http://bloodjournal.hematologylibrary.org Blood RSS feed -- recent REVIEW IN TRANSLATIONAL HEMATOLOGY articles 1528-0020 Blood 0006-4971 http://bloodjournal.hematologylibrary.org/icons/banner/title.gif http://bloodjournal.hematologylibrary.org http://bloodjournal.hematologylibrary.org/cgi/content/short/111/10/4862?rss=1 Human leukocyte antigen G (HLA-G) is a nonclassic major histocompatibility complex (MHC) class I molecule that functions as an immunomodulatory molecule capable of protecting fetal tissues from the maternal immune system. The relevance of HLA-G in other contexts was investigated soon afterward. Numerous studies have sought (and some have shown) the relevance of HLA-G in pathologic conditions, such as transplantation, autoimmunity, and cancer and hematologic malignancies. One of the main goals of the current research on HLA-G is now to use it in the clinic, either for diagnosis or as a therapeutic tool/target. For this, precise knowledge on the nature and functions of HLA-G is critical. We highlight here what we consider are recent key basic findings on the immunomodulatory function of HLA-G. These strengthen the case for considering HLA-G as clinically relevant.

]]> 2008-05-08 info:doi/10.1182/blood-2007-12-127662 American Society of Hematology 10 111 4870 2008-05-15 4862 REVIEW IN TRANSLATIONAL HEMATOLOGY