract] [Full Text] [PDF]   Amanda Waterstrat, Ying Liang, Carol F. Swiderski, Brent J. Shelton, and Gary Van Zant Congenic interval of CD45 / Ly-5 congenic mice contains multiple genes that may influence hematopoietic stem cell engraftment Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2008-03-143370 [Abstract] [Full Text] [PDF]   Kebede Hussein, Animesh D. Pardanani, Daniel L. van Dyke, Curtis A. Hanson, and Ayalew Tefferi International Prognostic Scoring System-independent cytogenetic risk categorization in primary myelofibrosis Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2009-08-240135 [Abstract] [Full Text] [PDF]   J K Makani, A N Komba, S E Cox, J Oruo, K Mwamtemi, J Kitundu, P Magesa, S Rwezaula, E Meda, J Mgaya, K Pallangyo, E Okiro, D Muturi, C R Newton, G Fegan, K Marsh, and T N Williams Malaria in patients with sickle cell anemia: burden, risk factors and outcome at outpatient clinic and during hospitalization Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2009-07-233528 [Abstract] [Full Text] [PDF]   Hozumi Motohashi, Momoko Kimura, Rie Fujita, Ai Inoue, Xiaoqing Pan, Mariko Takayama, Fumiki Katsuoka, Hiroyuki Aburatani, Emery H. Bresnick, and Masayuki Yamamoto NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2009-05-223107 [Abstract] [Full Text] [PDF]   Changlian Lu, Xiao-Yan Li, Yuexian Hu, R. Grant Rowe, and Stephen J. Weiss MT1-MMP controls human mesenchymal stem cell trafficking and differentiation Blood First Edition Paper, prepublished online November 9, 2009; DOI 10.1182/blood-2009-06-228494 [Abstract] [Full Text] [PDF]   6 November 2009 Pietro Sodani, Antonella Isgro, Javid Gaziev, Paola Polchi, Katia Paciaroni, Marco Marziali, Maria Domenica Simone, Andrea Roveda, Aldo Montuoro, Cecilia Alfieri, Gioia De Angelis, Cristiano Gallucci, Buket Erer, Giancarlo Isacchi, Francesco Zinno, Gaspare Adorno, Alessandro Lanti, Lawrence Faulkner, Manuela Testi, Marco Andreani, and Guido Lucarelli Purified T-depleted, CD34+ peripheral blood and bone marrow cell transplantation from haploidentical mother to child with thalassemia Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-05-218982 [Abstract] [Full Text] [PDF]   Meena Kanduri, Nicola Cahill, Hanna Goransson, Camilla Enstrom, Fergus Ryan, Anders Isaksson, and Richard Rosenquist Differential genome-wide array-based methylation profiles in prognostic subsets of chronic lymphocytic leukemia Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-07-232868 [Abstract] [Full Text] [PDF]   Hiroshi Watarai, Andrei Rybouchkin, Naomi Hongo, Yuko Nagata, Sakura Sakata, Etsuko Sekine, Nyambayar Dashtsoodol, Takuya Tashiro, Shin-ichiro Fujii, Kanako Shimizu, Kenji Mori, Kyoko Masuda, Hiroshi Kawamoto, Haruhiko Koseki, and Masaru Taniguchi Generation of functional NKT cells in vitro from embryonic stem cells bearing rearranged invariant V14-J18 TCR gene Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-04-217729 [Abstract] [Full Text] [PDF]   Celine Cougoule, Veronique Le Cabec, Renaud Poincloux, Talal Al Saati, Jean-Louis Mege, Guillaume Tabouret, Clifford A. Lowell, Nathalie Laviolette-Malirat, and Isabelle Maridonneau-Parini Three-dimensional migration of macrophages requires Hck for podosome organization and extracellular matrix proteolysis Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-04-218735 [Abstract] [Full Text] [PDF]   Jianhua Yu, Hsiaoyin Charlene Mao, Min Wei, Tiffany Hughes, Jianying Zhang, Il-kyoo Park, Shujun Liu, Susan McClory, Guido Marcucci, Rossana Trotta, and Michael A. Caligiuri CD94 surface density identifies a functional intermediary between the CD56bright and CD56dim human NK cell subsets Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-04-215491 [Abstract] [Full Text] [PDF]   Donald M. Arnold, Ishac Nazi, Aurelio Santos, Howard Chan, Nancy M. Heddle, Theodore E. Warkentin, and John G. Kelton Combination immunosuppressant therapy for patients with chronic refractory immune thrombocytopenic purpura Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-06-222448 [Abstract] [Full Text] [PDF]   R. Beedholm-Ebsen, K. van de Wetering, T. Hardlei, E. Nexo, P. Borst, and S. K. Moestrup Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-07-232587 [Abstract] [Full Text] [PDF]   Nicholas M. Andronicos, Emily I. Chen, Nagyung Baik, Hongdong Bai, Caitlin M. Parmer, William B. Kiosses, Mark P. Kamps, John R. Yates III, Robert J. Parmer, and Lindsey A. Miles Proteomics-based discovery of a novel, structurally unique, and developmentally regulated plasminogen receptor, Plg-RKT, a major regulator of cell surface plasminogen activation Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2008-11-188938 [Abstract] [Full Text] [PDF]   Daniel J. Bridges, James Bunn, Jan A. van Mourik, Georges Grau, Roger J.S. Preston, Malcolm Molyneux, Valery Combes, James S. O'Donnell, Bas de Laat, and Alister Craig Rapid activation of endothelial cells enables P. falciparum adhesion to platelet decorated von Willebrand factor strings Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-07-235150 [Abstract] [Full Text] [PDF]   Bing Z. Carter, Duncan H. Mak, Wendy D. Schober, Erich Koller, Clemencia Pinilla, Lyubomir T. Vassilev, John C. Reed, and Michael Andreeff Simultaneous activation of p53 and inhibition of XIAP enhance the activation of apoptosis signaling pathways in AML Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-03-212563 [Abstract] [Full Text] [PDF]   Anthony V Moorman, Lucy Chilton, Jennifer Wilkinson, Hannah M Ensor, Nick Bown, and Stephen J Proctor A population based cytogenetic study of adults with acute lymphoblastic leukaemia (ALL) Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-07-232124 [Abstract] [Full Text] [PDF]   Tao Wu, Jiangguo Lin, Miguel A. Cruz, Jing-Fei Dong, and Cheng Zhu Force-induced cleavage of single VWF A1A2A3-tridomains by ADAMTS-13 Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-03-210369 [Abstract] [Full Text] [PDF]   Caryn Y. Ito, Daniel C. Kirouac, Gerard J. Madlambayan, Mei Yu, Ian Rogers, and Peter W. Zandstra The AC133+CD38-, but not the rhodamine-low phenotype, tracks LTC-IC and SRC function in human cord blood ex vivo expansion cultures Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-07-228106 [Abstract] [Full Text] [PDF]   Jinah Han, Young Jun Koh, Hye Rin Moon, Hyun Gee Ryoo, Chung-Hyun Cho, Injune Kim, and Gou Young Koh Adipose tissue is an extramedullary reservoir for functional hematopoietic stem and progenitor cells Blood First Edition Paper, prepublished online November 6, 2009; DOI 10.1182/blood-2009-05-219923 [Abstract] [Full Text] [PDF]   4 November 2009 Martin Pelletier, Laura Maggi, Alessandra Micheletti, Elena Lazzeri, Nicola Tamassia, Claudio Costantini, Lorenzo Cosmi, Claudio Lunardi, Francesco Annunziato, Sergio Romagnani, and Marco A. Cassatella Evidence for a cross-talk between human neutrophils and Th17 cells Blood First Edition Paper, prepublished online November 4, 2009; DOI 10.1182/blood-2009-04-216085 [Abstract] [Full Text] [PDF] [Supplemental Methods and Figures]   Sujith Samarasinghe, Christoph Mancao, Martin Pule, Niga Nawroly, Helen Karlsson, Jennifer Brewin, Peter Openshaw, H. Bobby Gaspar, Paul Veys, and Persis J. Amrolia Functional characterization of alloreactive T-cells identifies CD25 and CD71 as optimal targets for a clinically applicable allodepletion strategy Blood First Edition Paper, prepublished online November 4, 2009; DOI 10.1182/blood-2009-08-235895 [Abstract] [Full Text] [PDF]   Jordan D Dimitrov, Suryasarathi Dasgupta, Ana-Maria Navarrete, Sandrine Delignat, Yohann Repesse, Yann Meslier, Cyril Planchais, Maud Teyssandier, Roberto Motterlini, Jagadeesh Bayry, Srinivas V Kaveri, and Sebastien Lacroix-Desmazes Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII Blood First Edition Paper, prepublished online November 4, 2009; DOI 10.1182/blood-2009-04-216408 [Abstract] [Full Text] [PDF]   Kate Vandyke, Stephen Fitter, Andrea L. Dewar, Timothy P. Hughes, and Andrew C.W. Zannettino Dysregulation of bone remodelling by imatinib mesylate Blood First Edition Paper, prepublished online November 4, 2009; DOI 10.1182/blood-2009-08-237404 [Abstract] [Full Text] [PDF]   Nicola Bonadies, Thomas Pabst, and Beatrice U. Mueller Heterozygous deletion of the PU.1 locus in human AML Blood First Edition Paper, prepublished online November 4, 2009; DOI 10.1182/blood-2009-03-212225 [Abstract] [Full Text] [PDF]   Isao Kobayashi, Hiromasa Ono, Tadaaki Moritomo, Koichiro Kano, Teruyuki Nakanishi, and Toshio Suda Comparative gene expression analysis of zebrafish and mammals identifies common regulators in hematopoietic stem cells Blood First Edition Paper, prepublished online November 4, 2009; DOI 10.1182/blood-2009-07-232322 [Abstract] [Full Text] [PDF]   3 November 2009 Luis I Sanchez-Abarca, Silvia Gutierrez-Cosio, Carlos Santamaria, Teresa Caballero-Velazquez, Belen Blanco, Carmen Herrero-Sanchez, Juan L Garcia, Soraya Carrancio, Pilar Hernandez-Campo, Francisco J Gonzalez, Teresa Flores, Laura Ciudad, Esteban Ballestar, Consuelo del Canizo, Jesus F San Miguel, and Jose A Perez-Simon Immunomodulatory effect of 5-azacytidine (5-azaC): potential role in the transplantation setting Blood First Edition Paper, prepublished online November 3, 2009; DOI 10.1182/blood-2009-03-210393 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Alfredo Dragani, Silvia Pascale, Antonio Recchiuti, Domenico Mattoscio, Stefano Lattanzio, Giovanna Petrucci, Luciana Mucci, Elisabetta Ferrante, Aida Habib, Franco O. Ranelletti, Giovanni Ciabattoni, Giovanni Davi, Carlo Patrono, and Bianca Rocca The contribution of cyclooxygenase-1 and -2 to persistent thromboxane biosynthesis in aspirin-treated essential thrombocythemia: implications for antiplatelet therapy Blood First Edition Paper, prepublished online November 3, 2009; DOI 10.1182/blood-2009-08-236679 [Abstract] [Full Text] [PDF]   Frank C. Cackowski, Judith L. Anderson, Kenneth D. Patrene, Rushir J. Choksi, Steven D. Shapiro, Jolene J. Windle, Harry C. Blair, and G. David Roodman Osteoclasts are important for bone angiogenesis Blood First Edition Paper, prepublished online November 3, 2009; DOI 10.1182/blood-2009-08-237628 [Abstract] [Full Text] [PDF]   Holger Weishaupt, Mikael Sigvardsson, and Joanne L. Attema Epigenetic chromatin states uniquely define the developmental plasticity of murine hematopoietic stem cells Blood First Edition Paper, prepublished online November 3, 2009; DOI 10.1182/blood-2009-07-235176 [Abstract] [Full Text] [PDF]   Francesco Forconi, Kathleen N. Potter, Isla Wheatley, Nikos Darzentas, Elisa Sozzi, Kostas Stamatopoulos, C. Ian Mockridge, Graham Packham, and Freda K. Stevenson The normal IGHV1-69-derived B-cell repertoire contains "stereotypic" patterns characteristic of unmutated CLL Blood First Edition Paper, prepublished online November 3, 2009; DOI 10.1182/blood-2009-06-225813 [Abstract] [Full Text] [PDF]   2 November 2009 Murielle Roussel, Philippe Moreau, Anne Huynh, Jean-Yves Mary, Clotaire Danho, Denis Caillot, Cyrille Hulin, Christophe Fruchart, Gerald Marit, Brigitte Pegourie, Pascal Lenain, Carla Araujo, Brigitte Kolb, Edouard Randriamalala, Bruno Royer, Anne-Marie Stoppa, Mammoun Dib, Veronique Dorvaux, Laurent Garderet, Claire Mathiot, Herve Avet-Loiseau, Jean-Luc Harousseau, and Michel Attal Bortezomib and high dose melphalan as conditioning regimen before autologous stem cell transplantation in patients with de novo multiple myeloma: a phase II study of the Intergroupe Francophone du Myelome (IFM) Blood First Edition Paper, prepublished online November 2, 2009; DOI 10.1182/blood-2009-06-229658 [Abstract] [Full Text] [PDF] [Supplemental Appendix]   Ashley N Mays, Neil Osheroff, Yuanyuan Xiao, Joseph L Wiemels, Carolyn A Felix, Jo Ann W Byl, Kandeepan Saravanamuttu, Andrew Peniket, Robert Corser, Cherry Chang, Christine Hoyle, Anne N Parker, Syed K Hasan, Francesco Lo-Coco, Ellen Solomon, and David Grimwade Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia Blood First Edition Paper, prepublished online November 2, 2009; DOI 10.1182/blood-2009-07-235051 [Abstract] [Full Text] [PDF] [Supplemental Figure]   30 October 2009 Scott E. James, Nural N. Orgun, Thomas F. Tedder, Mark J. Shlomchik, Michael C. Jensen, Yukang Lin, Philip D. Greenberg, and Oliver W. Press Antibody mediated B cell depletion prior to adoptive immunotherapy with T cells expressing CD20-specific chimeric T cell receptors facilitates eradication of leukemia in immunocompetent mice Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-08-232967 [Abstract] [Full Text] [PDF]   Toshiko Tanaka, Cindy N. Roy, Wenliang Yao, Amy Matteini, Richard D. Semba, Dan Arking, Jeremy D. Walston, Linda P. Fried, Andrew Singleton, Jack Guralnik, Goncalo R. Abecasis, Stefania Bandinelli, Dan L. Longo, and Luigi Ferrucci A genome-wide association analysis of serum iron concentrations Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-07-232496 [Abstract] [Full Text] [PDF]   David Garcia, Edward Libby, and Mark A. Crowther The new oral anticoagulants Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-09-241851 [Abstract] [Full Text] [PDF]   Anna Kalota and Alan M. Gewirtz A prototype nonpeptidyl, hydrazone class, thrombopoietin receptor agonist, SB-559457, is toxic to primary human myeloid leukemia cells Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-06-227751 [Abstract] [Full Text] [PDF]   Audrey Varin, Subhankar Mukhopadhyay, Georges Herbein, and Siamon Gordon Alternative activation of macrophages by IL-4 impairs phagocytosis of pathogens but potentiates microbial-induced signalling and cytokine secretion Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-08-236711 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Jun Yang, Xin Liu, Susan B. Nyland, Ranran Zhang, Lindsay K. Ryland, Kathleen Broeg, Kendall Thomas Baab, Nancy Ruth Jarbadan, Rosalyn Irby, and Thomas P. Loughran Jr. Platelet-derived growth factor mediates survival of leukemic large granular lymphocytes via an autocrine regulatory pathway Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-06-223719 [Abstract] [Full Text] [PDF]   Helen E Heslop, Karen S Slobod, Martin A Pule, Gregory A Hale, Alexandra Rousseau, Colton A Smith, Catherine M Bollard, Hao Liu, Meng-Fen Wu, Richard J Rochester, Persis J Amrolia, Julia L Hurwitz, Malcolm K Brenner, and Cliona M Rooney Long term outcome of EBV specific T-cell infusions to prevent or treat EBV-related lymphoproliferative disease in transplant recipients Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-08-239186 [Abstract] [Full Text] [PDF]   Sebastian J. Saur, Veena Sangkhae, Amy E. Geddis, Kenneth Kaushansky, and Ian S. Hitchcock Ubiquitination and degradation of the thrombopoietin receptor c-Mpl Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-06-227033 [Abstract] [Full Text] [PDF]   H. Dohner, E. H. Estey, S. Amadori, F. R. Appelbaum, T. Buchner, A. K. Burnett, H. Dombret, P. Fenaux, D. Grimwade, R. A. Larson, F. Lo Coco, T. Naoe, D. Niederwieser, G. J. Ossenkoppele, M. A. Sanz, J. Sierra, M. S. Tallman, B. Lowenberg, and C. D. Bloomfield Diagnosis and management of acute myeloid leukemia in adults: recommendations from an international expert panel,on behalf of the European LeukemiaNet Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-07-235358 [Abstract] [Full Text] [PDF]   Huining Kang, I-Ming Chen, Carla S. Wilson, Edward J. Bedrick, Richard C. Harvey, Susan R. Atlas, Meenakshi Devidas, Charles G. Mullighan, Xuefei Wang, Maurice Murphy, Kerem Ar, Walker Wharton, Michael J. Borowitz, W. Paul Bowman, Deepa Bhojwani, William L. Carroll, Bruce Matthew Camitta, Gregory H. Reaman, Malcolm A. Smith, James R. Downing, Stephen P. Hunger, and Cheryl L. Willman Gene expression classifiers for relapse-free survival and minimal residual disease improve risk classification and outcome prediction in pediatric B-precursor acute lymphoblastic leukemia Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-05-218560 [Abstract] [Full Text] [PDF]   Esther Carreras, Sean Turner, Mark Barton Frank, Nicholas Knowlton, Jeanette Osban, Michael Centola, Chae Gyu Park, Amie Simmons, Jose Alberola-Ila, and Susan Kovats Estrogen receptor signaling promotes dendritic cell differentiation by increasing expression of the transcription factor IRF4 Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-08-236935 [Abstract] [Full Text] [PDF]   Keguo Li, Yannick Blum, Anjali Verma, Zhong Liu, Kallal Pramanik, Noah R. Leigh, Chang Z. Chun, Ganesh V. Samant, Baofeng Zhao, Maija K. Garnaas, Mark A. Horswill, Stephen A. Stanhope, Paula E. North, Robert Q. Miao, George A. Wilkinson, Markus Affolter, and Ramani Ramchandran A non-coding antisense RNA in tie-1 locus regulates tie-1 function in vivo Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-09-242180 [Abstract] [Full Text] [PDF]   H M Lokhorst, B van der Holt, S Zweegman, E Vellenga, S Croockewit, M H van Oers, P von dem Borne, P Wijermans, R Schaafsma, O de Weerdt, S Wittebol, Michel Delforge, H Berenschot, G M Bos, K S Jie, H Sinnege, M van Marwijk-Kooy, P Joosten, M C Minnema, R Ammerlaan, and P Sonneveld A randomized phase III study on the effect of thalidomide combined with Adriamycin, dexamethasone (TAD), and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myeloma Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-05-222539 [Abstract] [Full Text] [PDF]   Susan Branford, Junia V Melo, and Timothy P. Hughes Selecting optimal second-line tyrosine kinase inhibitor therapy for chronic myeloid leukemia patients after imatinib failure - does the BCR-ABL mutation status really matter? Blood First Edition Paper, prepublished online October 30, 2009; DOI 10.1182/blood-2009-08-215939 [Abstract] [Full Text] [PDF]   28 October 2009 Nathalie Droin, Arnaud Jacquel, Jean-Baptiste Hendra, Cindy Racoeur, Caroline Truntzer, Delphine Pecqueur, Naima Benikhlef, Marion Ciudad, Leslie Guery, Valerie Jooste, Erick Dufour, Pierre Fenaux, Bruno Quesnel, Olivier Kosmider, Michaela Fontenay, Patrick Ducoroy, and Eric Solary Alpha-defensins secreted by dysplastic granulocytes inhibit the differentiation of monocytes in chronic myelomonocytic leukemia Blood First Edition Paper, prepublished online October 28, 2009; DOI 10.1182/blood-2009-05-224352 [Abstract] [Full Text] [PDF] [Supplemental Figures]   Xiang Li, Shunji Jia, Shaohe Wang, Yuemeng Wang, and Anming Meng Mta3-NuRD complex is a master regulator for initiation of primitive hematopoiesis in vertebrate embryos Blood First Edition Paper, prepublished online October 28, 2009; DOI 10.1182/blood-2009-06-227777 [Abstract] [Full Text] [PDF]   Lina Jansson and Jonas Larsson W41/W41 blastocyst complementation: a system for genetic modeling of hematopoiesis Blood First Edition Paper, prepublished online October 28, 2009; DOI 10.1182/blood-2009-07-235622 [Abstract] [Full Text] [PDF]   Stephan Bluml, Gordin Zupkovitz, Stefanie Kirchberger, Maria Seyerl, Valery N. Bochkov, Karl Stuhlmeier, Otto Majdic, Gerhard J. Zlabinger, Christian Seiser, and Johannes Stockl Epigenetic regulation of dendritic cell differentiation and function by oxidized phospholipids Blood First Edition Paper, prepublished online October 28, 2009; DOI 10.1182/blood-2008-11-191429 [Abstract] [Full Text] [PDF]   27 October 2009 C. L. Fisher, N. Pineault, C. Brookes, C. D. Helgason, H. Ohta, C. Bodner, J. L. Hess, R. K. Humphries, and H. W. Brock Loss-of-function Additional sex combs-like1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia Blood First Edition Paper, prepublished online October 27, 2009; DOI 10.1182/blood-2009-07-230698 [Abstract] [Full Text] [PDF]   Aaron Yun Chen, Elizabeth Yan Zhang, Wuxiang Guan, Fang Cheng, Steve Kleiboeker, Thomas M. Yankee, and Jianming Qiu The small 11kDa non-structural protein of human parvovirus B19 plays a key role in inducing apoptosis during B19 virus infection of primary erythroid progenitor cells Blood First Edition Paper, prepublished online October 27, 2009; DOI 10.1182/blood-2009-04-215756 [Abstract] [Full Text] [PDF]   Connie Duckers, Paolo Simioni, Luca Spiezia, Claudia Radu, Paolo Dabrilli, Sabrina Gavasso, Jan Rosing, and Elisabetta Castoldi Residual platelet factor V ensures thrombin generation in patients with severe congenital factor V deficiency and mild bleeding symptoms Blood First Edition Paper, prepublished online October 27, 2009; DOI 10.1182/blood-2009-08-237719 [Abstract] [Full Text] [PDF]   Elina Kivi, Kati Elima, Kristiina Aalto, Yvonne Nymalm, Kaisa Auvinen, Erkki Koivunen, Diana M. Otto, Paul R. Crocker, Tiina A. Salminen, Marko Salmi, and Sirpa Jalkanen Human Siglec-10 can bind to vascular adhesion protein-1 (VAP-1) and generate enzymatic products Blood First Edition Paper, prepublished online October 27, 2009; DOI 10.1182/blood-2009-04-219253 [Abstract] [Full Text] [PDF]   A. Keith Stewart, Paul G. Richardson, and Jesus F. San-Miguel How I treat multiple myeloma in younger patients Blood First Edition Paper, prepublished online October 27, 2009; DOI 10.1182/blood-2009-07-204651 [Abstract] [Full Text] [PDF]   Fumio Nakahara, Mamiko Sakata-Yanagimoto, Yukiko Komeno, Naoko Kato, Tomoyuki Uchida, Kyoko Haraguchi, Keiki Kumano, Yuka Harada, Hironori Harada, Jiro Kitaura, Seishi Ogawa, Mineo Kurokawa, Toshio Kitamura, and Shigeru Chiba Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia Blood First Edition Paper, prepublished online October 27, 2009; DOI 10.1182/blood-2009-05-222836 [Abstract] [Full Text] [PDF]   Iain Moore, Lisa Strain, Isabel Pappworth, David Kavanagh, Paul N Barlow, Andew P Herbert, Christoph Q Schmidt, Scott J Staniforth, Lucy V Holmes, Roy Ward, Lynn Morgan, Tim H J Goodship, and Kevin J Marchbank Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4 and with mutations in CFH, CFI, CD46, and C3 in patients with atypical haemolytic uraemic syndrome Blood First Edition Paper, prepublished online October 27, 2009; DOI 10.1182/blood-2009-05-221549 [Abstract] [Full Text] [PDF]   26 October 2009 Patrycja Sroczynska, Christophe Lancrin, Valerie Kouskoff, and Georges Lacaud The differential activities of Runx1 promoters define milestones during embryonic hematopoiesis Blood First Edition Paper, prepublished online October 26, 2009; DOI 10.1182/blood-2009-05-222307 [Abstract] [Full Text] [PDF]   23 October 2009 Dominique J.P.M. Stumpel, Pauline Schneider, Eddy H.J. van Roon, Judith M. Boer, Paola de Lorenzo, Maria G. Valsecchi, Renee X. de Menezes, Rob Pieters, and Ronald W. Stam Specific promoter methylation identifies different subgroups of MLL-rearranged infant acute lymphoblastic leukemia, influences clinical outcome, and provides therapeutic options Blood First Edition Paper, prepublished online October 23, 2009; DOI 10.1182/blood-2009-06-227660 [Abstract] [Full Text] [PDF] [Supplemental Results, Methods, Tables, and Figures]   Kim L. Rice, Itsaso Hormaeche, Sergei Doulatov, Jared M. Flatow, David Grimwade, Ken I. Mills, Magdalena Leiva, Julien Ablain, Charuta Ambardekar, Melanie J. McConnell, John E. Dick, and Jonathan D. Licht Comprehensive genomic screens identify a role for PLZF-RAR as a positive regulator of cell proliferation via direct regulation of c-MYC Blood First Edition Paper, prepublished online October 23, 2009; DOI 10.1182/blood-2009-03-206524 [Abstract] [Full Text] [PDF]   Roberto M. Lemoli, Valentina Salvestrini, Elisa Bianchi, Francesco Bertolini, Miriam Fogli, Marilina Amabile, Agostino Tafuri, Simona Salati, Roberta Zini, Nicoletta Testoni, Cristina Rabascio, Lara Rossi, Ines Martin-Padura, Fausto Castagnetti, Paola Marighetti, Giovanni Martinelli, Michele Baccarani, Sergio Ferrari, and Rossella Manfredini Molecular and functional analysis of the stem cell compartment of chronic myelogenous leukemia reveals the presence of a CD34- cell population with intrinsic resistance to imatinib Blood First Edition Paper, prepublished online October 23, 2009; DOI 10.1182/blood-2008-08-176016 [Abstract] [Full Text] [PDF]   Przemyslaw Juszczynski, Linfeng Chen, Evan O'Donnell, Jose M. Polo, Stella M. Ranuncolo, Riccardo Dalla-Favera, Ari Melnick, and Margaret A. Shipp BCL6 regulates tonic BCR signaling in diffuse large B-cell lymphomas by repressing the SYK phosphatase, PTPROt Blood First Edition Paper, prepublished online October 23, 2009; DOI 10.1182/blood-2009-02-204362 [Abstract] [Full Text] [PDF]   Cindy Banh, Celine Fugere, and Laurent Brossay Immunoregulatory functions of KLRG1 cadherin interactions are dependent on forward and reverse signaling Blood First Edition Paper, prepublished online October 23, 2009; DOI 10.1182/blood-2009-06-228353 [Abstract] [Full Text] [PDF]   Yacine Boulaftali, Frederic Adam, Laurence Venisse, Veronique Ollivier, Benjamin Richard, Sabrina Taieb, Denis Monard, Remi Favier, Marie-Christine Alessi, Marijke Bryckaert, Veronique Arocas, Martine Jandrot-Perrus, and Marie-Christine Bouton Anticoagulant and antithrombotic properties of platelet protease nexin-1 Blood First Edition Paper, prepublished online October 23, 2009; DOI 10.1182/blood-2009-04-217240 [Abstract] [Full Text] [PDF]   Bob Meek, Silvie Cloosen, Chiara Borsotti, Catharina H.M.J. Van Elssen, Joris Vanderlocht, Melanie C.A. Schnijderberg, Marjolein W.M. van der Poel, Bas Leewis, Reinout Hesselink, Markus G. Manz, Yoshimoto Katsura, Hiroshi Kawamoto, Wilfred T.V. Germeraad, and Gerard M.J. Bos In vitro differentiated T/NK cell progenitors derived from human CD34+ cells mature in the thymus Blood First Edition Paper, prepublished online October 23, 2009; DOI 10.1182/blood-2009-05-223990 [Abstract] [Full Text] [PDF]   22 October 2009 Ye Ding, Yuka Harada, Jun Imagawa, Akiro Kimura, and Hironori Harada AML1/RUNX1 point mutation possibly promotes leukemic transformation in myeloproliferative neoplasms Blood First Edition Paper, prepublished online October 22, 2009; DOI 10.1182/blood-2009-06-223982 [Abstract] [Full Text] [PDF]   John G Gribben How I treat CLL upfront Blood First Edition Paper, prepublished online October 22, 2009; DOI 10.1182/blood-2009-08-207126 [Abstract] [Full Text] [PDF]   Karl J. Aichberger, Karoline V. Gleixner, Irina Mirkina, Sabine Cerny-Reiterer, Barbara Peter, Veronika Ferenc, Michael Kneidinger, Christian Baumgartner, Matthias Mayerhofer, Alexander Gruze, Winfried F. Pickl, Christian Sillaber, and Peter Valent Identification of pro-apoptotic Bim as a tumor suppressorin neoplastic mast cells: role of KIT D816V and effects of various targeted drugs Blood First Edition Paper, prepublished online October 22, 2009; DOI 10.1182/blood-2008-08-175190 [Abstract] [Full Text] [PDF]   Jitka Malcikova, Jana Smardova, Ludmila Rocnova, Boris Tichy, Petr Kuglik, Vladimira Vranova, Sona Cejkova, Miluse Svitakova, Hana Skuhrova Francova, Yvona Brychtova, Michael Doubek, Martin Brejcha, Martin Klabusay, Jiri Mayer, Sarka Pospisilova, and Martin Trbusek Monoallelic and biallelic inactivation of TP53 gene in chronic lymphocytic leukemia: selection, impact on survival and response to DNA damage Blood First Edition Paper, prepublished online October 22, 2009; DOI 10.1182/blood-2009-07-234708 [Abstract] [Full Text] [PDF] [Supplemental Table and Figure]   Ramiro Garzon, Catherine E.A. Heaphy, Violaine Havelange, Muller Fabbri, Stefano Volinia, Twee Tsao, Nicola Zanesi, Steven M. Kornblau, Guido Marcucci, George A. Calin, Michael Andreeff, and Carlo M. Croce MicroRNA 29b functions in acute myeloid leukemia Blood First Edition Paper, prepublished online October 22, 2009; DOI 10.1182/blood-2009-03-211938 [Abstract] [Full Text] [PDF]   Julie Lacombe, Sabine Herblot, Shanti Rojas-Sutterlin, Andre Haman, Stephane Barakat, Norman N. Iscove, Guy Sauvageau, and Trang Hoang Scl regulates the quiescence and the long-term competence of hematopoietic stem cells Blood First Edition Paper, prepublished online October 22, 2009; DOI 10.1182/blood-2009-01-201384 [Abstract] [Full Text] [PDF]   Scott M. Vanderwerf, Johanna Svahn, Susan Olson, R. Keaney Rathbun, Christina Harrington, Jane Yates, Winifred Keeble, David C. Anderson, Praveen Anur, Noemi F. Pereira, Daniela V. Pilonetto, Ricardo Pasquini, and Grover C. Bagby TLR8-dependent TNF over-expression in Fanconi anemia group C cells Blood First Edition Paper, prepublished online October 22, 2009; DOI 10.1182/blood-2009-05-222414 [Abstract] [Full Text] [PDF]   21 October 2009 Michel Jourdan, Anouk Caraux, John De Vos, Genevieve Fiol, Marion Larroque, Chantal Cognot, Caroline Bret, Christophe Duperray, Dirk Hose, and Bernard Klein An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization Blood First Edition Paper, prepublished online October 21, 2009; DOI 10.1182/blood-2009-07-235960 [Abstract] [Full Text] [PDF] [Supplemental Methods, Tables, and Figures]   Thomas H. Chase, Bonnie L. Lyons, Roderick T. Bronson, Oded Foreman, Leah Rae Donahue, Lisa M. Burzenski, Bruce Gott, Priscilla Lane, Belinda Harris, Uta Ceglarek, Joachim Thiery, Henning Wittenburg, Jonathan N. Thon, Joseph E. Italiano Jr, Kenneth R. Johnson, and Leonard D. Shultz The mouse mutation "thrombocytopenia and cardiomyopathy" (trac) disrupts Abcg5: a spontaneous single gene model for human hereditary phytosterolemia/sitosterolemia Blood First Edition Paper, prepublished online October 21, 2009; DOI 10.1182/blood-2009-05-219808 [Abstract] [Full Text] [PDF]   Marta Lionetti, Marta Biasiolo, Luca Agnelli, Katia Todoerti, Laura Mosca, Sonia Fabris, Gabriele Sales, Giorgio Lambertenghi Deliliers, Silvio Bicciato, Luigia Lombardi, Stefania Bortoluzzi, and Antonino Neri Identification of microRNA expression patterns and definition of a microRNA/mRNA regulatory network in distinct molecular groups of multiple myeloma Blood First Edition Paper, prepublished online October 21, 2009; DOI 10.1182/blood-2009-08-237495 [Abstract] [Full Text] [PDF]   Drew Provan, Roberto Stasi, Adrian C. Newland, Victor S. Blanchette, Paula Bolton-Maggs, James B. Bussel, Beng H. Chong, Douglas B. Cines, Terry B. Gernsheimer, Bertrand Godeau, John Grainger, Ian Greer, Beverley J. Hunt, Paul A. Imbach, Gordon Lyons, Robert McMillan, Francesco Rodeghiero, Miguel A. Sanz, Michael Tarantino, Shirley Watson, Joan Young, and David J. Kuter International consensus report on the investigation and management of primary immune thrombocytopenia Blood First Edition Paper, prepublished online October 21, 2009; DOI 10.1182/blood-2009-06-225565 [Abstract] [Full Text] [PDF] [Supplemental Appendices]   20 October 2009 Michael R. Grever How I treat hairy cell leukemia Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-06-195370 [Abstract] [Full Text] [PDF]   Christiane L. Belele, Milton A. English, Jagman Chahal, Anthony Burnetti, Steven M. Finckbeiner, Gretchen Gibney, Martha Kirby, Raman Sood, and Paul Liu Differential requirement for Gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-05-224709 [Abstract] [Full Text] [PDF]   Ronen Ben-Ami, Russell E. Lewis, Konstantinos Leventakos, and Dimitrios P. Kontoyiannis Aspergillus fumigatus inhibits angiogenesis through the production of gliotoxin and other secondary metabolites Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-07-231209 [Abstract] [Full Text] [PDF]   Christoph Bucher, Lisa Jasperson, Christine Vogtenhuber, Emily Goren, Meghan Munger, Angela Panoskaltsis-Mortari, Pallavur Sivakumar, and Bruce R. Blazar IL-21 blockade reduces graft-versus-host-disease mortality by supporting inducible T regulatory cell generation Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-05-221135 [Abstract] [Full Text] [PDF]   Geraldine Blanchard-Rohner, Anoop S. Pulickal, Cornelia M. Jol-van der Zijde, Matthew D. Snape, and Andrew J. Pollard Appearance of peripheral blood plasma cells and memory B-cells in a primary and secondary immune response in humans Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-03-211052 [Abstract] [Full Text] [PDF]   Franck E. Nicolini, Michael J. Mauro, Giovanni Martinelli, Dong-Wook Kim, Simona Soverini, Martin C. Muller, Andreas Hochhaus, Jorge Cortes, Charles Chuah, Inge H. Dufva, Jane F. Apperley, Fumiharu Yagasaki, Jay D. Pearson, Senaka Peter, Cesar Sanz Rodriguez, Claude Preudhomme, Francis Giles, John M. Goldman, and Wei Zhou Epidemiological study on survival of chronic myeloid leukemia (CML) and Ph+ acute lymphoblastic leukemia (ALL) patients with BCR-ABL T315I mutation Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-04-219410 [Abstract] [Full Text] [PDF]   John C. Byrd, Thomas J. Kipps, Ian W. Flinn, Januaro Castro, Thomas S. Lin, William Wierda, Nyla Heerema, James Woodworth, Steve Hughes, Shabnam Tangri, Sarah Harris, Dee Wynne, Arturo Molina, Bryan Leigh, and Susan O'Brien Phase 1/2 study of lumiliximab combined with fludarabine, cyclophosphamide, and rituximab in patients with relapsed or refractory chronic lymphocytic leukemia Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-08-237727 [Abstract] [Full Text] [PDF]   Pier M. Mannucci, Roger E.G. Schutgens, Elena Santagostino, and Evelien P. Mauser-Bunschoten How I treat age-related morbidities in elderly persons with hemophilia Blood First Edition Paper, prepublished online October 20, 2009; DOI 10.1182/blood-2009-07-215665 [Abstract] [Full Text] [PDF]   16 October 2009 Shannon K. McWeeney, Lucy C. Pemberton, Marc M. Loriaux, Kristina Vartanian, Stephanie G. Willis, Gregory Yochum, Beth Wilmot, Yaron Turpaz, Raji Pillai, Brian J. Druker, Jennifer L. Snead, Mary MacPartlin, Stephen G. O'Brien, Junia V. Melo, Thoralf Lange, Christina A. Harrington, and Michael W. Deininger A gene expression signature of CD34+ cells to predict major cytogenetic response in chronic phase chronic myeloid leukemia patients treated with imatinib Blood First Edition Paper, prepublished online October 16, 2009; DOI 10.1182/blood-2009-03-210732 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Faten Bougaten, Cathy Quemener, Sabrina Kellouche, Benyoussef Naimi, Marie-Pierre Podgorniak, Guy Millot, Eric E Gabison, Fabien Calvo, Christine Dosquet, Celeste Lebbe, Suzanne Menashi, and Samia Mourah EMMPRIN promotes angiogenesis through HIF-2 mediated regulation of soluble VEGF isoforms and their receptor VEGFR-2 Blood First Edition Paper, prepublished online October 16, 2009; DOI 10.1182/blood-2009-04-217380 [Abstract] [Full Text] [PDF]   Anne-Marit Sponaas, Ana Paula Freitas do Rosario, Cecile Voisine, Beatris Mastelic, Joanne Thompson, Sandra Koernig, William Jarra, Laurent Renia, Marjorie Mauduit, Alexandre Potocnik, and Jean Langhorne Migrating monocytes recruited to the spleen play an important role in control of blood stage malaria Blood First Edition Paper, prepublished online October 16, 2009; DOI 10.1182/blood-2009-04-217489 [Abstract] [Full Text] [PDF] [Supplemental Table and Figures]   Lijuan Chen, Siqing Wang, Yiming Zhou, Xiaosong Wu, Igor Entin, Joshua Epstein, Shmuel Yaccoby, Wei Xiong, Bart Barlogie, John D. Shaughnessy Jr, and Fenghuang Zhan Identification of early growth response protein 1 (EGR-1) as a novel target for JUN-induced apoptosis in multiple myeloma Blood First Edition Paper, prepublished online October 16, 2009; DOI 10.1182/blood-2009-03-210526 [Abstract] [Full Text] [PDF]   14 October 2009 Nicholas T. Funderburg, Elizabeth Mayne, Scott F. Sieg, Robert Asaad, Wei Jiang, Magdalena Kalinowska, Angel A. Luciano, Wendy Stevens, Benigno Rodriguez, Jason M. Brenchley, Daniel C. Douek, and Michael M. Lederman Increased tissue factor expression on circulating monocytes in chronic HIV infection: relationship to in vivo coagulation and immune activation Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-03-210179 [Abstract] [Full Text] [PDF]   Huei-Ting Tsai, Neil E. Caporaso, Robert A. Kyle, Jerry A. Katzmann, Angela Dispenzieri, Richard B. Hayes, Gerald E Marti, Maher Albitar, Paolo Ghia, S. Vincent Rajkumar, and Ola Landgren Evidence of serum immunoglobulin abnormalities up to 9.8 years prior to diagnosis of chronic lymphocytic leukemia: a prospective study Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-08-237651 [Abstract] [Full Text] [PDF]   Bohua Li, Lei Zhao, Huaizu Guo, Chong Wang, Xunming Zhang, Lan Wu, Lin Chen, Qing Tong, Weizhu Qian, Hao Wang, and Yajun Guo Characterization of a rituximab variant with potent antitumor activity against rituximab-resistant B-cell lymphoma Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-06-225474 [Abstract] [Full Text] [PDF]   Tho Pham, Christopher J. Gregg, Felix Karp, Renee Chow, Vered Padler-Karavani, Hongzhi Cao, Xi Chen, Joseph L. Witztum, Nissi M. Varki, and Ajit Varki Evidence for a novel human-specific xeno-auto-antibody response against vascular endothelium Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-05-220400 [Abstract] [Full Text] [PDF]   Yongchao Wang, Warren Fiskus, Daniel G. Chong, Kathleen M. Buckley, Kavita Natarajan, Rekha Rao, Atul Joshi, Ramesh Balusu, Sanjay Koul, Jianguang Chen, Andrew Savoie, Celalettin Ustun, Anand P. Jillella, Peter Atadja, Ross L. Levine, and Kapil N. Bhalla Co-treatment with panobinostat and JAK2 inhibitor TG101209 attenuates JAK2V617F levels and signaling and exerts synergistic cytotoxic effects against human myeloproliferative neoplasm cells Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-05-222133 [Abstract] [Full Text] [PDF] [Supplemental Figure]   Andrew D Mumford, Ban B Dawood, Martina E Daly, Sherina L Murden, Michael D Williams, Majd B Protty, Jennifer C Spalton, Mark Wheatley, Stuart J Mundell, and Steve P Watson A novel thromboxane A2 receptor D304N variant which abrogates ligand binding in a patient with a bleeding diathesis Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-08-236976 [Abstract] [Full Text] [PDF]   David I. Marks, Elisabeth M. Paietta, Anthony V. Moorman, Susan M. Richards, Georgina Buck, Gordon DeWald, Adolfo Ferrando, Adele K. Fielding, Anthony H Goldstone, Rhett P. Ketterling, Mark R. Litzow, Selina M. Luger, Andrew K. McMillan, Marc Mansour, Jacob M. Rowe, Martin S. Tallman, and Hillard M. Lazarus T-cell acute lymphoblastic leukemia in adults: clinical features, immunophenotype, cytogenetics and outcome from the large randomised prospective trial (UKALL XII/ECOG 2993) Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-08-231217 [Abstract] [Full Text] [PDF] [Supplemental Methods]   Eva M. Trinidad, Monica Ballesteros, Jaime Zuloaga, Agustin Zapata, and Luis M. Alonso-Colmenar An impaired transendothelial migration potential of chronic lymphocytic leukemia cells can be linked to ephrin-A4 expression Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-03-210617 [Abstract] [Full Text] [PDF]   Rafijul Bari, Teresa Bell, Wai-Hang Leung, Queenie P. Vong, Wing Keung Chan, Neha Das Gupta, Martha Holladay, Barbara Rooney, and Wing Leung Significant functional heterogeneity among KIR2DL1 alleles and a pivotal role of Arginine245 Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-07-231977 [Abstract] [Full Text] [PDF]   Lisa K Jasperson, Christoph Bucher, Angela Panoskaltsis-Mortari, Andrew L Mellor, David H Munn, and Bruce R Blazar Inducing the tryptophan catabolic pathway, indoleamine 2,3-dioxygenase (IDO), for suppression of graft-versus-host disease (GVHD) lethality Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-06-227587 [Abstract] [Full Text] [PDF]   Maaike Luesink, Jeroen L. A. Pennings, Willemijn M. Wissink, Peter C.M. Linssen, Petra Muus, Rolph Pfundt, Theo J. M. de Witte, Bert A. van der Reijden, and Joop H. Jansen Chemokine induction by all-trans retinoic acid and arsenic trioxide in acute promyelocytic leukemia - triggering the differentiation syndrome Blood First Edition Paper, prepublished online October 14, 2009; DOI 10.1182/blood-2009-02-204834 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   12 October 2009 Daniel Corcos, Michael J. Osborn, Louise S. Matheson, Fatima Santos, Xiangang Zou, Jennifer A. Smith, Geoff Morgan, Amanda Hutchings, Maureen Hamon, David Oxley, and Marianne Bruggemann Immunoglobulin aggregation leading to Russell body formation is prevented by the antibody light chain Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-07-234864 [Abstract] [Full Text] [PDF] [Supplemental Table and Figure]   Gianantonio Rosti, Francesca Palandri, Fausto Castagnetti, Massimo Breccia, Luciano Levato, Gabriele Gugliotta, Adele Capucci, Michele Cedrone, Carmen Fava, Tamara Intermesoli, Giovanna Rege Cambrin, Fabio Stagno, Mario Tiribelli, Marilina Amabile, Simona Luatti, Angela Poerio, Simona Soverini, Nicoletta Testoni, Giovanni Martinelli, Giuliana Alimena, Fabrizio Pane, Giuseppe Saglio, and Michele Baccarani Nilotinib for the frontline treatment of Ph+ chronic myeloid leukemia Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-07-232595 [Abstract] [Full Text] [PDF]   Nancy A. Turner, Leticia Nolasco, Zaverio M. Ruggeri, and Joel L. Moake Endothelial cell ADAMTS-13 and VWF: production, release and VWF string cleavage Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-07-231597 [Abstract] [Full Text] [PDF]   Lesleigh S. Abbott, Mariana Deevska, Conrad V. Fernandez, David Dix, Victoria E. Price, Hao Wang, Louise Parker, Margaret Yhap, Colleen Fitzgerald, Dorothy R. Barnard, and Jason N. Berman The impact of prophylactic fresh frozen plasma and cryoprecipitate on the incidence of CNS thrombosis and hemorrhage in children with acute lymphoblastic leukemia receiving asparaginase Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-07-231084 [Abstract] [Full Text] [PDF]   Jonathan A Gutman, Cameron J Turtle, Thomas J Manley, Shelly Heimfeld, Irwin D Bernstein, Stanley R Riddell, and Colleen Delaney Single unit dominance following double unit umbilical cord blood transplantation coincides with a specific CD8+ T cell response against the non-engrafted unit Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-07-228999 [Abstract] [Full Text] [PDF]   Amber N. Stratman, Kristine M. Malotte, Rachel D. Mahan, Michael J. Davis, and George E. Davis Pericyte recruitment during vasculogenic tube assemblystimulates endothelial basement membrane matrix formation Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-05-222364 [Abstract] [Full Text] [PDF] [Supplemental Tables, Figures, and Videos]   Enjing Jin, Ju Liu, Jun-ichi Suehiro, Lei Yuan, Yoshiaki Okada, Vesna Nikolova-Krstevski, Kiichiro Yano, Lauren Janes, David Beeler, Katherine C. Spokes, Dan Li, Erzsebet Regan, Shou-Ching Shih, Peter Oettgen, Takashi Minami, and William C. Aird Differential roles for ETS, CREB and EGR binding sites in mediating VEGF receptor 1 expression in vivo Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-05-220434 [Abstract] [Full Text] [PDF]   Erin A. Kimbrel, Madeleine E. Lemieux, Xiaobo Xia, Tina N. Davis, Vivienne I. Rebel, and Andrew L. Kung Systematic in vivo structure-function analysis of p300 in hematopoiesis Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-04-217794 [Abstract] [Full Text] [PDF] [Supplemental Tables and Figures]   Raewyn Broady, Jie Yu, and Megan K. Levings ATG-induced expression of FOXP3 in human CD4+ T cells in vitro is associated with T cell activation and not the induction of FOXP3+ T regulatory cells Blood First Edition Paper, prepublished online October 12, 2009; DOI 10.1182/blood-2009-04-214437 [Abstract] [Full Text] [PDF]   7 October 2009 Zhao-Yang Wang, Ye-Xiong Li, Wei-Hu Wang, Jing Jin, Hua Wang, Yong-Wen Song, Qing-Feng Liu, Shu-Lian Wang, Yue-Ping Liu, Shu-Nan Qi, Hui Fang, Xin-Fan Liu, and Zi-Hao Yu Primary radiotherapy showed favorable outcome in treating extranodal nasal-type NK/T-cell lymphoma in children and adolescents Blood First Edition Paper, prepublished online October 7, 2009; DOI 10.1182/blood-2009-07-235853 [Abstract] [PDF]   Dalemari Crowther-Swanepoel, Mobshra Qureshi, Martin J. S. Dyer, Estella Matutes, Claire Dearden, Daniel Catovsky, and Richard S. Houlston Genetic variation in CXCR4 and risk of chronic lymphocytic leukemia Blood First Edition Paper, prepublished online October 7, 2009; DOI 10.1182/blood-2009-07-235184 [Abstract] [PDF]   Nicolaus Kroger, Ernst Holler, Guido Kobbe, Martin Bornhaeuser, Rainer Schwerdtfeger, Herrad Baurmann, Arnon Nagler, Wolfgang Bethge, Matthias Stelljes, Lutz Uharek, Hannes Wandt, Andreas Burchert, Paolo Corradini, Jorg Schubert, Martin Kaufmann, Peter Dreger, Gerald G. Wulf, Hermann Einsele, Tatjana Zabelina, Hans Michael Kvasnicka, Juergen Thiele, Ronald Brand, Axel R. Zander, Dietger Niederwieser, and Theo M. de Witte Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the Chronic Leukemia Working Party of the European Group for Blood and Marrow Transplantation (EBMT) Blood First Edition Paper, prepublished online October 7, 2009; DOI 10.1182/blood-2009-07-234880 [Abstract] [PDF]   Sandra Duber, Martin Hafner, Martina Krey, Stefan Lienenklaus, Bishnudeo Roy, Elias Hobeika, Michael Reth, Thorsten Buch, Ari Waisman, Karsten Kretschmer, and Siegfried Weiss Induction of B cell development in adult mice reveals the ability of bone marrow to produce B-1a cells Blood First Edition Paper, prepublished online October 7, 2009; DOI 10.1182/blood-2009-04-218156 [Abstract] [PDF] [Supplemental Table and Figures]   Junmei Chen, Xiaoyun Fu, Yi Wang, Minhua Ling, Brad McMullen, John Kulman, Dominic W. Chung, and Jose A. Lopez Oxidative modification of von Willebrand factor by neutrophil oxidants inhibits its cleavage by ADAMTS13 Blood First Edition Paper, prepublished online October 7, 2009; DOI 10.1182/blood-2009-03-213967 [Abstract] [PDF]   Thomas H Sisson, Mai-Huong Nguyen, Bi Yu, Margaret L Novak, Richard H Simon, and Timothy J Koh Urokinase-type plasminogen activator increases hepatocyte growth factor activity required for skeletal muscle regeneration Blood First Edition Paper, prepublished online October 7, 2009; DOI 10.1182/blood-2008-12-196212 [Abstract] [PDF]   6 October 2009 Jose A. Guerrero, Mark Kyei, Susan Russell, Junling Liu, T. Kent Gartner, Brian Storrie, and Jerry Ware Visualizing the von Willebrand factor/glycoprotein Ib-IX axis with a platelet-type von Willebrand disease mutation Blood First Edition Paper, prepublished online October 6, 2009; DOI 10.1182/blood-2009-03-210823 [Abstract] [PDF]   Jih-Luh Tang, Hsin-An Hou, Chien-Yuan Chen, Chieh-Yu Liu, Wen-Chien Chou, Mei-Hsuan Tseng, Chi-Fei Huang, Fen-Yu Lee, Ming-Chih Liu, Ming Yao, Shang-Yi Huang, Bor-Sheng Ko, Szu-Chun Hsu, Shang-Ju Wu, Woei Tsay, Yao-Chang Chen, Liang-In Lin, and Hwei-Fang Tien AML1/RUNX1 mutations in 470 adult patients with de novo acute myeloid leukemia: prognostic implication and interaction with other gene alterations Blood First Edition Paper, prepublished online October 6, 2009; DOI 10.1182/blood-2009-05-223784 [Abstract] [PDF]   Goichi Yoshimoto, Toshihiro Miyamoto, Siamak Jabbarzadeh-Tabrizi, Tadafumi Iino, Jennifer L. Rocnik, Yoshikane Kikushige, Yasuo Mori, Takahiro Shima, Hiromi Iwasaki, Katsuto Takenaka, Koji Nagafuji, Shin-ichi Mizuno, Hiroaki Niiro, Gary D. Gilliland, and Koichi Akashi FLT3-ITD upregulates MCL-1 to promote survival of stem cells in acute myeloid leukemia via FLT3-ITD-specific STAT5 activation Blood First Edition Paper, prepublished online October 6, 2009; DOI 10.1182/blood-2008-12-196055 [Abstract] [PDF]   5 October 2009 Jeffrey M. Milush, Brian R. Long, Jennifer E. Snyder-Cappione, Amedeo J. Cappione III, Vanessa A. York, Lishomwa C. Ndhlovu, Lewis L. Lanier, Jakob L. Michaelsson, and Douglas F. Nixon Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by co-expression of CD56, CD7, and CD4 Blood First Edition Paper, prepublished online October 5, 2009; DOI 10.1182/blood-2009-04-216374 [Abstract] [PDF]   Nicolas Gaudenzio, Nicolas Espagnole, Lennart T. Mars, Roland Liblau, Salvatore Valitutti, and Eric Espinosa Cell-cell cooperation at the T helper cell/mast cell immunological synapse Blood First Edition Paper, prepublished online October 5, 2009; DOI 10.1182/blood-2009-02-202648 [Abstract] [PDF]   Marina P. Sikara, John G. Routsias, Martina Samiotaki, George Panayotou, Haralampos M. Moutsopoulos, and Panayiotis G. Vlachoyiannopoulos 2 glycoprotein I (2GPI) binds platelet factor 4 (PF4): implications for the pathogenesis of antiphospholipid syndrome Blood First Edition Paper, prepublished online October 5, 2009; DOI 10.1182/blood-2009-03-206367 [Abstract] [PDF]   Jason A. Powell, Daniel Thomas, Emma F. Barry, Chung H. Kok, Barbara J. McClure, Anna Tsykin, L. Bik To, Anna Brown, Ian D. Lewis, Kirsten Herbert, Gregory J. Goodall, Terence P. Speed, Norio Asou, Bindya Jacob, Motomi Osato, David N. Haylock, Susan K. Nilsson, Richard J. D'Andrea, Angel F. Lopez, and Mark A. Guthridge Expression profiling of a hemopoietic cell survival transcriptome implicates osteopontin as a functional prognostic factor in AML Blood First Edition Paper, prepublished online October 5, 2009; DOI 10.1182/blood-2009-02-204818 [Abstract] [PDF]   Siao-Yi Wang, Suresh Veeramani, Emilian Racila, Jeffrey Cagley, David Fritzinger, Carl-Wilhelm Vogel, William St. John, and George J. Weiner Depletion of the C3 component of complement enhances the ability of rituximab-coated target cells to activate human NK cells and improves the efficacy of monoclonal antibody therapy in an in vivo model Blood First Edition Paper, prepublished online October 5, 2009; DOI 10.1182/blood-2009-01-200469 [Abstract] [PDF]   2 October 2009 Kunju Sridhar, Douglas T. Ross, Robert Tibshirani, Atul J. Butte, and Peter L. Greenberg Relationship of differential gene expression profiles in CD34+ myelodysplastic syndrome marrow cells to disease subtype and progression Blood First Edition Paper, prepublished online October 2, 2009; DOI 10.1182/blood-2009-08-236422 [Abstract] [PDF]   Arnaud Gandillet, Alicia G. Serrano, Stella Pearson, Michael Lie-A-Ling, Georges Lacaud, and Valerie Kouskoff Sox7-sustained expression alters the balance between proliferation and differentiation of hematopoietic progenitors at the onset of blood specification Blood First Edition Paper, prepublished online October 2, 2009; DOI 10.1182/blood-2009-06-226290 [Abstract] [PDF]   Stefan Kunert, Imke Meyer, Silke Fleischhauer, Martin Wannack, Janine Fiedler, Ramesh A. Shivdasani, and Harald Schulze The microtubule modulator RanBP10 plays a critical role in regulation of platelet discoid shape and degranulation Blood First Edition Paper, prepublished online October 2, 2009; DOI 10.1182/blood-2009-04-216804 [Abstract] [PDF] [Supplemental Figure]   1 October 2009 Julie A. Vrana, Jeffrey D Gamez, Benjamin J. Madden, Jason D. Theis, H. Robert Bergen III, and Ahmet Dogan Classification of amyloidosis by laser microdissection and mass spectrometry based proteomic analysis in clinical biopsy specimens Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-07-230722 [Abstract] [PDF] [Supplemental Methods, Tables, Figures, and Video]   Nicoletta Testoni, Giulia Marzocchi, Simona Luatti, Marilina Amabile, Carmen Baldazzi, Monica Stacchini, Mauro Nanni, Giovanna Rege-Cambrin, Emilia Giugliano, Ursula Giussani, Elisabetta Abruzzese, Simonetta Kerim, Maria Grazia Grimoldi, Alessandro Gozzetti, Barbara Crescenzi, Carlo Carcassi, Paolo Bernasconi, Antonio Cuneo, Francesco Albano, Giuseppina Fugazza, Alfonso Zaccaria, Giovanni Martinelli, Fabrizio Pane, Gianantonio Rosti, and Michele Baccarani Chronic myeloid leukemia: a prospective comparison of interphase fluorescence in situ hybridization and chromosome banding analysis for the definition of complete cytogenetic response, a study of the GIMEMA CML WP Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-07-229864 [Abstract] [PDF]   Martin S. Tallman and Jessica K. Altman How I treat acute promyelocytic leukemia Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-07-216457 [Abstract] [PDF]   Robert A. Campbell, Katherine A. Overmyer, Craig H. Selzman, Brett C. Sheridan, and Alisa S. Wolberg Contributions of extravascular and intravascular cells to fibrin network formation, structure, and stability Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-06-228940 [Abstract] [PDF]   Carlos Fernandez de Larrea, Maria Teresa Cibeira, Montserrat Elena, Juan Ignacio Arostegui, Laura Rosinol, Montserrat Rovira, Xavier Filella, Jordi Yague, and Joan Blade Abnormal serum free light chain ratio in patients with multiple myeloma in complete remission has strong association with the presence of oligoclonal bands: implications for stringent complete remission definition Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-06-224832 [Abstract] [PDF]   Daniel Lewandowski, Vilma Barroca, Frederic Duconge, Jan Bayer, Jeanne Tran Van Nhieu, Carine Pestourie, Pierre Fouchet, Bertrand Tavitian, and Paul-Henri Romeo In vivo cellular imaging pinpoints the role of reactive oxygen species in the early steps of adult hematopoietic reconstitution Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-05-222711 [Abstract] [PDF]   Luis A. Verduzco and David G. Nathan Sickle cell disease and stroke Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-05-220921 [Abstract] [PDF]   Jessica A. Van Ziffle and Clifford A. Lowell Neutrophil specific deletion of Syk kinase results in reduced host defense to bacterial infection Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-05-220806 [Abstract] [PDF] [Supplemental Methods and Figures]   Zhaohui Ye, Huichun Zhan, Prashant Mali, Sarah Dowey, Donna M. Williams, Yoon-Young Jang, Chi V. Dang, Jerry L. Spivak, Alison R. Moliterno, and Linzhao Cheng Human induced pluripotent stem cells from blood cells of healthy donors and patients with acquired blood disorders Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2009-04-217406 [Abstract] [PDF]   Florence C. Guibal, Meritxell Alberich-Jorda, Hideyo Hirai, Alexander Ebralidze, Elena Levantini, Annalisa Di Ruscio, Pu Zhang, Barbara A. Santana-Lemos, Donna Neuberg, Amy J. Wagers, Eduardo M. Rego, and Daniel G. Tenen Identification of a myeloid committed progenitor as the cancer initiating cell in acute promyelocytic leukemia Blood First Edition Paper, prepublished online October 1, 2009; DOI 10.1182/blood-2008-10-182071 [Abstract] [PDF] [Supplemental Methods, Tables, and Figures]   30 September 2009 Xiao-juan Zhu, Yan Shi, Jun Peng, Cheng-shan Guo, Ning-ning Shan, Ping Qin, Xue-bin Ji, and Ming Hou The effects of BAFF and BAFF-R-Fc fusion protein in immune thrombocytopenia Blood First Edition Paper, prepublished online September 30, 2009; DOI 10.1182/blood-2009-05-217513 [Abstract] [PDF]   Andrea Annoni, Brian D Brown, Alessio Cantore, Lucia Sergi Sergi, Luigi Naldini, and Maria-Grazia Roncarolo In vivo delivery of a microRNA regulated transgene induces antigen-specific regulatory T cells and promotes immunological tolerance Blood First Edition Paper, prepublished online September 30, 2009; DOI 10.1182/blood-2009-04-214569 [Abstract] [PDF]   29 September 2009 Jordan A. Shavit, Ani Manichaikul, Heidi L. Lemmerhirt, Karl W. Broman, and David Ginsburg Modifiers of von Willebrand factor identified by natural variation in inbred strains of mice Blood First Edition Paper, prepublished online September 29, 2009; DOI 10.1182/blood-2009-07-233213 [Abstract] [PDF]   Carlo Calissano, Rajendra N. Damle, Gregory Hayes, Elizabeth J. Murphy, Marc K. Hellerstein, Carol Moreno, Cristina Sison, Matthew S. Kaufman, Jonathan E. Kolitz, Steven L. Allen, Kanti R. Rai, and Nicholas Chiorazzi In vivo intra- and inter-clonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia Blood First Edition Paper, prepublished online September 29, 2009; DOI 10.1182/blood-2009-05-219634 [Abstract] [PDF]   Alexander Nystrom, Zabeena P. Shaik, Donald Gullberg, Thomas Krieg, Beate Eckes, Roy Zent, Ambra Pozzi, and Renato V. Iozzo Role of tyrosine phosphatase SHP-1 in the mechanism of endorepellin angiostatic activity Blood First Edition Paper, prepublished online September 29, 2009; DOI 10.1182/blood-2009-02-207134 [Abstract] [PDF]   Kate A Markey, Angela C Burman, Tatjana Banovic, Rachel D Kuns, Neil C Raffelt, Vanessa Rowe, Stuart D Olver, Alistair LJ Don, Edward S Morris, Allison R Pettit, Yana A Wilson, Renee J Robb, Louise M Randall, Heinrich Korner, Christian R Engwerda, Andrew D Clouston, Kelli PA MacDonald, and Geoffrey R Hill Soluble lymphotoxin is an important effector molecule in GVHD and GVL Blood First Edition Paper, prepublished online September 29, 2009; DOI 10.1182/blood-2009-01-199927 [Abstract] [PDF]   28 September 2009